ur impressions are the best the animation is amazing and ur efforts are unbelievable Seriously thank you i am joining hematology fellowship and i had no idea what ristocetin is and i am treating VWD patients without understanding the pathophys ur a hero
Im a medical technology laboratory's student. This video help me so much in hematology lesson Thank you so much for your great video ♥️ I'll wait for another great video 😅😁
What is your subspeciality? I really start to love heamatology when you make it easy ..I wish you can explain ECG ..if not who is the one I can listen to in explaining ECG
Dear Medicosis! Thanks for the great lecture as usual! The only thing I could never fully understand about RIPA💉: why does it show normal result in Glanzmann Thrombasthenia? How can normal aggregation occur if there is no actually normal interaction between GpIIbIIIa and fibrinogen receptor? Even if previous step (interaction between GpIb and vWF) is normal, the further step seems to me disturbed... And if GpIb and vWF interaction is enough for good or normal aggregation, so why is the bleeding time prolonged in Glanzmann?
Step 1 is adhesion, step 2 is aggregation. If step 1 is normal, but step 2 is abnormal (as in Glanzmann), then still, step 1 is normal, and therefore RIPA (which mainly measures step 1) is normal.
Ur videos are awesome , I watched all ur hematology section videos and ans of ur last question I think is Hairy cell Leukemia becoz this TRAP is also useful to distinguish hairy cell leukemia with other B cell lymphomas..
AHHHHH im so happy. i learned a lot again today. hema can be a son of a B but u make it easier. also i think the graph was incorrect cause it should start with a high OD? i don't know. EDIT: AHHHH so you used light transmitted for the Y axis instead of the OD?didn't notice that. also...TRAP positive cells are seen in hairy cell leukemia because they're the only cells resistant to tartrate staining
Thank you for the video. Why does desmopressin (ddavp) work for BS when the problem is gp1b and ddavp increases expression of vwf not gp1b? Best wishes. Yusuf
Because vWF binds to GP1b. What matters is the ligand-receptor complex. If we can’t increase the receptor, then at least we can increase the ligand to try to bind every single available receptor.
Great question! There’s a difference between in vivo and in vitro. Aggregometry is an in vitro lab test that measures aggregation (not adhesion). It’s artificially stimulating aggregation (whether adhesion is functioning or not).
Hello... I'm doc planning to make UA-cam educational videos. I like your way of presentation and would like to know the software you use to make your videos. Could you please share the details?
😍🖼Animated Mnemonics (Picmonic): www.picmonic.com/viphookup/medicosis/
💊 Cardiac Pharmacology Lectures:
www.medicosisperfectionalis.com/products/cardiac-pharmacology-course ...
- 💊Antibiotics Lectures: www.medicosisperfectionalis.com/
💉🩸50 hematology cases: www.medicosisperfectionalis.com/products/50-hematology-cases/
ur impressions are the best
the animation is amazing
and ur efforts are unbelievable
Seriously thank you
i am joining hematology fellowship and i had no idea what ristocetin is
and i am treating VWD patients without understanding the pathophys
ur a hero
Good luck 🍀
This channel is a treasure, thank you very much for your effort ❤️❤️
My pleasure!
Great video, but Ticagrelor is an orally administered direct-acting P2Y12-receptor antagonist and not Gp IIb/IIIa antagonist as mentioned in 02:14.
Im a medical technology laboratory's student. This video help me so much in hematology lesson
Thank you so much for your great video ♥️
I'll wait for another great video 😅😁
That’s awesome 👏
Thank you so much 😊
Can you please help me by sharing?
Sure. I've shared it to my friends 😁
Thanks
I appreciate you so much!
Hairy Cell Leukemia! Thanks for the video! I finally understood this damn thing 😂
You're very welcome 😊
What is your subspeciality? I really start to love heamatology when you make it easy ..I wish you can explain ECG ..if not who is the one I can listen to in explaining ECG
Thank you so much 😊
I don’t have a specialty!
Dear Medicosis! Thanks for the great lecture as usual!
The only thing I could never fully understand about RIPA💉: why does it show normal result in Glanzmann Thrombasthenia? How can normal aggregation occur if there is no actually normal interaction between GpIIbIIIa and fibrinogen receptor? Even if previous step (interaction between GpIb and vWF) is normal, the further step seems to me disturbed...
And if GpIb and vWF interaction is enough for good or normal aggregation, so why is the bleeding time prolonged in Glanzmann?
Step 1 is adhesion, step 2 is aggregation.
If step 1 is normal, but step 2 is abnormal (as in Glanzmann), then still, step 1 is normal, and therefore RIPA (which mainly measures step 1) is normal.
@@MedicosisPerfectionalis 🌺🌺🌺Thank you!!! Medicine definitely started to make perfect sense with you!!!
Great lecture with my hope
Thank you 😊
Ur videos are awesome , I watched all ur hematology section videos and ans of ur last question I think is Hairy cell Leukemia becoz this TRAP is also useful to distinguish hairy cell leukemia with other B cell lymphomas..
Excellent
You are the best
Thank you so much 😊
AHHHHH im so happy. i learned a lot again today. hema can be a son of a B but u make it easier. also i think the graph was incorrect cause it should start with a high OD? i don't know. EDIT: AHHHH so you used light transmitted for the Y axis instead of the OD?didn't notice that. also...TRAP positive cells are seen in hairy cell leukemia because they're the only cells resistant to tartrate staining
Won't aspirin therapy affect the second wave which needs the granules to be released
Thank you for the video. Why does desmopressin (ddavp) work for BS when the problem is gp1b and ddavp increases expression of vwf not gp1b? Best wishes. Yusuf
Because vWF binds to GP1b.
What matters is the ligand-receptor complex.
If we can’t increase the receptor, then at least we can increase the ligand to try to bind every single available receptor.
@@MedicosisPerfectionalis
Thanks for your prompt reply
My pleasure 😇
Where is the link of epinephrine adp collagen binding assay etc. Please tag me in
Thanks for your videos.how is aggregometry using epin,ADP,.. normal in BSS.there is no adhesion to aggregation occurs.
Great question!
There’s a difference between in vivo and in vitro. Aggregometry is an in vitro lab test that measures aggregation (not adhesion). It’s artificially stimulating aggregation (whether adhesion is functioning or not).
Thanks.now it's clear
In vitro.we supply platelets with ADP which
Released by step 1 in vivo
A lot of thanks!
It’s hairy cell leukemia
Amazing lectures!!!
What's the best way to measure aspirin efficacy?
Love your explanation n please make lectures on Ristocetin co factor assay and coagulation assays..
Thank you 🙏
I did a video about Ristocetin tests.
Thank you so much for the greatest explanation ever for RIPA . Is there a one vedio for all diseases together represented by RiPA .
Have you watched this?
Ristocetin Tests | Hematology: ua-cam.com/video/IpNM8h4Z8vU/v-deo.html/
@@MedicosisPerfectionalis No , thank you so much . I will watch it and make note of it now . I appreciate your help.
My pleasure 😇
Nice video on a uncommon topic. Is this important for step 2 ck?
Yes, especially the Ristocetin part at the end of the video.
@@MedicosisPerfectionalis thank you 😊
My pleasure 😇
I need a video about hepatic enchephalopathy please🤔
I will try
What if the bleeding is out the sphxinter
Haha 😂
@@MedicosisPerfectionalis a laugh a day keeps em away
Trust
Indeed!
Hey ....u were talking about the symptoms triad of different disease ..could pls say in which video it's available bcz I can't find!!
Which disease?
@@MedicosisPerfectionalis u told in the video that I have a symptoms triad of 40 different disease in the bronchial asthma video.
It’s a pdf file on my website called triads in medicine: www.medicosisperfectionalis.com/
Dear Medicosis, I love your lectures and presentations. However, if I may say, please slow down a little. Thank you!
Thank you!
Hello... I'm doc planning to make UA-cam educational videos. I like your way of presentation and would like to know the software you use to make your videos. Could you please share the details?
Thank you.
My pleasure 😇
Amazing
What would be the disorder with underlying platelet aggression, I wonder? Haha
I have hematology exam in a week, I’m sure m n u we can do this 😂🥵
❤
:)
Hairy cell leukaemia
HCL >>>> TRAP +
Hairy cell