Why Tuberculosis & Atherosclerosis are Siblings! | Episode 52

You can learn a lot about someone if you know their family members. That's why we're looking at Tuberculosis in this episode. 1.8 billion of the world's population has been infected by TB. Most of them have latent infection. 10.6 million had active infection in 2021. This common infectious disease has many similarities to atherosclerosis and we could learn a lot about plaque formation by looking at TB.
#tuberculosis #tb #atherosclerosis #ldl #cholesterol #metabolichealth
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[@jamesalles139]

Well then, to borrow from others:
Our shields (glycocalyx) are down long enough for inflammation to take hold (catch fire) in the endothelial layer / vascular wall.
The immune system dispatches fire trucks (lipoproteins) to deliver the firefighters.
Years ago, with rudimentary research tools, we found the outlines of turnout gear (cholesterol? maybe? phytosterols?) of firefighters at the scene of the conflagration, and deemed the fire trucks guilty of arson, and started impounding them (with statins).

[@palandromarco5761]

Good morning Doctor Low, I hope you continue with your technical videos at least every 15 days :-) The only thing that doesn't add up to me, having seen many of his videos, is having an overall picture. For example: why are those suffering from sickle cell anemia much more exposed to CVD risk? Why, for example, do those suffering from fibromuscular dysplasia have vascular problems even in the absence of inflammation or atherosclerosis?

[@vlmdrounds]

@palandromarco5761 Sickle Cell Anemia is a condition of chronic hypoxia and shortened lifespan of red blood cells.The cells are dysfunctional which makes them easily destroyed and they are also misshaped which makes them "sticky" with more likelihood to clog blood flow.
Fibromuscular dysplasia results in segmental disease of medium-small vessel musculature. Most commonly we see involvement of the tunica media and in that sense it may have some commonalities with Monckeberg's disease of the medial wall (which is different from intimal athersclerosis and is, indeed, thought to be non-inflammatory). So although we say "atherosclerosis", depending on context, we could be talking about different disease processes. hope that helps.
Every 15 days--okay, I will think about it. Any topics you want me to address?