GLP 1, Mounjaro, Wegovy & Ozempic: How These Affect Weight Loss & Metabolic Health | Dr. Rob Lustig
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- Опубліковано 28 тра 2024
- Medications, such as Ozempic, Mounjaro, Wegovy, and more, have become increasingly popular for weight loss. These drugs are glucagon-like peptide 1 (GLP-1) receptor agonists, and they mimic a hormone that, among other things, tells the brain a person is full so they eat less. But are they safe, and do they help improve metabolic health? Dr. Rob Lustig and Dr. Casey Means discuss these weight-loss drugs and their effects on the body, and why such medications likely won’t solve the obesity crisis, for which the food industry is culpable.
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📍What Rob Lustig, MD, & Casey Means, MD, discuss:
00:00 - Intro
06:24 - The mechanisms of action for weight-loss medications
09:07 - Dr. Casey Means shares her perception of the popularity of GLP-1 medications
13:19 - GLP-1 RAs lead to fat loss but also muscle loss
19:50 - Do GLP-1 RAs improve metabolic health?
22:29 - Dr. Lustig discusses the high cost of GLP-1 RAs
29:37 - Dr. Lustig makes the case for fixing the food problem
37:39 - How can patients use GLP-1 RAs as a jumpstart?
46:15 - Dr. Lustig shares his concerns about the use of GLP-1 RAs in children
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🔗 LINKS:
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Robert Lustig, MD: robertlustig.com
Metabolical by Robert Lustig, MD: robertlustig.com/metabolical/
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Connect with Casey Means, MD, on Twitter: / drcaseyskitchen - Наука та технологія
Any chance to hear these great talks via audio only?
Of course. A Whole New Level is available wherever you listen to podcasts 😊 podcasts.apple.com/us/podcast/levels-a-whole-new-level/id1563263076?i=1000624755998
Thank you for asking! Great to know
Me too
Yeah.....just don't watch the video and you have audio only.....
i thought this is what the utube music app does ?
I see a video with Dr lustig and I watch.
Haha same
Me too!
When you can watch someone like him with so much knowledge. It’s just a amazing. Ill watch the same video over and over.
Me too!
Always!
I am/WAS a severe sugar addict. It took me about 5 days to go through withdrawal. I am now on the other side of that. It CAN be done. I now eat Carnivore Diet. I feel EXTREMELY better physically and mentally. I AM better. I was able to wean off 7 prescription drugs. I now take 2. And I haven't even been on Carnivore that long, relatively. I am confident I'll be able to wean off the remaining 2 drugs within 3 months. I feel GREAT!
Ozempic was always going to be a short term solution for me. I was on this medication for 6 months while my body adjusted to a HFLC diet and intermittent fasting. I am now just doing the LCHF diet and fasting without the medication and still losing weight. It was helpful for me to change my lifestyle but I was concerned about the long term effects of this medication as well.
Ruby, this is exactly the real benefit to a drug like this. Short-term. It's a motivational tool, for people to see what's possible. Thank you for writing.
Good job! I’m concerned though that most people DON’T make the changes you did and go right back to their old poor eating when they stop
Maybe ozempic is usable as a gateway drug.....a gateway to a ketogenic way of eating.
@@kenadams5504 :) That may be. The gateway to better health.
@@drironmom6815 I agree. There is the temptation to see these medications as an excuse to continue on the same trajectory. My goal is to be off all my prescription meds, a healthy weight and ache and pain free.
Love monjaro , lost 70 lbs no longer diabetic in 7 months. Looking forward to the rest of my life. Never had food addiction.
Are you still taking it?
@@michellemartin5116 doctor still taking me down highest 10mg now at 5 mg.
How is your strength in the gym? Has it gone up or down? Has your athletic performance increased or decreased?
@@michellemartin5116
I have same question! ⬆️
But you're starving your body😢 Try Berberine!
29:20 and 35:43 - Based upon many comments here this rebound is not absolutely true as he claims. Many have used GLP-1 agonists as a kickstart to a more heathy mode of eating. I did that with Byetta a decade ago. When I stopped treatment after some months I would actually _imagine_ I was still on it and was able to continue the new eating habits. So, it really depends upon the person and the level of motivation and knowledge involved. True, a passive individual will most likely revert. [Edit] A few minutes later he _does_ acknowledge the possible use as kickstart to a healthier way of eating so he _is_ more nuanced but he remains doubtful of success in general.
I have type 2 diabetes. I started taking Ozempic in April. My A1C improved significantly since taking it. I lost 45 lbs and only 8 lbs from my goal weight and no longer being overweight. I eat a plant based whole food diet because that's what my body craves. I walk every day and swim when I can. My doctor decreased my blood pressure meds. In September I will decrease Ozempic from .5 to .25. Ozempic works for me. I'm in Canada and Ozempic is covered. Sandra
Did you walk and swim previously?
@@mballer No. Too many aches and pain from the weight.
What about your muscle mass???
@@SandraClarketake a DEXA scan. Keep track of muscle mass.
Were you microdosing?
Okay - so I am a 58 yo post menopausal women and I work out - weights, cardio and or walking daily!! I eat healthy home cooked meals - very little fruit and and or sugar. I cannot lose a pound. So to hear you say just use food - pisses me off. There has to be more and another reason why I am stuck. This is so frustrating and de-motivating.
just take this drug to lose weight. it kills the appetite... totally legit.
Try Maria Emmerich's channel. Keto Adapted, Maria mind body health. I am a post menopausal 70 yr old and couldn't shift my weight even though eating what I thought of as healthy. Through this web channel I've finally been able to lose fat but retained and built muscle. Try and see if it suits you.
hormones. I've been going thru the same thing.
You sound exactly like me! I am 54 had total hysterectomy. I couldn’t lose anything and tried since 42 yrs old, lift weight walk, HIIT low weight high reps, low carb, keto, low fat all of it and nothing helped. Finally I tried zepbound and I lose so far 13 pounds! No side effects so far because I am staying on the low does as long as possible and I am not eating crap. If u eat a lot of fats or sugar then I will get sick, if u over eat u feel sick. I don’t do any of those things. My visceral fat went down. Total fat went down and no I have not lost muscle! I gained 1 pound so far of muscle. Yes I do measure. U can make sure u eat protein and less fats and sugars and lift weights and walk and u can lose and not lose muscle. I feel like these people are being close minded. I understand they know what they know, but they need to watch those who actually did the other things along with the Zepbound. I am not saying that there may be something in the future that may cause side effects or dangers later. I hope not but being overweight is also a danger
He’s full of shit. Micro dose it. You are doing resisntant training so you’ll only lose fat, not muscle.
I was on Mounjaro from Sept. 22 until Dec. 2. I lost 24 lbs. I've been doing it on my own by eating right and have lost another 34 lbs. I am thankful for the boost/headstart I got from Mounjaro. I also understand the concerns around these drugs and said from the start that I wouldn't use it beyond Christmas 22. I love your work Dr. Lustig and I am thankful for this information. This confirms I made the right decision not to remain on Mounjaro. I am 64 and sarcopenia is NOT something I want!
Exactly the jump start they referred to.
When you lose weight on your own without resistance training 40 percent of the loss is muscle. He failed to mention that and also failed to mention that resistance training is important no matter how you lose weight.
@@sorrywrongplanet8873 that's with any diet. Life happens. I was a drill sergeant in the army and was always in great shape. I got depressed after my husband died, quit cooking and started eating at the drive thru when I got hungry. I didn't over eat, it was whatvI ate...which is why Dr. Lustigs work is relevent. I have converted my living room to a home gym and am now in the best shape of my life.
Love Dr. Lustig's passion and how easy he explains these issues!
I live with a partner on ozempic for type 2 diabetes. They had severe vomiting and had to reduce the dose to .5 u . I have noticed the facial changes, and loss of muscle changes to their leggs, i am a retired nurse and am very concerned. I am not diabetic and for 3 months stopped all sugar and eating only real food, and lost 38lbs, no vomiting no muscle loss in fact musle gain. They are also on a cholesterol blocking agent. I worked as a endocrine nurse, and coronary care nurse, medical surgical nurse for 40 years. When cholesterol blocking agents came, i was and other nurses were confused as much of our brain and every cell is of such. I am 67 he is 72. I see the future not so good. I disagree with his medications for his diabetes and his habits. As a young nurse dealing with diabetics, we encouraged low carbohydrate low to no sugar diets, now it seems to use medications and eat what you like. I cringe every day watching the pouring of several daily orange juice and two tablespoons of sugar in his coffee. Ozempic is in my humble opinion a bad drug, as with all cholesterol blocking agents. Statins and ozempic and his habits are killing him slowly. If i say something or try to reason with him, it is not so good, and i get the living with a nurse thing. He is my second partner who just does not get it, my partner of 30 years died in his sleep beside me as i slept of a massive heart attack his 3rd on autopsy the first and second he did nothing i could not get him to see the doctor. He was only 67. I feel i will see a repeat.
😟
I’m sorry! I totally understand the frustration and as a seasoned pharmacist, I’ve learned we can only share information and ultimately, a human will do exactly what he/she wants to do. Good or bad. Free will shoulda been withheld from some people, lol.
( you did your part )
Now that I live a LCHF diet, I can’t imagine having a relationship with someone who is not health conscious. I am divorced and one of the major obstacles I have is meeting someone healthy at my age, 49. There is so much high blood pressure, diabetes, ED, cholesterol issues that are now “acceptable “ as part of aging. I’d rather be alone, than be someone’s “diet police”.
@@TexasketogirlI can’t blame you for such decision. Best of luck to you as well
One of my life's saddest experiences is watching those I love and care for die slowly due to addiction, diabetes, heart disease because they will not change.
I was on mounjaro for 3 months helped me kick my soda & sugar addiction andlost 15 lbs. But it did help me eat less, been off it for 8 months lost another 10lbs. My cmg monitor helps me accountable to my dr. and myself. I’m still working on my diet and exercise but my A1C numbers are coming down.
I reversed my 26 years T2D since November 2021 by using CGM and eliminating many food which i stupidly I thought they are harmless. I have lost over 30lbs and discontinued many meds including 2 kinda insulin. My A1C has been 5.6 to 5.8 in 3 tests. I eat much less than before but interestingly enough I am less hungry. It’s hard but doable.
What was your fix. What foods or things helped. Thanks
frosting on a cake is very bad for me. But cheesecake or something with lots of butter/fat isn't as bad.
@@scoobtoober2975 I did keto like diet with lots of fasting at beginning. I am not big on fat neither. These days I am more relaxed. As I mentioned I am dealing with inherited very progresses diabetes. I don’t want to risk anything. My carb intake is as low as possible. I eat salad leafy greens and my only fruit is berries in my plain full fat yogurt.
How long did it take ?
@@scoobtoober2975 Think about it this way. If it was created by God (nature); you can eat it, but be careful things like excess fruit (used to be seasonal) can get you in trouble. If it is man created and altered avoid or eliminate. This is the hard part because even the natural foods are being altered to taste and produce more. So you have to be very selective and educated; read labels!. This is from a former pre diabetic that will follow her own advice till I die, hopefully peacefully from natural causes.
Thanks, amen to that. I'm grateful every day to know i'm living better than just a year ago. The think of how 1000 or 10000 year ago man kind lived. So scary and primitive. Here we are in a heated home safe from predators.@@200Nora
I'm 1 million percent certain if this was widely available when I was young I woulda jumped on it immediately. But I jumped onto every single weight loss trend and in the end I was right back at square one or worse. For those who benefit from it I'm glad. And I hope that in the long term it proves sustainable.
For $1300 per month, it would be cheaper to buy all the patient’s food and actually cure the patient.
Excellent comment
facts!!!!!!!
Very true. The problem is that most people would still eat unhealthy because of the availability of junk food.
Dr. Lustig, Dr. Elizabeth Bright and Dr. Ken Berry (all MD's) are AMAZING. I regularly watch any podcasts they're in. Also Dr. Shawn Baker, who is a surgeon and a powerhouse of knowledge on the Carnivore Diet. I am so grateful to these 4 physicians...
I was diagnosed with type 2 diabetes in October of 2021 and was started on ozempic. I went on a low carb diet and started fasting and lost 75 pounds in 10 months. I am no longer on diabetic medication. The ozempic helped curb my appetite but I had horrible constipation.
Mounjaro apparently doesn't strip the lean muscle to the same extent as the other GLP-1 inhibitors - gotta keep the Protein consumption up and exercise while taking these
If you fancy doing both that is..remember if you are having your appetite artificially suppressed you may struggle to consume the amount of protein required to maintain muscle mass and if you are left feeling lousy as it mimics starvation do you feel you'll have adequate energy available to really work hard in the gym lifting heavy to stimulate protein synthesis?
I have a friend at the gym who is 75 years old, but he's been bodybuilding since he was 14. He's been prescribed Mounjaro and swears by it. He is also on TRT to compensate for the inevitable sarcopenia.
However, he does show a significant decline in muscle in his face. And his strength and energy level have gone down in the gym. I support him in his choice, but would never do the same thing.
Ive lost 50 in 3 months and gained alot of muscle. Eat the high protein get in gym , lift and walk. Life changing. If you sit on your ass and eat same food you will lose muscle and fat. No crap.
Dr. Lustig is THE physician. An incredibly intelligent, passionate , LEGENDARY leader in medicine. I take notes when I watch his podcasts. He has transformed my way of eating and my way of understanding the role of what we consume on our health and how it directly affects all disease.
The effects many feel on Ozempic are similar to how I felt after I Detoxed off Sugar and Fake sugar. I was hungry often on sugar and now off sugar I rarely hungry. Big difference in addition to less appetite is food that is real/healthy tastes amazing, and I eat less in general but love the experience of eating. Vegetables are so good on their own without dressings and fluff. Also, Meat tastes better now than ever before. I really taste the subtly in fat and how it effects the flavor of meat. I only eat sugar in Whole Fruit, but it's fairly rare... Lustig has changed my life and I am forever indebted to his sharing of knowledge. Since April I have lost over 55 pounds. I love Moving and staying active and my energy is through the roof. Sugar made me so dependent on sugar for energy. Now I seem to have plenty and it's there when I need it not when I eat sugar. Need to get people off sugar and control will be back in the individuals' hands. Drugs just make us more dependent on big pharma. Now everything I eat feeds the gut and protects the liver. Thanks.
Why is it so hard for medicine to understand:
1. The liver makes all the glucose you need. You literally do not need to eat any. Any glucose you eat is "extra".
2. When you eat too much glucose (and of course fructose) you become metabolically sick.
And through the polyol pathway, excess glucose can be converted to fructose via sorbitol.
Big pharma’s influence. They are taught to regurgitate what they’re taught.
GLP1s don’t raise insulin in the absence of glucose. GLP1s potentiate glucose-stimulated insulin secretion. If you continue eating high processed carb diet you could actually raise insulin levels and worsen insulin resistance. With a low carb diet, you improve insulin sensitivity due to effects on satiety.
Thank you very much for the great discussion. Doctor Metabolical is a hero to me and the government needs to start listening to him and others like him.
My doctor treated my T2D with Ozempic until I quit using it after eight months. For me, the side-affects were absolutely horrible. Out of a week in between injections, I could count on not only two solid days of horrible nausea each week, but also frequent painful constipation. It was as though my digestive tract had come to a screeching halt. I knew it would slow down digestion, but it was simply too extreme for me to handle. Additionally, all of these symptoms would occasionally cause me to have panic attacks, usually at least one every three weeks or so. I transitioned from Ozempic treatment to a strict carnivore diet with intermittent fasting and continued to lose weight while swearing off all things sugar and starch (still sugar). My A1C is at its lowest it has ever been in a few years, (5.4). I felt it was the best solution to prevent rebound weight-gain, while also reducing bodily insulin production. I do not recommend using Ozempic at all. I recommend avoiding it at all costs. It's awful!
Dr. Ken, Barry and yourself have definitely change my life when it’s come too low carbohydrate high fat high protein, no sugar diet has changed my day-to-day life in an immeasurable way
I'm a severe T2 diabetic, and I had an endocrinologist start me on Ozempic a couple of years ago. While I was on the low introductory dose I lost 3-5 pounds, and I felt the appetite suppression and very mild nausea and slight constipation. What made me quit, though was that while my appetite was decreased, I sensed some mild depression symptoms - as you said I looked forward to eating as a reward, and it removed that as a motivator for me. I didn't like the feeling, and I read about other side effects, so I quit. My doctors tried to assure me that depression is not a symptom of this drug, but I stuck to my guns and refused to continue.
PLEASE WATCH ON YT:
DR. JASON FUNG ON DIABETIS AND HIS INSIGHT (NON BENEFITS) ON OZEMPIC! BEST! ✨️
Have you looked into Berberine, a natural supplement that works identical to metformin?
Have you tried a ketogenic diet? It's the one diet intervention proven to put T2D into remission.
Wasn't metformin by increasing insulin leading to more hyperinsulinimua making the problem worse.
Why not just add strength training as a requirement to get the Rx. Any fast diet will have the same effect on muscle mass. How do u feel about the keto diet with the ozepics?
When I was diagnosed Type2, I had 50% less energy, a lot of pain in my legs, decreased intelligence. I was prescribed Metformin to lower my sugar. Then this year I was prescribed Rybelsus and now my body and Brain are back to normal and it has made life worth living again.
I so admire Dr. LUSTIG'S work HE IS A REAL HERO
I'm a diabetic and am on Ozempic for a short term (6-9 months). It enabled me to get rid of daily insulin injections without affecting my BSLs. I am also expecting to lose enough weight to get off all diabetes medication as well as hypertension medication.
Lustig seems to focus on the weight loss aspect for the obese.
I wish he would focus on the diabetes aspect.
Perhaps in another video, this was on weight loss.
The two issues go hand in hand . Fix one the other follows.
Ppl who believe in Magical drugs are ‘lucky’, who knows, miracle happens everyday, right?!?
Start eating fatty meat and your diabetes will be gone because you will not be craving any carbs within ten days
Type 1 or type 2? Generally type 2 diabetes can be reversed with diet and intermittent fasting. Keto for a short time can be helpful but it's not necessary as long as you get rid of the processed food and sugar. It makes it easier though.
Intermittent fasting seems to be key. When we allow our insulin levels to drop naturally we can access the fat stored on our bodies. Insulin inhibits lipolysis, the presence of insulin prevents us from accessing stored fat and burning it. When we fast we do not enter starvation mode, fasting is muscle sparing. But when we eat a low calorie diet we do burn muscle. All of this is explained at length in Dr Fung's books and Dr Lustig also explains it.
Eating real food and getting rid of processed food, added sugars, starches and processed vegetable and seed oils is very important.
Dr Jason Fung has written two books on the topic of diabetes and obesity, both are life-changing. If you haven't heard of these books please take the time to find them and read them; The Obesity Code and The Diabetes Code.
This is good general information, I don't know your medical history but I do know the way to lose weight and keep it off and become healthy is by eating real food, intermittent fasting, getting reasonable exercise, good sleep and stress reduction. Exercise and movement are not for weight loss, they are for overall health.
It has been amazing for treating my diabetes. Three weeks ago bs was 500+. Today it wass 112 in morning. I've also started a carnivore diet per my doc.
I have 3 boxes sitting in my fridge. My hubby developed type 2 diabetes after taking a statin (he probably needed to loose 20 lbs) & he’d rather take 5 meds than change his diet. He hasn’t used these because I guess the 5 other meds are keeping things in line but he doesn’t look great, he’s had muscle loss & lots of loose skin on his legs. But when I suggest diet changes as he goes on a Rita’s custard run, he says I’m not a dr.
OMG..
"....he goes on a Rita’s custard run, .."
Sorry, I had to laugh.
But, on a more serious note, he really needs to make simple (and probably) minor changes to his diet. Over the past 20 years, I have gone from 305 lbs to 168 lbs as of this morning. I have maintain a weight in the range of 170 lbs -175 lbs now for about 4 years. All of this was accomplished by changing my diet in dramatic fashion (cutting 90% of sugar , eliminating fast food, eliminating processed food, eating and cooking REAL food).
In 2016, my lipid specialist did put me on Victoza for a year to attack my insulin resistance. These BEST and most permanent solution is to change to eat real food.
My had the same attitude so I told him “I am not going to change your diaper if anything happens to you”. Well! Needless to say he eats what I cook 😅
EVERYONE that loses weight loses muscle and fat, regardless of how they lose it. As long as patients eat enough calories and protein they shouldn’t lose muscle. And Semeglutide has been around for 15 years
I use a Carnivore diet that keeps me satiated with nutricious food . Boiled eggs , now, are my ozempic because a few of them dampen any food cravings I get .I avoid sarcopenia ( muscle wastage) , and I save about 1,270 dollars per month.
Imagine the loss Big Pharma would face if our country was healthy.
Agreed we need better and whole food, but there is a place for glp1s as well. Life changing and saving for many.
This is absolutely not what we see in clinical practice at our clinic regarding fat versus skeletal muscle loss. We also utilize hormone replacement therapy in combination with GLP1s. We also advocate for a proper human diet, this is critical. We have seen many patients with minimal skeletal muscle loss if this is approached correctly. Also, this is not about DIETS. This is about helping people with a tool to fix the real issues for those that struggle with obesity and that is a substance abuse problem related to chronic excessive processed / refined carbohydrate consumption. Then for most all roads lead back to not having a healthy emotional management system.
Which hormones are you replacing? The ones dampened by increased somatostatin? TSH?
Thank you!! This needed to be said! Not everyone is simply worried about looking good in a bathing suit- as this doctor is adamantly suggesting....
Thank you. I HAVE to lose weight fast because of IIH and because of severe cptsd I don't qualify for gastric bypass. My care team is there for me to make sure it all goes well. I gained most of my weight during périmenopause and because of medication I take . I wish this video was less negative. Less shaming
@@_Julie_Bee It can be very simple and straight forward. Semaglutide is great, eat high protein, high fat and as little carbohydrate as possible. But the elephant in the room is the relationship with food and addiction to processed refined foods. This must be dealt with to be successful.
@@SeanMathes I have none, so I'll be fine. Let's say my chef husband being trained in french cuisine contributed more than anything. Now, I'm on proteins, veggies , sugar doesn't even appeal to me. Side note, I'm also on topiramate, so it's a double whammy I guess. Thank you for your reply!
Dr Lustig makes such sense. I was on Ozempic and stopped a year ago because of gastric side effects and it has taken a year to resolve my issues. I now feel my bowel is normal. I came off it because I felt the juice was not worth the squeeze. For 2months my body tried to regain weight but I was able to keep it static and then started to lose weight again. So far have lost 133lbs over 2 years and my Hba1c is down to 5.9 and will probably be lower when I have my next test. I am off diabetic medication and if it stays below 6 I will be classified as my diabetes is in remission.
The worse food is what they serve patients in hospital, processed food every meal.
Have you tried keto? Virta Health's mission is t2 diabetes remission/reversal and keeping people that way and they swear by it. Jeff Volek is like Lustig, a real doctor and the real deal.
Tried Ozempic. Didn't do anything, but Keto does. Keyto is a life-changing device for people with metabolic syndrome trying to get healthier.
doing keto with ozempic. was already keto adapted when I started but this has reinforced it. i also exercise and increasws my protein intake. and was heading into to pre-diabetes. I manage side effects by not over eating. it hasnt been vanity driving this but heatlh. both parents dead way too early due to type 2 diabetes
So I was obese. Hi cholesterol. 34 BM1 210. 5'6" I'm down to 160 after a year. No side effects ye and ever. I just eat less not NOT all all. Starvation. and I try to eat healthy food and be conscientious of protein intake. Ive reduced major sugar intakes and I think Ive had alot of fat loss...maybe some muscle loss but I was in an accident in August that effected my exercise....which I always did my whole life. It seems like you're saying if I be health and food smart it may not be so bad. The problem WAS always psychological eating, Age, not responding to my body signals of whether I was hungry or full. I totally agree on the sugar issue. But I think this has helped me and Im trying to do it healthily. And I take multi vitamins
Thank you for your education and your fight to keep us healthy. Great questions and great answers. You are both great.
Thank u. I like the part where he talks about the food environment for kids. I fight and fight and fight about sugar. Most adults just do not get it. We had sugar when we were kids but its different now. Its crazy. Its not about weight it is about your metabolic health!
Food is not a reward. Food is a requirement a reward is being there for your family doing things you love and being happy food isn’t for happiness it’s for energy.
Thank you! Dr Lustig is amazing. He really understands obesity. I am 65, type 2 diabetic on insulin. I went from overweight to morbidly obese on insulin even when cutting out carbs and eating less. I have always felt that type 2 shouldn't be on insulin because the body is fighting the insulin with insulin resistance. Maybe it's all doctors can do to keep us alive at present. I was interested in Ozempic for diabetes but certainly don't think I want to lose muscle mass. Too expensive anyway. I have been diagnosed diabetic for 35 years. So much has changed and been understood since then. I am so glad you are looking at it holistically. Type 2 diabetics need to be trained and educated like you say!
Have you tried the Ketogenic diet and intermittent fasting?
I have been on Keto for more than 4 years now. Reversed diabetes, NAFLD, and a lot more ❤
Insulin tell your body to grow & that’s what it’s doing
Do you ever address thyroid disease?
@@aurapopescu1875
Been keto for about 2 years. It’s changed my life. 71, no meds, 22 BMI, 135#. Feeling 20 years younger. NOT WEIGHTED DOWN, and moving like a sloth!
I can tell you that I was pre diabetic and labeled obese for years. Now I am not. I can tell you what worked for me, a person who does not believe in diets, surgery, taking drugs, likes good food. At age 65, I am finally free.
Ozempic improves insulin sensitivity and even reverses diabetes in many patients . It improves cardiac health, and lowers cholesterol and triglycerides. Muscle loss is a concern , but this happens with all weight loss to a lesser extent. It’s important to consume adequate amounts of protein and participate in muscle building activities.
How can you increase protein if you can't eat. Stomach is always full and uncomfortable. I can go the whole day and never feel hungry. When I do try to eat, it is only a couple of mouthful.
How do you increase exercise if just walking is a major challenge? Lifting the legs feel like climbing a mountain. It is insane. Why would Anyone want to live in such a helpless state. I refuse to see my endocrinologist because she has ruined my health with this medication. I am diabetic and she thought I would lose weight but I put on 15 kilos. How can that happen when I eat so little? My Tsh shot up to over 20, B12 nosed dived . Death seems more attractive than living like this. This is not living, just waiting for death😢 This medication is a death pill and destroyer of health.
I never ate sugar or junk foods, packaged supermarket foods. I listened to all the health advice and followed recommendations to a T. Grew my veggies and fruit. Prepared meals from scratch, using fresh produce. Exercised all my life.
Who are we suppose to listen to? So many contradictory opinions. Vegans blame animals foods, and carnivores blame carbs & sugars.
Surely, with all the money spent on the research, we should have some consensus on how to eat.
If glp-1 agonists are designed to stop you from eating. I can do that on my own volution. I don't need not toxic drug to stop me eating. F***k that drug. I just need genuine advice based on rational science.- untainted, and unbiased.
@@mirellamatotek4294 It sounds to me like this may not be the best medication for you , and if you haven’t done so already , share all of your concerns with you doctor , they may have other options for you . Best of luck to you .
Muscle loss to a certain extent but 1:1 is not acceptable. And does it really increase insulin sensitivity? No, it makes more insulin. If it was more sensitive, you would need less. Because there is so much insulin, fat isn’t the primary source of fuel burning. The body can’t access the fat. That’s why muscle is being cannibalized.
@@Texasketogirl This medication only increases insulin secretion in response to meals containing glucose . How exactly it improves insulin sensitivity is not well understood.
@mirellamatotek4294 it sounds like you ALREADY KNOW what to do with your body type and knowledge!
Go for it !!!
I live in the UK and was given Rimonabant being a shy person it completely changed my personality and left me with chronic diarrhoea. We have a yellow card system of reporting problems and I submitted one. Luckily it was withdrawn worldwide in 2008. I am very sceptical about all new wonder drugs.
How did it change your personality, if you don't mind me asking? Did it cause disinhibition? Agitation? Aggression?
Oldstephanieb from being a shy retiring person I became more aggressive. Frankly I didn't give a d*mn. I had dogs at the time and someone challenged me about them and the thought crossed my mind if I had a gun I would shoot you and I would have done it as well. Diplomacy went out of the window. I submitted a yellow card adverse drug event. At that time cases were coming to light of other people becoming aggressive and the US banned it and then here in the UK they quickly banned it. However it did occur to me it would be a great defence in court it wasn't me your honour it was the tablets.
@@enidcronin9704 Have you heard of a paradoxical benzodiazepine reaction? It's when GABA overactivates your neurons. I can't be sure but it sounds like it may have happened to you, I'm so sorry. And lol I'm glad it didn't come to that! Our brain chemicals influence our behavior in such strange ways, but you bet every criminal would say the pills did it lol
Crazy to hear all the success stories! Good job to everyone who has tolerated these meds and is now living their best life! 🎉🎉🎉
Sadly the BS here is to actually recommend the right way to take these drugs! I am taking Mounjaro on my keto diet, now I am carnivore and lifting weights heavy and cardio in between. I’ve stalled at 7.5mg going to 10mg soon. I am down 60lbs and have another 70-80 lbs to go. To fix my insulin resistance I need massive zone 2 cardio. I think that’s actually the right therapy for weight loss. Combined with heavy resistance training.
Took Ozempic for 3 months. Thankfully, because I'm pre-diabetic, insurance covered it. The stomach pain was unbearable. I was afraid to eat most of the time because I needed to know I'd have quick access to a bathroom if I ate. And I only lost 8 pounds. Gained back 18 after stopping it. The only thing that works is fasting, keto, managing cortisol and glucose.
Wow! It's amazing!
Loss of muscle mass is really unhealthy and downright dangerous for older people, who are far less likely to regain that muscle mass. I’m a physician and getting bombarded with requests for prescriptions for this drug. I’ve never like the idea of it and I’ve refused. They go and find someone else to prescribe. Now I will send them a copy a this video.
Thank you for refusing to mistreat people.
Absolutely crazy cycle. With bodybuilders and fitness models they increase their testosterone injections, HGH injections and other PED injections while increasing their lifting so they actually lose fat and gain muscle at the same time, but of course, at what cost to the body. They don't care. 100's have told me - " if I can take injections, win Mr. Olympia two or three years in a row, then would be ok with dying". Fact. Crazy. Blind ambition. Athletes willing to die to win. Everyone thinks they are the "One" who will cheat death. It is the Opioid epidemic all over again !! Some get so desperate they travel to other countries. 6 month "vacations" to Thailand or Dubai becoming very popular 😢😢😢. Rather see these people get bariatric surgery or liposuction,.......
Can I ask - my Endo wants me to try Monjauro as I find myself in a weir position of being put on insulin but no other drug and I gained 30#
The Pharmacist printed out the Adverse reaction page for both Ozempic and Mounjaro and was alarmed by the 51% autoimmune response to Monjauro versus 1% Ohempuc Autoimmune response. I am already auto immune and have a big autoimmune cluster. Once the software is broken and the body makes antibodies to a particular tissue or hormone that’s it. Then you have declining organ function and a over worked or stressed immune system as sited by the CoVID research group in Europe - the folks having hardest time overcoming CoVID had really high levels of existing Antibodies. It was surmised that the body may be low on reserve and vitality of the immune system to effectively fight off new things
I just want a script for bioidentical testosterone to keep my heart, brain and adrenals intact. Thank you
I am a 78 year old woman who has used Mounjaro for a year. I have not lost muscle mass or strength, even as I have lost 35 pounds. The reason is that I follow a serious weight lifting program. Losing muscle mass and strength at an advanced age even while on this drug is by no means inevitable - if the patient is willing to participate in a weight lifting program.
Thank you, Dr. Robert Lustig for making this very valuable podcast to clear the concept about Semiglutide, GLP-1 analogues, and weight loss. Dr. Lustig, I appreciate your urge and desire to educate the general public on various controversial topics like this as well as all your videos so far.
I am a follower of your podcasts and I like all your topics.
I am a practicing Dermatologist for 35 years but, I have a liking for Medicine and hence keep myself up to date with the present situation.
You have a very assertive style of speaking which impress me.
I have purchased two of your books: Metabolical and Fat Chance.
In this video, you have touched upon the topic of children and their food intake. This is ideally the hot topic of today. The change can occur on an individual level only as the Market comes before Man for today's governments.
Hence, to sensitize the new generation, Nutritional literacy is absolutely essential in schools.
Keep it 👍 Dr. Robert Lustig.
I lost 87 lbs over the last 14 months by cutting sugar, increasing my sleep time/quality, and cooking at home more often.
I found your channel recently. I was doing a search on Amber Lynn to see how she's doing these days. I had unfollowed her about a year ago because she made me so sad. Have you ever just wanted to help someone, but knew you couldn't? That was how I felt about her. It breaks my heart to see a beautiful young woman destroying her body.
Your recent video on her popped up. Although you were brutally honest about her situation (some people would say "mean" LOL!), I still liked you because you provided some valuable information that everyone with a weight problem needs to hear. I really appreciate the Dr. Lustig link in this video.
I'm height/weight proportionate. It's taken me decades to figure out what works for me (I'm 68) , after years of chasing after the magic weight loss bullet, only to find out there isn't one. I didn't have surgery, and won't bore you my own plan, but I will say it's possible to lose 100 pounds and keep it off for more than five minutes.
Keep up the good work, and thank you for all you do. ❤
I am a nutrition educator working with the 4-11 yo population. I am happy to talk to you about how I educate kids to eat more fruit and veg - successfully!
Why not educate them to an animal based diet?
Trail mix for kids
He’s amazing! He’s saying everything I basically knew. I’m an RD and I advise my patients/clients in this way 👍👏. So proud of myself for being a rogue RD!!!
Dr lustig is a gift to humanity. Thank you!
Great talk, I definitely needed mounjaro to help me kick start my health journey. I lost 80lbs in 7 months. After I plateaued I realized that I lost lots of muscle and destroyed my metabolism. I then got off it and started real healthy living with high protein/fiber. Resistance training and walking.
I had great success with Wegovy because the extra weight I was carrying kept me from running as much as I wanted.
My Achilles would hurt so much and my heart rate got so high out of nowhere.
I lost 23 pounds on Wegovy and those problems went away.
I stopped wegovy a month ago and I've lost a couple more pounds since then =)
Wegovy is great but only if you're willing to transition into a healthier lifestyle afterwards.
I just started Ozempic, will be jumping to the .5 dosage in a couple of weeks. I'm glad i caught this video. I already knew i needed a lifestyle change and pantry change after starting this drug and that this wasn't a long term solution, but I'm going into this with the belief that this is only a head start in the right direction. Going to talk with my PCP about consulting with a nutritionist on my next appt. Thanks Dr Lustig for the insight!
You know there is exceptions to everything. Everyone is different. I was going to take it but I’m over 65 and cannot afford to lose muscle. MY daughter is on it and doing beautifully, no side effects. I am hoping these medications will improve and costs will come down.
A good friend of ours had quad bypass surgery. We asked if he was going to change anything in his life. He said "no" and now he's not here anymore. So sorry to anyone/everyone given the wrong information or didn't find it on your own. Or ignored what the good info was. So much miss information makes the truth hard to find. Thanks social media, censorship is not the right thing.
UA-cam is pretty good
How about promoting a high protein diet while using ozempic to prevent muscle loss……To say eating less equals starvation would suggest the whole intermittent fasting crowd would suffer the same consequence…. He goes on to say that someone with sugar addiction may suffer depression when cutting out sugar, so they shouldn’t use ozempic to help stop…… that is like saying all drug addicts and alcoholics should go ahead and keep drinking and doing drugs because they might get depressed when not using…… most of this discussion is so one-sided unscientific……… I do agree that the biggest issue here is that pharmaceutical companies run the country and it is a complete money grab…… I am not for or against anyone using ozempic and I do agree we should fix the food situation first
Thank you for asking the question about metabolic health. So far you are the only conversation I have seen that did so. It’s frustrating to hear that we “really don’t know” some of that answer. I hope you will do a follow up discussion when more evidence exists.
Thank you. Important and presented with easy to understand
As a nurse I’m glad you questioned how this works because I still don’t quite understand, I wonder why people don’t suffer hypoglycemia if they aren’t a diabetic and does it improve metabolic health. The people who I see that take it still eat poorly.
I took it for a few months and I’m not diabetic. I’m also in nursing school and we practiced taking blood sugar. I had eaten a TON of sugary foods (giant cookie, pizza, Starbucks drink) an hour prior and my blood sugar was only 77 😳 I stopped taking it but I did like the weight loss Im not gonna lie lol
Thank You for this!! I watched at 4am. I'm a recovering Carb addict. It's clear that most PCPs can not/will not own our long-term health - only we can do that. AND that takes time (to learn) and energy (to avoid processed food, sugar, exercise).
do GLP-1s address the addiction factors ? think agin
It is a radical treatment perhaps warranted by severe metabolic issues like high BMI, high H1A etc. I was put on it at .25mg and instructed to eat --- if I can -- starting with protein and then non startchy veggies and no white or starchy foods. Definitely no sugary things. I am 5' 8" and started at 212 lbs and now am 153 lbs. My face is emaciated looking, I've had to get physical therapy to rebuild muscle needed for balance and motion and my vocal cords have been stripped down so my voice is often a hoarse raspy whisper. My gut struggles to eject waste almost getting me into the ER several times. Yes; It worked at killing my urges to eat sugary things, but frankly what saved me was the warning to change what I eat!!!!! Stop the sugar!!! But now I have at age 80 the task of rebuilding from the loss of muscle and the loss of vocal cord tissue. Will my gut return to normal? I have trouble speaking; it's a good thing I learned to touch type! I could have done this in a slow measured less damaging way by adopting a low-carb (not necessarily high-fat) regimen. The way to lose fat is to burn it; not muscle.
I have heard about vagal nerve stimulation, I don't know if insurance covers it but maybe that would help? The vagus nerve controls a lot of the activity of the vocal chords. And I would try collagen for constipation, I am on a medication that also slows down the gut, but fiber left me gassy and bloated and didn't help but two scoops of beef collagen with some sugar free flavoring in a bottle of water (I get mine at Aldi) and poop there it is. If it doesn't work try more, it won't hurt you. And this may sound weird but maybe try carnivore? Dr. Kiltz is a great resource, he's a lil crazy but I got the collagen tip from him and he often has live YT chats where anyone can ask questions no matter what they eat.
Thank you for sharing! Learned a lot ❤
One of the best interviews between these two which says a lot since they have all been exceptional to date👍🏿👍🏿😀
Watching from Spore. Very succinct and well explained for non medical people. Thank you.
This episode was just amazing. Dr. Lustick is the leader of the food industry one of the best among Dr. Ludvik, Dr. Gregor, Dr. Campbell…. Great speech. Thank you so much. Dr Casey - she is a bomber 😮😮, I live the way she’s conducting this episode with dr Lustig ! What an amazing lecture! FREE🎉
Thank you for your explanation.
If you find his comments interesting you should get his recent book _Metabolical._ He is the _best_ explainer.
Here he says the biggest truth: kids’ food can’t be fixed because the environment they’re in is too toxic. In schools at birthdays parties, at friends’ places, in supermarkets etc.. eating real food has become a challenge. Only mindful adults can make it!
I love Dr RL most informative in this field.
I wonder if combining heavy resistance training with a GLP-1 agonist will diminish the sarcopenia side effect.
itasworked for me and not doing heavy lifting. just a balanced consistent resistance workout
@@Maevelikeschampagne - Good to know.
Enjoyed the talk. It was scary yet informative. Sent it to the friends and family. Hope they take heed to it.
Such a great honest video!
Dr Lustig, simply the best!
I took something called OMAD ( just one way of eating - not a diet ) and I lost 18 kgs / 39 lbs.
I felt so good on it - I ended up doing it for 7 years.
I only stopped because I ramped up weight training and wanted to re-sculpt my body.
I grew up in a place with no supermarkets and no medical centres.
For the past 50+ years, I have been surrounded by supermarkets, medical centres, and pharmacists.
I try to avoid visiting all three.
You mean the country?
These products are a life saver for the shareholders of the pharmaceutical companies who make them.
Skinny fat is bad too. Please keep up the research. We will listen very intensly
Thank you for posting this.
Blood glucose monitoring devices are super expensive unless you take insulin... I am in Canada..... it's good to talk about how healthy you can get... but most people can't afford it
What a fantastic informative interview. This is going straight to my favorites to share with others.
My friend in San Antonio, Texas is on Ozempic too so it's not just in L.A. btw I live in Joshua Tree so I meet lots of midwesterners who come here via LA.
IN Deed! A Whole New level!! Thank you DR Means and DR Lustig!! LOve you guys
So many people on earth should be listening to this SO valuable information. Not only that video but all of them you produce. We’re sick and the health care industry / big money often doesn’t give us the right answers because they don’t even know about it. It’s not different in Canada 🇨🇦
The disconnect between research and practice is a mess! We have everything about how to reverse metabolic disease and be healthy long term shown over and over and yet "sugar is bad" and the like is still fringe to most. ¯\_(ツ)_/¯
Thank you for addressing the questions that I had about the effect of increasing insulin secretion and weight while taking Ozempic.
This drug reminds me of SSRI when it first came out it was to help people get out of depression enough to start working on their root cause of their depression. Now 1/3 of the US takes it on a pretty continual basis. Never really have worked on the root cause of their issues or maybe they have become reliant on it (I know this is an oversimplification, but so was the discussion of Ozempic).
Thanks for the great information x😊
Thank you for sharing! 😊
I was struggling with increase in blood sugar and promised my obesity specialist that I would try Trulicity. I got Covid and 3 weeks later I took Trulicity for 2 months. I was selectively nauseous to meat which led to binging on carbs. When I dropped it, I was left with blood sugars about 300 and gained 20 pounds. I've fasted for 5 days to bring my blood sugar down and I'm starting over with a low carb diet and IF. This screwed me up when I've controlled my diabetes with no drugs for the last 5 years.
love both these guys
To comment on why people lose weight even though GLP 1 RAs stimulate insulin release, part of the explanation is that they only cause more insulin release during eating. In the fasting state, insulin levels are even lower with these meds than without them. And total daily insulin release is also lower.
Dr. Lustig is the best.
It’s too hard to cook some meat and some eggs have a salad. You’ll have to give up of the junk food but the energy levels feeling good. Every day is worth it.
Ive been on Oz, Weg, Sax, and Trulicity and while I initially lost weight, The past few my months have been a rollercoaster.
In my case Ive never ingested much sugar. Carbs,portion control and food chatter are my issues.
Coming off the med I sigbed uo for noom and several workout apps to increase activity and track intake. Kept it within Noom's weight loss zone but continued tl gain a 2 lbs a week. The toll is takes on your morale is understated and equivalent working 60 hrs and getting taxed to the point where your check is less than your normal weekly.
This is a captured market as coming off the med leds to weight gain. Many will stay on this dlr for decades.
Interesting to me is that at 66 and a loss of 15lbs I've found my overall outlook is highly improved. I've had minor side effects, loose stools for 1.5 days, 5 hours of minor nausea, 3 days of being overly tired. Thirty days in, I feel this drug has improved my life in ways not remarked on.
Please try this. Instead of some injection …. I started carnivore 11+ months ago. So many things healed! IBS (had for years)gone on 2 weeks. Itchy flaky eczema ear problem (over 6 yrs) also gone in less than a month Arthritis hands elbows and shoulder totally pain free and strong in a few months. Left hip pain gone. Gingivitis gums healed and receding gums grew back! Ovarian cyst Gone! And I don’t need reading glasses anymore! Had to share!! Plus .. Honeygirl no longer has skin problems After 8 yrs. She is spunkier and her coat is amazing. She eats the fresh meat with me! I was surprised at her healing all around. Alert. Full shiny coat. Happy. Friskie 10 yr old pup ❣️. And she’s been in freeze dried beef diet for 5 years!! This healed her!!! Also Im loosing all excess fat. Body is becoming stronger. Hair and nails are great. I was afraid to think that my spinal nerve pain and fused areas might get much better. But this week I have had several days with No Pain!! I feel 20 yrs younger. The healing seems to be from the things one doesn't eat. The meat protein is healing and rebuilding blocks. The fat is energy for cells etc
Big problem, when the weight is gained back, it is as fat, the muscle that is gone is not replaced, so you become fatter, have less muscle, so therefore have less ability to burn calories , because it is muscle that burns calories!
Novo Nordisk spent $3 billion to make a brand new production factory for this medication....
Yes Dr Means, why don't we spend this money on teaching people about food 🤔🧐