I SINCERELY AND DEEPLY appreciate your input as a medical professional with sympathy and empathy due to your experience with these life changing medications. I came to your channel by chance and am grateful to the algorithm for the connection! As I approach my goal, I am looking to titrate down to a maintenance dose and am ever so grateful for your expertise and generous sharing of resources and insights.
Thank you for the video! Dr. Joseph, I keep telling people in the GLP1 community how fabulous your channel is.Honestly, feel like I struck gold finding you. Many Blessings for the upcoming year! 🙏🙏
Hi Dr Kevin. My question is, do you use compounded Tirzepatide or brand name vials? And how do you preserve your left overs? I recently started compounded Tirzepatide and the instruction on the vial says discard unused portions after 28days of first puncture. I'm confused on how to make it strech longer than 28days if i decide to microdose. Thanks
Great video, Dr. Kevin Joseph. Looking forward to your next upload! I smashed that thumbs up button on your content. Keep up the fantastic work. Your insights into the clinical trials and the importance of careful dose management are really enlightening. What strategies do you recommend for individuals to maintain their weight without the medication if they decide to come off?
Thank you for the support and kind words! If you have to come off I definitely recommend continuing scheduled resistance and cardiovascular training, being conscience of what you eat and making sure you stay on top of your blood work routinely. I truly believe that health starts at the cellular level and builds up and I think your bloodwork is the perfect way to keep an eye on that!
Yes just what I needed to better understand the dosing on maintenance! Question if I’m down 38 pounds and need to lose more do I go up in mg or just go back to the beginning using 5mg to see if I’m losing on that dose???
Thanks for this Video. I decided to reduce my dosage (First Step from 7.5 to 6.5). Every seven days is easy for me - in order to avoid getting confused with my next shot day. Next step will be 5.5 mg… I like using the plotter to better understand what‘s happening and to be able to make a plan.
Interesting! I do believe everyone's maintenance dose (and weight loss dose!) Is different. I'm currently in maintenance on 7.5mg every 7 days. I briefly tried 5mg and felt too hungry. But I haven't tried playing with the days, ie dosing every 10 days or every 5 days. Also, I may want to lose more weight! How did you know when you were at your goal?
Absolutely. I started at 1.5mg every 7 days and actually had decent food noise suppression from the start. That has always been my issue so getting rid of that stopped me from binging and I was actually able to control my diet without much else. I eventually moved up to 1.5mg every 5 days after 5 months and then up to 2.5mg every 7 days after another 5 months. I'm currently at my goal weight of 200lbs so I titrated back down to 1.5mg every 7 days.
Thank you for your videos. How do you advise us in the UK to extend to every 14 days where the pen contains 4 doses and lasts 30days? Do we just waste some of the medicine? Thank you.
I do follow you and love your videos. Out of topic question. A1C 6.9 Started on MOUNJARO 5mg starting weight 178lb. Lost 4lb for the first month. Up to 7mg for 3months lost 5lb total of 9lb. Then went up to 10mg no weight lost for a month. Eating healthy, fasting, exercising doing all the "rigt things' just a little constipation no major side effect. Started in 9/9/24 and now 1/5/25. Total weight loss 10Ib is very frustrating, I have not yet checked my A1C but BS numbers are great total average of 101. Should I increase my dose? I know you'll say talk to my PC I will but what's your opinion? Please
Love your channel and will continue to watch regardless. I just wanted to provide some constructive feedback in case you’re interested. Please consider removing the background music-it makes it harder to follow since you already speak quite quickly. I usually listen at 0.8x speed to better grasp the information you share. Thank you for all that you do!
I'm always interested in constructive feedback! Thank you for that, I will definitely be more mindful of the background music going forward. Sorry I'm new to the whole youtube world and wanted to make my videos a little more engaging so I thought I would try and switch up the editing in this video and see how everyone liked it. Also I have such a bad habit of talking fast, an unfortunate skill you learn in the hospital :( Thank you for the support!
Hi doc great video! I was wondering if you were ever able to check out Dr. Jason Fung, and if so, did you form an opinion around his idea of muscle wasting during fasting as a survival imperative? I have another question for you. How would you advise me to find a Dr. to help me in my GLP-1/weight loss journey? I got my cardiologist to write the prescription for Mounjaro, but I don't think he's really up on the nuances of the drug and common treatment regimens. He's a great Doc, but this isn't his wheelhouse. The same is true for my PCP. Any thoughts you might have on locating someone credible, even if it was telehealth, would be awesome!
Hey Scott, I'm sorry I missed your comment earlier. I haven't had a chance to look into Dr. Fungs material but I have a week off starting tomorrow so I'm hoping I can look into it more after the holidays. As far as finding a provider thats well versed in GLP1s I would definitely look into endocrinologists in your area. They were the first to get an influx of patients on GLP1s after it was initially approved for T2DM so they should have alot of experience with it.
My concern about staying on this "forever" if needed is that the GLP-1 receptors may eventually downregulate, causing rebound hunger even while on the drug. What are your thoughts on this?
Good question. There isn't any data to really support this theory so the only thing I have to go off of is the fact that alot of my patients (myself included) have been on GLP1s for almost two years and have never noticed the type of situation you are describing. Yes GLP1 receptors do down regulate which is why there is a titration up period and eventually why the appetite suppression stops but even at maintenance I've only noticed normal hunger returning, nothing that I would consider as "rebound hunger". If anything I feel like I would be the type of person who would be prone to that because I have significant history of binge eating and since starting GLP1s I haven't binged once. yes there are days where the appetite suppression is less and I've eaten more, but never to the point of oblivion, which I used to daily in the past.
Many thanks for your informative videos. Couple of questions. Been on Semaglutide for 5 weeks with good results one thing I have noticed recently is ensuring I'm eating enough (I track my food daily) are there cases of people not losing weight because they are not eating enough calories while on Semaglutide? Also in regards to exercise - can you provide some general guidance on exercise routines - for some reason I'm worried of losing weight too fast if I exercise while on Semaglutide? Do you also have any thoughts on vitamins/minerals people should take daily while on Semaglutide? Thanks!
Any thought on 15 mg Mounjaro and haven’t lost a pound in 2 months no side affects and a little food noise. Type 2 diabetes. Dr suggested phentermine any thought?? Thank you!
Ugh I'm sorry to hear about the weight loss stall. Is this your first stall or has it been hard to lose weight on all of the doses? If its your first stall I would say give it some time, maybe even try increasing your calories for a week or two and then cutting back down. If you've had a hard time from the beginning then you may be a poor responder unfortunately. I would still try sticking it out though because the metabolic benefits are definitely helping in the background even if the scale isnt budging. You can definitely try phentermine but its an old school drug, lots of side effects such as poor sleep and jitters.
Thank you so much for replying!! I’ve been a slow responder. 45 pounds in a year. But my a1c is at 5.6 so definitely helping. I will definitely keep going as insurance covers it because I’m a type 2. Thanks again for your reply
I SINCERELY AND DEEPLY appreciate your input as a medical professional with sympathy and empathy due to your experience with these life changing medications. I came to your channel by chance and am grateful to the algorithm for the connection! As I approach my goal, I am looking to titrate down to a maintenance dose and am ever so grateful for your expertise and generous sharing of resources and insights.
Awesome video… thanks for sharing about the plotter… super helpful!
Thank you for the video! Dr. Joseph, I keep telling people in the GLP1 community how fabulous your channel is.Honestly, feel like I struck gold finding you. Many Blessings for the upcoming year! 🙏🙏
Aww thank you so much! Happy new year to you as well! Lets crush those health goals together!
Hi Dr Kevin. My question is, do you use compounded Tirzepatide or brand name vials? And how do you preserve your left overs?
I recently started compounded Tirzepatide and the instruction on the vial says discard unused portions after 28days of first puncture. I'm confused on how to make it strech longer than 28days if i decide to microdose. Thanks
I'll definitely watch this video again when I reach my goal. I'm halfway there so far!
Thats amazing! Keep it up!
Just read Zepbound was approved for sleep apnea… hoping my insurance will start covering it
I know! Its weird how news like this is what makes my day 😂 I really hope this helps expand coverage for even more people
Great video, Dr. Kevin Joseph. Looking forward to your next upload! I smashed that thumbs up button on your content. Keep up the fantastic work. Your insights into the clinical trials and the importance of careful dose management are really enlightening. What strategies do you recommend for individuals to maintain their weight without the medication if they decide to come off?
Thank you for the support and kind words! If you have to come off I definitely recommend continuing scheduled resistance and cardiovascular training, being conscience of what you eat and making sure you stay on top of your blood work routinely. I truly believe that health starts at the cellular level and builds up and I think your bloodwork is the perfect way to keep an eye on that!
Yes just what I needed to better understand the dosing on maintenance! Question if I’m down 38 pounds and need to lose more do I go up in mg or just go back to the beginning using 5mg to see if I’m losing on that dose???
Thanks for this Video. I decided to reduce my dosage (First Step from 7.5 to 6.5). Every seven days is easy for me - in order to avoid getting confused with my next shot day. Next step will be 5.5 mg… I like using the plotter to better understand what‘s happening and to be able to make a plan.
Perfect! Yea I find that every 7 days is easier as well because its so easy to lose track of shot day otherwise. Let me know how it goes!
Interesting! I do believe everyone's maintenance dose (and weight loss dose!) Is different. I'm currently in maintenance on 7.5mg every 7 days. I briefly tried 5mg and felt too hungry. But I haven't tried playing with the days, ie dosing every 10 days or every 5 days. Also, I may want to lose more weight! How did you know when you were at your goal?
Thanks
Great video. Can you tell us what your titration profile looked like on the way up? What worked well for you?
Absolutely. I started at 1.5mg every 7 days and actually had decent food noise suppression from the start. That has always been my issue so getting rid of that stopped me from binging and I was actually able to control my diet without much else. I eventually moved up to 1.5mg every 5 days after 5 months and then up to 2.5mg every 7 days after another 5 months. I'm currently at my goal weight of 200lbs so I titrated back down to 1.5mg every 7 days.
I may need to use semaglutide for maintenance with tirz going off shortage list.how to dose sema foe 7.5mg or 10mg tirz?
Thank you for your videos. How do you advise us in the UK to extend to every 14 days where the pen contains 4 doses and lasts 30days? Do we just waste some of the medicine? Thank you.
I do follow you and love your videos. Out of topic question. A1C 6.9 Started on MOUNJARO 5mg starting weight 178lb. Lost 4lb for the first month. Up to 7mg for 3months lost 5lb total of 9lb. Then went up to 10mg no weight lost for a month. Eating healthy, fasting, exercising doing all the "rigt things' just a little constipation no major side effect. Started in 9/9/24 and now 1/5/25. Total weight loss 10Ib is very frustrating, I have not yet checked my A1C but BS numbers are great total average of 101. Should I increase my dose? I know you'll say talk to my PC I will but what's your opinion? Please
Love your channel and will continue to watch regardless. I just wanted to provide some constructive feedback in case you’re interested. Please consider removing the background music-it makes it harder to follow since you already speak quite quickly. I usually listen at 0.8x speed to better grasp the information you share. Thank you for all that you do!
I'm always interested in constructive feedback! Thank you for that, I will definitely be more mindful of the background music going forward. Sorry I'm new to the whole youtube world and wanted to make my videos a little more engaging so I thought I would try and switch up the editing in this video and see how everyone liked it. Also I have such a bad habit of talking fast, an unfortunate skill you learn in the hospital :( Thank you for the support!
Hi doc great video! I was wondering if you were ever able to check out Dr. Jason Fung, and if so, did you form an opinion around his idea of muscle wasting during fasting as a survival imperative? I have another question for you. How would you advise me to find a Dr. to help me in my GLP-1/weight loss journey? I got my cardiologist to write the prescription for Mounjaro, but I don't think he's really up on the nuances of the drug and common treatment regimens. He's a great Doc, but this isn't his wheelhouse. The same is true for my PCP. Any thoughts you might have on locating someone credible, even if it was telehealth, would be awesome!
Hey Scott, I'm sorry I missed your comment earlier. I haven't had a chance to look into Dr. Fungs material but I have a week off starting tomorrow so I'm hoping I can look into it more after the holidays. As far as finding a provider thats well versed in GLP1s I would definitely look into endocrinologists in your area. They were the first to get an influx of patients on GLP1s after it was initially approved for T2DM so they should have alot of experience with it.
@@drkjoseph1 Thank you!
@@drkjoseph1 Yup, totally agree with the Endocrinologist route. That’s who introduced me to Zepbound.
Time stamps please. Thanks for these videos.
will do!
My concern about staying on this "forever" if needed is that the GLP-1 receptors may eventually downregulate, causing rebound hunger even while on the drug. What are your thoughts on this?
Good question. There isn't any data to really support this theory so the only thing I have to go off of is the fact that alot of my patients (myself included) have been on GLP1s for almost two years and have never noticed the type of situation you are describing. Yes GLP1 receptors do down regulate which is why there is a titration up period and eventually why the appetite suppression stops but even at maintenance I've only noticed normal hunger returning, nothing that I would consider as "rebound hunger". If anything I feel like I would be the type of person who would be prone to that because I have significant history of binge eating and since starting GLP1s I haven't binged once. yes there are days where the appetite suppression is less and I've eaten more, but never to the point of oblivion, which I used to daily in the past.
Many thanks for your informative videos. Couple of questions. Been on Semaglutide for 5 weeks with good results one thing I have noticed recently is ensuring I'm eating enough (I track my food daily) are there cases of people not losing weight because they are not eating enough calories while on Semaglutide? Also in regards to exercise - can you provide some general guidance on exercise routines - for some reason I'm worried of losing weight too fast if I exercise while on Semaglutide? Do you also have any thoughts on vitamins/minerals people should take daily while on Semaglutide? Thanks!
Any thought on 15 mg Mounjaro and haven’t lost a pound in 2 months no side affects and a little food noise. Type 2 diabetes. Dr suggested phentermine any thought?? Thank you!
These are all just a tool. It's impossible to lose without weight training and a proper diet.
No shit.
@@lisa9195 believe it or not there are many people that don't workout on glp1
Ugh I'm sorry to hear about the weight loss stall. Is this your first stall or has it been hard to lose weight on all of the doses? If its your first stall I would say give it some time, maybe even try increasing your calories for a week or two and then cutting back down. If you've had a hard time from the beginning then you may be a poor responder unfortunately. I would still try sticking it out though because the metabolic benefits are definitely helping in the background even if the scale isnt budging. You can definitely try phentermine but its an old school drug, lots of side effects such as poor sleep and jitters.
Thank you so much for replying!! I’ve been a slow responder. 45 pounds in a year. But my a1c is at 5.6 so definitely helping. I will definitely keep going as insurance covers it because I’m a type 2. Thanks again for your reply