Forgot to say! I don’t work/cooperate/affiliated with any supplement company. ⭕Imagine having access to ALL the BEST supplement routines for longevity in 30 seconds... it’s possible-> WellnessMessiah.com/Longevity
Hi I said, collagen powder is what I give my parents - I don't recommend anything to anyone. Dose - needs to be customized to the situation and protein intake of the person, exercise routine, etc.@@consumer1073
@@WellnessMessiah The NOW brand Super Antioxidants supplement appears not to even be sold on Amazon or other online markets. Even the NOW website shows it as backordered. From my own experience, this usually means it’s being discontinued or reformulated.🙏 Any other suggestions perhaps?
🎯 Key Takeaways for quick navigation: 00:00 🌱 *Taurine shows strong potential in protecting against aging, with suggested doses increasing with age, but its effects on neurotransmitters warrant caution and individualized approaches.* 04:33 💊 *Niacin (B3) and NAD boosters like NMN and NR have potential in age-related health, with NMN showing promise in muscle health and exercise performance in older individuals.* 09:30 🌿 *Ashwagandha may help regulate cortisol levels, aiding stress management, particularly during periods of chronic stress or intense physical activity.* 11:50 💪 *ALCAR (Acetyl-L-Carnitine) supports muscle health by aiding fat metabolism and reducing reliance on glucose, potentially preserving muscle function with age.* 14:49 ☀️ *Vitamin D supplementation needs to be tailored based on individual conversion rates and genetic factors, with a recommended starting dose of 4,000 to 5,000 units per day.* 17:24 💊 *B vitamins can enhance energy and reduce anxiety but should be taken cautiously to avoid excess, with a preference for obtaining them from food sources or low-dose supplementation during fasting.* 19:27 🦴 *Glucosamine and chondroitin may support joint health and longevity, although further research is needed to fully understand their impact and optimal dosages.* 20:51 💊 *Glucosamine and chondroitin supplementation may be associated with reduced total mortality risk, particularly in higher doses, according to research findings.* 22:00 🎯 *Individuals over the age of 65 may benefit from tailored supplement regimens to mitigate the risk of accelerated aging, including hormonal support, antioxidant defense, and enhanced protein intake.* 23:09 🔄 *Cycling DHEA cream usage and integrating antioxidants like quercetin may help support hormonal balance and protect against oxidative damage, particularly in individuals over 65.* 26:18 🍖 *Increased protein intake, particularly in powdered or collagen form, may be beneficial for individuals over 65 to compensate for reduced protein absorption and support soft tissue health.* Made with HARPA AI
Worthwhile to mention that D3 should always be taken with K2 and that they are both fat soluble (a ratio of 5000 IU D3 to 150-180 mcg K2 is commonly advocated, I cannot confirm if it is appropriate) not a bad idea to take small amounts of magnesium, zinc, calcium, copper and boron at the same time as this combo works for bone health (K2 is the superstar in this). Taurine is not a bad thing to take with NAC and Glycine as a thrice weekly detox as they tend to work well together (take at a different time to morning vitamins, I take at night), the actual amounts used should be 600mg to 1000mg each, if you are using more than that you may be putting yourself out of balance. The trio's effectiveness can be slightly boosted by taking with a very small amount of vitamin C and E, and a very weak B group supplement (mainly for the small B6 content) as these can help the effectiveness of the NAC, but B6 amount needed by the NAC would be less than 5mg (very dangerous to take too much B6 overall, do not rely on vitamin manufacturers to know safe dose as they make a lot of money off ALA sold to detox it).
Thanks for addressing those over 65. I have changed up my supplement routine since I hit retirement to target those aging issues. It has clearly made a difference.
many people know the longevity effect of taurine but they do not understand the mechanism. here it is: in the mitochondria there are two primary types of fuels to be burned: glucose and fatty acids. and there is a difference in ROS production between burning fat or glucose. if burning glucose, ROS production is going up. if you understand ROS then you understand, that it is very very damaging. sometimes the body needs it as a defense mechanism against a virus of bacteria or a cancer cell that is gone rouge. but of course ROS is damaging also organelles, cell walls etc. so, if ROS is not needed, it should be avoided. staying in fat burning mode is key for that. one factor - besides many other factors - is making sure that fat burning is running smoothly and fast enough. if it is too slow to produce enough ATP, the mitochondria is switching to glucose burning mode. what is making sure that fatty acids are oxidized ( =burned) fast enough? ==> the speed of the enzymes that are involved in that (krebs cycle etc.) is depending on the pH level of the surrounding. if the pH level is going down ( lower pH = more acidic ) then the fat burning enzymes are slowing down. this is a usual effect from a chemical reaction. the speed looks like an S-curve, or mathematically like a sigmiod-function. it this case this sigmoid function describes how fast the chemical reaction is. AN THIS IS WHERE TAURINE IS COMING IN: taurine is a pH buffer. that means it keeps the acidity from changing fast. and there is a chain of pH buffers from taurine in the mitochondria to carnosine in the cell to bicarbonate in the blood. in legal sports doping where the body should stay in fat burning in long endurance sport (cycling, running over many hours etc.) they supplement with sodium bicarbonate, beta-alanine (to make carnosine) and taurine to have enough of these pH buffers. so, now the anti aging mechanism should be clear. in one sentence, taurine optimizes fat burning which lowers ROS which is one cause of aging.
@@nikola_korneta Reactive Oxygen Species. it you eat a huge carb meal, the excess carbs get partially converted into fat. and then burned also as fat. it is not black and white. i don't care what you do, and i don't tell you what you have to do. i just explained the mechanism in the mitochondria. and people also eat fatty pork belly and eggs for thousands of years. so usually they didn't eat carbs only.
I agree with everything, the damage of glucose like you said, and I add and taurine does other things as well beside PH buffer against aging. It's quite remarkable...basically a "don't die" supplement.
I took ashwaganda for a long time, 3..4 days per week. I liked the effect on psychology and regulation of sex drive. However, and that's a big one: It caused inflammation of the liver, AST got as high as 40. When I took it off, all other things roughly the same, AST returned to 28 after 8 months. So, if you start taking it, observe your liver enzymes. In order to support the healing i ramped up the vitamin A, by food and by supplement
Thanks, good feedback. TBH I'm still researching it! Definitely has some anti-cortisol anti anxiety. It seems so far as "use to cover a hole" as needed supplement. I suspect it will reduce the side effects you mentioned. But - I'm not yet the expert on it quite yet. My current obsession is taurine...
@@airy252 I slipped into a quasi-chronic intake. Pills were around 400 mg powder. First I used it very occasionally, sh like every 2..3 weeks for 1..2 days. The suppression of cortisol allows the sex hormones to be produced. Better sleep, as its latin name particle suggest, was just another argument. Feeling then more balanced... Until i did a lab test for sth completely different. which exposed some intense stress for the liver. Some 15 years ago i tried another so-called adaptogen, rhodiola, but that quickly turned out to be very bad for deeper levels of psychology. At that time i made research grade cognitive tests (N=1), and i saw it did work and amazingly enhanced short term memory.
I've tried several brands of ashwa, and very large doses, and I have to say it's another typical "witch doctor" herb of the hundreds we've seen in the last fifty years.
Couple of things, Taurine taken on the empty stomach in the morning will stimulate your gllbladder and improve bile flow. This will help to prevent stones from forming also a good easy way to jump start your day. Second, vitamin E should be in tocotrienol form - this is important. I also add CaAKG and some other amino acids before workout, and creatine. Creatine not just gor musvle growth but for stress and mental health actually which was surprising to me…different doses for men and women because of the way it’s processed, gender specific things…also a quick note on micro-dosing melatonin after 40. A few more things I had really good success with if it’s interesting, I can write later! 😊👍
Re: Taurine. Recommend getting an amino acid profile which includes taurine. Then module diet, exercise and supplementation over time to get to high end of reference range. Makes no sense to just gobble many grams a day without testing. I'm 69 yo and have levels of a 30 to 40 yo according to data in studies and I only use 500 mg/d which I've taken for about 10 years for other reasons (vascular). Now taking 1 gram a day and will retest again soon. Same idea with Vitamin D (I take 5000 IU /d), Omega 3 index, test and modulate diet and supplementation and as needed. My D3 level is in 40 to 50 ng/ml range. Omega 3 index 7.8%, almost ideal ( i take about 600 mg of EPA and DHA, eat flaxseed and nuts and a little fish). Test when testing is available.
🎯 Key Takeaways for quick navigation: 00:00 🌟 *Cutting-edge longevity updates:* - Taurine, NMN, ashwagandha, and stress customization impact aging defense. - Personal insights on dosage and effects of various supplements. - Focus on optimizing aging defense protocols for individuals over 65. 01:23 💡 *Taurine benefits and dosage:* - Taurine shows strong potential in protecting against aging. - Dosage recommendation: around 1 gram per decade of age. - Individual responses vary; experimentation and cautious approach advised. 04:48 🔄 *NMN insights and dosing:* - Limited data on NMN's lifespan extension effects in humans. - Focus on muscle benefits and exercise performance over 60. - Recommended dose: 1 gram daily; individual response and quality of life improvements matter. 09:45 🌿 *Ashwagandha's role in stress management:* - Ashwagandha's potential to reduce cortisol levels during high-stress periods. - Importance of balanced cortisol levels for longevity. - Personal experimentation and cautious approach recommended. 11:50 💪 *ALCAR for muscle health:* - ALCAR aids in burning fat and reducing dependence on sugar for energy. - Personal experience suggests preservation of muscle vitality and youthfulness. - Dosing adjustment to 500 milligrams twice a day for a conservative approach. 14:49 ☀️ *Vitamin D supplementation:* - Importance of understanding vitamin D activation and conversion in the body. - Recommendations for dosage based on individual testing and genetic factors. - Addressing concerns about vitamin D toxicity and optimizing blood levels for health benefits. 17:24 🅱️ *B vitamins and aging:* - Adequate B vitamin levels linked to increased longevity and vitality. - Caution against excessive B vitamin intake, which may increase mortality. - Timing of supplementation during fasting and dosage adjustments for optimal results. 19:27 🦴 *Glucosamine for joint health:* - Glucosamine and chondroitin as building blocks for joint and ligament repair. - Potential benefits for preventing joint damage and promoting longevity. - Limited data on mortality reduction associated with glucosamine and chondroitin use. 20:51 ⚕️ *Glucosamine and chondroitin intake linked to 70% lower mortality risk according to a study.* 22:00 🦴 *Modification of supplements for individuals over 65 aims to counteract "runaway aging" by customizing longevity protocols.* 23:09 🧴 *Hormonal support recommended for individuals over 65, including DHEA cream for hormone production.* 24:05 🧠 *Antioxidant support becomes more crucial after age 65 to protect brain, eyes, and ears from oxidative damage.* 26:18 🍖 *Protein absorption decreases with age, particularly after 65, leading to a recommendation for extra collagen intake to support soft tissues and antioxidant defense system.* Made with HARPA AI
Congratulations, Rimon. I haven't been here for a while and on watching this, I observed with joy, the astronomical growth in your number of subscribers. I used to feel bad when your numbers were still low because I never quite understood why such an informative channel would be under subscribed. The only way is up for you now. I hope your wife continues to make a good recovery. Best wishes.
Love your content Rimon! Can you comment on the latest data on Niacin's metabolites (4PY) being linked to heart risk and inflammation? Does this also impact NMN/NR users? A video on this would be very helpful! Thank you for all you do
Yes. In short - I wouldn't be worried about it if you're healthy - not having history of cardiovascular disease. and yes, it affect NMN and NR much more than niacin. You will have to give up all benefits of NAD boosting. Long: 1. The study explored metabolic associations linked to outcomes, specifically focusing on correlations with individuals with a history of heart disease, not healthy subjects. It characterized these individuals as "stable patients" who had experienced a heart attack or a cerebrovascular event more than three years prior. 2. A key finding was the identification of a genetic variation in a segment of the population that hinders the processing of a niacin byproduct. This genetic anomaly could potentially be a contributing factor to their initial development of vascular diseases. The research pinpointed a genetic variant (rs10496731) significantly associated with altered levels of certain metabolites, suggesting a link to niacin metabolism. 3. However, there's a critical oversight regarding niacin. The metabolite 4PY, implicated in the study, results from niacinamide, not niacin. Niacin must be converted to NAD, which then becomes niacinamide. Notably, NMN and NR, precursors to NAD, produce significantly more niacinamide (and consequently 4PY) than niacin does. This suggests that for individuals with the mentioned genetic variant, niacin might be preferable over NMN and NR. 4. The preliminary conclusion indicates a subset of the population may experience adverse effects from NAD boosting, unable to efficiently eliminate certain byproducts, thus paying a "price" for increased NAD levels. 5. Additionally, the research underscores the potential benefits of TMG supplementation. TMG might not only mitigate heart disease risk by lowering homocysteine levels but also by reducing other harmful metabolites produced from niacinamide, which can be toxic in large quantities. 6. While the general use of niacin doesn't raise concerns, it's crucial to investigate the specific byproducts of NAD+ enhancement further. Are there methods to minimize these byproducts? Do certain individuals with genetic predispositions benefit less from NAD+ boosting compared to the broader population? These questions highlight the need for more nuanced studies and precise language in research findings, rather than attributing outcomes to niacin indiscriminately. Moreover, the study hints at potential kidney function implications, as methyl-niacinamide is typically expelled through the kidneys, not converted into 2PY and 4PY. This complexity is characteristic of metabolic studies, where determining causality can be challenging. It's possible that underlying detoxification issues could contribute to secondary cardiac events.
@WellnessMessiah Thank you! Very interesting answer. I do take TMG so that is reassuring. Leave it to you to find an oversight with respect to Niacin perhaps being preferred to NMN/NR! Great stuff. I will keep watching your videos for more as this issue develops!
Good video! Thanks for dividing supplement analysis into age groups (65). This is important for some supplements. I'm surprised you didn't do that for NMN, though. NMN is mostly used by older people to restore NAD levels to closer to youthful levels. I don't know if niacin can do as good of a job in older people. It is a good example of a supplement that doesn't make sense to use when younger, especially since it's expensive, but can be justified in older people.
C'est peut être utile pour des gens qui ont traversés de grosses périodes difficile où ils se sont abîmés avant l'heure non ? Une cure pour essayer de se régénérer Les niveaux de NAD dans ces cas là pour se réparer un peu, une bonne idée ou pas ??
@@mickaelcaeyman9927from Southern Colorado Rockies USA I'd say great Idea who determines adequate damage ,no one but ourselves,the Dr. Here seems as though he's experimented on him self and parents and found a great base for us to build from Peace
Good stuff...appreciate the info on taking care of our older parents. My mother so far has been fairly receptive to my suggestions. She's on medications so I don't want to overload her with supplements so suggestions such as bone brother are helpful. Being 65 myself..this stuff is important to me as well. Your work is appreciated.
Nice meeting you here. I have passion for 65+, it doesn't work well with youtube. I speak some about it in my updated supplement routine, what I do with my parents: wellnessmessiah.com/app
I live in Hawaii and we all live in our bathing suits getting lots of sunlight on our skin. It’s almost impossible to get vitamin d levels higher than 50 naturally from the sun. Only supplements can cause it to go higher.
It's interesting. It could be that supplemental vitamin D circumnavigate some skin regulation . On the other side, in the video I spoke about 70,000 years ago - people going with no clothes all day long. Large areas are back, chest.. these are still hidden vs the past.
I took 10,000 IU’s of quality Vit D throughout the pandemic. Never got sick BUT the skin on my hands and feet literally started peeling off because of Vit D toxicity. Taking powder form as opposed to natural sunlight will obviously be Absorbed differently. Like he said starting at 4000 IU’s should be fine.
Opinion: Yes, protein absorption may drop a bit with age, but exercising is best way to prevent muscle loss aside from many other benefits as we age. Get a scale which measures lean muscle mass and body fat and start tracking. If you start loosing lean mass on a good diet and exercise then consider a little more protein in the form of higher protein real food, Things like nuts and beans. Avoid the powders.
Some evidence that b6, b9 and b12 can build up in unexpected places, if it remained in the blood, absolutely yes it would be excreted but that doesn't always seem to be the case depending on amounts and the body's demand for them. Also very important to take the natural versions rather than the synthetic ie B6 version s/be P5P, and the methyl versions of B9 and B12 s/be taken so you are not dependant on your internal organs to convert them into the useable forms. B vitamins tend to need each other so taking a high amount of 1 without the others may have unpredictable affects... B6 is one to watch out for as amounts in supplements are often dangerous when taken long term (25-50 mg P5P is possibly the bodies tolerable upper limit from supplements, might be as little as 12-15mg if taking the synthetic form pyridoxine hydrochloride, however frankly this depends on many factors such as body weight and what other vitamins and minerals you take as supplements / diet more generally / medical conditions)
I think it depends on the type of B12, you should never ever high dose (or take at all) cyanocobalmine as it contains cyanide. Despite the amount is considered very safe, its not when you megadose as cyanide is very tough to get out of your body system. In other words, you give yourself a very slow cyanide poisoning if you high dose this type of B12. And you may know that cyanide is also barely tracable until you turn blue or get the typical almond like smell. But before that happens you probably died already. It can cause all kinds of weird health issues no one can explain before that. I take B12 as methylcobalmine as mouth spray, it has like 25000% RDA, but I only take 1 spray instead of the 4 recommended as daily dose. It doesnt feel right for me to dose this high, injections go up to even 125000% rda, but they say your body poorly absorbs B12 and you need these high doses to combat deficiency in order to absorb what you need to fix it in a fast rate. Those highdosed supplements aim for garanteed 100% absorbed RDA.
I also avoid all prescriptions if I can. I even turned down statins and I'm using nattokinase instead. Some study actually found it far more effective at removal of plaque. I don't care for nmn too pricey and I didn't notice any benefits personally.
Hey. Thanks again for the outstanding content. 😊 I've probably missed this somewhere but do you have any thoughts on a reputable glucosamine/chondroitin brand? Prayers for your wife's ongoing recovery (and the continued success of your channel 😉) 😊
Opposite. Chronic cortisol, ati-longevity and pro-divorce is "responsible" for the pandemic of diabetes and the pandemic of divorces and/or single mothers....
Are you aware that tocotrienol is 50 times more protective of fat oxidation than tocopherol? I learned this from an hour long interview on Modern HealthSpan about six months ago. I apologize for not knowing the doctor's name, but he spend most of his life studying tocotrienol. He also said that tocopherol diminishes the effect of tocotrienol, so they should not be taken together. For those who have had radiation treatment, I use tocotrienol together with pentoxyfilline to reduce fibrosis from radiation (see the papers of Dr. Sylvie Delanian for dosages.) This combination, although I used tocopherol until recently, has kept my throat open for decades. It is common for fibrosis to keep growing and fill the throat so that a feeding tube is required. Many ENT doctors know about this cocktail now, but not about tocotrienol.
Lifted weights till now, ( 50 years ,l 1 gram nmn has helped rotator cuff pain shoulder pain and the lack of pain has helped reverse gradually loss of strength
There's a lot of hype towards NMN and NR. Probably it's due to commercial interests. Niacin has been on the market for a long time and isn't a good business for labs
Ashwagandha may be a solution to my deadly lowering of blood pressure after eating my first meal 😞 Can I take it with NMN & Resveratrol & Supermedine together? Or a different time? I read in the article this Ashawanga may drop blood pressure so it may cause danger in my case. My problem may be because of my lower cortisol levels. I will check them hopefully. But in meanwhile I can order this supplement. Which company you advise, please?Thank you. Lately, they keep on sharing in the news this OMAD diet may kill us. Can you pls make a video about it pls? Many thanks. God Bless your wife & you🙏🙏
For CVD prevention, I’m taking 100mg of Niacin along with bergamot. I used to wash my supplements down with a protein smoothie that included banana, but I replaced the banana with apple because there’s a compound in banana that blocks the benefits of polyphenols found in berries and bergamot.
The comment about exercise and joints is valid. However not all exercise is equal on our joints. I swim & often use training aids like paddles and flippers. Increasing the load on my muscles but not joints. Win win
I take magnesium citrate in the morning and take magnesium taurate just before bed. Taurate is the salt of taurine, so the magnesium/taurine combo is great for many reasons, including healthy sleep. I also munch on some pumpkin seeds sometimes before bed because those are a good source of magnesium.
I too divide my magnesium need in different types of magnesium. I take magnesium taurate in the morning to also aid my morning intake of vit D (3000IU) and magtein (magnesium threonate) in the evening with my 2000IU vit D. During the day I take magnesium in my electrolyte tab due to me being chef I sweat a lot and need to replenish in plenty. I think this magnesium is glycinate, only the other two I buy specific. I like to spread doses even if it says I only need to take once a day, if possible I take half or try twice or three times a day. Shouldnt need to overdose unless known deficiency like I have for vit D, magnesium and probably B12.
@@AnnaMaria-zm8cv I take capsules daily of either wild caught cod liver oil or salmon oil for vitamin D, besides the sunshine. I get my omega 3s that way, too. Pumpkin seeds are also very high in magnesium. A handful before bed can help with sleep.
HI Rimon: i take niacin, first few days I got the flush but soon developed tolerance to it no longer have any flush with it, I suggest start with a low dose for a week and gradually increase , I take anywhere from 500 to 1500 mg Niacin flush per day, both for Mitochondria health and lipid profile.
Thank you so much Rimon for this video. I am a 70 yrs. old African American female in GOOD general health but do not feel the energy I used to since turning 70. I am on bio-Identical hormone replacement cream (16 yrs. now)--not due to any disease. It was elective for me as a way to manage aging. Is it OK for me to add DHEA cream? Also do I understand correctly that I can try either Niacin OR NMN? I don't need both? Thank you.
Huge Thank-you ! All Great Info. ! One Full Body/Brain , Natural Supplement that You Did Not Mention, I take Daily as well as My Mother in her Late 80's Is Creatine Monohydrate ! Your body produces Naturally but as We Age it is Imperative for Good Health and Longevity ! Cheers !
Yep, I'm 75 and take 5 grams a day along with my whey protein powder. I also take 3 grams hmb to ward off muscle wasting. He also didn't mention NAC and glycine.
I have never heard any expert suggest that NMN prevents cancer. I have experienced numerous benefits from NMN which I have been taking for five years and feel 10-20 years younger than my 70+ years.
Hi as I said - what matters is the end result. If NMN makes you happy, gives you what you want - nothing could be that.. not even the best studies. Results always win. Lots of love
Interested to find out if you’ve heard Chris Masterjohn’s warning of NMN supplementation leading to excessive filling of the niacin pool and epethial damage to vascularature. I need to try and read his post again because he’s incredibly technical. But he cautions against high dose NMN.
Thank you so much for the Great content, I trust you more than any one ,could you please share which brand of vitamin b3 ( niacin) and collagen do you use ?! Are you recommending whey protein for people over 55 or 60 it has all the amino acids especially for those who don't eat red meat alot maybe once a week?! Greatly appreciated 🙏❤😊
Thanks for this. You’ve convinced me to start taking Taurine for the first time. I didn’t fully understand when you take it and why and how to stop it interfering with sleep
NMN has incredibly improved my eczema on my hands which I have year round. I started NMN last week. Also, I was having crazy inflammation in my body which led to incredible hair loss and NMN has helped my hair to stop falling out. I take it with TMG. So far it’s a miracle supplement. PS I’m 31 years old.
Thanks to you, I take Niacin instead of NMN because of cost. I take a 500 mg capsule and just drink it throughout the day little at a time. I find that the body got used to the flush over time. I take resveratrol 3-500 mg every two days on days I dont work out. GlyNAC 3 grams every morning, Taurine 2,5 gr x 2 times a day. Thats it for now, until I get more money.
WHAT IS UR RESPONSE TO THIS AS WELL AS MORE RECENT UPDATES...!!?? "The average person should avoid niacin supplements now that we have reason to believe that taking too much niacin can potentially lead to an increased risk of developing cardiovascular disease,” Hazen said.Feb 19, 2024.Can you take niacin long term? A time-release form of niacin reduces flushing. But long-term use is associated with liver damage. Can you take niacin long term? A time-release form of niacin reduces flushing. But long-term use is associated with liver damage... 9:51
WHAT IS UR RESPONSE TO THIS AS WELL AS MORE RECENT UPDATES...!!?? "The average person should avoid niacin supplements now that we have reason to believe that taking too much niacin can potentially lead to an increased risk of developing cardiovascular disease,” Hazen said.Feb 19, 2024.Can you take niacin long term? A time-release form of niacin reduces flushing. But long-term use is associated with liver damage. Can you take niacin long term? A time-release form of niacin reduces flushing. But long-term use is associated with liver damage...
Question. Although as older individuals we absorb less of the protein we eat- it will still all count as calories? So we have to eat more calories to get the same amount of protein as when we were young?
Great information, thank you! I was researching into the NOW brand super antioxidants, and it seems that the bottle used to be $17, then the price was increased to almost $40, which does not really matter because it is not currently available; so I am thinking I may try to get quercetin on its own, and less you have a different suggestion.
Hi yeah $40 is too much. if you find 50mg quercetin that will do it... it's super strong be careful with extra doses. I explain more on quercetin doses and uses in this report: www.wellnessmessiah.com/gift
Hi Rimon, Happy to see you again. Very informative another podcast. Most appreciated. But lately after eating my first b/ fast my blood pressure is dropping. Normally I was on OMAD. But I’m afraid so much from low pressure so divided my meal into two, one is B/ fast am & dinner is latest 3 pm. If I eat protein I'm ok if not it drops to 80 / 59 or 85/59 Because of carbs, rare but & 102/ 56 or 90/59 mostly. something to do with my cortisol levels, they are low But is there a relationship with the molecules, I don't know🤷♀️ Once I went to a private clinic but couldn't find time to talk with the doctor, I had a flight to catch so wanted doc to give me the results on the phone but she refused it😢This was years ago. Also Next week they will monitor my BP 😛. Lack of protein caused some of these problems but now started to eat Turkey meat etc♥️ also began to take 500 of metamorfine. ( bought from abroad) Listen to our valuable Scientist Prof David Sinclair🙏 Thank you, Rimon most trustful and helpful videos., I keep on praying for your lovely wife🙏🌹♥️ God Bless you & your wife🙏🙏
I’ve been checking out Niacin by Now Supplements and noticed they have one without the flush. Is it just as good or is the one with the flush better? Also should you take TMG if you take Niacin?
I read about the B 12 problem. I have a question though. Did they they make a distinction between those who supplemented methylcobalamine and those who supplemented with cyanocobalamine? It's my bet there is a difference.
@@WellnessMessiah please clarify-- have read that you should not take taurine and glycine at the same time because they compete with each other for absorption
yes, I drink both coffee and green tea - all kinds. The best is - no sugar, no milk, both green tea and coffee (away from sleep) are good - not personal recommendation ) e.g people who have high BP should be careful, etc - just what I do.
Surprised that you do not address the issue of Homocysteine especially with your advocacy for vit B sups and the fact that >40% of the population have the MTHFR gene mutation - suplementing with methyl folate & methyl B12 -like Attia does - should reduce risk or maybe TMG sups
I can not easily mix Taurine with water. It floats on the top, makes a cork, very light, doesn't want to dissolve or mix in any way. I take capsules therefore.
@@babyreps365 I don't know. Over 100 dollars, maybe over 200 dollars.To be 75 years old and feel like 30 is worth it. Here's a tip. If you want to increase muscle strength and size (without exercise as I am a lazy bum) take BCAA and HMB. Branch Chain amino acids are anabolic for muscle while HMB, a metabolite normally produced from BCAA but in insufficient quantity is an anti-catabolite for muscle. For a specific muscle contract it at least 75 percent maximum and keep it that way for at least 30 seconds (I got that out of a physiology textbook many years ago.) And of course you must eat protein. Other supplements help too.
@@evarkf5303 I really should update my list. I don't think my doctor ever heard of most of them. I asked her about Honokiol and she never heard of it. It comes from Magnolia bark. I'll soon be ordering Urolithin A and PQQ. You couldn't possible get enough of the things I take in your diet every day. BTW the best source of PQQ is dark chocolate, 90 percent cocoa. I learn something new every day. I have many interests and extending my lifespan and healthspan is just one of them. To be honest some of them do scare me and some of them have resulted in blood tests out of the normal range and had to be terminated.
I need metholated B Vitamins. Other wise on deficiency. I have a metholated issue. The same with NAC I'm low on glutathione. So I have to take liposomal Glutathione
Are you at all concerned about the recent study showing cardiovascular inflammation from excess niacin intake? The metabolite of concern will likely be impacted by NMN as well. What are your thoughts? Thanks!
No, I looked into the study, I wouldn't worry about it. Here's why: 1. The study was metabolic association with outcome. That is, an association with sick people. A double weakness. Not a cause, but an association. Not healthy people, but people with a history of heart disease. But a heart attack or a cerebral event more than 3 years ago. Therefore, "stable patients". 2. They found that there is a genetic defect in part of the population that does not resolve from a byproduct of niacin. In fact, it is very possible that this genetic defect is the reason they initially developed vascular disease. "suggested that niacin metabolism was associated. Phenome-wide association analysis of the genetic variant rs10496731, which was significantly associated with both 2PY and 4PY levels,” 3. And here's the highlight. The researchers linked this to niacin. In my opinion, this is a serious mistake. The byproduct 4PY comes as a result of niacinamide. Not from niacin at all. That is, niacin needs to be converted to NAD which will turn into niacinamide. It's important to emphasize, NMN and NR produce much more niacinamide and therefore 4PY than niacin. This is actually a case for niacin and less for NR and NMN for people with this genetic defect. 4. The main conclusion currently is that there may be a certain group in the population paying a "price" for NAD boosting. They will get more NAD, but some will not be able to properly get rid of its byproducts. 5. And the second conclusion is that this strengthens the case for taking TMG. That is, it's very possible that TMG protects from heart diseases not only because it lowers homocysteine, but reduces other toxic metabolites we're not aware of from niacinamide (which is known to be toxic in high amounts... I mentioned that in my videos) 6. I wouldn't worry about niacin in general, but I would thoroughly examine the certain byproducts of NAD+ boosting. Maybe there are things we can do to reduce them? Maybe there are people with a genetic tendency who don't derive the value from them that the rest of the population does? These are important questions. But we need association studies and the use of precise terminology and not to lay the blame on "niacin". It could be that these metabolites also indicate kidney insufficiency. methyl-niacinamide would normally be excreted via the kidney. Not becoming 2PY and 4PY. That's what happens with metabolic studies, you never know what caused what... I wouldn't rule out difunctional detoxification underlying secondary cardiac event here
Wow, this is incredible research. I know many in our community are asking the question that I did. However, I don't think anyone has answered it as well as you did. I know it's tough to find the time, but you may want to do a short video on this as it's gold. Such important information and so well-researched. Thanks for all that you do!! And God Bless you and your wife. Wishing her a good recovery.@@WellnessMessiah
Thank you for sharing your insights, informative and much appreciated. I may be wrong, but you may want to double check the units Vit D (40-70 nmol/L ?). I think you meant ng/mL (?)
Hi I don't take or recommend quercetin - but per situation e.g. my parents. As for Stanfield & Quercetin, watch this: ua-cam.com/video/vj0oByINyIw/v-deo.html
Thankyou for the information. I have been taking some suplmentos of Bryan Johnson and Dr. Sinclair . I have not got a big bugget so I have tried the big green of Bryan. I have notice a diffrent and my friends have also. But I like your up date cause I can understand which are better for me. I have to say you look better so what you are doing is working. Thankyou once again. Love from Spain 👍♥️
@@WellnessMessiah I think you should do what you really like. I have notice a diffrent but we both know it is a long journey. Not all us can do what Bryan is doing cause it is not only the supplements, food, exercise and his skin care which is really important. But what I like of Bryan Johnson he put it all out for everybody. I think it has been three years and the last time I saw him wow he look so young. I have only been last summer on this journey. I have notice it I would love to do more but 🤷... But I have notice a diffrent in you for better so I think you should really go for it you are young. Sending love from Spain to both.♥️♥️
Warning on Vit D dose. How not to age showed a study that 3200 IU of D3 was best to prevent falls in older population. Higher (4000IU) made falls worse. Also the book said 4000IU for 3 years decreased bone mineral density - esp in women.
As for vitamin the B's, B1 has at least 2 forms, thiamine HCL and Benfotiamine. The main difference is thiamine HCL is water soluble and doesn't stay long in the body. The Benfotiamine form has a fat based casing that keeps it from getting into the urinary system. Last year, at 80, I started taking 600 mgs of Benfo a day for my neuropathy and it worked! At 80, I saw a video on taurine, tried it and couldn't believe how good I felt. It's amazing that the doctors had said nothing about these 2 vitamins. It is people like Rimon I have to thank for doing their job. I almost forgot Daphne Bryan's book on amazon who writes about her Parkinson's high dose thiamine treatment thanks to an Italian Dr. Costantinni. Acccordising to her, this therapy worked for some and not for others.
Most Botanical supplements are useless over the long term. They are highly inconsistent w.r.t purity, potency, efficacy & quality across batches over a long term period due to inconsistency in purity of ingredients sourced as well as poor small batch QA & testing methods. I have tried several brands (more than 100) over a 5 year period before concluding. Don't waste your money. Since then I only buy micronutrient based supplements (vitamins, amino acids, minerals, omegas, antioxidants etc ) , and that too from very select brands like thorne, douglas, pure, klaire, doublewood, integrative etc and NOT from below par brands which generally produce junk !
I take 54 supplements daily and I take all the amino acids. My last D³ level was 45!!! I have CKD and I passed my last physical exam with flying colors. I take triple Condroton Glucosamine and I wear rings on my fingers to see how well it works!!! (That and MK7) I am 63 and I feel like 45 years old again.
Hi I think it's fine. But timing matters a lot. I would take e.g. 500 mg NMN in the morning and after 8 hour 50mg niacin and again after 7-8 hours. Feeding NAD enzymes all day long. It's probably would be my future routine :)
Maybe it's the afternoon when you want to exercise, and not take a nap. I have taken taurine straight. But I had to take it separate from meals. Currently I take Magnesium Taurate with meals, twice a day.
The Life Extension Life BioActive Complete B-Complex product says on the label to take 2 capsules per day, NOT to take it twice per day. TWO capsules gives you a total of 300 mcg of B12. If, as you say in your video, the sweet spot for vitamin B12 is 400 to 800 mcg, then even if you take two capsules per day you still are beneath that threshhold. So, are you taking 2 capsules once per day or only 1 capsule per day?
The antioxidant blend you're feeding to your parents contains a solid wallop of dried green tea leaf, which can cause acute liver injury, as can ashwagandha (noted by other commentators) and niacin.
The green tea extract was an immediate concern of mine as well yet, if you recall Rimon emphasized that the dose he gives his parents is only ONE capsule daily. That’s 100 mg of green tea extract, considered a low range dose. Regarding the ashwagandha, it seems like it’s highly individualized. I have low cortisol and adrenal insufficiency but that’s complicated bc I take low dose prednisone (5mg) daily for connective tissue disease and also meds for Hashimoto’s/hypothyroidism… But I have also found info that ashwagandha is an adaptogen and therefore would modulate cortisol levels. Niacin continues to confuse me… now reading about cardiac concerns! 🤦🏻♀️ In the 70s it large doses were taken for mood disorders. But also, popular for enhanced athletic performance, especially body building! The flush was always more intense depending on how much simple carbs (sugar) you had ingested. It reacts to triglyceride levels in your blood… and reduces them…seriously! It’s why your body will “get used to” niacin after a time, but that’s because it reduces the triglycerides it reacts to… Which might then explain its cardiovascular 🫀 benefits, ha!
Hi, would you recommend a substitute for NOW super antioxidants ? I cannot find them anywhere. Perhaps they have discontinued ? Thank you in advance and for your in depth analysis/ recommendations for longevity and health!
Makes little sense on the surface... animals with low rate live much longer, centenarians have low body temp (affects metabolic rate), etc. Never looked into Ray work
Glucosamine and Chondroitin are considered to be anti-cholinergic. Since anti-cholinergics are believed to increase dementia risk, I stopped taking them. What is your opinion about the risk of taking these supplements?
Taurine is a GABA precursor which will calm you unless you have some genetic difference. You should take a smaller dose if there's a wakefulness effect. I only need 500mg per day which is enough to help with sleep but not change my brain too much. But cycling is important with any amino acid that can change neurotransmitters because that's a fragile balance
I am not sure where the idea that B vitamins are in highest concentrations in vegetables. I always thought that highest concentration and dosages of b vitamins you get from liver and other organs and meat.
Forgot to say! I don’t work/cooperate/affiliated with any supplement company.
⭕Imagine having access to ALL the BEST supplement routines for longevity in 30 seconds...
it’s possible-> WellnessMessiah.com/Longevity
you have a pencilneck
what protein do you recommend for 65+ parents and in what dose?
Hi I said, collagen powder is what I give my parents - I don't recommend anything to anyone. Dose - needs to be customized to the situation and protein intake of the person, exercise routine, etc.@@consumer1073
Is there any specific place/lab you recommend for getting NAD levels checked? Thanks
@@WellnessMessiah The NOW brand Super Antioxidants supplement appears not to even be sold on Amazon or other online markets. Even the NOW website shows it as backordered. From my own experience, this usually means it’s being discontinued or reformulated.🙏
Any other suggestions perhaps?
🎯 Key Takeaways for quick navigation:
00:00 🌱 *Taurine shows strong potential in protecting against aging, with suggested doses increasing with age, but its effects on neurotransmitters warrant caution and individualized approaches.*
04:33 💊 *Niacin (B3) and NAD boosters like NMN and NR have potential in age-related health, with NMN showing promise in muscle health and exercise performance in older individuals.*
09:30 🌿 *Ashwagandha may help regulate cortisol levels, aiding stress management, particularly during periods of chronic stress or intense physical activity.*
11:50 💪 *ALCAR (Acetyl-L-Carnitine) supports muscle health by aiding fat metabolism and reducing reliance on glucose, potentially preserving muscle function with age.*
14:49 ☀️ *Vitamin D supplementation needs to be tailored based on individual conversion rates and genetic factors, with a recommended starting dose of 4,000 to 5,000 units per day.*
17:24 💊 *B vitamins can enhance energy and reduce anxiety but should be taken cautiously to avoid excess, with a preference for obtaining them from food sources or low-dose supplementation during fasting.*
19:27 🦴 *Glucosamine and chondroitin may support joint health and longevity, although further research is needed to fully understand their impact and optimal dosages.*
20:51 💊 *Glucosamine and chondroitin supplementation may be associated with reduced total mortality risk, particularly in higher doses, according to research findings.*
22:00 🎯 *Individuals over the age of 65 may benefit from tailored supplement regimens to mitigate the risk of accelerated aging, including hormonal support, antioxidant defense, and enhanced protein intake.*
23:09 🔄 *Cycling DHEA cream usage and integrating antioxidants like quercetin may help support hormonal balance and protect against oxidative damage, particularly in individuals over 65.*
26:18 🍖 *Increased protein intake, particularly in powdered or collagen form, may be beneficial for individuals over 65 to compensate for reduced protein absorption and support soft tissue health.*
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Thank you.
Worthwhile to mention that D3 should always be taken with K2 and that they are both fat soluble (a ratio of 5000 IU D3 to 150-180 mcg K2 is commonly advocated, I cannot confirm if it is appropriate) not a bad idea to take small amounts of magnesium, zinc, calcium, copper and boron at the same time as this combo works for bone health (K2 is the superstar in this). Taurine is not a bad thing to take with NAC and Glycine as a thrice weekly detox as they tend to work well together (take at a different time to morning vitamins, I take at night), the actual amounts used should be 600mg to 1000mg each, if you are using more than that you may be putting yourself out of balance. The trio's effectiveness can be slightly boosted by taking with a very small amount of vitamin C and E, and a very weak B group supplement (mainly for the small B6 content) as these can help the effectiveness of the NAC, but B6 amount needed by the NAC would be less than 5mg (very dangerous to take too much B6 overall, do not rely on vitamin manufacturers to know safe dose as they make a lot of money off ALA sold to detox it).
Thank you for all you do🙏🏻
Thank you ❤
Thank you for the extra knowledge and summary.
I'm 92 with no medical problems or prescriptions, but my vitamins are getting out of hand. So many to take!
I’d marry you 😅
Blessing sir ❤
I’m with you! I take about 50 supplements a day in 3 divided doses: in the morning, with dinner and before bedtime.
Thanks for addressing those over 65. I have changed up my supplement routine since I hit retirement to target those aging issues. It has clearly made a difference.
Will review it and see, almost 63
many people know the longevity effect of taurine but they do not understand the mechanism.
here it is:
in the mitochondria there are two primary types of fuels to be burned: glucose and fatty acids.
and there is a difference in ROS production between burning fat or glucose. if burning glucose, ROS production is going up. if you understand ROS then you understand, that it is very very damaging. sometimes the body needs it as a defense mechanism against a virus of bacteria or a cancer cell that is gone rouge.
but of course ROS is damaging also organelles, cell walls etc.
so, if ROS is not needed, it should be avoided. staying in fat burning mode is key for that.
one factor - besides many other factors - is making sure that fat burning is running smoothly and fast enough. if it is too slow to produce enough ATP, the mitochondria is switching to glucose burning mode.
what is making sure that fatty acids are oxidized ( =burned) fast enough?
==> the speed of the enzymes that are involved in that (krebs cycle etc.) is depending on the pH level of the surrounding. if the pH level is going down ( lower pH = more acidic ) then the fat burning enzymes are slowing down. this is a usual effect from a chemical reaction. the speed looks like an S-curve, or mathematically like a sigmiod-function.
it this case this sigmoid function describes how fast the chemical reaction is.
AN THIS IS WHERE TAURINE IS COMING IN:
taurine is a pH buffer. that means it keeps the acidity from changing fast. and there is a chain of pH buffers from taurine in the mitochondria to carnosine in the cell to bicarbonate in the blood.
in legal sports doping where the body should stay in fat burning in long endurance sport (cycling, running over many hours etc.) they supplement with sodium bicarbonate, beta-alanine (to make carnosine) and taurine to have enough of these pH buffers.
so, now the anti aging mechanism should be clear. in one sentence, taurine optimizes fat burning which lowers ROS which is one cause of aging.
What's ROS? And what, to live longer we need to eat keto? Will never believe that. People lived on carbs for thousands of years.
@@nikola_korneta Reactive Oxygen Species. it you eat a huge carb meal, the excess carbs get partially converted into fat. and then burned also as fat. it is not black and white. i don't care what you do, and i don't tell you what you have to do. i just explained the mechanism in the mitochondria. and people also eat fatty pork belly and eggs for thousands of years. so usually they didn't eat carbs only.
I agree with everything, the damage of glucose like you said, and I add and taurine does other things as well beside PH buffer against aging. It's quite remarkable...basically a "don't die" supplement.
Yes but I not think we need between 33-60g as he says?
@@nikola_kornetano people have not lived on carbs for thousands of years! What a ridiculous comment !
I find your comments some of the best on the web. You deliver things directly.
I took ashwaganda for a long time, 3..4 days per week. I liked the effect on psychology and regulation of sex drive. However, and that's a big one: It caused inflammation of the liver, AST got as high as 40. When I took it off, all other things roughly the same, AST returned to 28 after 8 months. So, if you start taking it, observe your liver enzymes.
In order to support the healing i ramped up the vitamin A, by food and by supplement
How much dose did u take?
@gaston. Liver enzymes, also it messes with thyroid. I suggest being very careful with plant extracts
Thanks, good feedback.
TBH I'm still researching it! Definitely has some anti-cortisol anti anxiety.
It seems so far as "use to cover a hole" as needed supplement. I suspect it will reduce the side effects you mentioned. But - I'm not yet the expert on it quite yet. My current obsession is taurine...
@@airy252 I slipped into a quasi-chronic intake. Pills were around 400 mg powder. First I used it very occasionally, sh like every 2..3 weeks for 1..2 days.
The suppression of cortisol allows the sex hormones to be produced. Better sleep, as its latin name particle suggest, was just another argument. Feeling then more balanced...
Until i did a lab test for sth completely different. which exposed some intense stress for the liver.
Some 15 years ago i tried another so-called adaptogen, rhodiola, but that quickly turned out to be very bad for deeper levels of psychology. At that time i made research grade cognitive tests (N=1), and i saw it did work and amazingly enhanced short term memory.
I've tried several brands of ashwa, and very large doses, and I have to say it's another typical "witch doctor" herb of the hundreds we've seen in the last fifty years.
Couple of things, Taurine taken on the empty stomach in the morning will stimulate your gllbladder and improve bile flow. This will help to prevent stones from forming also a good easy way to jump start your day. Second, vitamin E should be in tocotrienol form - this is important. I also add CaAKG and some other amino acids before workout, and creatine. Creatine not just gor musvle growth but for stress and mental health actually which was surprising to me…different doses for men and women because of the way it’s processed, gender specific things…also a quick note on micro-dosing melatonin after 40. A few more things I had really good success with if it’s interesting, I can write later! 😊👍
Thank you AT! intelligent as usual
Women should take lower or higher doses of creatin compared to men?
@@danielstraka17 Women have lower creatine stores than men so yes, they should take less. 3g is probably enough
Thanks for your opinions and research on all of that. I hope that your wife continues to improve.
Vit D3 with K2
Re: Taurine. Recommend getting an amino acid profile which includes taurine. Then module diet, exercise and supplementation over time to get to high end of reference range. Makes no sense to just gobble many grams a day without testing. I'm 69 yo and have levels of a 30 to 40 yo according to data in studies and I only use 500 mg/d which I've taken for about 10 years for other reasons (vascular). Now taking 1 gram a day and will retest again soon. Same idea with Vitamin D (I take 5000 IU /d), Omega 3 index, test and modulate diet and supplementation and as needed. My D3 level is in 40 to 50 ng/ml range. Omega 3 index 7.8%, almost ideal ( i take about 600 mg of EPA and DHA, eat flaxseed and nuts and a little fish). Test when testing is available.
You take Taurine daily the past ten years? Do you ever take a break for a month before proceeding to prevent toxicity?
Most rcommend k2 with the d3.
We appreciate your sharing your thoughts on these supplements!! Thank you 👍🙄
🎯 Key Takeaways for quick navigation:
00:00 🌟 *Cutting-edge longevity updates:*
- Taurine, NMN, ashwagandha, and stress customization impact aging defense.
- Personal insights on dosage and effects of various supplements.
- Focus on optimizing aging defense protocols for individuals over 65.
01:23 💡 *Taurine benefits and dosage:*
- Taurine shows strong potential in protecting against aging.
- Dosage recommendation: around 1 gram per decade of age.
- Individual responses vary; experimentation and cautious approach advised.
04:48 🔄 *NMN insights and dosing:*
- Limited data on NMN's lifespan extension effects in humans.
- Focus on muscle benefits and exercise performance over 60.
- Recommended dose: 1 gram daily; individual response and quality of life improvements matter.
09:45 🌿 *Ashwagandha's role in stress management:*
- Ashwagandha's potential to reduce cortisol levels during high-stress periods.
- Importance of balanced cortisol levels for longevity.
- Personal experimentation and cautious approach recommended.
11:50 💪 *ALCAR for muscle health:*
- ALCAR aids in burning fat and reducing dependence on sugar for energy.
- Personal experience suggests preservation of muscle vitality and youthfulness.
- Dosing adjustment to 500 milligrams twice a day for a conservative approach.
14:49 ☀️ *Vitamin D supplementation:*
- Importance of understanding vitamin D activation and conversion in the body.
- Recommendations for dosage based on individual testing and genetic factors.
- Addressing concerns about vitamin D toxicity and optimizing blood levels for health benefits.
17:24 🅱️ *B vitamins and aging:*
- Adequate B vitamin levels linked to increased longevity and vitality.
- Caution against excessive B vitamin intake, which may increase mortality.
- Timing of supplementation during fasting and dosage adjustments for optimal results.
19:27 🦴 *Glucosamine for joint health:*
- Glucosamine and chondroitin as building blocks for joint and ligament repair.
- Potential benefits for preventing joint damage and promoting longevity.
- Limited data on mortality reduction associated with glucosamine and chondroitin use.
20:51 ⚕️ *Glucosamine and chondroitin intake linked to 70% lower mortality risk according to a study.*
22:00 🦴 *Modification of supplements for individuals over 65 aims to counteract "runaway aging" by customizing longevity protocols.*
23:09 🧴 *Hormonal support recommended for individuals over 65, including DHEA cream for hormone production.*
24:05 🧠 *Antioxidant support becomes more crucial after age 65 to protect brain, eyes, and ears from oxidative damage.*
26:18 🍖 *Protein absorption decreases with age, particularly after 65, leading to a recommendation for extra collagen intake to support soft tissues and antioxidant defense system.*
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Congratulations, Rimon. I haven't been here for a while and on watching this, I observed with joy, the astronomical growth in your number of subscribers. I used to feel bad when your numbers were still low because I never quite understood why such an informative channel would be under subscribed. The only way is up for you now. I hope your wife continues to make a good recovery. Best wishes.
Thanks a lot!
Great info as always!!🙏 What brand of fisetin do you recommend.
I appreciate your efforts and valuable informations,thanks a lot
Collagen doesn’t have a complete amino acid profile. It doesn’t count towards your protein for the day.
Love your content Rimon! Can you comment on the latest data on Niacin's metabolites (4PY) being linked to heart risk and inflammation? Does this also impact NMN/NR users? A video on this would be very helpful! Thank you for all you do
Yes. In short - I wouldn't be worried about it if you're healthy - not having history of cardiovascular disease. and yes, it affect NMN and NR much more than niacin. You will have to give up all benefits of NAD boosting.
Long:
1. The study explored metabolic associations linked to outcomes, specifically focusing on correlations with individuals with a history of heart disease, not healthy subjects. It characterized these individuals as "stable patients" who had experienced a heart attack or a cerebrovascular event more than three years prior.
2. A key finding was the identification of a genetic variation in a segment of the population that hinders the processing of a niacin byproduct. This genetic anomaly could potentially be a contributing factor to their initial development of vascular diseases. The research pinpointed a genetic variant (rs10496731) significantly associated with altered levels of certain metabolites, suggesting a link to niacin metabolism.
3. However, there's a critical oversight regarding niacin. The metabolite 4PY, implicated in the study, results from niacinamide, not niacin. Niacin must be converted to NAD, which then becomes niacinamide. Notably, NMN and NR, precursors to NAD, produce significantly more niacinamide (and consequently 4PY) than niacin does. This suggests that for individuals with the mentioned genetic variant, niacin might be preferable over NMN and NR.
4. The preliminary conclusion indicates a subset of the population may experience adverse effects from NAD boosting, unable to efficiently eliminate certain byproducts, thus paying a "price" for increased NAD levels.
5. Additionally, the research underscores the potential benefits of TMG supplementation. TMG might not only mitigate heart disease risk by lowering homocysteine levels but also by reducing other harmful metabolites produced from niacinamide, which can be toxic in large quantities.
6. While the general use of niacin doesn't raise concerns, it's crucial to investigate the specific byproducts of NAD+ enhancement further. Are there methods to minimize these byproducts? Do certain individuals with genetic predispositions benefit less from NAD+ boosting compared to the broader population?
These questions highlight the need for more nuanced studies and precise language in research findings, rather than attributing outcomes to niacin indiscriminately. Moreover, the study hints at potential kidney function implications, as methyl-niacinamide is typically expelled through the kidneys, not converted into 2PY and 4PY. This complexity is characteristic of metabolic studies, where determining causality can be challenging. It's possible that underlying detoxification issues could contribute to secondary cardiac events.
@WellnessMessiah Thank you! Very interesting answer. I do take TMG so that is reassuring. Leave it to you to find an oversight with respect to Niacin perhaps being preferred to NMN/NR! Great stuff. I will keep watching your videos for more as this issue develops!
Good video! Thanks for dividing supplement analysis into age groups (65). This is important for some supplements. I'm surprised you didn't do that for NMN, though. NMN is mostly used by older people to restore NAD levels to closer to youthful levels. I don't know if niacin can do as good of a job in older people. It is a good example of a supplement that doesn't make sense to use when younger, especially since it's expensive, but can be justified in older people.
Thank you I think I did say it's very good for 60+
C'est peut être utile pour des gens qui ont traversés de grosses périodes difficile où ils se sont abîmés avant l'heure non ? Une cure pour essayer de se régénérer Les niveaux de NAD dans ces cas là pour se réparer un peu, une bonne idée ou pas ??
@@mickaelcaeyman9927from Southern Colorado Rockies USA I'd say great Idea who determines adequate damage ,no one but ourselves,the Dr. Here seems as though he's experimented on him self and parents and found a great base for us to build from Peace
Very good advices, very good and wise, thank you
Oddly enough, English doesn't use an s after advice to make it plural. It's always 'advice' in both singular and plural cases. 🤔
@@User0resU-1 thank you! I will keep it in mid next time!
Great advice Rimon and very much appreciated here in China. Thank you
Great to meet your here, lot of love
Good stuff...appreciate the info on taking care of our older parents. My mother so far has been fairly receptive to my suggestions. She's on medications so I don't want to overload her with supplements so suggestions such as bone brother are helpful. Being 65 myself..this stuff is important to me as well. Your work is appreciated.
Nice meeting you here. I have passion for 65+, it doesn't work well with youtube. I speak some about it in my updated supplement routine, what I do with my parents: wellnessmessiah.com/app
I live in Hawaii and we all live in our bathing suits getting lots of sunlight on our skin. It’s almost impossible to get vitamin d levels higher than 50 naturally from the sun. Only supplements can cause it to go higher.
Sperti vitamin d lamp
It's interesting. It could be that supplemental vitamin D circumnavigate some skin regulation . On the other side, in the video I spoke about 70,000 years ago - people going with no clothes all day long. Large areas are back, chest.. these are still hidden vs the past.
I took 10,000 IU’s of quality Vit D throughout the pandemic. Never got sick BUT the skin on my hands and feet literally started peeling off because of Vit D toxicity.
Taking powder form as opposed to natural sunlight will obviously be
Absorbed differently.
Like he said starting at 4000 IU’s should be fine.
mb u used tons of antibacterial sops ,etc???
Opinion: Yes, protein absorption may drop a bit with age, but exercising is best way to prevent muscle loss aside from many other benefits as we age. Get a scale which measures lean muscle mass and body fat and start tracking. If you start loosing lean mass on a good diet and exercise then consider a little more protein in the form of higher protein real food, Things like nuts and beans. Avoid the powders.
Thank you you and Dr Gregor. Have him on your show
I thought B12, like other B vitamins, was water soluble. Therefore, any excess would be harmlessly excreted. Is that not so?
no so simple !
I thought that too. What's the harm? I was surprised like you
Some evidence that b6, b9 and b12 can build up in unexpected places, if it remained in the blood, absolutely yes it would be excreted but that doesn't always seem to be the case depending on amounts and the body's demand for them. Also very important to take the natural versions rather than the synthetic ie B6 version s/be P5P, and the methyl versions of B9 and B12 s/be taken so you are not dependant on your internal organs to convert them into the useable forms. B vitamins tend to need each other so taking a high amount of 1 without the others may have unpredictable affects... B6 is one to watch out for as amounts in supplements are often dangerous when taken long term (25-50 mg P5P is possibly the bodies tolerable upper limit from supplements, might be as little as 12-15mg if taking the synthetic form pyridoxine hydrochloride, however frankly this depends on many factors such as body weight and what other vitamins and minerals you take as supplements / diet more generally / medical conditions)
I think it depends on the type of B12, you should never ever high dose (or take at all) cyanocobalmine as it contains cyanide. Despite the amount is considered very safe, its not when you megadose as cyanide is very tough to get out of your body system. In other words, you give yourself a very slow cyanide poisoning if you high dose this type of B12. And you may know that cyanide is also barely tracable until you turn blue or get the typical almond like smell. But before that happens you probably died already. It can cause all kinds of weird health issues no one can explain before that. I take B12 as methylcobalmine as mouth spray, it has like 25000% RDA, but I only take 1 spray instead of the 4 recommended as daily dose. It doesnt feel right for me to dose this high, injections go up to even 125000% rda, but they say your body poorly absorbs B12 and you need these high doses to combat deficiency in order to absorb what you need to fix it in a fast rate. Those highdosed supplements aim for garanteed 100% absorbed RDA.
Awesome content... awesome knowledge! I take over 50 Supplements. NMN is by far my favorite. It really makes a difference with me. THX
Nice meeting you alexander, NMN is powerful, yet the lack of data still make it difficult to know exactly how and when
Great info. If worried about TMAO, take about 500mg of a garlic extract with your food. It will lower TMAO.
Didn't know that. Thank you!
I also avoid all prescriptions if I can. I even turned down statins and I'm using nattokinase instead. Some study actually found it far more effective at removal of plaque. I don't care for nmn too pricey and I didn't notice any benefits personally.
What is your nattokinase dosage per day?
im 84 .Loved this.
Lot of love, stay healthy!
Hey Ramon Love your channel.❤ What is best to mix the taurine powder with? The taste is pretty bad. I cannot swallow capsules either. Thank you
It should be tasteless... I would try magensium glycinate or glycine powder - it has a natural sweet taste
I’m surprised that you didn’t add GlyNac to your 65+ supplement routine. It’s better than exogenous antioxidants.
It causes ED in middle-aged males
Agreed research shows it greatly increases Glutathione a master protective antioxidant especially in the Liver
Hi It's impossbile to cover all 65+ here. I take NAC, therse are only the changes and updates... In patreon I published complete reports and brands
Hey. Thanks again for the outstanding content. 😊 I've probably missed this somewhere but do you have any thoughts on a reputable glucosamine/chondroitin brand?
Prayers for your wife's ongoing recovery (and the continued success of your channel 😉) 😊
The pro-longevity and pro-divorce hormone part cracked me up 😂 Great content
Opposite. Chronic cortisol, ati-longevity and pro-divorce is "responsible" for the pandemic of diabetes and the pandemic of divorces and/or single mothers....
Are you aware that tocotrienol is 50 times more protective of fat oxidation than tocopherol? I learned this from an hour long interview on Modern HealthSpan about six months ago. I apologize for not knowing the doctor's name, but he spend most of his life studying tocotrienol. He also said that tocopherol diminishes the effect of tocotrienol, so they should not be taken together.
For those who have had radiation treatment, I use tocotrienol together with pentoxyfilline to reduce fibrosis from radiation (see the papers of Dr. Sylvie Delanian for dosages.) This combination, although I used tocopherol until recently, has kept my throat open for decades. It is common for fibrosis to keep growing and fill the throat so that a feeding tube is required. Many ENT doctors know about this cocktail now, but not about tocotrienol.
Anyone have any recs for a good DHEA cream? I’m on the capsules but need to switch. Or do folks get an rx & have it compounded? Thanks!
I’d love to know too
Lifted weights till now, ( 50 years ,l 1 gram nmn has helped rotator cuff pain shoulder pain and the lack of pain has helped reverse gradually loss of strength
There's a lot of hype towards NMN and NR. Probably it's due to commercial interests. Niacin has been on the market for a long time and isn't a good business for labs
I eat yeast spread once-twice a week therefore I don't have to bother with niacin or b-Complex supplements, nonetheless overpriced NMN...
@@danielstraka17 how does yeast raise your NAD levels. What does it have?
10:50
iirc l-ornithine does reduce cortisol as well
Ashwagandha may be a solution to my deadly lowering of blood pressure after eating my first meal 😞
Can I take it with NMN & Resveratrol & Supermedine together? Or a different time?
I read in the article this Ashawanga may drop blood pressure so it may cause danger in my case.
My problem may be because of my lower cortisol levels.
I will check them hopefully.
But in meanwhile I can order this supplement.
Which company you advise, please?Thank you.
Lately, they keep on sharing in the news this OMAD diet may kill us. Can you pls make a video about it pls?
Many thanks.
God Bless your wife & you🙏🙏
For CVD prevention, I’m taking 100mg of Niacin along with bergamot. I used to wash my supplements down with a protein smoothie that included banana, but I replaced the banana with apple because there’s a compound in banana that blocks the benefits of polyphenols found in berries and bergamot.
The comment about exercise and joints is valid. However not all exercise is equal on our joints. I swim & often use training aids like paddles and flippers. Increasing the load on my muscles but not joints. Win win
Yes of course. The video is too long to get into subtle influence of exercise on joints...
I take magnesium citrate in the morning and take magnesium taurate just before bed. Taurate is the salt of taurine, so the magnesium/taurine combo is great for many reasons, including healthy sleep. I also munch on some pumpkin seeds sometimes before bed because those are a good source of magnesium.
Sounds good protocol! well done
I too divide my magnesium need in different types of magnesium. I take magnesium taurate in the morning to also aid my morning intake of vit D (3000IU) and magtein (magnesium threonate) in the evening with my 2000IU vit D. During the day I take magnesium in my electrolyte tab due to me being chef I sweat a lot and need to replenish in plenty. I think this magnesium is glycinate, only the other two I buy specific. I like to spread doses even if it says I only need to take once a day, if possible I take half or try twice or three times a day. Shouldnt need to overdose unless known deficiency like I have for vit D, magnesium and probably B12.
@@AnnaMaria-zm8cv I take capsules daily of either wild caught cod liver oil or salmon oil for vitamin D, besides the sunshine. I get my omega 3s that way, too. Pumpkin seeds are also very high in magnesium. A handful before bed can help with sleep.
HI Rimon: i take niacin, first few days I got the flush but soon developed tolerance to it no longer have any flush with it, I suggest start with a low dose for a week and gradually increase , I take anywhere from 500 to 1500 mg Niacin flush per day, both for Mitochondria health and lipid profile.
Keep an eye on your liver enzymes. Niacin at 1000- 1500 mg can damage the liver.
Like your channel very much ❤
Thank you so much Rimon for this video. I am a 70 yrs. old African American female in GOOD general health but do not feel the energy I used to since turning 70. I am on bio-Identical hormone replacement cream (16 yrs. now)--not due to any disease. It was elective for me as a way to manage aging. Is it OK for me to add DHEA cream? Also do I understand correctly that I can try either Niacin OR NMN? I don't need both? Thank you.
You should look over Tulsi - holy basil. It’s so wonderful against stress and more.
Huge Thank-you ! All Great Info. ! One Full Body/Brain , Natural Supplement that You Did Not Mention, I take Daily as well as My Mother in her Late 80's Is Creatine Monohydrate ! Your body produces Naturally but as We Age it is Imperative for Good Health and Longevity ! Cheers !
Yep, I'm 75 and take 5 grams a day along with my whey protein powder. I also take 3 grams hmb to ward off muscle wasting. He also didn't mention NAC and glycine.
Hi Johnny there are only the changes and updates... In patreon I published complete reports and brands
@@WellnessMessiah Title of Video ...Longvevity Supplements ! ! Creatine Monohydrate Should Be In The Top TWO ! And Was Omited ? ? ?
Was hoping resveratrol , apigenin, astraxanthin and tumerec would also be covered
Only the changes and updates... In patreon I published complete reports and brands
Carnatine - 1 to 1.5g, not 1g to 1.5mg. Just a mistake, of course. But worth pointing out, so nobody gets confused.
Yes correct thank you
I have never heard any expert suggest that NMN prevents cancer. I have experienced numerous benefits from NMN which I have been taking for five years and feel 10-20 years younger than my 70+ years.
My comment, of course, relates to the ITP results which show no life extension in mice taking NR.
Hi as I said - what matters is the end result. If NMN makes you happy, gives you what you want - nothing could be that.. not even the best studies. Results always win. Lots of love
Wonderful presentation and presenter , comments out of this world, kicks ss, Peace
Interested to find out if you’ve heard Chris Masterjohn’s warning of NMN supplementation leading to excessive filling of the niacin pool and epethial damage to vascularature. I need to try and read his post again because he’s incredibly technical. But he cautions against high dose NMN.
Thank you so much for the Great content, I trust you more than any one ,could you please share which brand of vitamin b3 ( niacin) and collagen do you use ?! Are you recommending whey protein for people over 55 or 60 it has all the amino acids especially for those who don't eat red meat alot maybe once a week?! Greatly appreciated 🙏❤😊
Hi Monir, trust yourself more than me. This is what I do. The brands, I share with my mid-level patreons www.patreon.com/WellnessMessiah
Error in your vitamin D blood test target: I think you mean 40-70 ng/mL, not nmol/L, because 40-70 nmol/L is only 16-28 ng/mL.
yes, you're right!
Thanks for this. You’ve convinced me to start taking Taurine for the first time. I didn’t fully understand when you take it and why and how to stop it interfering with sleep
NMN has incredibly improved my eczema on my hands which I have year round. I started NMN last week. Also, I was having crazy inflammation in my body which led to incredible hair loss and NMN has helped my hair to stop falling out. I take it with TMG. So far it’s a miracle supplement. PS I’m 31 years old.
What is your dose of nmn?
Thanks to you, I take Niacin instead of NMN because of cost. I take a 500 mg capsule and just drink it throughout the day little at a time. I find that the body got used to the flush over time. I take resveratrol 3-500 mg every two days on days I dont work out. GlyNAC 3 grams every morning, Taurine 2,5 gr x 2 times a day. Thats it for now, until I get more money.
WHAT IS UR RESPONSE TO THIS AS WELL AS MORE RECENT UPDATES...!!??
"The average person should avoid niacin supplements now that we have reason to believe that taking too much niacin can potentially lead to an increased risk of developing cardiovascular disease,” Hazen said.Feb 19, 2024.Can you take niacin long term?
A time-release form of niacin reduces flushing. But long-term use is associated with liver damage.
Can you take niacin long term?
A time-release form of niacin reduces flushing. But long-term use is associated with liver damage... 9:51
WHAT IS UR RESPONSE TO THIS AS WELL AS MORE RECENT UPDATES...!!??
"The average person should avoid niacin supplements now that we have reason to believe that taking too much niacin can potentially lead to an increased risk of developing cardiovascular disease,” Hazen said.Feb 19, 2024.Can you take niacin long term?
A time-release form of niacin reduces flushing. But long-term use is associated with liver damage.
Can you take niacin long term?
A time-release form of niacin reduces flushing. But long-term use is associated with liver damage...
@@hiasenchazz6375 yeah, I don't take time release. duh
Yooo you gotta do intracellular NAD+ (powered form) water soluble and raised me levels from 27 to 50 in a week
HI, What lab do you use to get NAD levels checked? thx!
Question. Although as older individuals we absorb less of the protein we eat- it will still all count as calories? So we have to eat more calories to get the same amount of protein as when we were young?
Great information, thank you! I was researching into the NOW brand super antioxidants, and it seems that the bottle used to be $17, then the price was increased to almost $40, which does not really matter because it is not currently available; so I am thinking I may try to get quercetin on its own, and less you have a different suggestion.
Hi yeah $40 is too much. if you find 50mg quercetin that will do it... it's super strong be careful with extra doses. I explain more on quercetin doses and uses in this report:
www.wellnessmessiah.com/gift
Hi Rimon, Happy to see you again. Very informative another podcast.
Most appreciated.
But lately after eating my first b/ fast my blood pressure is dropping. Normally I was on OMAD.
But I’m afraid so much from low pressure so divided my meal into two, one is B/ fast am & dinner is latest 3 pm.
If I eat protein I'm ok if not it drops to 80 / 59 or 85/59 Because of carbs,
rare but
& 102/ 56 or 90/59 mostly. something to do with my cortisol levels, they are low
But is there a relationship with the molecules, I don't know🤷♀️
Once I went to a private clinic but couldn't find time to talk with the doctor, I had a flight to catch so wanted doc to give me the results on the phone but she refused it😢This was years ago.
Also Next week they will monitor my BP 😛.
Lack of protein caused some of these problems but now started to eat Turkey meat etc♥️ also began to take 500 of metamorfine. ( bought from abroad) Listen to our valuable Scientist Prof David Sinclair🙏
Thank you, Rimon most trustful and helpful videos.,
I keep on praying for your lovely wife🙏🌹♥️
God Bless you & your wife🙏🙏
I’ve been checking out Niacin by Now Supplements and noticed they have one without the flush. Is it just as good or is the one with the flush better? Also should you take TMG if you take Niacin?
Great Video and Glad You addressed 'over 65's'❤!
Could You kindly share the Brand of Collagen You give Your parents.😊
Hi Jenny... my priority is first bovine vs marine - bovine better if you can. No fillers, no taste, Non GMO. just pure. and you should be OK!
I read about the B 12 problem. I have a question though. Did they they make a distinction between those who supplemented methylcobalamine and those who supplemented with cyanocobalamine? It's my bet there is a difference.
No. It's a good distinction like you said... BUT I remember they measured blood B12. I need to check this
Thank you for your incredible work!
What do you put that 5g of taurine into, Rimon? I've been taking capsules but will probably switch to the powder. 💠
Hi into my collagen powder, with magnesium glycinate which adds taste- naturaly sweet :)
@@WellnessMessiah please clarify-- have read that you should not take taurine and glycine at the same time because they compete with each other for absorption
Thanks for the medical advice and personal recommendation 😂🎉
You're welcome!
NMN is just a derivative of Vitamin B3, shouldn't be too hype over the substance. Anyway thank you for your information.
Thank you very much for you proposals, which I apricate a lot
Hi Rimon, do you still drink coffee or matcha? what do you think is best if I ever to choose only one?
yes, I drink both coffee and green tea - all kinds. The best is - no sugar, no milk, both green tea and coffee (away from sleep) are good - not personal recommendation ) e.g people who have high BP should be careful, etc - just what I do.
Surprised that you do not address the issue of Homocysteine especially with your advocacy for vit B sups and the fact that >40% of the population have the MTHFR gene mutation - suplementing with methyl folate & methyl B12 -like Attia does - should reduce risk or maybe TMG sups
I can not easily mix Taurine with water. It floats on the top, makes a cork, very light, doesn't want to dissolve or mix in any way. I take capsules therefore.
Good info, hard to understand sometimes though. So you only take 50mg of niacine per day or 50mg a few times per day?
separated, so I take 100-150 mg per day. Usually every 8 hours - the time to consume the average NAD molecule.
I've been taking all of these and many more, over 100 different supplements every day.
How much do you spend on supplements per day, week, month?
Over 100??
@@babyreps365 I don't know. Over 100 dollars, maybe over 200 dollars.To be 75 years old and feel like 30 is worth it. Here's a tip. If you want to increase muscle strength and size (without exercise as I am a lazy bum) take BCAA and HMB. Branch Chain amino acids are anabolic for muscle while HMB, a metabolite normally produced from BCAA but in insufficient quantity is an anti-catabolite for muscle. For a specific muscle contract it at least 75 percent maximum and keep it that way for at least 30 seconds (I got that out of a physiology textbook many years ago.) And of course you must eat protein. Other supplements help too.
@@evarkf5303 I really should update my list. I don't think my doctor ever heard of most of them. I asked her about Honokiol and she never heard of it. It comes from Magnolia bark. I'll soon be ordering Urolithin A and PQQ. You couldn't possible get enough of the things I take in your diet every day. BTW the best source of PQQ is dark chocolate, 90 percent cocoa. I learn something new every day. I have many interests and extending my lifespan and healthspan is just one of them. To be honest some of them do scare me and some of them have resulted in blood tests out of the normal range and had to be terminated.
Only 100? You're left behind mark!
Thanks for the thorough review.
I need metholated B Vitamins. Other wise on deficiency. I have a metholated issue. The same with NAC I'm low on glutathione. So I have to take liposomal Glutathione
Are you at all concerned about the recent study showing cardiovascular inflammation from excess niacin intake? The metabolite of concern will likely be impacted by NMN as well. What are your thoughts? Thanks!
No, I looked into the study, I wouldn't worry about it. Here's why:
1. The study was metabolic association with outcome.
That is, an association with sick people. A double weakness. Not a cause, but an association. Not healthy people, but people with a history of heart disease. But a heart attack or a cerebral event more than 3 years ago. Therefore, "stable patients".
2. They found that there is a genetic defect in part of the population that does not resolve from a byproduct of niacin. In fact, it is very possible that this genetic defect is the reason they initially developed vascular disease.
"suggested that niacin metabolism was associated. Phenome-wide association analysis of the genetic variant rs10496731, which was significantly associated with both 2PY and 4PY levels,”
3. And here's the highlight. The researchers linked this to niacin. In my opinion, this is a serious mistake. The byproduct 4PY comes as a result of niacinamide. Not from niacin at all. That is, niacin needs to be converted to NAD which will turn into niacinamide.
It's important to emphasize, NMN and NR produce much more niacinamide and therefore 4PY than niacin. This is actually a case for niacin and less for NR and NMN for people with this genetic defect.
4. The main conclusion currently is that there may be a certain group in the population paying a "price" for NAD boosting. They will get more NAD, but some will not be able to properly get rid of its byproducts.
5. And the second conclusion is that this strengthens the case for taking TMG. That is, it's very possible that TMG protects from heart diseases not only because it lowers homocysteine, but reduces other toxic metabolites we're not aware of from niacinamide (which is known to be toxic in high amounts... I mentioned that in my videos)
6. I wouldn't worry about niacin in general, but I would thoroughly examine the certain byproducts of NAD+ boosting. Maybe there are things we can do to reduce them? Maybe there are people with a genetic tendency who don't derive the value from them that the rest of the population does?
These are important questions.
But we need association studies and the use of precise terminology and not to lay the blame on "niacin".
It could be that these metabolites also indicate kidney insufficiency.
methyl-niacinamide would normally be excreted via the kidney. Not becoming 2PY and 4PY.
That's what happens with metabolic studies, you never know what caused what... I wouldn't rule out difunctional detoxification underlying secondary cardiac event here
Wow, this is incredible research. I know many in our community are asking the question that I did. However, I don't think anyone has answered it as well as you did. I know it's tough to find the time, but you may want to do a short video on this as it's gold. Such important information and so well-researched. Thanks for all that you do!! And God Bless you and your wife. Wishing her a good recovery.@@WellnessMessiah
Thank you for sharing your insights, informative and much appreciated. I may be wrong, but you may want to double check the units Vit D (40-70 nmol/L ?). I think you meant ng/mL (?)
Yes you're correct it's a mistake
This is confusing. You recommend quercetine but B. Stanfield don't.
Who is right ?
Hi I don't take or recommend quercetin - but per situation e.g. my parents. As for Stanfield & Quercetin, watch this:
ua-cam.com/video/vj0oByINyIw/v-deo.html
Thankyou for the information. I have been taking some suplmentos of Bryan Johnson and Dr. Sinclair . I have not got a big bugget so I have tried the big green of Bryan. I have notice a diffrent and my friends have also. But I like your up date cause I can understand which are better for me. I have to say you look better so what you are doing is working. Thankyou once again. Love from Spain 👍♥️
Thanks for the complement. I get some push to show my body too BTW. That itis important for my channel. What do you think?
@@WellnessMessiah I think you should do what you really like. I have notice a diffrent but we both know it is a long journey.
Not all us can do what Bryan is doing cause it is not only the supplements, food, exercise and his skin care which is really important. But what I like of Bryan Johnson he put it all out for everybody. I think it has been three years and the last time I saw him wow he look so young.
I have only been last summer on this journey. I have notice it I would love to do more but 🤷...
But I have notice a diffrent in you for better so I think you should really go for it you are young. Sending love from Spain to both.♥️♥️
Warning on Vit D dose. How not to age showed a study that 3200 IU of D3 was best to prevent falls in older population. Higher (4000IU) made falls worse. Also the book said 4000IU for 3 years decreased bone mineral density - esp in women.
Are you measuring your epigenetic biomarkers?
As for vitamin the B's, B1 has at least 2 forms, thiamine HCL and Benfotiamine. The main difference is thiamine HCL is water soluble and doesn't stay long in the body. The Benfotiamine form has a fat based casing that keeps it from getting into the urinary system. Last year, at 80, I started taking 600 mgs of Benfo a day for my neuropathy and it worked! At 80, I saw a video on taurine, tried it and couldn't believe how good I felt. It's amazing that the doctors had said nothing about these 2 vitamins. It is people like Rimon I have to thank for doing their job. I almost forgot Daphne Bryan's book on amazon who writes about her Parkinson's high dose thiamine treatment thanks to an Italian Dr. Costantinni. Acccordising to her, this therapy worked for some and not for others.
Most Botanical supplements are useless over the long term. They are highly inconsistent w.r.t purity, potency, efficacy & quality across batches over a long term period due to inconsistency in purity of ingredients sourced as well as poor small batch QA & testing methods.
I have tried several brands (more than 100) over a 5 year period before concluding. Don't waste your money.
Since then I only buy micronutrient based supplements (vitamins, amino acids, minerals, omegas, antioxidants etc ) , and that too from very select brands like thorne, douglas, pure, klaire, doublewood, integrative etc and NOT from below par brands which generally produce junk !
I take 54 supplements daily and I take all the amino acids. My last D³ level was 45!!! I have CKD and I passed my last physical exam with flying colors. I take triple Condroton Glucosamine and I wear rings on my fingers to see how well it works!!! (That and MK7) I am 63 and I feel like 45 years old again.
Don't forget about your creatine monohydrate.
You said we need to take a gram of MNM a day. But how about taking Niacin (I take 500 mg of sustained release) + 500 mg of NMN?
Hi I think it's fine. But timing matters a lot. I would take e.g. 500 mg NMN in the morning and after 8 hour 50mg niacin and again after 7-8 hours. Feeding NAD enzymes all day long. It's probably would be my future routine :)
Good information.
Maybe it's the afternoon when you want to exercise, and not take a nap. I have taken taurine straight. But I had to take it separate from meals. Currently I take Magnesium Taurate with meals, twice a day.
The Life Extension Life BioActive Complete B-Complex product says on the label to take 2 capsules per day, NOT to take it twice per day. TWO capsules gives you a total of 300 mcg of B12. If, as you say in your video, the sweet spot for vitamin B12 is 400 to 800 mcg, then even if you take two capsules per day you still are beneath that threshhold. So, are you taking 2 capsules once per day or only 1 capsule per day?
HI Rimon, what you think of NAC?? And for over 60?
I like it and take it in my collagen powder. Check my complete supplement routine with updates even few months:
wellnessmessiah.com/app
The antioxidant blend you're feeding to your parents contains a solid wallop of dried green tea leaf, which can cause acute liver injury, as can ashwagandha (noted by other commentators) and niacin.
The green tea extract was an immediate concern of mine as well yet, if you recall Rimon emphasized that the dose he gives his parents is only ONE capsule daily. That’s 100 mg of green tea extract, considered a low range dose.
Regarding the ashwagandha, it seems like it’s highly individualized. I have low cortisol and adrenal insufficiency but that’s complicated bc I take low dose prednisone (5mg) daily for connective tissue disease and also meds for Hashimoto’s/hypothyroidism…
But I have also found info that ashwagandha is an adaptogen and therefore would modulate cortisol levels.
Niacin continues to confuse me… now reading about cardiac concerns! 🤦🏻♀️ In the 70s it large doses were taken for mood disorders. But also, popular for enhanced athletic performance, especially body building! The flush was always more intense depending on how much simple carbs (sugar) you had ingested. It reacts to triglyceride levels in your blood… and reduces them…seriously! It’s why your body will “get used to” niacin after a time, but that’s because it reduces the triglycerides it reacts to… Which might then explain its cardiovascular 🫀 benefits, ha!
Hi, would you recommend a substitute for NOW super antioxidants ? I cannot find them anywhere. Perhaps they have discontinued ? Thank you in advance and for your in depth analysis/ recommendations for longevity and health!
Rimon, what do you think of Ray Peat's approach that advises to keep metabolic rate high including to prolong life?.
Makes little sense on the surface... animals with low rate live much longer, centenarians have low body temp (affects metabolic rate), etc. Never looked into Ray work
@@WellnessMessiah Maybe you could chat about it with some of his proponents such as Georgi Dinkov, Mike Fave.
@@WellnessMessiah ua-cam.com/video/3cI9xCbtq1U/v-deo.htmlsi=w0X17ITlqlTnH3Ed
Glucosamine and Chondroitin are considered to be anti-cholinergic. Since anti-cholinergics are believed to increase dementia risk, I stopped taking them. What is your opinion about the risk of taking these supplements?
Taurine is a GABA precursor which will calm you unless you have some genetic difference. You should take a smaller dose if there's a wakefulness effect. I only need 500mg per day which is enough to help with sleep but not change my brain too much. But cycling is important with any amino acid that can change neurotransmitters because that's a fragile balance
Yes vanessa it helps me to sleep too. If I take too much - I wake up after 4-5 hours for no apparent reason :)
Great content!
What is your take on oral EDTA to lower cardiovascular plaque. From what I've seen it may be useful on a cycled basis.
I am not sure where the idea that B vitamins are in highest concentrations in vegetables. I always thought that highest concentration and dosages of b vitamins you get from liver and other organs and meat.
Is it better to take supplements during the fasting period?