Who are you!? And why are you just so amazing? Please continue. I’m shouting you out at graduation!! Thank you for being a magical deliverer of the teachings of this once evil subject which is actually fun now.
People don't realise how important public speaking skills are for a teacher... I have tried to watch the same topic elsewhere but fell asleep in the middle of the video... You just are amazing Prof...
@@studybiology9673 This was 2 years ago, I am graduated now and passed Biochem with an A, but from what I remember, that exam went terribly lmao. But it would've been even worse without this video, so my original point still stands, this man is a life saver!
No matter ho much technology advances,The best way to study is by Classroom method and anyday the Erase board explanation will have edge over those fancy presentations..Because teacher can never get involved with the teaching by that premade presentations and You prove that again and again. You dont have an idea How many videos and sites I have browsed to go through this Tandem enzyme regulation..And You explained it ridiculously easily. Thanks a ton man !!!
but also only because of advanced technology this method works for many, the key difference is that you have the ability to pause or rewind, which you can't do irl in class
@@praisehart7737 it's not exactly like that: putting myself in professors skin, how is it professors fault that I zoned out for 15 mins, and I don't feel like studying rn, I rather do it in 40 mins. You can't just listening to a lecture when you are tired of it and don't feel like you are accepting all the information, you can't just stop and look up some other topic, which you missed, and spend like 30 mins learning that first and then coming back to this one
You have no idea how much I love biochemistry now thanks to you!!! I used to HATE it with a passion before I found your videos!!!!! Thank you so much!!!!!!!!!!
restudying gluconeogenesis for my MCAT & I can say this is probably the best source I have had for information. Better than khan academy and Kaplan MCAT test prep
This man is very good in teaching because he made work simple by adding jokes that makes fun in lectures. Is so amazing and I look for his channel first before others
If I discovered your channel during my biochem class maybe I understood the subject better. I'm just here because I felt the need to review these pathways because this is heavily related to the subjects I have trouble understanding with :( Thank you sir for making such efforts to help students understand these complex subjects. Keep the passion burning. Salute to your team!
If you ever go out of your mind and decide to visit a shitty town of Belgrade, Serbia-you have a place to stay free of charge. I am not even kidding. You are my hero! Thank you so much. I am bad at memorizing, but understand logic-and that is what you use. Simply amazing :)
One more error, around 20:37. Although Glucagon, Epi, and NE activate PKA and can stimulate glycogen breakdown, which is a GNG favoring process, Epi and NE inhibit the enzyme F-2,6 BPASE which is a GNG enzyme. From this we can deduce that Epi/NE are glycolysis favoring as they're promoting glucose mobilization for immediate use as opposed to relieving stored glucose (glycogen) for the purpose of maintaining homeostatic energy demands.
At 7.48 you probably meant "in the muscle" not "in the liver". Otherwise it would be Glucokinase not Hexokinase Great video as always mate you guys are a blessing
Thanks again for all the videos! Just a random question/suggestion: would it be possible for you to put a final picture of the board in the end? Sometimes it would be really helpful to check a little detail instead of watching the whole video again! But anyways, I'd really like to thank you for all the content. Y'all are just amazing
I am eternally grateful for your videos. I've watched a few of them several times and I have your diagrams in my head which help me remember what is going on during all these metabolism pathways and cycles :-)
Everyday when biochemistry professor starts the new lecture I just check the topic's title and search inside ninja nerd's videos if its available I feel really confident then I even don't want to lesson professor lectures😁😁
Thanks so much!! You man is a true legend, and your videos is so valuable, you make a very complicated and long topic that I hated in Uni into a story with smiley enzymes and simple metabolism :) Thanks for being there and always trying to make your best and for the tonnes of efforts that is placed in these videos, Looking forward for more videos Ninja Nerd!!
Also Glucagon phosphorylates Pyruvate Kinase and therefore inhibits conversion of PEP back into Pyruvate. This has the effect of diverting PEP to the synthesis of glucose!
hii sir ur lectures are really fruitfull the way u explain the things is very esay to understand ..i mostly follow ur lectures for my MACs exam preparations.bravo and praiseworthy...
From now on, I should pay the tuition for you. Btw, you're videos are not boring at all, I enjoy watching them . Biochemistry is fun with YOU and ONLY YOU.
You are seriously a life saver!Ive read few comments and totally can relate with them you truly are very good at your work.I see you erasing your mistakes with your fingers pls use a finger cap or something as those ink molecules can be harmful or even carcinogenic.Your safety is very important to your students and your family! one of your students from India❤️
You are amazing man my appreciation to you, biochimistry is so cool with your explanation and encourage student to love the whole medicine big thks dude)
I have a question: why does a higher ADP/ATP ratio (as in a low energy state within the cell) inhibit Pyruvate Carboxylase and Fructose 1,6 Bisphosphatase? Don't we need more energy in a low energy state? And so shouldn't gluconeogenesis increase when the cell has low energy, so more glucose is made and can be broken down for energy?
Your like osm sir Really your videos boosting me confidence in biochemistry Our teachers just read ppt, rather they explain nothing, u r saving me in building up my subject in biochemistry Thank u very much😊
Actually there are ads now, I don't if they're new, but yes I always watch them. Least I can do now. Will definitely donate to this channel after becoming a doctor.
*Reading Biochem for hours* Me: Finally a break... Now let's watch what I have been studding for hours in a 20 min video to relax Thank you SO much!!! A lot of love from a wanna be Pharmacist in Greece
I think there's an error around 14:50 when talking about ADP & acetyl CoA's influence towards pyruvate carboxylase activity. High levels of acetyl CoA would indicate we are in a fed state, there's a surplus of energy. If that's the case then high acetyl CoA would inhibit pyruvate carboxylase activity. Additionally, if ADP is high, we are in a low energy state; therefore, we would want to increase pyruvate carboxylase activity to produce more OAA and eventually more glucose via GNG.
There is an over abundance of acetyl-CoA from fatty acid beta oxidation, which won't be that high except in fasting state. It's also the process behind ketogenesis.
Great explanation of the Cori Cycle. I am a 60-year old pre-diabetic (no medications) and wear a continuous glucose monitor to track my glucose. When I start doing a vigorous activity like tennis singles, my glucose will spike from 100 to over 200 after 30 minutes of playing. Within 20 minutes of stopping play, the blood glucose returns to around 100. Is the Cori Cycle involved in this?
Great stuff! It would be helpfull though to tell that the cori cycle happens when oxygen is low, if not the muscle cells will use the krebs cycle. And the alanine cycle is for additional glucose during exercise or fasting.
2:30 its actually 3 ATP, because glucose 6 phosphate already has a phosphate, so you only have to invest 1 ATP to get 4 ATP back, That's one advantage of turning glucose into glycogen.
glucokinase vs hexokinase The main difference between hexokinase and glucokinase is that the hexokinase is an enzyme present in all cells whereas the glucokinase is an enzyme only present in the liver but you daid that Hexokinase is in the liver ? Am I wrong? last thing I really admire you you are the best I am from Saudi And all the medicine student recommended you to
This man is single-handedly saving the grades of students taking biochem
Agree
Who are you!? And why are you just so amazing? Please continue. I’m shouting you out at graduation!! Thank you for being a magical deliverer of the teachings of this once evil subject which is actually fun now.
People don't realise how important public speaking skills are for a teacher... I have tried to watch the same topic elsewhere but fell asleep in the middle of the video... You just are amazing Prof...
Biochem exam is in 36 hours, you have saved my life! Thank you!
Mines too
How was it?
@@studybiology9673 This was 2 years ago, I am graduated now and passed Biochem with an A, but from what I remember, that exam went terribly lmao. But it would've been even worse without this video, so my original point still stands, this man is a life saver!
@@SilentEagle2029 👍👍👍
@@SilentEagle2029 ooo congrats
No matter ho much technology advances,The best way to study is by Classroom method and anyday the Erase board explanation will have edge over those fancy presentations..Because teacher can never get involved with the teaching by that premade presentations and You prove that again and again.
You dont have an idea How many videos and sites I have browsed to go through this Tandem enzyme regulation..And You explained it ridiculously easily. Thanks a ton man !!!
the best way is teaching on board and then showing gross pics through slides.
but also only because of advanced technology this method works for many, the key difference is that you have the ability to pause or rewind, which you can't do irl in class
@@signalrod2213 if more professors allowed students to take them back without making them feel bad that'll be the case in real life too
@@praisehart7737 it's not exactly like that: putting myself in professors skin, how is it professors fault that I zoned out for 15 mins, and I don't feel like studying rn, I rather do it in 40 mins. You can't just listening to a lecture when you are tired of it and don't feel like you are accepting all the information, you can't just stop and look up some other topic, which you missed, and spend like 30 mins learning that first and then coming back to this one
@@praisehart7737 it's subjective, but personally for me studying in class is 15 times less productive than on my own in front of a screen
Man those videos should have a millions views
+Frajw Ggg Hopefully someday soon! Thank you so much!
I strongly agree with you!!
"one mor thing, to finish off" - Half the video left.
JK'ing my friend, love your videos. Biochem exam in 2 days and you give me confidence.
Dude, what's your day job? are you a doctor? professor? The One? Thank you for everything!!!
He's a super hero 😁
He is Engg
He is ninja
You've saved my education! Thank you from the bottom of my heart.
-from a pharmacy student in Syria.
Imma developing a huge crush on this dude due to my admiration towards this teaching skills 😭 u literally save me each and every time T~T
You have no idea how much I love biochemistry now thanks to you!!! I used to HATE it with a passion before I found your videos!!!!! Thank you so much!!!!!!!!!!
same here :D
@@karinsedlakova6316 Same here. Started to love it because of him. It's fascinating how our body deals with everything, really asthonishing.
Same too.
restudying gluconeogenesis for my MCAT & I can say this is probably the best source I have had for information. Better than khan academy and Kaplan MCAT test prep
i have been seeing many of your videos and i just want to say thank you! you´re so so so good at explaining!!!
This man is very good in teaching because he made work simple by adding jokes that makes fun in lectures. Is so amazing and I look for his channel first before others
If I discovered your channel during my biochem class maybe I understood the subject better. I'm just here because I felt the need to review these pathways because this is heavily related to the subjects I have trouble understanding with :(
Thank you sir for making such efforts to help students understand these complex subjects. Keep the passion burning. Salute to your team!
If you ever go out of your mind and decide to visit a shitty town of Belgrade, Serbia-you have a place to stay free of charge. I am not even kidding. You are my hero! Thank you so much. I am bad at memorizing, but understand logic-and that is what you use. Simply amazing :)
This was so intense, but it was worth watching. I watched it twice and understood the concept. Thank you, Zack!!!
You simply make the best biochemistry-videos!!! Thanks so much man!
Your videos are amazing. They deserve a million. Some silly youtubers buy a t-shirt and get 1 million that I don't agree with You deserve everything
One more error, around 20:37. Although Glucagon, Epi, and NE activate PKA and can stimulate glycogen breakdown, which is a GNG favoring process, Epi and NE inhibit the enzyme F-2,6 BPASE which is a GNG enzyme. From this we can deduce that Epi/NE are glycolysis favoring as they're promoting glucose mobilization for immediate use as opposed to relieving stored glucose (glycogen) for the purpose of maintaining homeostatic energy demands.
19:50 absolutely nooothing lamo
Wait i dont get that reference lol
At 7.48 you probably meant "in the muscle" not "in the liver". Otherwise it would be Glucokinase not Hexokinase
Great video as always mate you guys are a blessing
Gucokinase is just one specific isoform of Hexokinases -> Glucokinase = Hexokinase4
yeah, it should be glucokinase cause we're in muscle
the last two minutes of this video >>>> literally everything
teacher who I never have like him , thanks from all my heart
What a beautiful way to explain biochemistry, I entIrely love your channel!
Thanks again for all the videos! Just a random question/suggestion: would it be possible for you to put a final picture of the board in the end? Sometimes it would be really helpful to check a little detail instead of watching the whole video again! But anyways, I'd really like to thank you for all the content. Y'all are just amazing
This is something we have recently started to do in all of our videos. Thanks for the suggestion!
Ninja Nerd Science wow thanks! That's just great. Can you please check my previous comment on the gluconeogenesis video? :)
Andreia Filipa Lopes Sousa +1
this channel deserves 1 million subscribers and moooreee
Really amazing lecture.... Now I am interested to study biochemistry.. Thanks a lot for giving me hope ❤❤❤
Best bio-chem vids in the UA-cam.
thank you for making this difficult topics easier to us
You are even better than khan academy 💀for real.thank you❤
way better, its not even close tbh
It was absolutely fun and enjoyable, thanks for being there, you're a miracle that happened in my life ❤❤
I am eternally grateful for your videos. I've watched a few of them several times and I have your diagrams in my head which help me remember what is going on during all these metabolism pathways and cycles :-)
shoutout to this man for making me pass biochem
Everyday when biochemistry professor starts the new lecture I just check the topic's title and search inside ninja nerd's videos if its available I feel really confident then I even don't want to lesson professor lectures😁😁
Thanks so much!! You man is a true legend, and your videos is so valuable, you make a very complicated and long topic that I hated in Uni into a story with smiley enzymes and simple metabolism :) Thanks for being there and always trying to make your best and for the tonnes of efforts that is placed in these videos, Looking forward for more videos Ninja Nerd!!
Also Glucagon phosphorylates Pyruvate Kinase and therefore inhibits conversion of PEP back into Pyruvate.
This has the effect of diverting PEP to the synthesis of glucose!
you save my life! as a pharmacy student!
No one can compete such a great legend 🙂
hii sir ur lectures are really fruitfull the way u explain the things is very esay to understand ..i mostly follow ur lectures for my MACs exam preparations.bravo and praiseworthy...
From now on, I should pay the tuition for you. Btw, you're videos are not boring at all, I enjoy watching them . Biochemistry is fun with YOU and ONLY YOU.
We are grateful for ppl like you. Thank you bro
Thank u so much .... 👌✨
It's awesome ....
MashAllah ....
May ALLAH ♥️ bless u with endless blessings ✨😊
You are seriously a life saver!Ive read few comments and totally can relate with them you truly are very good at your work.I see you erasing your mistakes with your fingers pls use a finger cap or something as those ink molecules can be harmful or even carcinogenic.Your safety is very important to your students and your family!
one of your students from India❤️
You are amazing man my appreciation to you, biochimistry is so cool with your explanation and encourage student to love the whole medicine big thks dude)
Biochem exam is in 15 hrs and he's gonna save me❣️
How beautiful it was.....thank you sir❤️
Seriously dude ...such a wonderful explanation .. thankyou for making me understand this concept
Love from India
Thank you so much sir
7:44 In muscle, it's hexokinase. Liver: glucokinase
Thank you so much! Im a huge fan here from the Philippines. I am currently taking my 3rd year in college.
you are simply great, students from Serbia support you!!
استمر في نفع البشرية يا زكريا ❤
I have a question: why does a higher ADP/ATP ratio (as in a low energy state within the cell) inhibit Pyruvate Carboxylase and Fructose 1,6 Bisphosphatase? Don't we need more energy in a low energy state? And so shouldn't gluconeogenesis increase when the cell has low energy, so more glucose is made and can be broken down for energy?
u the best dude .... seriously u saved my life !!
Your like osm sir
Really your videos boosting me confidence in biochemistry
Our teachers just read ppt, rather they explain nothing, u r saving me in building up my subject in biochemistry
Thank u very much😊
Great video. You are very talented !
sir, if you put a long ads at the end of the video, I gladly watch it to support you and your team
Actually there are ads now, I don't if they're new, but yes I always watch them.
Least I can do now.
Will definitely donate to this channel after becoming a doctor.
@@waqarsarfraz4205 Same, watching ads is the only way I can support them financially. NEED MONEY ASAP.
You are the best thing that i found on youtube brother❤️😍
Another source of lactate comes from red blood cells which can only carry out anaerobic respiration. Keep up the good work.
FYI Your education method rocks !
+Anna Firoozi thank you so much for your kind words I'm so happy that we were able to help!
Thanks sir today I clear my biochemistry only because of you
*Reading Biochem for hours*
Me: Finally a break... Now let's watch what I have been studding for hours in a 20 min video to relax
Thank you SO much!!! A lot of love from a wanna be Pharmacist in Greece
Man those videos should have a millions views
I think there's an error around 14:50 when talking about ADP & acetyl CoA's influence towards pyruvate carboxylase activity. High levels of acetyl CoA would indicate we are in a fed state, there's a surplus of energy. If that's the case then high acetyl CoA would inhibit pyruvate carboxylase activity. Additionally, if ADP is high, we are in a low energy state; therefore, we would want to increase pyruvate carboxylase activity to produce more OAA and eventually more glucose via GNG.
There is an over abundance of acetyl-CoA from fatty acid beta oxidation, which won't be that high except in fasting state. It's also the process behind ketogenesis.
I love your lecturers sir just keep it up 🙏🙏
best teacher out there!
explained
AMAZİNG!!!
!!رائع الشرح
Açıklama şahane!!!
It's awesome , u deserve the very best Mr😇💯
Amazing explanation.Thanks Sir
Great explanation of the Cori Cycle. I am a 60-year old pre-diabetic (no medications) and wear a continuous glucose monitor to track my glucose. When I start doing a vigorous activity like tennis singles, my glucose will spike from 100 to over 200 after 30 minutes of playing. Within 20 minutes of stopping play, the blood glucose returns to around 100. Is the Cori Cycle involved in this?
I like your singing “absolutely nothing~~” :-D
Thanks a lot for clearing the whole concept
Great stuff! It would be helpfull though to tell that the cori cycle happens when oxygen is low, if not the muscle cells will use the krebs cycle. And the alanine cycle is for additional glucose during exercise or fasting.
Muchas gracias, muy bonito la interrelación entre el músculo, hígado y sangre en la gluconeogenesis.
Great explanations! Thanks a lot ! (:
This is an amazing explanation
You are KING ❤️
2:30 its actually 3 ATP, because glucose 6 phosphate already has a phosphate, so you only have to invest 1 ATP to get 4 ATP back, That's one advantage of turning glucose into glycogen.
You make med school possible 😂😂 Seriously, I'm just loving biochemistry
Wizard of metabolism 🧚🏻♀️
This is just some devil level teaching, thanku
better than khan or that balding dude
Wow!! Thank you!
who is balding dude haha?
Of course he's far better
glucokinase vs hexokinase
The main difference between hexokinase and glucokinase is that the hexokinase is an enzyme present in all cells whereas the glucokinase is an enzyme only present in the liver
but you daid that Hexokinase is in the liver ? Am I wrong?
last thing I really admire you you are the best I am from Saudi And all the medicine student recommended you to
@@drownedingames488 maybe aklectures ?
Zach, thank you so much, I finally understood it thanks to you💓💓💓
Man you make it so easy, thanks alot
Thank you so much!!
Perfect teaching process ❤❤😍
Sir, You are amazing ❤️
Great video, Thank you
THANK YOU SOOOO MUCH!! YOU'RE A LIFE SAVER ❤
You are the reason I'm not going to bomb my MCAT. Thank you.
Thankuu so much...your teaching method outstanding
Thank you so much ❤❤
perfect explanation!
Thank you so much
Thank you for this great inspiration
God bless this man
Well Done 🎉
"P.E.P.C.K is a whole different animal" 😂
Thank you for amazing lectures
Thank you so much! This was amazing.
Super u are clearly understand
I'm just imagining who you learnt from because the person is a legend who produced another legend mightier than him