Neuroinflammation in Alzheimer's Disease: The Role of Neutrophils

Learning objectives 
Understand the mechanisms by which neutrophils are able to infiltrate the brain.
Learn how neutrophil degranulation can lead to brain damage through the release of toxic granule contents.
Explore the findings and implications of research conducted by Volkman et al. and Zenaro et al. that provide evidence of the involvement of neutrophils in Alzheimer's disease-associated neuronal damage.

[@danielhunt3622]

Fantastic stuff! I'm endeavoring to understand how HDAC6 and apoE4 fit into this panoply of genetic chicanery. My understanding is that HDAC6 usually enables efflux of triglycerides and other lipoproteins, while the apoE4 isoform inhibits triglyceride efflux. Thus leading to the amyloid buildup in microglia. Is it the resulting fibroblasts from pyroptosis and channel exiting action that induce neuronal death? Maybe I heed to watch again. Not only do I have to fight AD, but also ADHD apparently.