I discovered your channel about a month before taking the MCAT, and I am so so glad I did! Your videos are so helpful, I don't think I would have done nearly as well as I did without them. I can only imagine how much time you must've spent making these videos, so from the bottom of my heart thank you for all your hard work! I hope medical school is treating you well.
Hello sorry to ask you but I will be taking the mcat in two months and I super worried do you recommend any study strategy or any advise for me please let me know.
I really like the fact that u show us the bigger picture and give us a visual map to see how pathways are connected to each other without making it too complex
Very high energy which I found a bit annoying at first, but by the end of the video I understood my entire anki deck on lipids that has been confusing me for DAYS. Well done, sir. Well done. Lipids have now have a legit connection to the other concepts in my biochemistry/metabolism semantic network Keep doing you my man. And thank you!
This is so incredibly valuable and insightful. It adds much needed depth to some of the review books. Understanding how the various lipids are formed via the mechanisms makes it easier to remember content about lipids!
So what I meant is that the -OH on the original compound is lost…. But that OH gets an added H+ and leaves as a water molecule… so to clarify the -OH on the original molecule is lost as a water molecule
Can someone help! At 1:35, he adds electrons to the OH group so that it can leave. However, I though OH- was a bad leaving group so how does that work??
There are biological enzymes that stabilize the OH, therefore facilitating the OH to leave as a leaving group… a common example is an enzyme protonates OH so it can leave as H2O
14:20 time stamp. The carbohydrate has a positive formal on the oxygen and I'm guessing delta positive on the carbon. Shouldn't O- as an nucleophile attack the formal positive charge O, instead of the carbon. I'm assuming there is no serious steric hinderance. Can anyone explain why it attacks C and not O?
Also, keep in mind that generally speaking, biological enzymes catalyze all these reactions, which allow formation of several highly unstable intermediates.
I discovered your channel about a month before taking the MCAT, and I am so so glad I did! Your videos are so helpful, I don't think I would have done nearly as well as I did without them. I can only imagine how much time you must've spent making these videos, so from the bottom of my heart thank you for all your hard work! I hope medical school is treating you well.
Hello sorry to ask you but I will be taking the mcat in two months and I super worried do you recommend any study strategy or any advise for me please let me know.
@@ibtihagalnooh4078 I would recommend checking out r/mcat on reddit, there's a ton of helpful study tips!
I really like the fact that u show us the bigger picture and give us a visual map to see how pathways are connected to each other without making it too complex
this guy making so many doctors through these videos! thank you!
Wow! absolutely amazing! I got how this works now! Thank you very much!
thank you so much for taking the time to make these videos! they're so helpful!
Amazing explanation! Far the best I have seen so far! Short and on point! Excellent!
you sir have just saved me hours of headaches dealing with lipids. THANK YOU
Very high energy which I found a bit annoying at first, but by the end of the video I understood my entire anki deck on lipids that has been confusing me for DAYS. Well done, sir. Well done. Lipids have now have a legit connection to the other concepts in my biochemistry/metabolism semantic network Keep doing you my man. And thank you!
Ehhh, I found it funny if anything. It makes Biochemistry more interesting and a welcome change from my monotone teacher.
Excellent review, thank you.
This is so incredibly valuable and insightful. It adds much needed depth to some of the review books. Understanding how the various lipids are formed via the mechanisms makes it easier to remember content about lipids!
You are a lifesaver sir!!
Keep up the good work🙏🏾🙏🏾
“It doesn’t matter what compound it is, but just as long as you have an hydroxyl group you can add it.” -❣️
bless your soul wow
You are amazing thank you so much
That was awesome
Right, on brother.
YOU are the GOAT
I love these
AMAZING AMAZING AMAZING
This is EXACTLY what I needed for the MCAT. THANK YOU x A MILLION
How did it go? The MCAT? Did these videos help?
@@shanarobinson7672 I think it went well!!!! Scores come out June 27 so I’ll update u then🫣🫣
@@jasminesturn Wishing you the best goddess! I hope you got it!!!
@@jasminesturn Update 🫣
GANG GANG AYEEE TYSM!!!
you are a beautiful man. thank you.
Best!!!
I don’t understand what should be done to make a leaving group?
literally used this video for a game called the password game, thanks
You can add it!
Man, I love you
11:16 Before making a sphingolipid, wouldn't the fatty acid be activated as a fatty-acyl CoA?
can tyrosine and threonine be also added to it the same way as serine since they both have an alcohol group attached to them?
Yes, as long as there is an hydroxyl group you can add it.
Take your time please
in mechanism 1, you say there is released a OH. However, in my class they say that this mechanism produces H20. What am I missing?
So what I meant is that the -OH on the original compound is lost…. But that OH gets an added H+ and leaves as a water molecule… so to clarify the -OH on the original molecule is lost as a water molecule
Can someone help! At 1:35, he adds electrons to the OH group so that it can leave. However, I though OH- was a bad leaving group so how does that work??
There are biological enzymes that stabilize the OH, therefore facilitating the OH to leave as a leaving group… a common example is an enzyme protonates OH so it can leave as H2O
@@sciencesimplified3890 I apologize as I realize you answered this in a different comment!! But thank you so much for such a quick response!
So Cholesterol is made from glucose interesting . So carbohydrates are building block of lipids hmm
14:20 time stamp. The carbohydrate has a positive formal on the oxygen and I'm guessing delta positive on the carbon. Shouldn't O- as an nucleophile attack the formal positive charge O, instead of the carbon. I'm assuming there is no serious steric hinderance. Can anyone explain why it attacks C and not O?
Attacking the carbon push’s the double bond Pi electrons into the oxygen, effectively removing the +1 charge on oxygen.
Also, keep in mind that generally speaking, biological enzymes catalyze all these reactions, which allow formation of several highly unstable intermediates.
Makes sense! Thank you for the explanation.@@sciencesimplified3890
Whoops! I assumed that it had to be stable intermediates. Thank you :) @@joeamrine7450
This video is very well explained, however i think there is a better way to show the slides without having to pick the "layers". Thanks!