Відео

12:45 blows my mind a little to think of some ancient human who had everything going for him genetically, except his neutrophils weren't funky and therefore the whole of him is put on the curb for garbage day. but then, i suppose this adaptation and countless others happened way before humans? thanks for the great lectures.

thank you

great video. great teacher

I love your passion for R!! I hope soon I can share the same passion for it 😂

If europeans treat asylum seekers as people why are many countries now denying them? Seems like this leftist attitude had changed since this video was originally published. Was getting a lot out of this video until you started injecting politics into it

Your video Is best I have found on UA-cam for the principle of phase contrast I will recommend it to my colleagues thumbs up for the graphic dedication you put but you didn't put the ocular lens in most diagram

Are you from New Zealand??

Odd E(e)nglish. Is he from New Zealand? He tends to say "conneections".

What the hell is this 😱

excellent synopsis and enjoyed the delivery

That column graph in the beginning is worth s*** mate! You can't compare grouped results with non-grouped results!! That's basic statistics!!!!

I love how excited he is talking about it all.

This makes me love statistics even more.

Amazing class. Thanks a lot.

Hi Dr where can topical mebendazole be found?

Amazing! Thank you very much for this video, it was very clear and super informative. Will be working with this technique in a couple of weeks!

You are really good! Can you explain reference based imputation?

"Amyloid is not toxic without microglia"? This suggests that overactive microglia are the issue not amyloid. So much pointing in that direction.

How do you equate the fact that some AD patients don't have an amyloid buildup? Perhaps the disease progression doesn't start with amyloid?

Scratching never felt so good

Oh I am teh 800 view and also the 5th comment nice

thanks hyou are helpin me in my ee

amazing presentation btw..<3

i am a Master student want to pursue PhD in these kind of experiments how do i pursue it?

Sounds like the characteristics of cancer. Candida = Cancer?

incredible! it's a true skill to be able to explain things like this well - thank you!

Hello, what if you accidentally use nominal data type instead of continuous datatype for numerical data? Will the results be different?

These videos are awesome!

As a high school student learnin about alzheimer's for a project, Thoroughly enjoyed the video!

What if one of your diseases is th 1 the other th 2?

Somewhat disappointing that Jack does not mention that the alpha secretase pathway is actually promoting neuroplasticity while the beta amyloid pathway which is traditionally thought of as pathogenic is also physiologically recruited for synaptic pruning, and for immune defense.

Superb review. I've been listening to reviews on inflammation in Alzheimer's disease for decades. This is one of the best overviews. First rate and intelligible

i must have seen this whole video like 10 times i stg

Very interesting and helpful video! You make it so easy to understand, thank you!

Love to know how this information can help people with Autoimmune? So many people suffer and all that’s available are drugs with loads of side effects that suppress the whole immune system. Please make another video if your aware of available treatments that have been successful.

what are the implications of this on immunotherapy and glioblastoma?

I hope my doctor learn from you how to break dome the information and present will

please can you send the ligne code to import data in R-jamovi. i ved use the same code witch i frecently use it in R studio but it does not work with me

This is a very good explanation, sir. Thank you

Nice explanation

Thank you so much for the explanation. Have you heard of the impact of the enzyme Glutaminylcyclase which produces neuro toxic pyro glu amyloid or N3pE? It it meant to significantly drive the oligomerisation, inflammation and ptau. Also in your last video you did not mention it.

The accelerating and clumping seem to be indicative of prion disease. Some scientist are beginning to equate Alzheimer disease with prions. From what you are saying in this video I can not see the connection. What do you think?

Production ideas

hello

Fantastic stuff! I'm endeavoring to understand how HDAC6 and apoE4 fit into this panoply of genetic chicanery. My understanding is that HDAC6 usually enables efflux of triglycerides and other lipoproteins, while the apoE4 isoform inhibits triglyceride efflux. Thus leading to the amyloid buildup in microglia. Is it the resulting fibroblasts from pyroptosis and channel exiting action that induce neuronal death? Maybe I heed to watch again. Not only do I have to fight AD, but also ADHD apparently. Maybe there's some glial dopamine inhibition going on. Thank you for your work!

thank you very much for this video, very helpful. I would like to ask whether the silver ions bind because the DNA is acid and so donates electrons, or because the DNA itself is normally negatively charged due to the presence of negatively charged phosphate groups all over the backbone. Thank you!

That actually could have killed me, and it would have if I continued to take the unethical doctors psych abuse

I don't think many people care about the ability to predict how future samples work, but to learn about the true population. We are interested in parameters, not statistics. At least in science that is, and mainly when we take this statistical modeling to its ultimate purpose: inference about the real world.

8:21 This is technically not true. If I measure 1 bear, and then measure 1 ant, on almost all metrics I can create an estimation that can classify future instances of bears or ants into their corresponding classes. The bottom-line is that the less true variance there exists between the classifications in your data, the more data you will need to establish a significant difference. But after a certain point, 1 instance of two classes is enough to establish the scale of the expected effect size given we got a larger sample. One datapoint estimates the true mean, just worse than a sample with any amount of variance.

I have a FACINATION with VIRUSES AND BACTIERIA..infarct?, I have a FACINATION with anything microscopic, it's a whole different world which truly amazed me!!! 🤔🥸😳