Fatty Acid (Beta) Oxidation
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- Опубліковано 18 чер 2024
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I never comment on UA-cam videos but this channel is phenomenal. Honestly, he does a better job then the paid subscription services I use to prepare for boards. I appreciate you sir
Shit, he does a better job than the professors that are PAID TO TEACH US.
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I seriously can't thank you enough! you're a lifesaver Dirty
Honestly, your chanell helped so much with my exam prep for my nutrition bioscience bachelor. Everything is boiled down to the important information. How you explain and display topics just clicks for me!
Your channel tells us the essentials of what we need to know. It is definitely my favourite high yield resource i have found. Thankyou so much!!!!
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I never fully understand this concepts.
Now- everything understood and condensed in my brain.
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Legend. Thank you so much for your videos. You, the organic chemistry tutor, and khan academy are the first three creators/teachers I will give money to just as a way of saying thank you for helping me achieve my goals in university and beyond. Having high quality upper level education available for free on UA-cam will change the world one day. Thanks again to you and your team.
Please never stop making videos you're literally saving lives out here
finally understood what I was reading after watching this vid! Thanks! Simple explanation, fast and AWESOME!
very helpful videos! Thank you very much, I am studying for the MCAT to take it next month and your videos are saving me I never understood biochem the way I do now! The best biochem pathway videos, are simplified and gives the main point and are not overwhelming!
You are highly capable of learning, memorizing and teaching. I could understand fatty acid oxidation as you mentioned the focus on long chain fatty acids. Congratulations for your contributions to us all. From Brazil, thank you. 👏👏👏🙏
lost for words. thank you so much, from the bottom of my heart.
Hey @Dirty Medicine one thing I think would be helpful in future videos is after going over a topic. Immediately do a couple of questions pertaining to said just covered material. Or provide a hotlink to one of your high yield questions that pertains to the just covered material. As always great job.
Dude, your videos are saving my butt. I'm having to cram and these videos are coming in clutch!
Very helpful. Simplifies complex concepts so well. Thank you so much sir. You just saved me going through thousands of lecture slides
I appreciate the time you took to make this-make sense! thank you!!
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Awesome explanation!! Never seen such a kind-hearted person who's willing to give his time for free just to spread knowledge!! I salut u for it!
He makes mega $$$$ from the 30 ads in this video
I swear Im sooooooo upset with myself that I didn't find your channel sooner. I have exams in less than 3 weeks and Im only now learning this concept properly looolllll Better late than never though. THANKS MUCHHHHH
Amaizing video..
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As clear as day now. Many thanks
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Thanks a lot for this well explaining! .. thanks also to my senior for advising me to watch this amazing video
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perfect for my shelf exam form biochemistry. Thank you tons!!!!!!!!!!!!!!!!!
god i hate that i have to learn this in medical school, but i appreacite your content making it bearable and fun.
Thank you Dirty
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Your mnemonics are clever and helpful, even though you say they're stupid.
Thank you very much! This video is very helpful
I rarely leave comments but this was extremely helpful and had to say THANK YOU
SOOO FREAKING GREAT!!! Love ur explanations! THANK YOU! SO helpful for my STEP prep rn
This channel is undersubscribed. These videos are awesome.
Thanks! Please share with friends, colleagues, etc. Would love more subscribers
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dr ryan is quaking... excellent job
very concise explanation!
Amazing explanation!
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10:55 it's already in the mitochondria, it just has 2 membranes, so acyl-coa first diffuses through porins and then it's inside. Also you forgot to mention the enzyme Carnitine Acylcarnitine translocase which moves acyl carnitine through the inner membrane, CAT-2 does something else. CAT-2 puts coa back onto the acetyl group and actively transports carnitine back over to the outer membrane of the mitochondria. Otherwise good video
This is so enjoyable and understandable
Thanks a lot!!!
The best educational videos
Smart presentation as always.
Thanks for the fantastic channel
just a simple mistake in (MCAD deficiency) is it actually hypoketotic hypoglycemia the same as carntine deficiency
Just awesome!
Tanks alot learning from Nigeria got an A in the course tanks
Hello dirty medicine , can you add the slides file you explain to the video description and it will be useful to me
Thank you for the nice job you do and best wishes.
God bless you!
Love your expression "long amount" (length, quantity) !!
Thank you!
I didn’t hear you mention the role of Carnitine Acyl Translocase (CACT) in the carnitinie shuttle system?Is it to be ignored?
i love your videos!!!
love you, thanks
8 people must've accidentally hit the dislike button on their way over to the like button, cuz these videos are awesome
No they are the textbook printers who can see that a only a short/medium time remains for them to be relevant.
thank you
Thank you
ty very much :)
Thank you----!
My heroooooo
this is so great
Lmao Dirty you said exactly what I've been thinking for all of Dedicated when you were like "the reason why this is high yield is because...well it's just some minutiae you have to memorize" STEP would not be the beast it is if they cut out all the random bullshit
That's fantastic
Thanks!👏
Nice job
Bro You are the best
idk how high yield this is but the carnitine system is only used by FA with 14-22 carbons
Please add this to the biochemistry playlist
Thank you sir
Nice video 👍
Glycolysis link please am unable to search it. BTW you are awesome
Amazing 👏 🙀
Thanks 👍 for ur videos but what of the main pathway of lipolysis
So excellent.
couple of things tho
in primary carnitine deficiency, the carnitine cannot be taken up by skeletal and cardiac muscle.
there is also secondary carnitine deficiency, which is secondary to defects in beta oxidation that lead to a built up of acyl carnitine. This acyl carnitine is lost in the urine... and this leads to a carnitine deficiency.
There is also decreased carnitine synthesis in liver disease or in patients using valproic acid (use of this drug reduces renal reabsorption of carnitine)
CPT-II deficiency as you mentioned also effects liver and kidney, other than skeletal muscle. but the form that affects the skeletal muscle is most common and severe. Treatment here includes avoidance of fasting use of high carb diet and supplementation with medium chain fatty acids
plus following the involvement of fatty acyl coA dehydrogenase. Couple of other enzymes are involved like 2 3 enoyl coA hydratase then 3 hydroxy acyl coA dehydrogenase and 3 ketoacyl coA thiolase. An oxidation then a hydration then another oxidation followed by a cleavage
Hey dude, you seem to know to know your shit. Would you be kind enough to elucidate why MCAD results in NON ketogenic hypoglycemia? like why would it be different from primary carnitine deficiency which is HYPO ketogenic
@@deadricchampion6856 FA says hypoketotic for both so just go with that
The whole video is extremely high yield point
Wouldnt you get hypoketotic hypoglycemia in MCAD because you arent making acetyl-CoA and hence cant make ketone body synthesis?
Good very good
I love you seriously
So in first aid it says that MCAD is hypoketotic/hypoglycemic but on the video states that MCAD is nonketotic. I just wanted to know how to distinguish between the two?
i am confuse also, is Ketotic of non Ketotic?
In Myopathic Cat-2 and primary acylcarnitine, would the treatment be the same as Medium Chain Fatty acyl-Co Deh. Deficiency? I.e avoid fasting and eat high carbs?
But why does medium chain acyl co DH deffiency cause hyperammonemia?
Why do you make a distinction between non-ketotic and hypo-ketotic? In both instances, ketones cannot be produced. Thanks!
You said that the fatty acid will diffuse to mitochondrial membrane and then it will need carnitine to move into mitochondria so at the point of carnitine deficiency you are saying that there is no carnitine to take the fatty acid in mitochondrial membrane 🤔🤔 I heard like that
These biochemistry videos are all you need to pass Step 1 (better than Turco/BnB/Lecturio/Kaplan/Sketchy/Pixorize)
Thank you for your videos dirty!
Please what is produced during incomplete oxidation of fatty acid?
Omg thank sm
legend 😍
Maybe a dumb question, hypoketotic vs non-ketotic? hypo ketones are low, but still deteactable? non, they're undetectable?
Anyone know what the difference between non-ketotic and hypoketotic hypoglycemia is? Asking for a friend...
Can Cetyle coa get coverted back yo pyruvate to creat more glucose?
Dirty I have a question for you. WHY and HOW the fatty Acyl-CO-A crosses freely through the outer membrane without any help but not through the inner membrane????🤔🤔🤔
Dude i know you are a great person by providing these content but according to Uworld your Disease page has some errors on it please correct it BOTH SYSTEMIC PRIMARY CARNITINE DEFICIENCY AND MEDIUM CHAIN FATTY ACYL COA DEHYDROGENASE DEFICIENCY CAN HAVE HYPOKETOTIC HYPOGLYCEMIA
That’s what he said. ‘Non-ketonic’ meaning hypoketonic
Does beta oxidation of fatty acids occur strictly in the liver and nowhere else in the body?
What if there's 13 carbon?
is Myopathic CAT-2 deficiency high yield?
why does systemic primary carnitine deficiency show hypoketosis while medium chain fatty acyl coA dehydrogenase deficiency shows no ketones? shouldn't they both show no ketones based on the logic in the pathways shown?
They both show no ketones. Hypoketosis = no ketones
@@thsmusicboy how do we differentiate between both clinically?