TIMESTAMPS 00:55 Dopamine and serotonin similarities 00:17 Precursors 01:40 Derivatives: noradrenaline and melatonin 02:03 psychology of neurotransmitters: motivation vs Happiness 02:30 Social behavior 02:48 Memory and learning 03:00 Attention, memory consolidation, hippocampus, and long-term memory 03:35 Low dopamine vs low serotonin 04:41 High dopamine vs high serotonin 05:30 Dopaminergic networks vs serotonergic system 06:12 Tonic vs phasic release 07:40 Summary 08:45 subscribe & questions
How can I know which one I prefer ?! Give us the highest foods / supplement ; stimulation for serotonin or dopamine I want to see clear effect but without any side effect out of curiosity
Having ADHD-PI and Depression is a nightmare. This video informed me more and hopefully will help me find a good treatment during these difficult times. ❤
Thanks for this informative video I hope u could help me with my problem I got dengue fever in The last week of august,24 along with asthamic bronchitus, therfore quit 25 year old habbit of smoking For the last month I have been experiencing all sorts of emotional imbalance such as fear, insecurity, lack of sleep and so on My question is if this is due to quitting cold turkey or it is a post dengue complication and most important of all will it normalize with passage of time Thanks and all the best
Amazing content! Neuro-endocrinology and Psychiatry has been my passion since 2000! I am a firm believer of the notion that hormones = neurotransmitters = cytokines => Mind IS the Body and vice versa. Thank you so much for your effort.
Thank you for the crystal clear explanation. There is a lot to take in for a non- scientific person like me, so I think that I will have to watch your video again to really assimilate the content.Please keep making these video.Your calm gentle manner of speaking is a great help.
Brilliant video. I’ve been dealing with anxiety lately. The info here makes me realise a lot about some of my life choices and recent situations. Thank you 🙏🏼
Thank you for creating such an informative and enjoyable video. Your clarity in explaining the role of Serotonin/Dopamine in our behavior was truly impressive. Your professional yet graceful demeanor made the content engaging and easy to follow. I also appreciated the balanced use of graphics and figures, which were both clear and intuitive, greatly enhancing the overall understanding of the topic. Excellent work!
High fat carnivore diet was the best dopamine detox for me. I managed to balance my hormones, completely cure my depression, anxiety and addictions. 5 years carnivore. Best decision of my life.
@@iaminkaland Inflation affects every one and should be eliminated as much as possible. No one is immune to inflammation, All processed foods, coffee, sugar, alcohol, drugs and seed oils cause inflammation. There are no depression, or diabetic in nature.
This materials is so good and important I wish more people to know about this. Thank you for your effort to sharing this information and make this video. Kudos!
I really liked this video! Concise, clear and to the point. Could you perhaps cover Oxytocin in one of your upcoming videos and how to supplement it correctly?
This explains so much. I was diagnosed with Parkinson's 2 years ago. I've always loved writing & recording music, but now I just can't bring myself to pick up a guitar. There's simply no sense of purpose.
I'm sorry to hear. Sounds like low dopamine. You could try some lifestyle ways to boost it too. Ask your healthcare provider tips. There plenty tools spanning from cold showers, exercise, nutritional approaches, etc!
hi! you really explained these two neurotransmitters really well!! I really appreciated your content! it was easy to follow and also kept attention. I solely came for a quick review and in the end, I was definitely far from disappointed. Thanks! And, have a great day! 😊
What a great knowledge..really informative...thank u so much for such intriguing video....u look so elegant n adorable...god bless u dear ❤ subscribed ur channel also♥️😇
Thanks for this informative video I hope u could help me with my problem I got dengue fever in The last week of august,24 along with asthamic bronchitus, therfore quit 25 year old habbit of smoking For the last month I have been experiencing all sorts of emotional imbalance such as fear, insecurity, lack of sleep and so on My question is if this is due to quitting cold turkey or it is a post dengue complication and most important of all will it normalize with passage of time Thanks and all the best
Hi Inka!! I am very happy that the algorithm made this video in my feed, because i am aware of dopamine and serotonin since two years ago and i thought i knew everything about these amazing hormones but you proved me wrong 😅. I have to watch your other related videos as well during this week. Thank you very much for your amazing video 🥰🥰
Im being treated for PTSD and MDD and have gone from serotonin, norepinephrine and now Dopamine. I prefer the dopamine but need something when I have attacks. without dopamine, I won't get out of bed.
Great explanation. Very good slides. May I suggest to include the availability of the micronutrients necessary for the production of dopamine and serotonin and, also, the enzyme that degrades monoamines. I have subscribed to your channel. Thank you for this high quality content. 👏👏👏🙏
Your comment, transparently masquerading as constructive criticism is obviously you mr attempt at trying to conspicuously venerate yourself in front of strangers on the internet. What does that say about you? Why don’t you make your own video with the content you suggested? That was not the subject of this video.
Considering that L-tyrosine is instrumental in the production of dopamine, it makes sense now that when I supplement with 500mg L-tyrosine and vitamin B6, my focus and social energy levels increase. Note: I typically only take supplemental L-tyrosine on the rare days where I am required to be at my peak performance (work related). Thank you for this video, it clairfied several questions I had regarding these 2 neurotransmitters.
One thing that I noticed in regards to telling my co-workers/friends about my use of L-Tyrosine... several of them are Hispanic and the "L-" was confusing them. A few of us went out to dinner one evening and one of them said they couldn't find the supplement. Turns out, she was looking for El Tyrosine! I explained that the L was referring to the left-handed version of the molecule... so it was the letter L. That led to a humorous discussion about how I made a similar mistake when I moved to the Southern United States from my homeland of Canada. One of my co-workers shouted "Ole'!" about something, and I naturally thought he had shouted "Au Lait!" (With milk!!). I found it rather confusing. I thought that maybe Hispanic people really have a thing for dairy?!? This was because my mind was still processing in French Canadian. It has been an inside joke for some time now 😅 Cafe' Ole'!!
I had multple traumatic brain injuries. i was a dopamine junkie. Had to work on my serotonin as well. Lots of problems with speach, memory.m...even ptsd and parkensons.
Recovery may too optimistic a word...managing my condition...that is the trick. Very few good videos on this subject. If you want to know more read up on Traumatic Brain Injuries, Axonal Shearing (blast injuries), Larium/Mefloquine poisoning (chemically damages neural pathways, Long Term Stress effects on the brain, Multiple Schlerosis/Parkensons/Huntington Disease, Football and Brain Injury, and pay particular attention to the fact that soldiers are 7 to 14 times as likely to develop Parkensons or similar Brain disorders. Lots to learn. If this is happening to you...well, you probably won't be able to see the effect by yourself. Others will. Listen to what they say and get help. Hope that helps someone Phil
@@philliplopez1501 Thank you Phillip for sharing this. These are all heavy conditions and definitely need lifelong health management and adjusting. I could make more videos about them if it's any help! I have some experience with working with these conditions and am keen to learn more about them, too.
I think that would be very helpful. There are certainly people who suffer from one or more of these conditions but are unaware of the cause; thus have little to no hope for improvement. Thanks for the video
I'm 59 and I recently had to quit eating animal protein because of my metabolism. It was damaging my thyroid and my kidneys. I switched to plant protein supplements with all of the amino acids in balanced quantities. I've realized that if I don't take these supplements and a handful of vitamins and mineral I can barely function. I can feel the power of protein fixing my nervous system. I also have a daily banana habit. I had no idea bananas were good for your brain now I know why I'm eating them.
Thank you for wonderful explanation. Lifetime of depression (age 11-67) is under control due to Rx and vitamins. Recent brain injury from Pfizer Omicron 19 Vaccine 2020 Has inspired me to learn more about brain chemistry, synapses, benefits of B and D and of course keep the body moving. 👏👏👏
Thank you for sharing your experience- sounds like you’re on a right track forward 🙏🧠 keep going and welcome to the channel! Feel free to keep us updated on your progress
TIMESTAMPS 00:55 Dopamine and serotonin similarities 00:17 Precursors 01:40 Derivatives: noradrenaline and melatonin 02:03 psychology of neurotransmitters: motivation vs Happiness 02:30 Social behavior 02:48 Memory and learning 03:00 Attention, memory consolidation, hippocampus, and long-term memory 03:35 Low dopamine vs low serotonin 04:41 High dopamine vs high serotonin 05:30 Dopaminergic networks vs serotonergic system 06:12 Tonic vs phasic release 07:40 Summary 08:45 subscribe & questions
Your explanation is so helpful to understand the actions of these transmitters. Would you help me find more information about 5-HT2A -2C receptor distribution in the mesolimbic and VMPFC, DLPFC, and Insula-amygdala pathways? And can you tell me the easiest source (illustrated books, videos, or your simple explanation, then it would be so beautiful !!) to know more about the different pathways of every neurotransmitter or modulator and its functions in depth? Finally, I am from India and have a background in the good old way of teaching mukhaa-mukha patana, i.e., face-to-face teaching and learning, in Ayurveda. And I am learning about the new thought processes of consciousness, i.e., neuroscience, neuropsychology, and other disciplines. Both of us have a common topic: yoga (yogam), especially the Paatanjala school of yoga. I hope you can feel the warmth and happiness that I am having because of this "eureka moment." When we get someone, we hope they can understand and share what we know. Thank you 5:54
Hey I believe I answered your other comments about the neurotransmitters. I also did a yoga teacher training in India and travel there couple times a year. I love India. Thanks for the comment. Sending warm wishes! Hope you're well.
Curious about the gap between the two and how it impacts our state of being and perception. When serotonin is artificially increased it produces one state of being, when dopamine is also increased at the same time the experience is completely different.
Good review, although I found your focus on the trophic production of both NT to lack any emphasis on inhibition and/or reuptake, as this is the root cause of many related therapeutic interventions and such imperative mechanisms to consider.
The root cause of mental health issues must be first examined and in most cases, antidepressants are not even necessary when you start healing the root cause. It can be inflammation, autoimmunity, mold, virus, trauma, etc
After serotonin is released into the space between neurons (the synaptic gap), it either 1) binds to the next neuron, 2) is broken down, or 3) is *taken back* up by the original neuron that released it. This reabsorption is called "reuptake." SSRIs block reabsorption by blocking the receptor that does it. So, serotonin stays in the gap longer, stimulating the next neuron for longer. This prolongs its effects.
Hi Dr. Land, I waa wondering what the cool down time in the dopamine slump is. So, 20 minutes of continuous stimulation creates a 50% dip in valence which is on a downward trajectory, but if you cease stimulation dopamine signaling goes back to baseline, so what is that time period? I think its somewhere between a minute and 20 minutes, but I'm guessing.
Hey great question. There's no singular trajectory of dopamine. In this study, they stimulated the cells so it's not similar to real-world dopaminergic response. Depends on the method (i.e., what dopaminergic drug of choice; exercise, coffee, gaming, chocolate, etc), the person's baseline dopamine, dopamine receptor density, amount of stimulation, etc. For example, cold exposure and exercise can cause a steady increase in dopamine for hours. Hope it helped.
Thank you for this video. I thought i have low dopamine but after watching your video i also share some symptoms of high dopamine {gambling, binge drinking, binge eating}, so i am confused..How do i know for sure whether im high or low in dopamine?
Dopamiine fluctuations are normal. It sounds more like you're at dopamine *imbalance*. I strongly recommend you to watch my and Dr Anna Lembke's dopamine episode which explains it. ua-cam.com/video/_WDgdVzSUZs/v-deo.html
That's an excellent question. Yes, there's a condition called dopamine dysregulation syndrome (DDS). While it's not equivalent to serotonin syndrome, this condition is characterized by overactivity of dopaminergic systems. It might occur in people who are chronically taking dopaminergic drugs like Levodopa. The symptoms include things like gambling, hypersexuality, binge eating and shopping, mania, hypomania, severe mood swings o hyperkinesia (involuntary movement) Thanks for asking, hope it helped!
I am sorry my question made things a little bit confusing my doubts are : can you please tell me about the pathways of mesolimbic, VMPFC, DLPFC, Insula-Amydala: 1). How are they connected? 2). What types of neurotransmitters are acting on or modulating these neuronal networks?. Which networks have5-HT2A-2C receptors as the predominant receptors in these networks.? 4). Can you recommend any illustrated books or videos of lectures that describe these networks?
Hey, no worries. Hope this helps 1) You can divide the mesolimbic pathway into lateral and medial ones. Lateral dopaminergic neurons (saliency/attention system) = Substantia Nigra (SN) Pars Compacta --> lateral NAC --> lateral and dorsolateral PFC. Medial dopamine neurons (reward system) medial posterior VTA → ventromedial Substantia Nigra----> ACC and medial PFC *For dopamine, see this video* ua-cam.com/video/xfjQ4R1OGhk/v-deo.html *I love this article:* pubmed.ncbi.nlm.nih.gov/30711326/ 2) The neurotransmitters are complex. 5HT2A is expressed around the CNS. Some rich areas include PFC, basal ganglia, ACC, thalamus, and hippocampus, for example. 4) I wish I could. The article I mentioned above is excellent for dopaminergic mesolimbic networks, and my video explains its mechanism in reward processing. Otherwise, just PubMed.
Hey, this is a hard question to answer not knowing more about your situation. First thing would be to consult mental health professional and developing a holistically structured plan forward. I know this is not much of help but I truly can’t say much more than this without further information . I’m also a lisenced psychologist with anonline therapy. You can read more about it in my webpage
Which enzymes activate these two neurotransmitters? Can you just name the category 1 to 6? (I mean oxidoredox, transfer, hydrox etc. I am curious because complex psychological things like motivation, memory issues etc need more than just small molecules like Sertn and Dopa.
For both dopamine and serotonin, the enzymes involved fall under the oxidoreductase, lyases, and transferase categories, with specific enzymes for each neurotransmitter. Dopamine --> Tyrosine hydroxylase (hydroxylase - oxidoreductase) converts tyrosine to L-dopa --> DOPA decarboxylase (decarboxylase - lyase category) converts L-DOPA into dopamine. Serotonin --> Tryptophan hydroxylase (hydroxylase - oxidoreductase) converts tryptophan to 5-HTP --> Aromatic L-amino acid decarboxylase (decarboxylase - lyase category) converts 5-HTP to serotonin Both neurotransmitters are broken down by monoamine oxidase (MAO), an enzyme in the oxidoreductase category
Serotonin does cause hallucinations. Selective serotonin releasing agents like MDAI and PMA have hallucinogenic effects because serotonin activates intracellular 5ht2a like psychedelics
? Foods for sleep? You mention banana for serotonin melatonin thus eaten lunchtime? Arvo? Dessert? Ratio of protein to carbohydrates? Maybe hi protein no fat plain yoghurt with a banana and tsp almond spread, pepita seeds? Thankyou.
High-protein at the first half of the day (e.g. turkey,chicken,fish,dairy,eggs, grass-fed beef. if there’s no allergies). Higher Carbs in the evening, low protein. Banana is good, pumpkin seeds, yogurt, vegetables.
TIMESTAMPS
00:55 Dopamine and serotonin similarities
00:17 Precursors
01:40 Derivatives: noradrenaline and melatonin
02:03 psychology of neurotransmitters: motivation vs Happiness
02:30 Social behavior
02:48 Memory and learning
03:00 Attention, memory consolidation, hippocampus, and long-term memory
03:35 Low dopamine vs low serotonin
04:41 High dopamine vs high serotonin
05:30 Dopaminergic networks vs serotonergic system
06:12 Tonic vs phasic release
07:40 Summary
08:45 subscribe & questions
How can I know which one I prefer ?!
Give us the highest foods / supplement ; stimulation for serotonin or dopamine
I want to see clear effect but without any side effect out of curiosity
Well explained. Thank you!!
❤️❤️❤️
The brain is fascinating in every way
Dopamine is pleasure - excitement & serotonin is happiness - contentment. I prefer serotonin over dopamine. Thanks ❤
This video released my serotonin.
Great !
😂😂😂😂😂😂😂
"You can't do things with a leg that you can do with an arm" Challenge accepted! Great info, thank you. 🙂
lol that's funny. lmk how it went!
Glad it resonated!
chimps can, chumps cant lol
The more I learn about ourselves the more I can see all the beautiful details GOD created all in perfect
Having ADHD-PI and Depression is a nightmare. This video informed me more and hopefully will help me find a good treatment during these difficult times. ❤
I'm sorry to hear that! Glad it helped a little.
Thanks for this informative video
I hope u could help me with my problem
I got dengue fever in The last week of august,24 along with asthamic bronchitus, therfore quit 25 year old habbit of smoking
For the last month I have been experiencing all sorts of emotional imbalance such as fear, insecurity, lack of sleep and so on
My question is if this is due to quitting cold turkey or it is a post dengue complication and most important of all will it normalize with passage of time
Thanks and all the best
Very good video
Thank u b ❤
Your accent is so soothing and beautiful to hear ,makes the Knowledge more interesting and engaging .thanks
Thank you. Glad to hear. Welcome to the channel
Amazing content! Neuro-endocrinology and Psychiatry has been my passion since 2000! I am a firm believer of the notion that hormones = neurotransmitters = cytokines => Mind IS the Body and vice versa. Thank you so much for your effort.
Thanks. Glad you liked it.
Thank you for the crystal clear explanation. There is a lot to take in for a non- scientific person like me, so I think that I will have to watch your video again to really assimilate the content.Please keep making these video.Your calm gentle manner of speaking is a great help.
Thank you for the feedback and I'm glad to hear you found it helpful! Welcome to the channel.
Good comparison between the two neurotransmitters!
Glad you liked it! ⭐
I like the look and feel of your presentation 👨💻
Thanks for this
thanks alot doctor you saved me
Thanks for watching
came for the knowledge, stayed for the accent
Only in this channel
im in love❤
Came and stayed for the knowledge😊
@@ljkoh20052000able Glad to hear you like the content! thank you.
I stayed for the eyes.
I just found you! You're a keeper and I'm sure I'll enjoy every video ! Best of everything! 🎉
Hi, Thanks so much for your kind words. Glad to hear you're finding the vids useful. Welcome to the channel.
Brilliant video. I’ve been dealing with anxiety lately. The info here makes me realise a lot about some of my life choices and recent situations. Thank you 🙏🏼
Glad to hear it resonated and sorry to hear about your anxiety. I hope this helped!
@@iaminkaland thank you so much
Much learned about the role played by the two transmitters!
Thank you so much!
This is helpful for people struggling with addiction more so understanding reasons for zombie scrolling on social media.
Glad to hear it was helpful
Very informative, and excellent organization and delivery! Thank you for sharing!
Great to hear. Thank you
Thank you for creating such an informative and enjoyable video. Your clarity in explaining the role of Serotonin/Dopamine in our behavior was truly impressive. Your professional yet graceful demeanor made the content engaging and easy to follow. I also appreciated the balanced use of graphics and figures, which were both clear and intuitive, greatly enhancing the overall understanding of the topic. Excellent work!
Thank you, I appreciate you a lot!
thank you for giving you knowledge out freely , you explained it very well and spoke clearly .
@@larrylazza3157 glad to hear it resonated
High fat carnivore diet was the best dopamine detox for me.
I managed to balance my hormones, completely cure my depression, anxiety and addictions.
5 years carnivore. Best decision of my life.
Carnivore is great!
@@iaminkaland Inflation affects every one and should be eliminated as much as possible. No one is immune to inflammation,
All processed foods, coffee, sugar, alcohol, drugs and seed oils cause inflammation. There are no depression, or diabetic in nature.
@@desmomotodesmomoto2033grains too.
You should have a million subs's.
Thank you
This materials is so good and important I wish more people to know about this. Thank you for your effort to sharing this information and make this video. Kudos!
Thanks for commenting and I'm glad to hear it helped
came for knowledge, stayed for accent and looks
I really liked this video! Concise, clear and to the point. Could you perhaps cover Oxytocin in one of your upcoming videos and how to supplement it correctly?
Thanks! Will do
I noticed most people in the city are stressed snd aggressive because They are on some form of caffeine. Thank you 🙏 for the confirmation
This explains so much. I was diagnosed with Parkinson's 2 years ago. I've always loved writing & recording music, but now I just can't bring myself to pick up a guitar. There's simply no sense of purpose.
I'm sorry to hear. Sounds like low dopamine. You could try some lifestyle ways to boost it too. Ask your healthcare provider tips. There plenty tools spanning from cold showers, exercise, nutritional approaches, etc!
@@iaminkaland Thank you 🙏
Thank you Inka.
Glad to hear it was helpful
Thank you Doctor for the clear, concise information you shared❤.
Glad to hear it helped.
Thank you so much for a very clear explanation.
Thanks for watching!
You Rock! Thank you for the clarifications.
Glad to hear it was helpful!
Thank you, I can imagine preparing such a comprehensive and detailed comparison would've been quite an effort
Thank you for the comment. When it's your passion, it doesn't feel effortful ! happy to share
hi! you really explained these two neurotransmitters really well!! I really appreciated your content! it was easy to follow and also kept attention. I solely came for a quick review and in the end, I was definitely far from disappointed. Thanks! And, have a great day! 😊
Hey, Glad you liked it! Welcome to the channel. Have a great day 😊
Good and clear explanation
Thanks for watching!
❤Gtreat job
What a great knowledge..really informative...thank u so much for such intriguing video....u look so elegant n adorable...god bless u dear ❤ subscribed ur channel also♥️😇
Thanks for watching and subscribing!
Thanks for this informative video
I hope u could help me with my problem
I got dengue fever in The last week of august,24 along with asthamic bronchitus, therfore quit 25 year old habbit of smoking
For the last month I have been experiencing all sorts of emotional imbalance such as fear, insecurity, lack of sleep and so on
My question is if this is due to quitting cold turkey or it is a post dengue complication and most important of all will it normalize with passage of time
Thanks and all the best
Smart and beautiful Estonian❤Love your knowledge and blue eyes❤
Thank you. Very well explained.
Glad it resonated.
good video very closely explained exactly the same i though but you explained it perfectly and in more details 👌
Gad to hear it resonated and thank you for the comment
Hi Inka!! I am very happy that the algorithm made this video in my feed, because i am aware of dopamine and serotonin since two years ago and i thought i knew everything about these amazing hormones but you proved me wrong 😅. I have to watch your other related videos as well during this week. Thank you very much for your amazing video 🥰🥰
Hi, I’m so happy your found it useful! Welcome to the channel :)
Thank you for a good explanation. I learned a lot from this.
Glad to hear ! Thanks for the comment.
Im being treated for PTSD and MDD and have gone from serotonin, norepinephrine and now Dopamine. I prefer the dopamine but need something when I have attacks. without dopamine, I won't get out of bed.
Love this format. Thank you.
Thanks glad you like it
great video, thanks
Thanks for watching!
Thank You
Thanks for watching!
EXcellent Inka best on the tube
Thank you
Great explanation. Very good slides. May I suggest to include the availability of the micronutrients necessary for the production of dopamine and serotonin and, also, the enzyme that degrades monoamines. I have subscribed to your channel. Thank you for this high quality content. 👏👏👏🙏
Thank you so much for this comment!
I'll make a video on that too! Welcome to the channel!
Your comment, transparently masquerading as constructive criticism is obviously you mr attempt at trying to conspicuously venerate yourself in front of strangers on the internet. What does that say about you? Why don’t you make your own video with the content you suggested? That was not the subject of this video.
Thank you! Quite accessible explanation about the two hormones. Gave me some valuable info
Glad to hear! Welcome to the channel
Thanks you easy to understand
Glad to hear
Very informative, thank you🙂...
Glad to hear 🙏 thank you for the comment!
That's wonderful ❤
Thank you 🙏
Thank you 🙏
Thanks for sharing . Excellent.
So nice of you
Fantastic video, Inka! 💯👍🏼
Thank you Isabella ❤️
Considering that L-tyrosine is instrumental in the production of dopamine, it makes sense now that when I supplement with 500mg L-tyrosine and vitamin B6, my focus and social energy levels increase. Note: I typically only take supplemental L-tyrosine on the rare days where I am required to be at my peak performance (work related). Thank you for this video, it clairfied several questions I had regarding these 2 neurotransmitters.
One thing that I noticed in regards to telling my co-workers/friends about my use of L-Tyrosine... several of them are Hispanic and the "L-" was confusing them. A few of us went out to dinner one evening and one of them said they couldn't find the supplement. Turns out, she was looking for El Tyrosine! I explained that the L was referring to the left-handed version of the molecule... so it was the letter L. That led to a humorous discussion about how I made a similar mistake when I moved to the Southern United States from my homeland of Canada. One of my co-workers shouted "Ole'!" about something, and I naturally thought he had shouted "Au Lait!" (With milk!!). I found it rather confusing. I thought that maybe Hispanic people really have a thing for dairy?!? This was because my mind was still processing in French Canadian. It has been an inside joke for some time now 😅 Cafe' Ole'!!
Wow. This is a great video!
Glad to hear it was helpful
Great video! Keep bringing us such amazing and clear content!
Glad you found it helpful
I had multple traumatic brain injuries. i was a dopamine junkie. Had to work on my serotonin as well. Lots of problems with speach, memory.m...even ptsd and parkensons.
Sorry to hear about the injuries. I hope the recovery is going well.
Recovery may too optimistic a word...managing my condition...that is the trick.
Very few good videos on this subject. If you want to know more read up on Traumatic Brain Injuries, Axonal Shearing (blast injuries), Larium/Mefloquine poisoning (chemically damages neural pathways, Long Term Stress effects on the brain, Multiple Schlerosis/Parkensons/Huntington Disease, Football and Brain Injury, and pay particular attention to the fact that soldiers are 7 to 14 times as likely to develop Parkensons or similar Brain disorders.
Lots to learn. If this is happening to you...well, you probably won't be able to see the effect by yourself. Others will. Listen to what they say and get help.
Hope that helps someone
Phil
@@philliplopez1501 Thank you Phillip for sharing this. These are all heavy conditions and definitely need lifelong health management and adjusting. I could make more videos about them if it's any help! I have some experience with working with these conditions and am keen to learn more about them, too.
I think that would be very helpful. There are certainly people who suffer from one or more of these conditions but are unaware of the cause; thus have little to no hope for improvement.
Thanks for the video
@@philliplopez1501 You're right. Thank you for the reminder.
Excellent work!
Carry on. ❤
Thank you glad you liked it
Great clip thanks 🙏 ❤
@@bobby3849 glad to hear it was helpful
I'm 59 and I recently had to quit eating animal protein because of my metabolism. It was damaging my thyroid and my kidneys. I switched to plant protein supplements with all of the amino acids in balanced quantities. I've realized that if I don't take these supplements and a handful of vitamins and mineral I can barely function. I can feel the power of protein fixing my nervous system. I also have a daily banana habit. I had no idea bananas were good for your brain now I know why I'm eating them.
@truescotsman4103 - I appreciate your comment. When you say "metabolism" - were you unable to lose weight on animal protein?
I wish you success and fulfillment in life ❤
Thank you!
Thank you very much for these infos. Does cerebral infarction effect dopamine release?
It can
@@iaminkaland Thank you.
@@iaminkaland Thank you.
Thank you very much for this video. It was very informative. I enjoyed your examples.🤩
Happy you found it useful. Thank you for the comment
Thank you for wonderful explanation. Lifetime of depression (age 11-67) is under control due to Rx and vitamins. Recent brain injury from Pfizer Omicron 19 Vaccine 2020 Has inspired me to learn more about brain chemistry, synapses, benefits of B and D and of course keep the body moving. 👏👏👏
Thank you for sharing your experience- sounds like you’re on a right track forward 🙏🧠 keep going and welcome to the channel! Feel free to keep us updated on your progress
Thank you! now i understand
Thanks for the comment. Great to hear it was clear
TIMESTAMPS
00:55 Dopamine and serotonin similarities
00:17 Precursors
01:40 Derivatives: noradrenaline and melatonin
02:03 psychology of neurotransmitters: motivation vs Happiness
02:30 Social behavior
02:48 Memory and learning
03:00 Attention, memory consolidation, hippocampus, and long-term memory
03:35 Low dopamine vs low serotonin
04:41 High dopamine vs high serotonin
05:30 Dopaminergic networks vs serotonergic system
06:12 Tonic vs phasic release
07:40 Summary
08:45 subscribe & questions
Great video! Thank you 🙏
Glad you liked it
Your explanation is so helpful to understand the actions of these transmitters. Would you help me find more information about 5-HT2A -2C receptor distribution in the mesolimbic and VMPFC, DLPFC, and Insula-amygdala pathways? And can you tell me the easiest source (illustrated books, videos, or your simple explanation, then it would be so beautiful !!) to know more about the different pathways of every neurotransmitter or modulator and its functions in depth? Finally, I am from India and have a background in the good old way of teaching mukhaa-mukha patana, i.e., face-to-face teaching and learning, in Ayurveda. And I am learning about the new thought processes of consciousness, i.e., neuroscience, neuropsychology, and other disciplines. Both of us have a common topic: yoga (yogam), especially the Paatanjala school of yoga. I hope you can feel the warmth and happiness that I am having because of this "eureka moment." When we get someone, we hope they can understand and share what we know.
Thank you 5:54
Hey I believe I answered your other comments about the neurotransmitters. I also did a yoga teacher training in India and travel there couple times a year. I love India. Thanks for the comment. Sending warm wishes! Hope you're well.
Thanks
Glad to help!
Execellent
Thanks for watching!
Curious about the gap between the two and how it impacts our state of being and perception. When serotonin is artificially increased it produces one state of being, when dopamine is also increased at the same time the experience is completely different.
You are great 😊
Thank you glad you found it useful
very informative
Glad to hear you found it useful. Thank you for the comment.
thanks! Gorgeous and inteligent....video ;)
Good presention and highly appriciated for adovcacy and general awareness۔ From Hyderabad, Pakistan۔
Thank you very much
Good review, although I found your focus on the trophic production of both NT to lack any emphasis on inhibition and/or reuptake, as this is the root cause of many related therapeutic interventions and such imperative mechanisms to consider.
@@KitchenDog03 thanks for the review - might do a follow up video covering those :)
Fantastic
Thank you
Brilliant 👏
Glad u liked it!
Hello i need ur help !
I love that you know your stuff..
Lots of reading
Excellently explained
Glad you liked it!
Did u create all of this or where their precious pioneers?
I made it based on scientific articles
Very well explained.
Amazing idea about the 10 min
Thanks I appreciate it. I'm tying to be effective in my deliveyr
@@Maryyeager220 I think this refers to the title that's "Everything Under 10 minutes"
I have never been so much invested in learning new things
Should you have your hormones levels tested before you try an anti-depressant? What is test name?
The root cause of mental health issues must be first examined and in most cases, antidepressants are not even necessary when you start healing the root cause. It can be inflammation, autoimmunity, mold, virus, trauma, etc
What is the purpose of SSRI's? They inhibit the "re-uptake" of serotonin but what does that mean?
After serotonin is released into the space between neurons (the synaptic gap), it either 1) binds to the next neuron, 2) is broken down, or 3) is *taken back* up by the original neuron that released it. This reabsorption is called "reuptake." SSRIs block reabsorption by blocking the receptor that does it. So, serotonin stays in the gap longer, stimulating the next neuron for longer. This prolongs its effects.
Hi Dr. Land, I waa wondering what the cool down time in the dopamine slump is. So, 20 minutes of continuous stimulation creates a 50% dip in valence which is on a downward trajectory, but if you cease stimulation dopamine signaling goes back to baseline, so what is that time period? I think its somewhere between a minute and 20 minutes, but I'm guessing.
Hey great question. There's no singular trajectory of dopamine. In this study, they stimulated the cells so it's not similar to real-world dopaminergic response. Depends on the method (i.e., what dopaminergic drug of choice; exercise, coffee, gaming, chocolate, etc), the person's baseline dopamine, dopamine receptor density, amount of stimulation, etc. For example, cold exposure and exercise can cause a steady increase in dopamine for hours. Hope it helped.
High Dopamine , that’s me. Oh my. Thank you
Thanks for watching
Thank you for this video. I thought i have low dopamine but after watching your video i also share some symptoms of high dopamine {gambling, binge drinking, binge eating}, so i am confused..How do i know for sure whether im high or low in dopamine?
Dopamiine fluctuations are normal. It sounds more like you're at dopamine *imbalance*. I strongly recommend you to watch my and Dr Anna Lembke's dopamine episode which explains it.
ua-cam.com/video/_WDgdVzSUZs/v-deo.html
Hi, I have taken over dose of meth crystal ice (drug) only once about a month ago now I'm face low dopamine and low serotonin, what should I do?
Is there an equivalent to serotonin syndrome for dopamine, or is it not necessarily dangerous in the same way?
That's an excellent question. Yes, there's a condition called dopamine dysregulation syndrome (DDS). While it's not equivalent to serotonin syndrome, this condition is characterized by overactivity of dopaminergic systems. It might occur in people who are chronically taking dopaminergic drugs like Levodopa. The symptoms include things like gambling, hypersexuality, binge eating and shopping, mania, hypomania, severe mood swings o hyperkinesia (involuntary movement)
Thanks for asking, hope it helped!
I am sorry my question made things a little bit confusing my doubts are : can you please tell me about the pathways of mesolimbic, VMPFC, DLPFC, Insula-Amydala: 1). How are they connected? 2). What types of neurotransmitters are acting on or modulating these neuronal networks?. Which networks have5-HT2A-2C receptors as the predominant receptors in these networks.? 4). Can you recommend any illustrated books or videos of lectures that describe these networks?
Hey, no worries. Hope this helps
1) You can divide the mesolimbic pathway into lateral and medial ones.
Lateral dopaminergic neurons (saliency/attention system) = Substantia Nigra (SN) Pars Compacta --> lateral NAC --> lateral and dorsolateral PFC.
Medial dopamine neurons (reward system)
medial posterior VTA → ventromedial Substantia Nigra----> ACC and medial PFC
*For dopamine, see this video*
ua-cam.com/video/xfjQ4R1OGhk/v-deo.html
*I love this article:*
pubmed.ncbi.nlm.nih.gov/30711326/
2) The neurotransmitters are complex. 5HT2A is expressed around the CNS. Some rich areas include PFC, basal ganglia, ACC, thalamus, and hippocampus, for example.
4) I wish I could. The article I mentioned above is excellent for dopaminergic mesolimbic networks, and my video explains its mechanism in reward processing. Otherwise, just PubMed.
I wonder if there’re tests for that🤔
@@2104T34 yes there’s urine test for neurotransmitters
I am 16 years old and i am having lots of anxiety and depression . What should i do?
Hey, this is a hard question to answer not knowing more about your situation. First thing would be to consult mental health professional and developing a holistically structured plan forward. I know this is not much of help but I truly can’t say much more than this without further information . I’m also a lisenced psychologist with anonline therapy. You can read more about it in my webpage
@@iaminkaland yesterday I went to a psychologist in a city and they gave me something called "escitalopram"
Which enzymes activate these two neurotransmitters? Can you just name the category 1 to 6? (I mean oxidoredox, transfer, hydrox etc. I am curious because complex psychological things like motivation, memory issues etc need more than just small molecules like Sertn and Dopa.
For both dopamine and serotonin, the enzymes involved fall under the oxidoreductase, lyases, and transferase categories, with specific enzymes for each neurotransmitter.
Dopamine
--> Tyrosine hydroxylase (hydroxylase - oxidoreductase) converts tyrosine to L-dopa
--> DOPA decarboxylase (decarboxylase - lyase category) converts L-DOPA into dopamine.
Serotonin
--> Tryptophan hydroxylase (hydroxylase - oxidoreductase) converts tryptophan to 5-HTP
--> Aromatic L-amino acid decarboxylase (decarboxylase - lyase category) converts 5-HTP to serotonin
Both neurotransmitters are broken down by monoamine oxidase (MAO), an enzyme in the oxidoreductase category
Why serotonin binding to 5HT2A receptors does not cause hallucinations?
That's a serotonin receptor :)
@@iaminkaland When binding to this same receptor, many psychedelics (lsd, psilocybin, dmt) cause hallucinations, but serotonin doesn't.
Serotonin does cause hallucinations. Selective serotonin releasing agents like MDAI and PMA have hallucinogenic effects because serotonin activates intracellular 5ht2a like psychedelics
? Foods for sleep? You mention banana for serotonin melatonin thus eaten lunchtime? Arvo? Dessert? Ratio of protein to carbohydrates? Maybe hi protein no fat plain yoghurt with a banana and tsp almond spread, pepita seeds? Thankyou.
High-protein at the first half of the day (e.g. turkey,chicken,fish,dairy,eggs, grass-fed beef. if there’s no allergies). Higher Carbs in the evening, low protein. Banana is good, pumpkin seeds, yogurt, vegetables.