Genetic determinants of metabolic syndrome and associated factors in children and adolescents

Dr. Rajini Nagrani
Leibniz Institute for Prevention Research and Epidemiology (BIPS)
Bremen | Germany
Part of the webinar
Metabolomics India 2024
Title
Genetic determinants of metabolic syndrome and associated factors in children and adolescents
This talk explores genetic influences on childhood obesity and metabolic syndrome (MetS). Findings highlight significant associations between obesity-related polygenic risk scores (PRS) and MetS markers, including BMI and waist circumference, with variations by lifestyle and sociodemographic factors such as dietary fiber intake and parental education. Notably, SNPs in the FTO and CETP genes emerge as key drivers of genetic predisposition to MetS. These results suggest that early risk identification using PRS, combined with targeted lifestyle interventions, may help mitigate long-term metabolic health risks in high-risk children.
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