Thanks be to God for that woman who discovered the Cori cycle! I hope God blesses many other people with knowledge like you so that His goodness is always known!
Your NAD+ to NADH is in the wrong place. The reduction occurs at glyceraldehyde-3-phosphate dehydrogenase. It seems to be incorrect on all of the videos in the series. Maybe put an addendum in the description.
@@Jasmine-ll8quAt 1:14, F1,6P goes to DHAP + G3AP (Aldolase). This is one step earlier than the actual step, it's supposed to form when G3AP goes to 1,3BPG (G3AP DH). Basically the E circle should be moved down one set of double arrows and it'd be correct. Nice eye Kris, I didn't notice that until you pointed it out!
2:02 small correction : the problem of not having enough NAD+ in glycolysis is NOT the lack of production of ATP during glycolysis. ATP is mainly produced in the ETC, NOT glycolysis. The actual reason is that if we dont have any NAD+ its likely we dont have a lot of oxygen. The ETC turns NADH into NAD+, among other things of course, so a lack of oxygen is directly related to low NAD+ concentration. Lack of oxygen is bad because the ETC requires oxygen for ATP synthesis. But this is not an issue inside of glycolysis. You do mention this, but you make it seem like ATP production inside of glycolysis is the issue! Which kind of yes, but only under anearobic conditions, otherwise ATP production is not a problem for glycolysis EDIT: addendum : lactic acid serves as a signaling molecule fatigue as far as I know and only causes muscle fatigue in the very short term. DOMS (delayed onset muscle fatigue) - so what is most commonly known as muscle fatigue is not caused by lactic acid buildup since lactic acid levels are typically declining to baseline within an hour. DOMS is primarily caused by (micro) injuries to muscle tissue and the accompanying inflammation. Research also suggests that lactic acid might serve as a signaling molecule to heal strained muscle! This is just an addendum though for anyone interested
9:08 - so it says that liver is taking lactate and making glucose with it. My question is - during strenuous exercise, does that mean liver is running both gluconeogenesis and glycolysis at the same time? I assume it must do a lot of glycolysis to make ATP to support the body, but how does that align with it doing gluconeogenesis? Edit: if anyone's interested, I did some research. It seems like liver mainly does glycolysis during FED state, when things are chill and it's just storing energy. During exercise, it seems like liver's job is to put out as much glucose as possible, so it's actually running gluconeogenesis and glycogenolysis. So it turns out this aligns with having to convert lactate.
Thanks be to God for that woman who discovered the Cori cycle! I hope God blesses many other people with knowledge like you so that His goodness is always known!
I'm a second-year medical student studying for boards, and I still come back to your videos. You got me through MCAT, and now onto STEP!
Thank you so much for imparting your knowledge and connections in a clear and direct way, you're amazing for sharing this!
4:46 the ambulance blaring its siren outside my house
Fucking love this intensity coupled with a very clear and in-depth explanation
This is great. Thanks for the help! You deserve many more views and subscribers
Love your videos, and extremely helpful that you keep repeating and emphasizing necessary facts!
Your NAD+ to NADH is in the wrong place. The reduction occurs at glyceraldehyde-3-phosphate dehydrogenase. It seems to be incorrect on all of the videos in the series. Maybe put an addendum in the description.
How should it be instead? :/
@@Jasmine-ll8quAt 1:14, F1,6P goes to DHAP + G3AP (Aldolase). This is one step earlier than the actual step, it's supposed to form when G3AP goes to 1,3BPG (G3AP DH). Basically the E circle should be moved down one set of double arrows and it'd be correct.
Nice eye Kris, I didn't notice that until you pointed it out!
thank you so much! I learned more in this video than I have with my biochem professor all semester.
this might be the best mcat video ever made
AWESOME!! Can you please make videos about lab techniques for the mcat like column chromatography?
2:02 small correction : the problem of not having enough NAD+ in glycolysis is NOT the lack of production of ATP during glycolysis. ATP is mainly produced in the ETC, NOT glycolysis. The actual reason is that if we dont have any NAD+ its likely we dont have a lot of oxygen. The ETC turns NADH into NAD+, among other things of course, so a lack of oxygen is directly related to low NAD+ concentration. Lack of oxygen is bad because the ETC requires oxygen for ATP synthesis. But this is not an issue inside of glycolysis. You do mention this, but you make it seem like ATP production inside of glycolysis is the issue! Which kind of yes, but only under anearobic conditions, otherwise ATP production is not a problem for glycolysis
EDIT: addendum : lactic acid serves as a signaling molecule fatigue as far as I know and only causes muscle fatigue in the very short term. DOMS (delayed onset muscle fatigue) - so what is most commonly known as muscle fatigue is not caused by lactic acid buildup since lactic acid levels are typically declining to baseline within an hour. DOMS is primarily caused by (micro) injuries to muscle tissue and the accompanying inflammation. Research also suggests that lactic acid might serve as a signaling molecule to heal strained muscle!
This is just an addendum though for anyone interested
9:08 - so it says that liver is taking lactate and making glucose with it. My question is - during strenuous exercise, does that mean liver is running both gluconeogenesis and glycolysis at the same time? I assume it must do a lot of glycolysis to make ATP to support the body, but how does that align with it doing gluconeogenesis?
Edit: if anyone's interested, I did some research. It seems like liver mainly does glycolysis during FED state, when things are chill and it's just storing energy. During exercise, it seems like liver's job is to put out as much glucose as possible, so it's actually running gluconeogenesis and glycogenolysis. So it turns out this aligns with having to convert lactate.
when you almost cure cancer... love your videos!! :))
ur the goat