Look into Tribulus for libido. Been using for years and is awesome. Also I use berberine+yohimbine+cardarine as pre-workout. Very good results as well.
Great job! It would be nice if you check finasteride, lycopene and beta sitosterol for prostate enlargement for us older guys who watch your channel! 👴 I am sure you can make many jokes about that, too!
I take taurine for sleep. For me it has a dramatic effect, turning a broken night's sleep of two hours max, to a full six solid hours. It reduces 'stress' dreams as well.
@@canowyrmsworks but needs more liberal dosing. A gram or so does little but for me a 3g or higher dose actually lowers my bp and makes me dopey, although less productive
12:44 a classic case. A whole phd invalidated 😢 i feel your pain though. So many people are just seeking to affirm their positions, not learn, and can’t react appropriately. Thanks for the work that you do! I look forward to following the channel again once you finish your second phd 😉
I would recommend eating fresh orange peppers. They're a great source of Lutein and Zeaxanthin, as well as many other vitamins and minerals. And they're pretty and make a delicious snack.
Nic - As always, your video is factual, economical and actionable. This summary overview is a fabulous holiday gift. I focus on nutrients from unprocessed foods based on my doctor’s recommendations, your videos and those of Gil Carvalho. My use of supplements is sparing, but always includes a daily multivitamin. You provide a valuable service to society. 🎄
Fantastic video! I’m 57 and would love to see a similar video focused specifically on supplements for longevity. I suspect some supplements that score lower for sleep or other effects might rank higher when evaluated for their impact on lifespan. One question I often ask about age-related declines is whether we need to optimize all factors, considering the limiting factor might be the one you're most deficient in-like the “law of limiting factors,” where a water barrel’s capacity is determined by its shortest plank. If it helps me live longer, I don’t mind taking a lot of supplements!
@@Physionic I like both and as usual, your presentation was very well done. At 68 and on a limited budget, I am using Lutein and Zeaxanthin, Omega 3s, and Creatine (on my 2 workout days). I used taurine for about 6 months but was not convinced that it helped that much. I also use GlyNac. I try to keep up with the latest studies and you provide a great service.
Gotta be honest ,ß-Alanine was my "creatine for long duration work". I respond really good to it, increases in lighter loads and cardio work tremendously. I have ADHD and am really disappointed in lions mane but also *very* happy with rhodiola. Hope better quality research will emerge soon
It's important to note, as he carefully does, that these evaluations are only with respect to particular purposes. In particular, glycine is evaluated only for sleep support. This says nothing about it's possible support for glutathione synthesis or collagen synthesis. Or, for that matter, any other potential benefits.
If you are eating adequate protein, there is no way that your glutathione synthesis is limited by glycine. In general it's non-essential and very abundant, so pretty much all your physiological needs will be met. What you are doing with supplementing straight up glycin is inducing a peak in blood concentration, which will allow you to harness its neurological effects (as it's an NMDA agonist as well as some other effects)
@@LucaBl I don't know about glutathione synthesis, but I heard you might be short on glycine for collagen synthesis. Never been a fan of that "non-essential" classification. I think the way you should think about is it, that you don't die because of a deficit in it. But you might not be functioning optimally either. Just because the body could make some things, doesn't mean it does it in sufficient quantity. Just look at creatin. Glycine makes up only 5% of the amino acids in most proteins, but a third in collagen. I think you can make an argument, that you could be short on glycine, even if your total protein intake is "adequate" (assuming your definition isn't like 2g/lb or something crazy like that). The paper "A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis" is an interesting read on that topic.
Hearing about Berberine here - it reminded me of a lab test of a whole bunch of Berberine supplements. Most of them did not contain the declared amount, with a few even bellow 5 % of what was supposed to be in the pills. It made me a little bit sceptical about how many of those studies actually rigorously test what they feed the test subjects.
@@jankadlcek608 saw the same video, the testing on a lot of these is flawed and biased, research some brands and what's in them, NOW seems to be consistently good and they also test other brands for content
Appreciate videos like this, especially since I don't have the education to properly analyze studies myself and I want to know. I have macular degeneration, so my supplement has lutein, zeaxanthin and astaxanthin plus other nutrients. I just started taurine because of a 70+ year old's comment that his eye health has improved, but never heard of taurine for sleep, another big problem now at 66 years old. Only 1g a day in the morning to start. I'd always heard you shouldn't take a single amino acid as a supplement because of potential imbalance. I keep hearing about creatine and this video is pushing me more towards trying it. Very interested in nattokinase as people have told me nattokinase can be more beneficial than vitamin K2 MK-7, which I take 120mcg of now. Vitamin K2 MK-7 actually seems to have lowered my A1c from 5.4 to 5.0, something I didn't expect. Again, thanks for all the work!
Great summary. I have borderline hypertension. I started taking creatine a few weeks ago. I am reading moderate increase in BP. Googling this was inconclusive, some studies found creatine raised BP but most were neutral so inconclusive. Would love to see a deep dive on this as a lot of us are taking meds for BP control, don't want to make it worse.
I find that 500 MG of Niacinamide a day has a very positive effect on my Photodamaged skin. More so than astaxanthin. The scaly redish skin on my forehead which routinely gets Zapped with liquid Nitrogen by my dermatologist is now smooth and healthy and there were some great Studies on this effect.
B12 is probably the safest and most effective B for people to take. B6 is a tricky one as has both positive and negative points for populations as whole , with a net positive, however if do blood work may find out negative portion is n/a to yourself. Niacinamide is pretty safe to apply directly to skin . With B complexes and all most things , just try and eat a great diet of all the colours. Vegans should strongly consider eating adding yeast flakes to foods for B12 , and good sources of choline
Good job! I enjoy your work. I first heard of Taurine in the early 1980's... I read an article about young cats dying (heart attacks) from Taurine deficiency. According to the article cat food manufacturers started adding Taurine to the mix after realizing this.. Some people take it for afib.. That seems like a relevant use for it, and vegans are very likely to develop a Taurine deficiency unless they supplement..
@@Christopher-b1p Menschen können zwar Taurin in kleinen Mengen bilden, einen Teil sollten auch wir mit der Nahrung zufügen. Ausserdem lässt die Taurinbildung im Alter stark nach. Also ist eine Supplementierung durchaus sinnvoll.
I learned a lot! In the age of constant misinformation it's good to have a trustworthy source that doesn't "hype up" these substances and provides *actual* evidence. Good job 👍
Many thanks for your hard work and expertise! Would you comment on Nattokinase’s ability to prevent platelet aggregation and clot prevention. Again thank you!
With Taurine i have the concern that it could lead to GABA receptor downregulation. There was a study with mice that were fed with Taurine and as a result got those down regulating effects. Of course this were mice and i don't know how reliable this study was. But there are also reports of user that get rebound anxiety when the effect of Taurine fades.
I looked at a paper on this. The researchers had concerns about taurine when other gaba agonist were used. That is, other things that bind to GABA receptors. Overall, they found a benefit to using taurine, as it delayed seizures. Taurine itself is difficult to find in food, apparently, apart from s Algae
@@Christopher-b1p sorry. i have translation but it is wrong to asume that everybody has it. For those who eat meat. Highest amounts of taurine are in small muscles. Wings, hearts, etc. So you will get some Taurine with your food as long as you eat meat.
I'm there with you subjectively on Rhodiola! I've also heard enough murmurs from others that--to your point--I expect better research to suss out its true benefits.
Taurine and Glycine are relatively cheap. I used to use 3 teaspoons of sugar in my coffee, now just 1 plus 1/4 teaspoon of Glycine which is not as sweet as sugar (the fructose part), but comparable to glucose.
Love your work. Great videos. I don't see a video on ALPHA LIPOIC ACID. It's touted as a "super antioxidant" @ 300 to 500 mg doses I believe. I've taken it off and on for years in the hopes of it having potent anti-aging effects. I believe it has some side effects for diabetics, which I am not so no issue there. If you could research this thoroughly, like only you can, I would love to know if there is merit in taking this supplement or should I move on. Thank you in advance.
berberine lowed my glucose. It's always been in the upper/mid 90's...for at least the past decade. It had dropped to the upper 80s the past year and I've been taking berberine (not for the glucose though). This isn't a huge change I suppose but pretty clear it had some effect in that area. I'm going to stick with natto understanding results thus far are not great. I've had a few stents and need to do what I can in that area. It's not expensive. As always appreciate the info.
I was recently told by my doctor that he thought I had a type of vertigo that envolved christals in my ear that affects my head movements and causes dizziness. He referred me to a physical therapist. My first appointment is still two days from now. I saw a video about creatine and remembered I had some. Within a few hours of taking about 7 grams some of the head movements that made me dizzy for the last week, didn't make me dizzy. It has only been three days and thngs seem to be improving. I give creatine an A also. My blood pressue is also lower after my doctor suggested i take higher doses, I take lower doses than before.
This was great! I (and I'm sure many of the folks in r/supplements and r/longevity) love to see this with a longevity lens. NR, GlyNAC, Magnesium, Rapamycin (aka snake oil), the works.
Contrary to some of the critical reviews you mentioned, I independently reviewed information about all of the same micronutrients (except Rhodiola) and came to roughly the same conclusions. That's a good indicator that there is a lot of noise out there, but also good signal. Great work.
I always appreciate your work. I take berberine in combination with metformin for sugar control. Initially I took berberine once a day and didn't notice effect. It is highly promoted for sugar management and other health benefits. I'm not sure I saw any scientific studies. Sad to hear it's not supported. Wonder if it's the same for cinnamon and allulose.
Your videos are an excellent view for anyone who uses supplements. Have scientific studies been done on possible synergistic effects of combining like supplements? For example, do the three supplements improve effectiveness if Taurine, aged garlic, and omega-3 slightly reduce blood pressure?
There are a few studies sprinkled in here and there that do that, but most of them stick to single interventions. I think it'll be years before we get much granularity on which molecules to put together for greater effectiveness - a lot of that is guesswork at this point.
Hey, Nick. As you found out, and as I'm sure you already knew, "you can't please them all". However, rest assured, for of the extensive analysis that you did do (that someone may have vehemently and perhaps egregiously disagreed with) is most assuredly going to help many others to make an informed choice of their own. 🙌🏻
Among several other suplements I also take lutein & zeaxanthin but in combination with omega-3 because (if I'm not mistaken) lutein ataches to DHA & is, just like vitD, soluble in fat. So, I take it with fish oil to cover both ends.
What would be interesting is to also consider the quantities using in these studies. Often the amounts consumed are WAY above what is usually available as supplements. If one were to consume these amounts it would be incredibly expensive and possibly impractical
an effective proteolytic/fibrinogen dissolver dose is 1 or 2 caps of hi strength lumbrokinase plus 1 or 2 ea of nattokinase, serrapeptase and some protein enzymes like papain or bromelain in the morning away from food
Omega 369 pills caused Atrial fibrillation and vein/artery pain in my left leg. After stopping it, the symptoms disappeared. Another disappointment was Milk Thistle supplements, caused my liver to twist in pain. Same thing after stopping the intake, the symptoms disappeared. Guess we should always listen to our bodies, no matter what metadata studies say.
As an individual with genetic hypercholesterolemia, Taurine has been a real game changer. As I'm exposed to increased oxidative stress due to raised LDL, Taurine helped me to get this down by a lot. I don't have quantitative data on that, but the most clear sign was that I faced the begin of growing grey hair in my mid 30s which are now almost completely gone!
Was (pleasantly) surprised astaxanthin was reviewed in regard to the skin rather the eyes! Are you planning anything more related to skin health? Good info in this area is scarce and in need of commentary from scientific minds like yourself. Keep up with the good work 👍🏻
Great video. It would be interesting to see video about Black ginger which i think has surprisingly wide range of coverage in the ncbi but it is not so popular at least in europe.
I have found that creatine excellent for constipation. In fact, 'too excellent'! As little as a quarter teaspoon cleans me out. I know that the HCL version is supposed to be better but I find it hard to get motivated to try it with my experience so far.
Thank you Nic! Your analysis' of supplement studies are greatly appreciated. Love your comment on the peanut galley commenters. Can you imagine the comments Einstein would have gotten if he had posted on social media? 😊
Thanks for your explanation. Could you analyse combination of effects of creatine, CoQ10, and lipoic acid effect on young and old people? If they are effective, what are the disages?
SEED OILS, PLEASE HELP US are they ok? Inflammatory, bad for cells, gut microbiome? There is so much back and forth. I know deep frying is bad but what about salad dressings?
There is a lot of misinformation about seed.oils out there. Most oils are full of.mono and polyunsaturated fats, which are good for you. Also, you may find some omega 3's in some oils.
Creatine tanks my HRV every time. I have done 3 different tests, HRV tanks, HR increases even with extra attention paid to hydration status and keeping my training volume identical. I hate that it does that as I otherwise note benefit but decided the downside may not be worth it.
Hi Nic thanks for the video. 1) I wonder whether a healthy person with a healthy and normal lifestyle (i.e. not a competitive athlete) would notice any changes if they took your top 3 supplements? 2. can I use such standard recommendations at all, as I don't know whether they fit my personal life situation and individual body at all?
Can't answer the second question, because I don't know your situation, but the first point is 'yes it would have an effect', although if a person 'feels' an effect or not is difficult to say. I don't 'feel' the effects of creatine, but then again, I don't have a parallel version of myself to compare against, so one's feelings probably aren't a great metric. As for the lutein and zeaxanthin, that's a long term effect, so you definitely won't feel those unless maybe you get routine eye exams (less of a feeling than an objective measure). Hope it helps!
I’m giving this video an A+ for usefulness and most relevant highly used supplements Your work is so useful to me. I like to think of myself as being super objective cardiologist but oddly persuaded by your anecdote about rhodiola🗿. I guess I’m human after all!
Has anyone had a bad experience with berberine? I tried it for 3 months daily, and didnt see improvement in my Cholesterol (my original reason for taking Berberine). I had huge increase in my TSH (Thyroid-stimulating hormone) during the time. Any one experienced this? In my last blood test my TSH was that of a patient with hypothyroidism and Ive never had problem with my thyroid before..
I have been taking Lutein for awhile now and I definitely noticed a difference in my eyesight. I am 73 and although my eyes are pretty good, they are better after taking this sup. I will try some Zeaxanthin as well. Edit- turns out my Lutein suppliment also contains Zeaxanthin and Astraxanthin. It is a blueberry extract.
I worked in stats with demographic data and sometimes I think the “normal curve” and “significance difference” is kinda simplistic depending on the field they are being used in. But the sizes of some of the studies don’t seem valid given just a statistical difference is what is being determined. Your grade system makes more sense.
I take a ton of supplements. How about Taurine containing TUDCA? Or what about serrepeptase? Another supplement I'm big on is thiamine--TTFD and Benfotiamine.
You regularly and properly mention the "gold standard" of double-blind placebo controlled studies. Could you do a video discussing the concept of the obecalp effect?
Do you have a video on the GlyNAC combo? I was reading GlyNAC + Taurine might be good for men over 45 so I've got a few years yet but I'm hoping there'll be some high quality research before I reach that age!
I’d like to see your analysis on omega-3 for stroke prevention, cognitive decline, pulmonary effects. All of these are touted by various sources. The stroke prevention is of particular interest to me. I heard one source say that has an effect that prevents red blood cells from sticking together.
I wish I did not have possible hypertension-boosting effects from creatine, as I lose quite a lot of possible benefits, taking only omegas out of this list, but I missed lutein and zeaxanthin before and here is something to check out! I will definitely retry creatine as well with different parameters like a considerably lower BFP, but this will take a long time to get there.
![Oxalates cause Cancer. [Science Explained]](http://i.ytimg.com/vi/nkA6Iswy880/mqdefault.jpg)
Omega-3 Investigation: ua-cam.com/video/tX7xzzIhQgw/v-deo.htmlsi=zL67_qq7NHfBtWwE
Taurine Investigation: ua-cam.com/video/JawPF4VwQg0/v-deo.htmlsi=RE_PSmlCFqi6povu
Berberine Investigation: ua-cam.com/video/IfEraWY8sXI/v-deo.htmlsi=BzNawycQCGXNQOqx
Glycine Investigation: ua-cam.com/video/HxZl9LPV_7Q/v-deo.htmlsi=VhHvDFTI82-i3pur
Rhodiola Rosea Investigation: ua-cam.com/video/CgTguN3nFPw/v-deo.htmlsi=0GrHHwXHIub-s1hi
Creatine Investigation: ua-cam.com/video/EF96KabVAXM/v-deo.htmlsi=t4eQfr1uB13jehta
Nattokinase Investigation: ua-cam.com/video/Ts-BZoy7dAU/v-deo.htmlsi=dmfaUFqKgQObbHJe
Astaxathin Investigation: ua-cam.com/video/gI5XyVY_-n8/v-deo.htmlsi=vGQ4nRb1zQ5fwb9c
Lutein and Zeaxanthin Investigation: ua-cam.com/video/OqkMMWPSEWo/v-deo.htmlsi=mJKuOtDlEnCiYcs_
Lion’s Mane Investigation: ua-cam.com/video/-XnHgRVOov0/v-deo.htmlsi=oPNYTRKMSF1Oso_S
Beta-Alanine Investigation: ua-cam.com/video/Z-x076J2tfE/v-deo.htmlsi=as2LViBiMnm_W_la
Look into Tribulus for libido. Been using for years and is awesome.
Also I use berberine+yohimbine+cardarine as pre-workout. Very good results as well.
Great job! It would be nice if you check finasteride, lycopene and beta sitosterol for prostate enlargement for us older guys who watch your channel! 👴 I am sure you can make many jokes about that, too!
Gorgeous
🎉
What about SR9009?
I take taurine for sleep. For me it has a dramatic effect, turning a broken night's sleep of two hours max, to a full six solid hours. It reduces 'stress' dreams as well.
This is new to me. When do you take it relative to when you sleep?
@@canowyrms If I take 5 grams of Taurine, it will usually put me to sleep in about 30 minutes.
How much do you take? And do you take it on its own or with food?
@@canowyrmsworks but needs more liberal dosing. A gram or so does little but for me a 3g or higher dose actually lowers my bp and makes me dopey, although less productive
What an excellent way to summarise your longer form content. Incredibly helpful!
Psychiatrist and neuroscientist (MD/PhD) here - I give creatine an A for cognitive performance AND depression in addition to for athletic performance
Great for hair reduction too!
@@ericmaclaurin8525
And the growth of kidney stones.
Are there Contra- indications to taking creatine please? Should a U&E Blood test, be taken? 🎉Tnx
@@ericmaclaurin8525 uhhh no
@@ericmaclaurin8525 No good evidence for that.
12:44 a classic case. A whole phd invalidated 😢 i feel your pain though. So many people are just seeking to affirm their positions, not learn, and can’t react appropriately. Thanks for the work that you do! I look forward to following the channel again once you finish your second phd 😉
Nic, thanks for making these videos without a sign of subjectivity concerning the studies. Love your work!
Thanks. I can't cost justify joining Insiders on CPP plus OAS, but I certainly recognize the value being provided and appreciate it.
You didn't need to donate in that case, but thank you - I appreciate it. You watching and getting value is enough.
I would recommend eating fresh orange peppers. They're a great source of Lutein and Zeaxanthin, as well as many other vitamins and minerals. And they're pretty and make a delicious snack.
Just had one chopped up in my omelette as I watched the video. Eat your orange fruits and veggies kids!
Orange bell pepper or is it a orange pepper mix breed fruit veggie?
@@Dmachtz Oange bell pepper.
Organic only people we are being poisoned with glyphosate
Love these videos! Thank you for doing them and for all your time you put into them!
Glad you like them! Thanks for watching
Nic - As always, your video is factual, economical and actionable. This summary overview is a fabulous holiday gift. I focus on nutrients from unprocessed foods based on my doctor’s recommendations, your videos and those of Gil Carvalho. My use of supplements is sparing, but always includes a daily multivitamin. You provide a valuable service to society. 🎄
I love that you included your general recommendations at the end. Good video!
Fantastic video!
I’m 57 and would love to see a similar video focused specifically on supplements for longevity.
I suspect some supplements that score lower for sleep or other effects might rank higher when evaluated for their impact on lifespan.
One question I often ask about age-related declines is whether we need to optimize all factors, considering the limiting factor might be the one you're most deficient in-like the “law of limiting factors,” where a water barrel’s capacity is determined by its shortest plank.
If it helps me live longer, I don’t mind taking a lot of supplements!
I started taking Lutein & Zeaxanthin after watching your video on it. I spoke to my eye dr who also recommended it. thank you.
Me too.
And?
What happened?
Are they calling you eagle eye now?
Cool!
@@mballer too early to tell. my next dr appt is oct 2025.
How about astaxanthin. Reversed the post-cataract surgery film in my eye. Not just my opinion, both were diagnosed (film, then “no evidence of film”).
Thanks for doing all this heavy lifting for us Nic!
My pleasure! Thanks for tuning in :)
Love the short form over long format depending on my "appetite" and band width some days versus others! Thanks!
Thank you for this summary! I really appreciate it.
Glad it was helpful!
Well that was an excellent presentation. I bet this type of rapid fire summary proves to be popular, even though I like your more long form material.
I prefer the long form and details, too, but I try to appease both crowds.
@@Physionic I like both and as usual, your presentation was very well done. At 68 and on a limited budget, I am using Lutein and Zeaxanthin, Omega 3s, and Creatine (on my 2 workout days). I used taurine for about 6 months but was not convinced that it helped that much. I also use GlyNac. I try to keep up with the latest studies and you provide a great service.
Looks like you're doing things perfectly :)
That’s a GREAT double evaluation Nick 👌👌
Thanks!
You're GOATed and we appreciate you! Very effectively presented high yield information!
This video is like a meta-analysis of Physionic's other videos. It provides the same type of broad summary of numerous other findings on supplements.
Haha! Great way to put it!
Gotta be honest ,ß-Alanine was my "creatine for long duration work".
I respond really good to it, increases in lighter loads and cardio work tremendously.
I have ADHD and am really disappointed in lions mane but also *very* happy with rhodiola. Hope better quality research will emerge soon
It's important to note, as he carefully does, that these evaluations are only with respect to particular purposes. In particular, glycine is evaluated only for sleep support. This says nothing about it's possible support for glutathione synthesis or collagen synthesis. Or, for that matter, any other potential benefits.
His conclusion doesn't take that into account at all.
If you are eating adequate protein, there is no way that your glutathione synthesis is limited by glycine. In general it's non-essential and very abundant, so pretty much all your physiological needs will be met. What you are doing with supplementing straight up glycin is inducing a peak in blood concentration, which will allow you to harness its neurological effects (as it's an NMDA agonist as well as some other effects)
@@LucaBl I don't know about glutathione synthesis, but I heard you might be short on glycine for collagen synthesis. Never been a fan of that "non-essential" classification. I think the way you should think about is it, that you don't die because of a deficit in it. But you might not be functioning optimally either. Just because the body could make some things, doesn't mean it does it in sufficient quantity. Just look at creatin.
Glycine makes up only 5% of the amino acids in most proteins, but a third in collagen. I think you can make an argument, that you could be short on glycine, even if your total protein intake is "adequate" (assuming your definition isn't like 2g/lb or something crazy like that).
The paper "A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis" is an interesting read on that topic.
Hearing about Berberine here - it reminded me of a lab test of a whole bunch of Berberine supplements. Most of them did not contain the declared amount, with a few even bellow 5 % of what was supposed to be in the pills. It made me a little bit sceptical about how many of those studies actually rigorously test what they feed the test subjects.
@@jankadlcek608 saw the same video, the testing on a lot of these is flawed and biased, research some brands and what's in them, NOW seems to be consistently good and they also test other brands for content
Appreciate videos like this, especially since I don't have the education to properly analyze studies myself and I want to know. I have macular degeneration, so my supplement has lutein, zeaxanthin and astaxanthin plus other nutrients. I just started taurine because of a 70+ year old's comment that his eye health has improved, but never heard of taurine for sleep, another big problem now at 66 years old. Only 1g a day in the morning to start. I'd always heard you shouldn't take a single amino acid as a supplement because of potential imbalance. I keep hearing about creatine and this video is pushing me more towards trying it. Very interested in nattokinase as people have told me nattokinase can be more beneficial than vitamin K2 MK-7, which I take 120mcg of now. Vitamin K2 MK-7 actually seems to have lowered my A1c from 5.4 to 5.0, something I didn't expect. Again, thanks for all the work!
Great summary. I have borderline hypertension. I started taking creatine a few weeks ago. I am reading moderate increase in BP. Googling this was inconclusive, some studies found creatine raised BP but most were neutral so inconclusive. Would love to see a deep dive on this as a lot of us are taking meds for BP control, don't want to make it worse.
Fabulous work young man. Big respect for your analysis.
I find that 500 MG of Niacinamide a day has a very positive effect on my Photodamaged skin. More so than astaxanthin. The scaly redish skin on my forehead which routinely gets Zapped with liquid Nitrogen by my dermatologist is now smooth and healthy and there were some great Studies on this effect.
Niacinamide is one supp I don’t and haven’t taken very much in the past even when I was taking a ton of them! Has this helped “age spots”?
B12 is probably the safest and most effective B for people to take. B6 is a tricky one as has both positive and negative points for populations as whole , with a net positive, however if do blood work may find out negative portion is n/a to yourself.
Niacinamide is pretty safe to apply directly to skin .
With B complexes and all most things , just try and eat a great diet of all the colours. Vegans should strongly consider eating adding yeast flakes to foods for B12 , and good sources of choline
Good job! I enjoy your work. I first heard of Taurine in the early 1980's... I read an article about young cats dying (heart attacks) from Taurine deficiency. According to the article cat food manufacturers started adding Taurine to the mix after realizing this.. Some people take it for afib.. That seems like a relevant use for it, and vegans are very likely to develop a Taurine deficiency unless they supplement..
Cats require taurine, as opposed to human beings.
@@Christopher-b1p Menschen können zwar Taurin in kleinen Mengen bilden, einen Teil sollten auch wir mit der Nahrung zufügen. Ausserdem lässt die Taurinbildung im Alter stark nach. Also ist eine Supplementierung durchaus sinnvoll.
I learned a lot! In the age of constant misinformation it's good to have a trustworthy source that doesn't "hype up" these substances and provides *actual* evidence. Good job 👍
Humans have always existed in an age of constant misinformation…. Much less now, then ever before! Yet only the capable and enduring find the truth.
Many thanks for your hard work and expertise!
Would you comment on Nattokinase’s ability to prevent platelet aggregation and clot prevention. Again thank you!
One of your best videos
Thank you and Merry Christmas!🍻
Sure thing - Merry Christmas!
These are great bro. Love these types of videos
Great overview. Thanks.
Great information your one of my favorite resources on supplements 😊
Cheers from Oz🇦🇺
Great to hear!
Outstanding and Congrats on the PHD.
Doc Keep up the great hard work .Your always going to get people who will disagree, so I won't worry that's human nature. In my book you scored a 💯
With Taurine i have the concern that it could lead to GABA receptor downregulation. There was a study with mice that were fed with Taurine and as a result got those down regulating effects. Of course this were mice and i don't know how reliable this study was.
But there are also reports of user that get rebound anxiety when the effect of Taurine fades.
I looked at a paper on this. The researchers had concerns about taurine when other gaba agonist were used. That is, other things that bind to GABA receptors. Overall, they found a benefit to using taurine, as it delayed seizures. Taurine itself is difficult to find in food, apparently, apart from s
Algae
@@Christopher-b1p Taurin ist in kleinen Muskeln enthalten. Als Fleischesser ist es also durchaus möglich, etwas Taurin mit der Nahrung aufzunehmen.
@@hiraijo1582 Translation?
@@Christopher-b1p sorry. i have translation but it is wrong to asume that everybody has it. For those who eat meat. Highest amounts of taurine are in small muscles. Wings, hearts, etc. So you will get some Taurine with your food as long as you eat meat.
@hiraijo1582 Quite right. I was thinking only of the fact that taurine is low in plants. Thank you for correcting me!
I'm there with you subjectively on Rhodiola! I've also heard enough murmurs from others that--to your point--I expect better research to suss out its true benefits.
Taurine and Glycine are relatively cheap. I used to use 3 teaspoons of sugar in my coffee, now just 1 plus 1/4 teaspoon of Glycine which is not as sweet as sugar (the fructose part), but comparable to glucose.
Love your work. Great videos. I don't see a video on ALPHA LIPOIC ACID. It's touted as a "super antioxidant" @ 300 to 500 mg doses I believe. I've taken it off and on for years in the hopes of it having potent anti-aging effects. I believe it has some side effects for diabetics, which I am not so no issue there. If you could research this thoroughly, like only you can, I would love to know if there is merit in taking this supplement or should I move on. Thank you in advance.
Thank you. This channel is reliably informative and engaging. Much appreciated.
Thank you very much for this video.
berberine lowed my glucose. It's always been in the upper/mid 90's...for at least the past decade. It had dropped to the upper 80s the past year and I've been taking berberine (not for the glucose though). This isn't a huge change I suppose but pretty clear it had some effect in that area. I'm going to stick with natto understanding results thus far are not great. I've had a few stents and need to do what I can in that area. It's not expensive. As always appreciate the info.
I was recently told by my doctor that he thought I had a type of vertigo that envolved christals in my ear that affects my head movements and causes dizziness. He referred me to a physical therapist. My first appointment is still two days from now. I saw a video about creatine and remembered I had some. Within a few hours of taking about 7 grams some of the head movements that made me dizzy for the last week, didn't make me dizzy. It has only been three days and thngs seem to be improving. I give creatine an A also. My blood pressue is also lower after my doctor suggested i take higher doses, I take lower doses than before.
Nice haircut, great video thnx for ranks, def on them all still just in case 💪wanna be strong like u
Love your analysis Nick. My vote for the next is lithium orotate. I think you'll be surprised!
Thank you for this information.. grateful for all you do ❤️❤️❤️
Is there a brand of lutein/zeax you can recommend ?
This was great! I (and I'm sure many of the folks in r/supplements and r/longevity) love to see this with a longevity lens. NR, GlyNAC, Magnesium, Rapamycin (aka snake oil), the works.
Contrary to some of the critical reviews you mentioned, I independently reviewed information about all of the same micronutrients (except Rhodiola) and came to roughly the same conclusions. That's a good indicator that there is a lot of noise out there, but also good signal. Great work.
I always appreciate your work. I take berberine in combination with metformin for sugar control. Initially I took berberine once a day and didn't notice effect. It is highly promoted for sugar management and other health benefits. I'm not sure I saw any scientific studies. Sad to hear it's not supported. Wonder if it's the same for cinnamon and allulose.
He gave berberine a C, then changed it to a B.
Great summary as always, I'd be interested in your examination of phosphatidylserine if you have any on cognitive health
Just saw a video on this and came here to find some trusted knowledge about it. Sadly it seems he hasn’t reviewed the stuff yet.
Your videos are an excellent view for anyone who uses supplements. Have scientific studies been done on possible synergistic effects of combining like supplements? For example, do the three supplements improve effectiveness if Taurine, aged garlic, and omega-3 slightly reduce blood pressure?
There are a few studies sprinkled in here and there that do that, but most of them stick to single interventions. I think it'll be years before we get much granularity on which molecules to put together for greater effectiveness - a lot of that is guesswork at this point.
Hey, Nick. As you found out, and as I'm sure you already knew, "you can't please them all". However, rest assured, for of the extensive analysis that you did do (that someone may have vehemently and perhaps egregiously disagreed with) is most assuredly going to help many others to make an informed choice of their own. 🙌🏻
Oh, for sure. Thanks for perspective shift. :)
Thank you. A great useful review.
best channel on supps, hands down
Thanks Nick. You've confirmed I take too many supplements. 😂 I always appreciate your analysis.
Among several other suplements I also take lutein & zeaxanthin but in combination with omega-3 because (if I'm not mistaken) lutein ataches to DHA & is, just like vitD, soluble in fat. So, I take it with fish oil to cover both ends.
What would be interesting is to also consider the quantities using in these studies. Often the amounts consumed are WAY above what is usually available as supplements. If one were to consume these amounts it would be incredibly expensive and possibly impractical
Happy-Holidays!-Thank-you-for-being-you-on-UA-cam.-General-question-from-an-oldster:-I-only-take-one-pill-a-day-of-any-supplement.-If-this-is-an-underdose,-does-it-still-help-a-little,-or-is-it-a-waste-unless-you-hit-a-threshhold?-Asking-for-a-friend!
an effective proteolytic/fibrinogen dissolver dose is 1 or 2 caps of hi strength lumbrokinase plus 1 or 2 ea of nattokinase, serrapeptase and some protein enzymes like papain or bromelain in the morning away from food
Omega 369 pills caused Atrial fibrillation and vein/artery pain in my left leg. After stopping it, the symptoms disappeared. Another disappointment was Milk Thistle supplements, caused my liver to twist in pain. Same thing after stopping the intake, the symptoms disappeared. Guess we should always listen to our bodies, no matter what metadata studies say.
As an individual with genetic hypercholesterolemia, Taurine has been a real game changer. As I'm exposed to increased oxidative stress due to raised LDL, Taurine helped me to get this down by a lot. I don't have quantitative data on that, but the most clear sign was that I faced the begin of growing grey hair in my mid 30s which are now almost completely gone!
What is your Taurine dosage?
Great post. Thanks Nic.
Was (pleasantly) surprised astaxanthin was reviewed in regard to the skin rather the eyes!
Are you planning anything more related to skin health? Good info in this area is scarce and in need of commentary from scientific minds like yourself.
Keep up with the good work 👍🏻
Plenty! Many videos
Thanks, this was very helpful.
Thanks a lot for this summary video 😊
Great work. Have you ever reviewed Hawthorn Berries for blood pressure?
Awesome video!! What do you think about vitamin D?
Great video.
It would be interesting to see video about Black ginger which i think has surprisingly wide range of coverage in the ncbi but it is not so popular at least in europe.
Have you looked at whether there's a significant association between creatine supplementation and prostate cancer risk?
I have found that creatine excellent for constipation. In fact, 'too excellent'! As little as a quarter teaspoon cleans me out. I know that the HCL version is supposed to be better but I find it hard to get motivated to try it with my experience so far.
Thank you Nic! Your analysis' of supplement studies are greatly appreciated.
Love your comment on the peanut galley commenters. Can you imagine the comments Einstein would have gotten if he had posted on social media? 😊
Thanks for the summary. Is creatine still your vote for president for people who are indifferent on athletic performance enhancement?
Yep
Great Video!, informative and to the point, thanks
Thanks for your explanation. Could you analyse combination of effects of creatine, CoQ10, and lipoic acid effect on young and old people?
If they are effective, what are the disages?
SEED OILS, PLEASE HELP US are they ok? Inflammatory, bad for cells, gut microbiome? There is so much back and forth. I know deep frying is bad but what about salad dressings?
There is a lot of misinformation about seed.oils out there. Most oils are full of.mono and polyunsaturated fats, which are good for you. Also, you may find some omega 3's in some oils.
Hi Nicolas, can you do a check on NAC, SOD,.AKG, and Fisetin?
Great work. Thanks.
Please do more on sleep supplements
Creatine tanks my HRV every time. I have done 3 different tests, HRV tanks, HR increases even with extra attention paid to hydration status and keeping my training volume identical. I hate that it does that as I otherwise note benefit but decided the downside may not be worth it.
Hi Nic thanks for the video. 1) I wonder whether a healthy person with a healthy and normal lifestyle (i.e. not a competitive athlete) would notice any changes if they took your top 3 supplements? 2. can I use such standard recommendations at all, as I don't know whether they fit my personal life situation and individual body at all?
Can't answer the second question, because I don't know your situation, but the first point is 'yes it would have an effect', although if a person 'feels' an effect or not is difficult to say. I don't 'feel' the effects of creatine, but then again, I don't have a parallel version of myself to compare against, so one's feelings probably aren't a great metric. As for the lutein and zeaxanthin, that's a long term effect, so you definitely won't feel those unless maybe you get routine eye exams (less of a feeling than an objective measure). Hope it helps!
Can you look at lycopene for skin as well? It seems more researched than astaxanthin.
Milk thistle has been a game changer - NAFLD made me nauseous for years, started taking Legalon daily, helped immediately.
I’m giving this video an A+ for usefulness and most relevant highly used supplements
Your work is so useful to me. I like to think of myself as being super objective cardiologist but oddly persuaded by your anecdote about rhodiola🗿. I guess I’m human after all!
Has anyone had a bad experience with berberine? I tried it for 3 months daily, and didnt see improvement in my Cholesterol (my original reason for taking Berberine). I had huge increase in my TSH (Thyroid-stimulating hormone) during the time. Any one experienced this? In my last blood test my TSH was that of a patient with hypothyroidism and Ive never had problem with my thyroid before..
bruh. hericium is def an A for me on cognition.
I have been taking Lutein for awhile now and I definitely noticed a difference in my eyesight. I am 73 and although my eyes are pretty good, they are better after taking this sup. I will try some Zeaxanthin as well. Edit- turns out my Lutein suppliment also contains Zeaxanthin and Astraxanthin. It is a blueberry extract.
I worked in stats with demographic data and sometimes I think the “normal curve” and “significance difference” is kinda simplistic depending on the field they are being used in. But the sizes of some of the studies don’t seem valid given just a statistical difference is what is being determined. Your grade system makes more sense.
Agreed - statistical significance is too simplistic. It's fine, but there are other considerations, as well.
Can you do a vid on pre, pro, and post biotics? Are they worth it, how to take them if beneficial?
Thanks a ton to YT algo for recommending this video & thanks to the creator too!!
Thank you too!
Woaa 250k !! Nice growth !!
Thanks!
I take a ton of supplements. How about Taurine containing TUDCA? Or what about serrepeptase? Another supplement I'm big on is thiamine--TTFD and Benfotiamine.
You regularly and properly mention the "gold standard" of double-blind placebo controlled studies. Could you do a video discussing the concept of the obecalp effect?
Do you have a video on the GlyNAC combo? I was reading GlyNAC + Taurine might be good for men over 45 so I've got a few years yet but I'm hoping there'll be some high quality research before I reach that age!
I’d like to see your analysis on omega-3 for stroke prevention, cognitive decline, pulmonary effects. All of these are touted by various sources. The stroke prevention is of particular interest to me. I heard one source say that has an effect that prevents red blood cells from sticking together.
Yup: trustworthy is my assessment of your channel. Thank you for your analyses.
Thanks! Kind of you
I wish I did not have possible hypertension-boosting effects from creatine, as I lose quite a lot of possible benefits, taking only omegas out of this list, but I missed lutein and zeaxanthin before and here is something to check out! I will definitely retry creatine as well with different parameters like a considerably lower BFP, but this will take a long time to get there.
For Lutein & Zeaxanthin
What brand does one/you recommend?
Offered together to supplement?
Thank You!
Thank you!