Ashwagandha - Antistress and Adaptogenic Effects
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- Опубліковано 27 сер 2024
- Antistress and Adaptogenic Effects of Ashwagandha
Continuing with the series about the effects of Ashwagandha. Today we will discuss the anti-stress and adaptogenic effects of this herb. Ashwagandha helps improve neuronal plasticity, regeneration, and reduce damage and death of these cells. Ashwagandha triggers the upregulation of HSP70 proteins to accomplish this effect. Let's review.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Thursday, Aug. 3 2023
Pharmaceutics | Free Full-Text | Ashwagandha (Withania somnifera)-Current Research on the Health-Promoting Activities: A Narrative Review
www.mdpi.com/1...
Evidence-Based Efficacy of Adaptogens in Fatigue, and Molecular M...: Ingenta Connect
www.ingentacon...
Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target - PMC
www.ncbi.nlm.n....
Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress - ScienceDirect
www.sciencedir...
Phytotherapy Research | Medicinal Chemistry Journal | Wiley Online Library
onlinelibrary....
Frontiers | c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease
www.frontiersi...
Frontiers | DAF-16/FOXO Transcription Factor in Aging and Longevity
www.frontiersi...
I would love to see you break down more plant medicine like this
Being a Ayurveda consultant practitioner we used we used as daily basis in different ailments. What you have explained scientifically is unbelievable . It will definitely help my professional carrier. Thank you Dr. Been
You are welcome.
@DrBeenMedicalLectures Love all of your videos Dr. Been. You have been a blessing for all your priceless knowledge. If you would not mind checking out anhedonia studies with ashwagandha. I've been a naturopathic Dr. For a good while. I have used the different types of ashwagandha ( Sensoril, Shoden and KSM 66 form) in my practice. Thanks again for all you hard work.
Will check. Thank you.
❤
See my new comment on main page for study on adrenal hypo function from ashwaghanda. Other studies show a ~24% drop in morning cortisol with reg use. Caution should be used in any cases with chronic corticosteroids use (prednisone etc), confirmed clinical adrenal insufficiency (vs adrenal fatigue) or Addison’s Disease. Please read the study I give in main page comment. Newer ones show it’s acting like a hydrocortisone drug. Good in right application.
Your ashwaghanda drawing is so adorable 🥰
Thank you
BTW, love the pictures you draw.
Thank you 😍
TIMESTAMPS and SUMMARY
Ashwagandha, or Indian Ginseng is an Indian herb with adaptogenic effects that helps the body adapt to stress, reduces its negative impact, and has various other health benefits.This video continues the discussion and primarily focuses on Heat Shock Protein 70 (Hsp 70) and pathways affected by that.
00:00 🌿 Ashwagandha has an adaptogenic and anti-stress effect by helping broken proteins in cells stay healthy, which in turn helps the cells take care of stress and alleviate it.
01:52 Collection of STUDIES: Ashwagandha (Withania Somnifera) Current Research on the Health Promoting Activities: A narrative Review
02:23 🌿 used for over 3000 years helping the body adapt to stress and reduce its negative impact by regulating metabolism, acting as an antioxidant, and stimulating the immune system.Has been proven to have neuroprotective, adaptogenic, sleep-inducing, anti-inflammatory, antimicrobial, cardioprotective, and anti-diabetic effects.
03:24 Quick review: Dr Been covered these previously: Active Components are Phytochemicals Withanolides and Alkaloids. Anti-Cancer effects. Anti-Inflammatory effects.
04:00 TODAY: Adaptogenic effects of Ashwagandha and stresses both physical and mental..
05:46 🌿 How? Ashwagandha is a metabolic regulator that reduces stress-induced cortisol, hyperglycemia, reverses the increase in: triglycerides, epinephrine, creatinine levels, and interleukin 6, AST and ALT (liver enzymes) and helps with immune system changes.
08:08 🌿 Helps combat the harmful effects of stress by addressing dysfunctions within cells caused by increased cortisol and adrenaline/epinephrine levels which can cause increased: liver enzymes, gastric ulcers, sexual dysfunction, cognitive deficit, mental depression, immunosuppression, and other organ damage due to kidney dysfunction, and hormonal imbalances.
10:53 STRESS MECHANISMS: Proteins inside cells can become denatured (like a fried egg) due to various factors such as heat, acidity, inflammation, enzymes, toxins, and viruses, leading to cellular distress.
12:27 🧬 ***FOR this talk CELLS=NEURONS: Denatured proteins can become tangled and form clumps that can disrupt normal cellular processes, making it difficult for the cell to correct or digest these denatured proteins (especially in the neuronal system) and so they cannot be effectively removed by the caspase and ubiquitination systems.Then we need heat shock proteins, specifically chaperon mediated autophagy type systems, to help prevent protein denaturation and maintain protein integrity within cells.
15:45 Heat shock proteins help stabilize proteins (against denaturation or aggregations) during times of stress in cells, and can be increased through autophagy, intermittent fasting, resveratrol, and coffee.
17:27 🌿 Ashwagandha helps protect cells from dying and getting damaged under stress by upregulating the heat shock proteins (HSP 70 especially), which in turn trigger the JNK pathway for neuronal plasticity, regeneration, reduces cell death and senescence, and can prevent cells from becoming permanently damaged under stress.
21:30 🌿 DAF 16/FOXO Pathway activation: Ashwagandha helps protect cells by integrating various protective pathways, such as JNK pathway, AMPK pathway, TOR pathway, insulin IGF-1 pathway, and more.
24:35 🌿 Ashwagandha has adaptogenic effects, reduces stress, improves exercise performance, and has potential anti-aging and anti-cancer properties through the HSP pathway.
24:43 STUDY: Evidence Based Efficacy of Adaptogens in Fatigue and Molecular Mechanisms relate to their Stress protective activity
25:00 Phyto-adaptogenic effects and can help reduce stress by regulating key mediators of the stress response, such as cortisol and nitric oxide.Ashwagandha and other adaptogenic plants increase the expression of stress sensor protein HSP 70, which in turn enhances resilience and regulates resistance to stress, making them potential drug targets for their chaperone function.
26:00 STUDY: Heat Shock Protein 70(Hsp70) as Emerging Drug Target
26:30 STUDY: Adaptogenic activity of Withania Somnifera: an experimental study using a rat model of chronic stress. Ashwagandha has been shown to improve various negative effects of chronic stress in rats, such as hyperglycemia, cognitive deficits, and immunosuppression, indicating its significant anti-stress and adaptogenic properties.
27:32 STUDY: Adaptogenic activity of a novel, withanolide-free aqueous fraction from the roots of Withania somnifera. Ashwagandha has been shown to improve exercise performance, increase tolerance for hypoxia, and potentially modulate aging and longevity through various signaling pathways.
28:00 STUDY: c-JUN N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease: Ashwagandha helps reduce stress, aging, and cancer development by increasing the HSP pathway, which increase the DAF-16/FOXO pathway making it beneficial for brain health and longevity.
29:47 Please LIKE, SUBSCRIBE and SHARE. Or get Access to Tonnes of Dr BEEN lectures (link in the description). THANKS for all forms of support!
App Eightify and Human-in-the-Loop JMC
Wow! Thank-you.
Being a unani/ greek consultant I feel so proud that u mention many things about asgandh what our books mention
Very good to know.
Yesss this is exactly what I’m craving, epic breakdowns on health mechanisms particularly bio hacking nice love it thanks dr been!
Here we are 😀
Our Marvelous Dr. Been has done it again. This is such valuable information. I agree with another commenter that we would love to see you address more natural herbs that heal.
Niiiiice . I just started this lovely herb a month ago and I definitely noticed many positive effects!
Good to know.
What a lovely coincidence that you put out this video. I just started taking this a few weeks ago and I love it. Thank you for sharing. 🙏🏻
My pleasure.
GOT STRESS? A timely look at Ashwaganda! Thanks Dr. Been. (I'm adding it back to my supplement stack; I hadn't realized its full potential.) Loved the ARTWORK! (I always do, as it also helps me remember.) Thanks for the many ways you teach and entertain us. 😉 🙏
My pleasure. Thank you for liking the art.
Fascinating, DrBeen!
Thank you
Ashwagandha was instrumental in overcoming PTSD.
Great work Dr many thanks for this amazing discussion ❤😊
You are welcome.
Thank you Dr Syed.
Welcome.
I think we have to use this off and on, rather than non -stop. Woujld like to hear more about this. Also about KSM-66.
In April 2023, Denmark banned ashwagandha.
Bearing in mind that we live in a world where scientific studies lack scientific rigor and that studies are often designed to show the desired results, should we believe the Danish authorities or the ashwagandha industry?
I will have to read on this topic. Thank you for your addition.
Love your artwork! Excellent video as always! Plan on utilizing Ashwaganda shortly (following cortisol level test results) for 80-year old suffering from extreme intractable insomnia following vaccine injury - will let you know if it proves helpful; will be trying KSM-66 (root extract) first, if not sufficiently effective will then try Sensoril (root and leaves).
Good luck. Praying for your recovery.
@craig8031 I'm in the same place with insomnia. Most nights (4 out of 7) I'm unable to sleep at all. When I recently added nausea to my symptoms, it prompted me to think about mast cells and histamine intolerance. I then did genetic testing (which is relatively inexpensive these days, for just the raw data) which confirmed some faulty histamine genes & enzymes. Good to know, as it's easier to treat those sx than the insomnia. Best of luck to you!
Im suffering with long covid (17 months). Im going to try it, hope it will work in my case. Thanks for such a valuable information.
I started taking it because of my issues with long Covid and it has eased some of my symptoms and general anxiety. It is not a cure-all, but has definitely made a difference for me. I hope you have some success. It doesn’t hurt to try.
Are the illustrations your own work??? 😮 THEY ARE AMAZING, also the writing, the colors you use.... beautiful. Very clear!
Thank you! I will try this! I have friends who said it worked for them.
Welcome.
Love you bro!
Thank you
@@DrBeenMedicalLectures You have been a beacon, Sir!
Hail from Mississipi, where according to media, we hate everyone - but that is not true.
Finnish saunas at 180 F increase HSPs by 49%, but not infrared saunas. If in Florida just take a walk outside. Or, sit in a hot car with the heat on for a few minutes.
Interesting.
HAHAHAHA! true, I think.Florida is just a little muggy.
@DrBeen Medical Lectures
I’d really like to see your daily supplement intake.
I’m on several but not Ashwaghanda (edit: yet).
Ashwagandha is possibly safe when used for up to 3 months. The long-term safety of ashwagandha is not known. Large doses of ashwagandha might cause stomach upset, diarrhea, and vomiting. Rarely, liver problems, including severe liver failure and a need for liver transplantation, might occur.
As does water
I usually muscle-test usage. I'm amazed that more people don't modulate their intake of anything medicinal with some sort of self-test. Our bodies are constantly shifting in need of any kind of supplement. We have lost that part of the brain that knew what herb to take and what dosage. It can be reactivated.
Fascinating.
Thank you
I SUFFER TERRIABLE STRESS .ANXIETY CRYING ETC . THIS HAS BEEN 100 TIMES WORSE DUE TO MY EXSTREEM PAIN FOR OVER 2YRS DAMAGE FROM THE VAXX ASTRVEN. MY LIFE IS QUITE TERRIFING .THIS TALK IS VERY INTERESTING ...GOOD
I have been using this herb through knowledge of Ayurveda treatments. I use the powdered product 1/4 tsp mixed with Ghee and Honey in equal amounts. I think this is a good way to try the herb because you get the taste and if the body likes the taste then it is probably needed for a long as the taste is acceptable. So for a period of time, until the healing is accomplished. Then the body would reject the taste and one can stop the herb. One way to experiment with it's use.
Hi Thank you so much for the such an amazing videos. I explored your channel a week ago. in this video you emphasize almost every facet of ashwagandha in regards of impact of it on metabolism. You didn’t touch deeply effect of ashwagandha on Nitric oxide synthesis. can you extract this topic a little bit please.Nitric oxide interaction with Ashwagandha..thanks again..
I'm getting quite a few supplements on the counter, now another one?
I love your drawings and explanations!
That all sounds very helpful.
Can you plaese add an information how it could affect people with autoimmundeseases? Might it be a contraindication?
And are there any known side effects?
On your drawings, I don't mind the handwriting, but I find it hard to read.
Thanks for all your great work!
Thank you ❤
My sister was recently diagnosed with ALS. Do you think that Ashwaganda would be beneficial?
For people. With Hashimoto it is good?
I would like to know the answer as well. There is so much conflicting info out there. One says its good for Lupus, Bad for Hashimotos. I have Hashimotos and know I can feel a difference in a good way, cognitive, good sleep, energy. My daughter has both lupus and hashimotos. So should we take it or shouldnt we???? and no doctor I know here on Maui would be able to answer that. Help @DrBeenMedicalLetures
Mayo clinic had some info on this. It said in a case study it revved the thyroid if taken with thyroid meds. Might be an outlier, but worth considering. Symptoms stopped when ashwagandha stopped.
@@tamaraspillis612 Thx for replying. I wonder ....if it revs the thyroid to produce throxine (is that what you mean ?), then maybe no need to take the 75 mg of Levo? Interesting......
What about taking Ashwagandha while having a fever, is it recommended?
Denature meaning to change from the original condition? Damaged cells.
Similar to an egg when it gets fried. Its proteins are denatured by heat.
@@DrBeenMedicalLectures our own body overheats our cells. Am I to assume that cells by themselves have fevers or does this happen when the whole body has a fever. I was suffering from pigeon fever and had problems breathing. I had been using the inhalers. About two years ago I ended up with a collapsed lung and pneumonia in the other lung in November of 21 just after Thanksgiving. Had a temperature of 104•F. After I healed from the lung problems I no longer needed the inhaler. In case you might wonder about my age, I turned 76 July 23. I'm going to try that ashwagandha.
I’m going to take this again for bed. I am not sleeping as my brain won’t stop. Under so much stress lately.
What is your knowledge of 5-HTP?
Doxage in mg or mcg to take by capsule pls?
Does marijuana do similar effects on the human body?
These have other mechanisms.
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