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I do follow you and love your videos. Out of topic question. A1C 6.9 Started on MOUNJARO 5mg starting weight 178lb. Lost 4lb for the first month. Up to 7mg for 3months lost 5lb total of 9lb. Then went up to 10mg no weight lost for a month. Eating healthy, fasting, exercising doing all the "rigt things' just a little constipation no major side effect. Started in 9/9/24 and now 1/5/25. Total weight loss 10Ib is very frustrating, I have not yet checked my A1C but BS numbers are great total average of 101. Should I increase my dose? I know you'll say talk to my PC I will but what's your opinion? Please

1mg twice a week seems to be effective for a starter. I am trying it with pre-diabetes. Also lifestyle mods and Berberine

Doc. Ghrelin manipulation is a terrible move for gh.

Appreciate the detailed explanation. Thank you.

Your videos have helped me so much! Thanks for taking the time to do this.

At the end of the day, the drugs help you eat less? So the actual weight loss is still going to be based on your calories in vs out?

Is there no schedule for semaglutide?

I SINCERELY AND DEEPLY appreciate your input as a medical professional with sympathy and empathy due to your experience with these life changing medications. I came to your channel by chance and am grateful to the algorithm for the connection! As I approach my goal, I am looking to titrate down to a maintenance dose and am ever so grateful for your expertise and generous sharing of resources and insights.

Does GLP1's put any markers on the red blood cells? I just about died from Warm Autoimmune Hemolytic Anemia. I had some sort of markers on RBC's and my T cells starting attacking them faster than I was producing them. I am curious if any markers could cause this condition to return.

I use Mounjaro to manage food noise/cravings and as a byproduct lose weight. Now 7 months along I have lost 45 lbs. but I have had to continue to titrate up my dose to maintain the food noise management. I am now at 10 mg weekly and the side effects are now problematic. I am interested in microdosing but have trouble understanding how 1 mg/week will manage my food noise when 7.5 mg currently does not. Thanks Tony

Thanks for this. Not a lot of thorough info on this on YT or online.

Really helpful information I have struggled trying to find a maintenance dose that maintains appetite control I look forward to trying microdosing.

Love this! Need doctors that think outside the box and offer really root cause treatment options and knowledge. Not simply medications that bandaid ailments. Great job!

Thank you for your videos. How do you advise us in the UK to extend to every 14 days where the pen contains 4 doses and lasts 30days? Do we just waste some of the medicine? Thank you.

Interesting! I do believe everyone's maintenance dose (and weight loss dose!) Is different. I'm currently in maintenance on 7.5mg every 7 days. I briefly tried 5mg and felt too hungry. But I haven't tried playing with the days, ie dosing every 10 days or every 5 days. Also, I may want to lose more weight! How did you know when you were at your goal?

Dr. thank you for the info. I do have the same question as @e.samoor8323 if you can help with this question that will be great. thank you @e.samoor8323 1 day ago Hi Dr Kevin. My question is, do you use compounded Tirzepatide or brand name vials? And how do you preserve your left overs? I recently started compounded Tirzepatide and the instruction on the vial says discard unused portions after 28days of first puncture. I'm confused on how to make it strech longer than 28days if i decide to microdose

Super helpful! Thank you!!!

Great video. Can you tell us what your titration profile looked like on the way up? What worked well for you?

My concern about staying on this "forever" if needed is that the GLP-1 receptors may eventually downregulate, causing rebound hunger even while on the drug. What are your thoughts on this?

Time stamps please. Thanks for these videos.

Thanks for this Video. I decided to reduce my dosage (First Step from 7.5 to 6.5). Every seven days is easy for me - in order to avoid getting confused with my next shot day. Next step will be 5.5 mg… I like using the plotter to better understand what‘s happening and to be able to make a plan.

Great video, Dr. Kevin Joseph. Looking forward to your next upload! I smashed that thumbs up button on your content. Keep up the fantastic work. Your insights into the clinical trials and the importance of careful dose management are really enlightening. What strategies do you recommend for individuals to maintain their weight without the medication if they decide to come off?

Thank you for taking the time to make another awesome video! All your videos have been so valuable to me on my journey with Tirzepatide. I also respond to a much lower dose than is recommended and am losing 2 pounds per week so far. I'm not sure why but I was unable to get the plotter you linked to work, but I found an app called Shotsy that works the same way. It is a game changer to see how the levels decrease over time and correlate that with hunger and other symptoms. Now I am dosing Tirzepatide every five days. Please keep making your informative videos!!

Thanks

Many thanks for your informative videos. Couple of questions. Been on Semaglutide for 5 weeks with good results one thing I have noticed recently is ensuring I'm eating enough (I track my food daily) are there cases of people not losing weight because they are not eating enough calories while on Semaglutide? Also in regards to exercise - can you provide some general guidance on exercise routines - for some reason I'm worried of losing weight too fast if I exercise while on Semaglutide? Do you also have any thoughts on vitamins/minerals people should take daily while on Semaglutide? Thanks!

I'll definitely watch this video again when I reach my goal. I'm halfway there so far!

Love your channel and will continue to watch regardless. I just wanted to provide some constructive feedback in case you’re interested. Please consider removing the background music-it makes it harder to follow since you already speak quite quickly. I usually listen at 0.8x speed to better grasp the information you share. Thank you for all that you do!

I may need to use semaglutide for maintenance with tirz going off shortage list.how to dose sema foe 7.5mg or 10mg tirz?

Hi Dr Kevin. My question is, do you use compounded Tirzepatide or brand name vials? And how do you preserve your left overs? I recently started compounded Tirzepatide and the instruction on the vial says discard unused portions after 28days of first puncture. I'm confused on how to make it strech longer than 28days if i decide to microdose. Thanks

Thank you for the video! Dr. Joseph, I keep telling people in the GLP1 community how fabulous your channel is.Honestly, feel like I struck gold finding you. Many Blessings for the upcoming year! 🙏🙏

Hi doc great video! I was wondering if you were ever able to check out Dr. Jason Fung, and if so, did you form an opinion around his idea of muscle wasting during fasting as a survival imperative? I have another question for you. How would you advise me to find a Dr. to help me in my GLP-1/weight loss journey? I got my cardiologist to write the prescription for Mounjaro, but I don't think he's really up on the nuances of the drug and common treatment regimens. He's a great Doc, but this isn't his wheelhouse. The same is true for my PCP. Any thoughts you might have on locating someone credible, even if it was telehealth, would be awesome!

Any thought on 15 mg Mounjaro and haven’t lost a pound in 2 months no side affects and a little food noise. Type 2 diabetes. Dr suggested phentermine any thought?? Thank you!

Just read Zepbound was approved for sleep apnea… hoping my insurance will start covering it

what was your motsc protocol please ?

I did not like it. I think tirzepatide is the best for weight loss. I gained 1 lb on reta during my first 2 weeks. By the end of the month, i was only down 3 lbs. With tirzepatide, i lost 8lbs on week one. The swelling i had on retra concerned me so much i couldnt wait to get off it.

How can I find a provider who is skilled with peptides? I am getting my GLP1 through an online provider, so they are probably not a solution, and my PCP is clueless in this area.

I’m so pleased you are feeling so much better. My bmi isn’t really really bad it’s 32. But I have to change. I’m 51. I’ve started on mounjarno this week at 2.5mg this week. No side effects. I like the idea of slow and steady

Thanks for this video Dr.Kevin. Your story and the way you educate subscribers is greatly appreciated. I was curious about your thoughts on 5-Amino-1MQ as an adjunct to Tirzepetide? Not a whole lot of long term data on 5-Amino-1MQ at all.

Hi Dr. Joseph - could you share the dosing schedule for NAD+? And can you take it indefinitely or do you need to do on/off cycles for NAD+ the way one does for BPC-157?