- 177
- 40 162
biocrates life sciences
Приєднався 15 чер 2015
biocrates life sciences ag - The future of research and health
A new approach to metabolomic phenotyping
Metabolomic phenotyping has the power to transform our understanding of health and disease. Just a few microliters of sample material can tell us how a person’s genetics, behavior and environment work together to influence their health. Having the knowledge of what takes place at the cellular level, allows us to improve the overall individual wellbeing.
With decades of experience across multiple disciplines, biocrates makes standardized metabolomics accessible and quantifiable. Our phenotyping kits and services support scientists around the world to make new discoveries in research, nutrition and personalized health.
A new approach to metabolomic phenotyping
Metabolomic phenotyping has the power to transform our understanding of health and disease. Just a few microliters of sample material can tell us how a person’s genetics, behavior and environment work together to influence their health. Having the knowledge of what takes place at the cellular level, allows us to improve the overall individual wellbeing.
With decades of experience across multiple disciplines, biocrates makes standardized metabolomics accessible and quantifiable. Our phenotyping kits and services support scientists around the world to make new discoveries in research, nutrition and personalized health.
Exploring early-life metabolomic signatures in high-risk children
Sreedevi Sreekumar
National Institute of Mental Health and Neurosciences (NIMHANS)
Bengaluru | India
Part of the event
Metabolomics India 2024
Title
Exploring early-life metabolomic signatures in high-risk children with externalizing disorders: potential indicators of neurodevelopment and cognition
Externalizing disorders (ED) are marked by impulsivity and aggression, often stemming from adverse childhood experiences. These experiences increase susceptibility to impulse control disorders in adulthood, though underlying biological mechanisms are not fully understood. Metabolomics offers insight into disease-related pathways, potentially identifying biomarkers for early ED diagnosis. This study aims to discover novel early-life metabolomic markers linked to neurodevelopment and cognitive regulation, forming a predictive biomarker panel for psychiatric vulnerability. Children under 18 with familial ED risk will be recruited from the c-VEDA cohort, which explores genomic impacts on neurodevelopment and vulnerability to externalizing disorders. Using LC-MS for global metabolomic profiling and GC-MS for Short Chain Fatty Acids (SCFA) and fatty acid analysis on plasma samples, results will be correlated with neurocognitive and MRI data to assess vulnerability to ED. This study uniquely examines early-life metabolomic signatures in relation to cognitive and neurodevelopmental markers, providing pioneering insights into ED susceptibility in India. By analyzing early-life metabolomic profiles, this research aims to establish an economical biomarker panel for screening ED risk, offering potential diagnostic and therapeutic applications for those susceptible to externalizing disorders.
biocrates.com
National Institute of Mental Health and Neurosciences (NIMHANS)
Bengaluru | India
Part of the event
Metabolomics India 2024
Title
Exploring early-life metabolomic signatures in high-risk children with externalizing disorders: potential indicators of neurodevelopment and cognition
Externalizing disorders (ED) are marked by impulsivity and aggression, often stemming from adverse childhood experiences. These experiences increase susceptibility to impulse control disorders in adulthood, though underlying biological mechanisms are not fully understood. Metabolomics offers insight into disease-related pathways, potentially identifying biomarkers for early ED diagnosis. This study aims to discover novel early-life metabolomic markers linked to neurodevelopment and cognitive regulation, forming a predictive biomarker panel for psychiatric vulnerability. Children under 18 with familial ED risk will be recruited from the c-VEDA cohort, which explores genomic impacts on neurodevelopment and vulnerability to externalizing disorders. Using LC-MS for global metabolomic profiling and GC-MS for Short Chain Fatty Acids (SCFA) and fatty acid analysis on plasma samples, results will be correlated with neurocognitive and MRI data to assess vulnerability to ED. This study uniquely examines early-life metabolomic signatures in relation to cognitive and neurodevelopmental markers, providing pioneering insights into ED susceptibility in India. By analyzing early-life metabolomic profiles, this research aims to establish an economical biomarker panel for screening ED risk, offering potential diagnostic and therapeutic applications for those susceptible to externalizing disorders.
biocrates.com
Переглядів: 30
Відео
Paving the way to personalized nutrition: insights from ayurveda and metabolomics
Переглядів 70День тому
Prof. Dr. Kanwal Preet Kochhar All India Institute of Medical Sciences (AIIMS) New Delhi | India Dr. Jyoti Arora All India Institute of Ayurveda (AIIA) New Delhi | India Part of the webinar Metabolomics India 2024 Title Paving the way to personalized nutrition: insights from ayurveda and metabolomics With lifestyle-related metabolic disorders on the rise, effective personalized nutrition approa...
How to advance your metabolomics research impact using a strategic communication approach
Переглядів 40День тому
Dr. Gargi Roy Goswami Kroynas Digital Kolkata | India Part of the webinar Metabolomics India 2024 Title How to advance your metabolomics research impact using a strategic communication approach In today’s rapidly evolving scientific landscape, publishing groundbreaking research is just the first step. Ensuring that your work gains the visibility it deserves is crucial for advancing your career ...
Molecular mechanisms of the host immune response to toxoplasma gondii infection
Переглядів 14День тому
Dr. Hafiz Arshad University of Glasgow Glasgow | United Kingdom Part of the webinar Metabolomics India 2024 Title Molecular mechanisms of the host immune response to toxoplasma gondii infection T. gondii infection during pregnancy can cause abortion or congenital disease. Events in the maternal-foetal interface, where immunological changes occur, are critical in determining the pregnancy outcom...
Quantify the impact - How technological advancements foster the medicine of tomorrow
Переглядів 13День тому
Dr. Alice Limonciel biocrates life sciences ag Innsbruck | Austria Part of the webinar Metabolomics India 2024 Title Quantify the impact - How technological advancements foster the medicine of tomorrow biocrates.com
Representation matters - introducing SAMS - South Asians in Mass Spectrometry
Переглядів 14День тому
Dr. Baljit Ubhi Panome Bio St. Louis | United States Part of the webinar Metabolomics India 2024 Title Representation matters - introducing SAMS - South Asians in Mass Spectrometry Representation is vital in advancing equity and innovation across scientific fields. South Asians in Mass Spectrometry (SAMS) is a community-driven initiative that champions diversity within mass spectrometry by empo...
LC-MS based lipidomics to understand cholesterol metabolism in mammals
Переглядів 24День тому
Aakash Chandramouli Indian Institute of Science Education and Research (IISER) Pune | India Part of the webinar Metabolomics India 2024 Title LC-MS based lipidomics to understand cholesterol metabolism in mammals Abstract Cholesterol is pivotal to mammalian lipid metabolism, and its dysregulation is associated with several human diseases. Physiologically, cholesterol is tightly regulated throug...
Spatial lipidomics and proteomics of atherosclerotic plaques in male and female hyperlipidemic mice
Переглядів 30День тому
Dr. Robin Joshi Institute of Translational Medicine and Therapeutics (ITMAT) University of Pennsylvania, USA Philadelphia | United States Part of the webinar Metabolomics India 2024 Title Spatial lipidomics and proteomics of atherosclerotic plaques in male and female hyperlipidemic mice Atherosclerosis is a severe chronic inflammatory disease involving multiple cell types that causes plaques to...
Genetic determinants of metabolic syndrome and associated factors in children and adolescents
Переглядів 12День тому
Dr. Rajini Nagrani Leibniz Institute for Prevention Research and Epidemiology (BIPS) Bremen | Germany Part of the webinar Metabolomics India 2024 Title Genetic determinants of metabolic syndrome and associated factors in children and adolescents This talk explores genetic influences on childhood obesity and metabolic syndrome (MetS). Findings highlight significant associations between obesity-r...
From complexity to coherence: investigative physiology for multi-omics insights
Переглядів 35День тому
Prof. Dr. Kareenhalli V. Venkatesh Indian Institute of Technology (IIT) Mumbai | India Part of the webinar Metabolomics India 2024 Title Keynote lecture | From complexity to coherence: investigative physiology for multi-omics insights in R&D and precision health Human physiology is an ensemble of various biological processes spanning from intracellular molecular interactions to the whole-body p...
Introduction to metabolomics in action
Переглядів 4521 день тому
Candace Guerrero, Ph.D. University of Minnesota Assistant Director of the Center for Metabolomics and Proteomics Part of the webinar Metabolomics in action Title Introduction This lunch and learn event, sponsored by biocrates life sciences and hosted by Dr. Candace Guerrero, Assistant Director of the Center for Metabolomics and Proteomics at UMN, will feature presentations on cutting-edge resea...
Investigating the stool and plasma metabolome of people with HIV
Переглядів 3721 день тому
Chris Basting, MS University of Minnesota Researcher 6 Part of the webinar Metabolomics in action Title Investigating the stool and plasma metabolome of people with HIV This lunch and learn event, sponsored by biocrates life sciences and hosted by Dr. Candace Guerrero, Assistant Director of the Center for Metabolomics and Proteomics at UMN, will feature presentations on cutting-edge research in...
Metabolomics of sepsis and critical illness
Переглядів 2821 день тому
Elizabeth Lusczek, Ph.D. University of Minnesota Associate Professor Part of the webinar Metabolomics in action Title Metabolomics of sepsis and critical illness This lunch and learn event, sponsored by biocrates life sciences and hosted by Dr. Candace Guerrero, Assistant Director of the Center for Metabolomics and Proteomics at UMN, will feature presentations on cutting-edge research in metabo...
Developing a baseline metabolomic signature associated with COVID-19 severity
Переглядів 1721 день тому
Kaifeng Yang University of Minnesota Ph.D. student Part of the webinar Metabolomics in action Title Developing a baseline metabolomic signature associated with COVID-19 severity: Insights from prospective trials encompassing 13 U.S. centers This lunch and learn event, sponsored by biocrates life sciences and hosted by Dr. Candace Guerrero, Assistant Director of the Center for Metabolomics and P...
Fast-tracking interpretation and sharing of lipidomic data with standardized methods
Переглядів 11621 день тому
Alice Limonciel, Ph.D. biocrates life sciences ag CSO Part of the webinar Lipidomics | From planning to interpretation and sharing Title Fast-tracking interpretation and sharing of lipidomic data with standardized methods Abstract Although they can be measured with similar analytical methods, lipidomics and metabolomics datasets are often analyzed differently when it comes to statistics. These ...
Common pitfalls in clinical metabolomics: A guide from sample collection to data analysis
Переглядів 5421 день тому
Common pitfalls in clinical metabolomics: A guide from sample collection to data analysis
Metabolomics meets microbiome - Investigating host response with quantitative metabolomics
Переглядів 118Місяць тому
Metabolomics meets microbiome - Investigating host response with quantitative metabolomics
Elucidating the impact of food-derived microbial metabolites on intestinal health
Переглядів 175Місяць тому
Elucidating the impact of food-derived microbial metabolites on intestinal health
Standardizing targeted metabolomics studies using Agilent 6495 LC/TQ in concert with biocrates
Переглядів 127Місяць тому
Standardizing targeted metabolomics studies using Agilent 6495 LC/TQ in concert with biocrates
Standardized metabolomics kits for quantitative and reproducible results
Переглядів 89Місяць тому
Standardized metabolomics kits for quantitative and reproducible results
Metabolomic profiling of Cohort Consortium identifies prodromal biomarkers for Parkinson’s Disease
Переглядів 332 місяці тому
Metabolomic profiling of Cohort Consortium identifies prodromal biomarkers for Parkinson’s Disease
Characterizing the metabolome in pediatric severe traumatic brain injury
Переглядів 642 місяці тому
Characterizing the metabolome in pediatric severe traumatic brain injury
The new dogma of microbial bile acid metabolism
Переглядів 1152 місяці тому
The new dogma of microbial bile acid metabolism
Bacterial metabotypes & the medicine of tomorrow | Audrey Le Gouellec
Переглядів 3273 місяці тому
Bacterial metabotypes & the medicine of tomorrow | Audrey Le Gouellec
Metabolomic epidemiology & childhood obesity | Sandi Azab
Переглядів 1674 місяці тому
Metabolomic epidemiology & childhood obesity | Sandi Azab
Mystical import of plate runs in LIMS
Переглядів 754 місяці тому
Mystical import of plate runs in LIMS
The enchanted monitoring tool in WebIDQ
Переглядів 464 місяці тому
The enchanted monitoring tool in WebIDQ
The sorcery of LC integration in WebIDQ's Quantification module
Переглядів 544 місяці тому
The sorcery of LC integration in WebIDQ's Quantification module
Data interpretation tools to unleash the full impact of metabolomics“
Переглядів 2175 місяців тому
Data interpretation tools to unleash the full impact of metabolomics“
Very important topic!
Hi, could you please make detailed videos about other parts of quantification as well. Thank you very much.
Thank you very much for your feedback. Indeed, there will be new videos soon. Do you want to share more specifically which aspect of quantification we could cover?
@@biocratesCould you please explain the Validations in more detail
Hi, could you please make detailed videos about other parts of quantification as well. Thank you very much.
Hello Dr. Joshi, can you please share the video of sample preparation for metabolomic analysis
;pve this
I'd suggest you try another aspect of vide style for more engagement. Do you understand this?
Awesome content🥰
For a person with bipolar 2 disorder, I found this enlightening! Thank you and all curious scientists.
Thank you for your comment - This is very motivating to carry on supporting the science.
Hurry with these studies 😭😭 I’m suffering a post drug syndrome from finasteride and I’m pretty sure it had a lot to do with the gut microbiome because my gi zoom test is missing so many bacteria AND we have people recover though fmt plus iodine. I’m like 99.9 percent sure it has to do with epigenetic gut microbiome link
Thank you for your informative presentation
Çok güzel olmuş
Did you try diet? Low protein, low fat, plant diets?
"Promo SM"
What foods or supplements do I need to eat/take to resolve this? I took clindamycin and it destroyed the bacteria that make secondary bile acids. Then I got c diff. Took Dificid and it killed c diff but my symptoms remain. It’s been 7 months and no change. Probiotics don’t help and I can’t eat dairy or red meat because it makes the diarrhea worse. I’m getting no nutrients and my GI doc just shrugs and says to do a colonoscopy. Which will reveal nothing we don’t already know. My calprotectin is 260 and blood clots are coming out when I use the bathroom. If you can just say what’s worked for others without giving medical advice that would be appreciated.
What are some of the most effective ways to lower kynurenine other than a vitamin B6/P5P?
Kynurenine and its derivatives help regulate the immune response and can be helpful to fight infections. Chronic inflammation and certain cancers are cases where one may want to lower the conversion of tryptophan to kynurenine. Diets that lower inflammation have been used to do this. You can read more about that in the following article. biocrates.com/mom-kynurenine/ (Kynurenine and nutrition)
Very informative. Thank you....loved it!
Thank you for your comment.
Good work
An inspirational motivational and surprising me true MS real life story sheerazmultiplesclerosis.blogspot.com/?m=1
So Latrobe university in Australia is getting news coverage currently about this as the reason behind long Covid but you put this out a year ago.
Thank you for sharing, Sara. It is really important to gain understanding of underlying biochemistry and metabolism to treat conditions.
The omf have been talking about this a few years now. Glad it's gaining traction
@@69birdboy OMF as in Open Medicine Foundation?
I thank 🙏God for my Life ❤️ I survive Cancer, Everyone help me appreciate 🙏(Doctor Izeduwa 1) on UA-cam. He gave me the cure for Cancer and I have been tested free on (3)test Scan.😊..
Thank you for sharing very important information where we will find answers. I wanted to mention that I have done a lot of research on Pyridoxal 5 Phosphate (P5P doe short)and I want to share that in this comment. P5P is essential for converting Niacin to Tryptophan and Tryptophan back to Niacin. Additionally, It is essential in the following processes. Converting Tryptophan to 5HTP, 5HTP to Serotonin, Niacin to Tryptophan, Carnitine and Homocysteine Metabolism, and Glutathione synthesis. It is critical in maintaining intracellular Magnesium levels, and is needed by Histamine, Norepinephrine, and Acetylcholine for their metabolism. It has many more responsibilities than this, and it is essential in the Kynurenine pathways as well. From some of the newer research, it reveals that when their is a buildup of Serotonin and/or Kynurenine, that P5P plays a significant role, as it is needed for their many pathways. Unfortunately, P5P is depleted in foods by cooking, processing/refining of foods, heat and improper storage. I hope this information is helpful. Thank you for sharing your research.
very interesting
Again, we see that details are critical in approximating an understanding of nature. Thank you for this upload.
我娃这学期有一门AI课。
So interesting.
0:51 rtn.in.net