Cori Cycle | Lactic Acid Metabolism | Purpose and Importance in Anaerobic Metabolism
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- Опубліковано 6 гру 2017
- Lesson on the Cori cycle, introducing the importance and purpose of the Cori cycle and discussing how the Cori cycle can recycle lactic acid, produced from anaerobic metabolism in skeletal muscle, in the liver to form glucose through gluconeogenesis. Intensive exercise and other hypoxic conditions induce anaerobic metabolism in muscle cells, which leads to the production of lactic acid from pyruvate via the enzyme lactate dehydrogenase (LDH). If this lactic acid is left in the muscle cell, the pH of the muscle cell can decrease and cause detrimental effects to the muscle. Therefore, the lactic acid is transported out of the muscle cell through specific transporters located in the muscle cell membrane. The hydrogen ions from the lactic acid are then buffered by the blood and/or removed from the blood in the form of carbon dioxide. The remaining lactate is transported into the liver, where it can be used as a precursor for gluconeogenesis.
Hey everyone! Here is a lesson on the Cori cycle and lactic acid metabolism. In this lesson, you will learn the differences between aerobic and anaerobic metabolism in skeletal muscle, and how lactic acid is produced. You will also learn how that lactic acid is transported out of the cell and into the blood, and how the blood buffers and removes excessive hydrogen ions (protons) produced from lactic acid hydrolysis. This video then discusses how the lactate is transported into the liver hepatocyte, and how the lactate is used as a precursor for gluconeogenesis.
I hope you found this video helpful! If you did find this video helpful, please like this video and consider subscribing to my channel to show your support for my medical education videos :)
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DISCLAIMER: This video is for educational purposes only and information in this lesson SHOULD NOT be used for medical purposes alone. Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
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HI SIR. awesome lecture you explainded the reason behind these steps, cleared so many of my doubts. thank you from the bottom of my heart. please continue the good work. you rock champ
BEST CORI CYCLE EXPLANATION ON YT THANK YOUUUU
Thank you so much, so clear, and so useful.
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thank you so much for this lecture
Very clear explanation
Is the pyruvate to lactate formation in the presence of LDH a proton consuming or proton releasing reaction? What is the latest research on this?
Excellent
Thank you
worth to watch
Bravo!
Great!
thank you!!
Liver has high oxygen meaning ETC can proceed hence the high levels of NAD in the liver. Writing this down helps my thought process so i might as well share it ! Pls correct me if im wrong and b nice abt it
Solid video, but I think there’s a mistake towards end? On the skeletal muscle side NADH is getting oxidized and on the liver side, it shows NAD+ getting reduced for the same reaction
Because the reaction is going in the opposite direction.
Thanks - but one thing I don't understand is why lactic acid production causes an increase in acidity when the reaction that turns pyruvate into lactate is a h+ ion acceptor? Lactate then dissociates, but is the net effect an increase in h+? From what I am reading lactate is an important fuel, especially for the heart and brain, and not just in hypoxic conditions.
Hi Joe, just stumbled in to this presentation and I can't answer your question, but I think this article does:
www.ncbi.nlm.nih.gov/pmc/articles/PMC4343186/
Hi JJ and Ralph see Understanding Lactate - Paul Marik from Royal North Shore Hospital & UTS smacc.net.au/2016/05/understanding-lactate-paul-marik/ Acidosis is caused by reactions other than lactate production. Every time ATP is broken down to ADP and Pi, a proton is released. Lactate saves the day by becoming Lactic acid and removing the proton.
why doesnt the regenerated pyruvate from the lactic acid go into the mitochondria for cellular respiration? going all the way back into glucose via gluconeogenesis seems inefficient.
Maybe I understood your explanation wrongly, but the truth is that lactate is produced as a buffer for protons generated in non-mitochondrial ATP production (Robergs et. al). otherwise good!
can we supplement mtc1? what increases it?
when pyruvate is converted to lactate, why there is a proton released? I think the proton should on the pyruvate side.
Does lactic acid exist in human metabolism? What is the latest research on this?
Is the cori cycle the same as homolactic fermention?
How much atps are formed in fermintation??
Are lactate levels increased in T2 diabetics? If so, what is preventing pyruvate (for glycolysis) from entering the TCA/Kerb Cycle?
Yes, inflammation in diebetics restricts blood flow(oxygen),leading to hypoxic areas which make the cori system work harder,to clear the lactic acid being formed.
You can have both anorobic and areorobic energy production happening at the same time in your body, the problems start happening when it becomes more anaerobic for longer periods.
Hope that helps
How does pyruvate overcome pyruvate kinase, since that enzyme only proceeds in one direction?
You're right. Pyruvate kinase is an irreversible enzyme, so the cell needs to bypass that step in order to "recycle" pyruvate back to glucose. I talk about this in detail in my Gluconeogenesis video - but briefly, the cell uses pyruvate carboxylase to convert pyruvate to oxaloacetate in the mitochondria. Oxaloacetate gets converted to malate by malate dehydrogenase, and that malate leaves the mitochondria and enters the cytosol. In the cytosol, malate gets converted back to oxaloacetate by malate dehydrogenase again, and then the oxaloacetate gets converted to phosphoenolpyruvate by PEP carboxykinase.
There are two other irreversible steps in the glycolysis pathway that are also bypassed by the cell - please check out my Gluconeogenesis video for more details on that.
Hope that explanation helps :)
Can cori cycle result in liver glycogen formation?
Hi sir my son is 2 and half years suffering from elivated lactatic acid ( IEM) by birth what is life sir my son tell me pls 🙏
Explain me sir my son problem life long ya some time
5:52
didn't get, where exactly came a proton H+ in reaction "from pyruvate to lactat". can someone provide a link with an explanation of mechanism this reaction?
I think he got it wrong with the H+. H+ should have come from the Glycolisis. Glucose forms 2 pyruvates, 2H+ and the electrons from the H go to NAD+ to NADH. Those H+ cause acidic conditions and need to be taken care of. In absence of oxygene, they join the pyruvate to form Lactic Acid. Correct if I am wrong. I'm still getting to know this stuff.
Form wikipedia/glycolisis: "The overall process of glycolysis is:
Glucose + 2 NAD+ + 2 ADP + 2 Pi → 2 pyruvate + 2 NADH + 2 H+ + 2 ATP"
And then: Pyruvate + NADH + H+ → lactate + NAD+. I don't think H+ gets into the bloodstream. Never found a source telling MCT1 is resposible for that. Lactic fermentation is the process to get rid of H+ and recover NAD+ from NADH
Does the transformation of lactic acid back to glucose require oxygen? It is not mentioned here. Thank you very much.
this was nice explanation
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