The mnemonic for G-Protein Coupled Receptors could be improved by writing "Go to AC for Craps and Poka". Poka (as opposed to Poker) helps remember PKA even better! Credit to Meryl Braun for the idea!
I just noticed Dopamine wasn't included as a GPCR! It affects Gs (b1), Gi (a2), and Gq (a1) as well as D1 and D2 receptors. I'm still trying to understand more of its effects though
The amount of joy it brings me when I look up a concept on UA-cam and see that you have a video on it is immeasurable. I just know that a concept that I was struggling with is going to suddenly become way more understandble 💖
I SPENT AN HOUR TRYING TO UNDERSTAND THIS USING MY PROFESSORS LECTURE AND NOTES AND BY THE END I WAS STILL CONFUSED. BY WATCHING THIS VIDEO I UNDERSTOOD RIGHT AWAY. THANK YOU SO MUCH FROM THE BOTTOM OF MY HEART REALLY
Thank you for your clear explanation. Just for the fact, i like to point out that MAP-kinase-kinase-kinase is called Raf, MAP-kinase-kinase is called Mek and MAP-kinase is called Erk. (You mentioned MAP-kinase-kinase-kinase controls Raf and so on at time 13:20 to 13:27).
Yeah, that actually confused me. Raf IS the MAP3K, like Erk is the MAP2K... He said it like if they were non enzymatic proteins being controlled by something else.
As a nursing student, I watch a LOT of educational videos, but this is the first that led me to actually comment. Very solid video, very helpful. You made a lot more sense than my professor explaining this topic, and I find your mnemonic memorable. Thank you!
i literally just decided i was going to take the Ls on these questions, and then BOOM! Dirty saves the day 🥳bring on the signal transduction q's IM READYYYYYY 😤
Also, keep in mind everyone that: - increased levels of GTPase = decreased Gq/Gs/Gi activation. - if they talk about activation of a G-protein followed by a phospholipid cleavage = Gq pathway
Thank you so much. I never understood this for first two years of med school. Finally today I needed to understand this for pharmacology and YOU somehow sprinkled sense into it. THANKS A LOT ONCE AGAIN.
Hey! Thank you for your biochemistry videos they helped me a lot last semester. I wish you could do more videos like this one because it appears now in my molecular biology course and only you can save me from this awful course 🙏🏻🙏🏻🙏🏻
Hello! Thank you very much Mr dirty for this video it really helped me break down this complex topic uno something easily understandable with extra learning and I am hoping to see a topic on : apoptosis and necrosis on day arigatou go sai ma su and may God bless you😁
Wow I've been needing a mnemonic for thisss! Thank you!!! Do you have a video on the Heme synthesis pathway & porphyrias? I haven't found it and I can't think of a mnemonic! I always forget the steps for this pathway!
15:45 so you end on a high note and feel like you dominated this video 😂😂. Reminds me of Yuval Harari's book, Homo Deus and all the talk about our biochemistry there. Thanks for the great video ❤
a mnemonic for the substrates was literally layed out for us, I dont know if he didnt mention it because it was obvious and everyone knows them or if it was seriously missed. its the first letter of all substrates in the same order he had in the video for G protein coupled receptors Gs and Gi the substrates are: FLAT CCHHAMP GG. or FLAT CHAMP cggh (pronounced sugah) the 2 Gs can remind you that its Gs AND Gi and the theme of things in pairs of 2 should remind you that its H2 and ADH V2 for Gq: GOAT HAG , there is only 1 goat so its linked to V1 and H1 for RAS: remember its associated with growth and insulin is an anabolic peptide + Growth factors. letters are random IIPFE cGMP; its associated with dilators as he mentioned. NO ANP BNP and Endothelial derived RELAXATION factor are all dialators
Thank you so much for this video. Can you please make a video on genetic/molecular markers for cancers? Also a video on general immunology would be helpful. Thank you.
Do beta blockers block the Gs pathway preventing it from occurring? Or do they somehow activate the G inhibitory pathway? How does the cell know if the alpha subunit is supposed to activate Gi or Gs?
when I can't remember the Gas activates the Adenyl Cyclase pathway, I think of that song GAS GAS GAS I'm gonna STEP ON THE GAS, which gets the adenyl cyclase pathway going...
Do inverse agonists cause the opposite biological cell function to be activated compared to antagonists? Or do they rather cause a more pronounced neutralization of the receptor?
inverse agonists work opposite for example in response to vasodilation antagonist will neutralise it however inverse agonist would cause vasoconstriction
The great dirty🙌:Tells mnemonics to memorize the pathways Meanwhile dirty:forgets to tell mnemonics to memorize the hormones 🥲 Bold of you to assume that we can memorize that ourselves 🤐
The mnemonic for G-Protein Coupled Receptors could be improved by writing "Go to AC for Craps and Poka". Poka (as opposed to Poker) helps remember PKA even better! Credit to Meryl Braun for the idea!
Super explanation sir
you da man
God bless bro
or just read it in a british accent haha
I just noticed Dopamine wasn't included as a GPCR! It affects Gs (b1), Gi (a2), and Gq (a1) as well as D1 and D2 receptors. I'm still trying to understand more of its effects though
"any financial support will help but if you dont donate im still going to make free videos anyway. ", this guy is legend
The amount of joy it brings me when I look up a concept on UA-cam and see that you have a video on it is immeasurable. I just know that a concept that I was struggling with is going to suddenly become way more understandble 💖
I SPENT AN HOUR TRYING TO UNDERSTAND THIS USING MY PROFESSORS LECTURE AND NOTES AND BY THE END I WAS STILL CONFUSED. BY WATCHING THIS VIDEO I UNDERSTOOD RIGHT AWAY. THANK YOU SO MUCH FROM THE BOTTOM OF MY HEART REALLY
I just spent a half hour looking at this page in First Aid completely lost. I could kiss you right now.
you had NO business going this hard 😩🔥
omg where on the FA (page/ FA year)?
@@laurabou1244 They barelyyyy talk about it. It's ridiculous. Page 337 in the 2020 edition.
Oh my god, I was just stating how I wish there was a video on this, thank you so much step in 4 weeks!
came back, 1.5 weeks. prayers please
How did it go? Any surprises?
Thank you for your clear explanation. Just for the fact, i like to point out that MAP-kinase-kinase-kinase is called Raf, MAP-kinase-kinase is called Mek and MAP-kinase is called Erk. (You mentioned MAP-kinase-kinase-kinase controls Raf and so on at time 13:20 to 13:27).
Yeah, that actually confused me. Raf IS the MAP3K, like Erk is the MAP2K... He said it like if they were non enzymatic proteins being controlled by something else.
As a nursing student, I watch a LOT of educational videos, but this is the first that led me to actually comment. Very solid video, very helpful. You made a lot more sense than my professor explaining this topic, and I find your mnemonic memorable. Thank you!
This is the only video on transduction I have found so far that ACTUALLY talks about everything we're studying. Thank you!
i literally just decided i was going to take the Ls on these questions, and then BOOM! Dirty saves the day 🥳bring on the signal transduction q's IM READYYYYYY 😤
Why take an L on anything dude?
Get those pts. You know like 20 questions is the difference between like 50 points lol
This is game day baby! Stay hungry
OMG Thank you!! What my professor couldn't teach me in 1 month you taught me in 17 minutes!!
We should call you Dr Big Picture! Thanks a million! I can never thank you enough for simplifying what seemed un-understandable
Also, keep in mind everyone that:
- increased levels of GTPase = decreased Gq/Gs/Gi activation.
- if they talk about activation of a G-protein followed by a phospholipid cleavage = Gq pathway
..and my Phd professor making 6 figure income couldn’t explain it in 2 hours lecture-shame. Bless you Sir!
Thank you so much. I never understood this for first two years of med school. Finally today I needed to understand this for pharmacology and YOU somehow sprinkled sense into it. THANKS A LOT ONCE AGAIN.
Love your channel & you deserve a million+ followers!! I couldn't thank you enough!!
OMG this is god sent!! Was in dire need of this!
it is important video for medical student, it,s help full and give good idea about signal transaction.
You didn't talk about non receptor tyrosine kinase (the Jak/stat) which is driving me insane. Please help
See medicosis Perfictionalis he explained this top clearly…. JAK GET PIG😂
Cytokine → Receptor → JAK → Phosphorylated STAT → Gene Regulation.
The only video on this topic that I like
I promise I'll donate frequently once I get a job
Interesting presentation .Thank you so much .
this was the clearest explanation!
BLESS U FOR MAKING THIS!!!! my exam is in two weeks!
Hey! Thank you for your biochemistry videos they helped me a lot last semester. I wish you could do more videos like this one because it appears now in my molecular biology course and only you can save me from this awful course 🙏🏻🙏🏻🙏🏻
finally a video that connects Ras w/ Receptor TK.
Wow! This is my tomorrow exam's test content!
Hello! Thank you very much Mr dirty for this video it really helped me break down this complex topic uno something easily understandable with extra learning and I am hoping to see a topic on : apoptosis and necrosis on day arigatou go sai ma su and may God bless you😁
I don't comment on videos often, but damn.... thanks, man!!! ❤
Wow I like me a lot this one video.i am pharmacist especiallized in Pharmacokinetics
Wow I've been needing a mnemonic for thisss! Thank you!!! Do you have a video on the Heme synthesis pathway & porphyrias? I haven't found it and I can't think of a mnemonic! I always forget the steps for this pathway!
Not yet, but it's one of the videos in my queue that should be coming soon. I've already done some of the slides
He does now baby!!!
15:45 so you end on a high note and feel like you dominated this video 😂😂. Reminds me of Yuval Harari's book, Homo Deus and all the talk about our biochemistry there.
Thanks for the great video ❤
Dirty, T_TI love you so muchhhhhhhhhh. You save me from a mess!!!
finally!!!
You are amazing
Step in three days. Perfect timing, Dirty!
3 years later and your video unironically made me enjoy this lmfao
It's comprehensive !
Thanks a lot
So so grateful for your videos
a mnemonic for the substrates was literally layed out for us, I dont know if he didnt mention it because it was obvious and everyone knows them or if it was seriously missed. its the first letter of all substrates in the same order he had in the video
for G protein coupled receptors Gs and Gi the substrates are: FLAT CCHHAMP GG. or FLAT CHAMP cggh (pronounced sugah) the 2 Gs can remind you that its Gs AND Gi and the theme of things in pairs of 2 should remind you that its H2 and ADH V2
for Gq: GOAT HAG , there is only 1 goat so its linked to V1 and H1
for RAS: remember its associated with growth and insulin is an anabolic peptide + Growth factors. letters are random IIPFE
cGMP; its associated with dilators as he mentioned. NO ANP BNP and Endothelial derived RELAXATION factor are all dialators
still doesn't get old. thanks
Ras is activated by grb+sos
Gdp - gtp is used in gpcr but in rtk it's different 😬😬
Thanks a million… you just saved my brain😂😂
OMG thank you sooooo much！！！
Really appreciate your help.
Brilliant video! 👏👏👏👏👏
Thank you very much for your video. It was very helpful
all killa no filla! thanks!
Superb
Thank you so much....you are blessing👍😀
There's absolutely no errors, in this video and the entire content of this video is relevant in (May 14) 2024, right?
Because I'm ready to memorize this for Step 1
New Dirty?! ITS GONNA BE A GREAT DAY!
ok Xavieriteeeee!!! and this vid def saved my life!
@@anianoelle7033 Hey Ania, It is literally amazing!
yesssir!
@@sadhrahamza once its up then its stuck!
you saved my life thank you
Thank you so much! It really helped!
Thank you. You did an amazing job
thanks you. do you have any good way of remembering the hormones related to each pathway
For IP3 mediated: GOAT HAG:- GnRH, Oxytocin, ADH V1, TRH, Histamine H1, Gastrin
For cAMP: FLAT CHAMPs CHuGG:- FSH, LH, ACTH, TSH, CRH, Histamine H2, ADH v2, MSH, PTH, Calcitonin, hCG, Glucagon, GHRH
@@actionman4593 legend
Awesome video...❤ ...BUTTT!!!!!!
Why didn't you just save us the stress of checking the abbreviations 😢
However...10/10
Great video
Excellent.
Thank you so much for this video. Can you please make a video on genetic/molecular markers for cancers? Also a video on general immunology would be helpful. Thank you.
Best taught by najeeb sir
just what i neeeded!!! thank u
Nice work
For Non Receptor Tyrosine Kinase pathway(JAK STAT)
see Medicolis PERFICTIONALIS
I thoughts ras was activated by GEF which is activated by SOS bound to grb2 which is bound to the rtk
Do beta blockers block the Gs pathway preventing it from occurring? Or do they somehow activate the G inhibitory pathway?
How does the cell know if the alpha subunit is supposed to activate Gi or Gs?
Thank you so much sir . It was very helpful video 🙏🙏
Thanks for this great video, but as a question,Angiotensin2 signaling
doesn't work through Gs?
Anyone biology students here
Me and I'm doing terrible
I thought ERK is MAP Kinase? So MAP kinase kinase controls the phosphorylation of ERK because it is the kinase for MAP kinase.
Thank you so much Dirty!!
awesome video!
Thanks!
Great video! thank you for that!
Thankyou Sir.. much obliged 😀🙏🏻
I wish i could make my own medical school and hire you as a professor
when I can't remember the Gas activates the Adenyl Cyclase pathway, I think of that song GAS GAS GAS I'm gonna STEP ON THE GAS, which gets the adenyl cyclase pathway going...
but what about janus kinase receptors? Jak-stat?
You are the best bro
Thank you so much for this video
thank you this video was amazing
Saviour saviour 💕💕💕💕💕💕💕
Great one!
Any video on cytokine receptors and jak/stat pathways
Thank you! Very helpful!
Yaay I asked for this! Thank you!! 💕
hey, you have a nice picture like me :) twinsies
@@PrideofPitchers oh gosh, that’s right 😂
neat and tidy! cheers, my duuude.
Do inverse agonists cause the opposite biological cell function to be activated compared to antagonists? Or do they rather cause a more pronounced neutralization of the receptor?
inverse agonists work opposite for example in response to vasodilation antagonist will neutralise it however inverse agonist would cause vasoconstriction
is there a chance that I could get your presentation?
Thank you so much
Good video
His Mickey Mouse-sounding impression of us is spot on lol
amazing!
which protein does serotonin use?
may God bless you, may your pillow be cold on both sides at night when you sleep.
One minor mistake occured in the video, IP3 causes the calcium release from SR rather than ER.
Huge thanks sir!
thank you so so much🙏
I love this video
I LOVE THIS!!!!
Thank you
What about the signaling pathway for ACH?
The great dirty🙌:Tells mnemonics to memorize the pathways
Meanwhile dirty:forgets to tell mnemonics to memorize the hormones 🥲
Bold of you to assume that we can memorize that ourselves 🤐