A Discussion of Supplements for Longevity and Health with
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- Опубліковано 5 сер 2024
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0:00 - Introduction
1:05 - Nicotinamide Mononucleotide (NMN)
17:14 - Creatine
20:25 - Collagen Peptides
25:58 - Thoughts on Meta-Analyses
29:18 - Hyaluronic Acid
34:08 - Taurine
37:42 - Thoughts on Mouse Studies
39:55 - Do Blood Markers Matter for Longevity?
42:29 - Trusting Science/Experts
44:05 - Dr. Stanfield’s Motivations for Clinical Education
53:12 - Ending Remarks
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Merry Christmas to everyone who celebrates. Have a wonderful day.
Same to you brother. Have a Happy New year too. 🎉
Merry Christmas 🎄
This post lowkey made my day. 🙏🏼☺️ thank you!
Merry Christmas!
You both are certainly making for a brighter future ahead. Thanks for all your hard work. For once it’s very refreshing seeing and watching a sincere discussion on UA-cam. I really like this style.
Thanks for having me on your channel, Nic. Wishing you and everyone here a very Merry Christmas
Merry Christmas!
.....ironically, I've had the Life Extension brand of NAD+ sitting among my supplements collection for a year before yet taking it as I wanted to keep researching & get blood workup. It has an interesting formula I just again looked, but I can't yet understand the connection of NNM & NAD????
Also, i Sure wish you guys would review a new form of ionized? NAC called Augmented NAC.
....
made in Switzerland which is I guess ionized & far more powerful. They have set up some kind of advocacy campaign called "zero spike Project", so I just don't know what to make about all this & sudden invention of Augmented NAC!
It is directed to Long Covid & Covid infections. Been emailing back & forth with them to see if it could help ME/CFS EBV & if they have any studies, but nothing other than Dr's reports it helps to fully or partially resolve. Saw a vid or comment about this Augmented NAC few weeks ago, so they have a US distributor & will just try it. I've been taking Life Extension NAC 2 weeks now 600mg 2x daily & nothing yet. I saw "HIS" vid on spike protein protocol for NAC, Nattokinase, Bromelain, & doing the same also.
I'd like to say I have "The Original Covid" of 18 yrs that started from noxious sewer gas poisoning from major sewer vent risers that collapsed behind our kitchen / bathroom walls in a plumbing chase way in my 28 story hi-rise here in Fl. Not only were we exposed to years of VOC H2S/SO2 , but serious viral, bacterial, & fungal load in this gas.....very similar to that hi-rise in Beijing with sewer plumbing problems that speaks SARS through the building many years back!!!!! Seems f'n hopeless.
Maybe we can get him to do a vid about this Augmented NAC to help others then buy stock in the company! LoL.🤕🤔
Being a layman and only seeking to stay alive for as long as possible and remain vital while doing it, I appreciate the nerds' contribution to finding the facts. Unlearned people like me have to rely on the interpretation and discernment skills we have and take some chances. Thanks for taking the time to let us listen in on the discussion.
My mother recently passed at 100 years of age. During her lifetime many folks ridiculed her for being a "health food nut". They all died decades before mom!!! Also, she never had a doctor or took any prescription drugs, but DID take lots of Vitamin E and other vitamins!
Nice to see both of you interact.
Dude, your humour is growing on me. It's so bad but you commit so well it works.
😜
His "humor" just makes me grimace.
At 73 I found that playing my guitar was becoming more difficult. For example - I Feel Fine by the Beatles starts with a bar chord with a pinky stretch. I was flubbing the pinky about 50% of the time. After supplementing with taurine for two weeks, I'm playing that chord with no problems. I didn't start taking taurine with any exceptions regarding guitar playing. Just an observation.
Very interesting!🤔
When you started taking taurine, did you make any other changes? (drinking more water, exercising more, new hobby with your hands, etc). Just wondering.
I'm also noticing unmistakable improvements with Taurine.
Sweet lord please make this a regular pod Nick. Your breakdown of collagen peptide metabolism was covered in a way that's not on UA-cam. It's MASSIVE for burn victims to observe and consider their options when recovering.
Two of my top three health(span) guides in a terrific discussion! I love your comparing notes and I hope you make this a regular feature on both your channels. Also, nice shout-out to the third of my favorites, Gil Carvalho. You all perform a terrific public service and I wish you more success into the New Year.
I didn't quite like Brad, but now I started to like him :) Thanks Nicolas for bringing him up into your channel
This discussion It´s perfect example about what I ever thought about supplements. No sensationalism, no "marketing booms", no confirmation bias... Thank you both for your great job!!.
You two should have a regular podcast together. It would be a great pairing.
Two of my favorites. Awesome. Merry Christmas!
My 2 favorite nutritioneers in the same video! What a gift! I’m 65 day 10 on nmn: a big 0 so far. And I was hoping for even just some placebo.
To be fair, your source matters a lot. Renue is where I got mine. Originally got it from a source with no benefits.
Secondly I suffered from terrible sleep quality. 3 weeks after NMN 1G a day I was getting 5-7 hours and feeling better than in my 20s. Can't be placebo. Started other supplements afterwards to ensure I knew what benefits I sustained.
All that can be GUARANTEED is that your NAD+ is boosted. What that means to you individually is completely different than anyone else.
The fact you didn't see any benefits shows you probably already have healthy cellular activity. It's worse for me that I got a benefit, because it shows I was unhealthy prior.
@@MajorCanadado you take capsules or powder? If powder, do you dissolve the powder under the tongue, or swallow it? Thanks
I’ve taken DNA’s NMN powder sublingually for almost two years. No impact that I can see. I work out more now that I’m retired so I’m in good shape but I attribute non of it to NMN. Creative is likely the one supplement that gave me results in just a few weeks. With the potential cognitive benefits, I’d suggest creatine is likely the most beneficial supplement that I take.
I taks two different NMN , thats very good,
Nic, watching your videos taps me into a constant stream of coordinated health information, a gift that keeps on giving.
Great episode! Thanks for sharing your conversation with him!
I listen to and watch both Dr. Stanfield and your videos. I stopped taking resveratrol and stick to blueberries and other berries now because of Brad. I also take collagen peptides now because of both of you. Thanks for being critical science based thinkers and distillers of scientific studies to spread knowledge in the age of not just misinformation but disinformation. Merry Christmas , you two are a gift of reason and sound judgement to the world.
thank you for posting this, normally Christmas youtube slows down. This is most welcomed. Merry Christmas also.
Excellent discussion! Thanks for bringing it!
nice, looking forward to listening through this discussion
Great you do this together!
Merry Christmas! Hope you get a break but thanks for the regular uploads.
😊 Really awesome to see that you had Brad Stanfield on. You two have been my "go to" for the past year or two when I want to hear any analysis on a particular supplement or drug. Having had cancer, I read a multitude of studies trying to weed through all the b.s. things that people anecdotally try to throw out there regarding "curing" cancer. Luckily I had learned how to read and analyze studies at some point in college and I think it's an important skill for people to have to be able to recognize bias or confidence among other aspects to be able to analyze a study. I appreciate the knowledge and breakdown you provide in particular. I had found Brad's channel before finding your channel. It was somewhat angering to listen to some of the other "health advice" channels knowing that lots of what they were doing fed into clickbait sensationalist topics. Many of them aren't giving a full honest assessment of things. When I found Brad it was quite refreshing. He basically gave a very honest and accurate "cliff notes" assessment of any particular study or meta analysis on a subject. He doesn't get into the specifics a lot and gives enough information for the average layperson to get a grasp of the subject. Then when I found your channel I was so pumped to hear someone give the same kind of honest and unbiased assessment while getting more into the details of the mechanisms of what is going on. Brad's "cliff note" style will likely be more popular because I would bet the majority of people don't understand enough or don't care to understand enough to hear the more in depth analysis. But honestly I love it! I have noticed that you changed your format at some point to do both styles. Really smart move for the algorithm and people's attention span. But please keep the "in depth" stuff available like you have been. It's awesome! I expect that you both get a little boost in subscribers and views after this video since you both likely have viewers that never even knew about the other person. Keep up the awesome work! We need to get you and Brad on Rogan, Huberman, or Friedman's podcast to help amplify the accurate analysis of information. Thanks to you both!
Im a nerd appreciating all the hard work you do, in fact I adore you for it!
Excellent video. Nic, Gil, and Brad are the trifecta of sound nutritional/longevity information sources. 💠
So who is Gil?
Subbed to both of you, very interesting podcast, thank you.
Very good podcast. I follow both of you and i admire the most.
I learn more from listening to your posts than any other on the internet! Thank you!
This is an awesome collaboration. Thank you. 🙏 ❤
No placebo for my old dogs:
One at age now 9, has been “lame” for about 3 years, a leg broken in puppyhood at age 4 weeks, and acting up on her every single day after noon, after morning activities (she’s a high energy vizsla). After a couple of months on NMN (powder sprinkled on her food) her lame leg is NORMAL and FULLY FUNCTIONAL, no more limping after noon.
So then I decided to give it to my other 13 year old dog who was getting cranky (obviously pain or discomfort causing it) and going blind from cataracts. After 3 months for her, she’s stopped running into walls and furniture, and is behaving like she did 7 years ago!
So I tried it for older age aches, and a 7-year shoulder injury has healed!! And those aches and pains are gone. It took a few months for full effect, 1g per day.
If placebo, fine. Something worked. I’ll take it.
I suspect NMN only works for older age with depletion of parts of the NAD cycle and cellular repair.
Great conversation between you two! Love this format❤
Great show thanks again!
Solid episode, thanks for putting the info out there. Have either of you looked more into Amla for lowering LDL?
YOU TWO ARE AMAZING .....resilience, discipline, creativity , critical thinking it's all here
nice vibe between the two of you, thx!
thank you so much to help us to know what seem to work and what is just "marketing". I follow both of your channel and the channel "Nutrition made simple!"
I love you both, Brad and Nicolas. Thank you for all the valuable information.
My two favs on a video together!! Made my day!!
Excellent stuff guys. I think I've definitely found my new source of reason and also wicked to see a fellow Kiwi on top of this!
Nice talk!
Thanks
This is fabulous!!!
❤❤❤❤❤
I'm not sure if it says more about me or more about you (and your quirky humor I enjoy) but when Dr Brad said he had started taking hyaluronic acid "for skin health" I almost expected a quick camera cut to your face as you quipped "Foreskin health!"
Yeah, it's probably more about me. You must admit it wouldn't be wholly inconsistent with your humor. :)
Merry Christmas and thanks for all the videos this year! You've added a ton to my knowledge and I'm appreciative for it!
LOL Not just you I picked up on that pun too.
Two great guys!!
How did I miss this!? My two favorite experts on UA-cam.
two of my favorite UA-camrs together
NMN and exercise in those of us >60 is definitely a positive.
At 70 I agree. 500-750 mgs every morning with same of TMG. I work out daily, though lightly, and it does seem to have put a spring back in my step.
At 50 i do not se much benefit from 1000 mg of mnm. Creatine on the other hand has been much better.
Excellent video, I enjoy both of your UA-cam channels. I like that your information is backed by studies not hype. Too many channels make unrealistic claims on to the latest longevity supplements based on the most tentative of evidence.
In 1826 President John Adams was 90 and eating pretty good. What types of unregulated synthetic vitamins, supplements and fortified foods was he eating for his entire life? And how does the human body react to a synthetic unknown foreign supplement that it does not recognize? Which disease does the DNA instruct the body to promote?
Thanks Nick for this talk, Dr. Brad, your skins is the best I have seen , amazing. I have a question is taking Whey protein associated with formation of gallstone or bile sludge, bile duct obstruction?
thanks
I’ve been taking NMN/NR for a few years and I’ve felt a benefit
Merry Christmas to you too
I clicked on the video because it's Christmas morning and I wanted to give you the like. Will listen later.
I'm very lucky if I assimilate anything out of these discussions because I'm not work close to being on a level with you guys but from listening to you I trust your intellectual prowess and I do pull some tidbits out that may come together for me in the Long haul
Happy Christmas Nic 🎄
Good discussion. Love both you guys. I take all the supplements in this video NR (NAD precursor), creatine, collagen peptides, HA, and taurine. I may stop taking NR.
Thanks, great discussion. What about supplementation with red light?
This was great! Only supplement I'm currently taking is collagen. Been taking it daily for a while. How much is recommended to actually get results?
I really trust your reseaches and think you are a trustful source of information. I would like to hear your thoughts on spirulina and chlorella🙏
Where was the discussion on GlyNAC? That seems to be the real possibility of life extension through supplementation.Thank you though for the subjects discussed in this UA-cam.
I started following Dr Sinclair's protocol a couple of years ago feel great look great 100 % had a huge difference in my health and life clearly the study's are missing something big for me the change has been huge 52 years old
me too NMN+Collagen protein make my skin more health
Damn how did I not catch that one yet. That's great...would really love some more of these in terms of longevity supplements.
Skin health/wrinkles etc - Vita C/Ascorbic Acid has also has proven to work very well. Also, wherever possible it is best to heal from the inside as opposed to the outside.
I'm highly interested in the photomodulation effects of light at cellular level, nobody yet i think, researched narrowband spike light from IR LED light vs wideband noise light from filament light using only a red filter. Since a year I'm using wideband IR and bc i wasn't able yet to measure the amount of shorter wavelength content like UV, I use additional sunblocker cream to attenuate the UV part of the spectrum. Bc i think, the filter i have could still pass damaging UV radiation. And i use this light sometimes for hours.
500 Watt filament wideband.
Happy Holiday Seasons to you and all your viewers.
In the era where everyone claims to be a doctor, skepticism arises when they say, "let me tell you …” I prefer, "let me show you with these stats, charts, and peer-reviewed studies …” Interestingly, there's a popular UA-cam “Doctor” with millions of views in various languages addressing health issues-a chiropractor, of all professions.
I appreciate your channel. I used to follow Dr. Brad, a young physician yet to complete his residency. Although he underwent standard medical training(heavy course work), his research knowledge is limited. He references studies from China, raising concerns about reliability. Moreover, he takes personal digs at other research scientists like Dr. Sinclair, who holds a PhD, not an MD. This is just my perspective.
can honestly say that I have never noticed any improvement from any supplement I have taken..
Given our daily variations in energy based on sleep, diet, stress it can be very difficult to recognize the effects of a supplement. I find the best supplement to be a really good night sleep and a long walk in the fresh air. Nothing makes me feel better
Creatine for strength and mood has been my only benefits. The rest no difference (nmn included)
And then Olive oil for skin benefits.
tell me more about niacin.
is it bad or good?
is there a safe way to take or WHEN to take?
I have not come a single Dr here in the good old US of A that will order a test for a potential change. It is ALWAYS after the fact. I think it makes it easier for them in terms of diagnosis and treatment.
thanxxxx!!!!
Great to see Dr. Brad in conversation rather than in presentation mode. It would be wonderful to see more of him in this format.
22:00
Just a small addition and a question on the discussion on collagen:
The study on burn victims used soy flour in a porridge for the placebo group, not isolated soy protein or other more processed proteins. The texture (and possibly bio-availability) difference is huge because of the 20% fibre soy flour contains. Try to make porridge with collagen, soy protein and soy flour at home if you do not believe me. The recipe is in the study.
Do collagen peptide receptors also respond to other peptides/amino acids? I mean, a collagen peptide can be cut in several ways and so it's shape can differ.
Whoa! This is like two universes colliding❤
That is what I thought - Dr Brad is a bog standard mainstream Doc imo. and Physionic is on the cutting edge of intra-cellular biology - strange collab.
I would watch you knitting for 5 hours, no problems.
Please do a fair and honest review of Gary Brecka's comments on the Joe Rogan podcast. Knowing someone with an MD degree/background would have differing opinions, it just seems like you're more open to an honest review. And he has good results behind his claims with some of his "patients". Would love to hear your thoughts on gene specific therapy - methylation, celtic sea salt curing migraines, etc.
I really, really wish you would get back on Twitter as I think it would help you grow your influence with not too much effort. Regardless... Props on your excellent work👍
Excellent yt … thank you …
Thanks, informative. I would be interested in your evaluation of the C15:0 supplement Fatty 15.
Yes, they make big claims like similar effects to Rapamycin on anti aging and I’ve only seen their own clinical study for their evidence (so possible bias)
Dr Stanfield changes his mind more than a teenage girl.
How?
@@matthewsouthwellexample :
"Kurkuma is useless" vs later "it is beneficial".
But it doesn't matter. I'm sure the older he gets (although he tries to prevent it 😂) the more consisten easy nuanced he will be. It's the circle of life.
Tom Cruise, Clint Eastwood, Jack Nicholson they got a 1000x better when they aged lolll
Which is why we respect him. No ego at all. Only driven by the data.
Right! His suggestion to live a long life is to get jabbed ever 4 months for multiple viruses is the opposite of longevity, it’s a fact it destroy your immune system!! He lost my attention when he said we should be updated on all vaxes in his longevity tips vid, In my country that would be 4 times a yr! No thanks !!
@@lv1985aa This!
Wondering how you find out the molecular weight of a given hyaluronic supplement. Really enjoyed it; thank you both.
It's usually on the label or, if on Amazon, the Q&A section has someone asking and getting an answer from the brand. If no luck there, just calling/email the company will get you the answer, but most reputable companies will have this info on their label (or website).
Unless labelled, I think it's safe to assume it's low MW (as it's cheaper). Just like fish oil is typically in ethyl esther form unless it's labelled with "triglycerides". So far in US, I've only come across DoNotAge that labels its hayluronic acid as high MW.
Merry Christmas! Did you ever look at research about red light therapy?
Collagen supplements work for avoiding skin problem at old age. I don't know about wrinkles, because I don't have anything which worries me in that regard.
The reason why Whey Protein isn't enough when you are older is that you don't get enough of those amino acids which are most abundant in collagen. Glycine, proline, and hydroxyproline.
Yes, the body can produce them to some degree from other amino acids. But, at least when older, that's not enough.
I do supplement with about 12 g a day of hydrolyzed collagen, and with a lot of glycine. And it cured some skin problems I got at age 70 or so.
But if I had known more when younger, I would have supplemented with collagen then too. The turn around of collagen slows down if you doesn't get what's needed to build it. And the quality of it in different parts of the body deteriorates. You just see it only in the skin!
@25:30- there are at least *ten* systematic reviews/meta-analyses of collagen supplementation, mostly for skin. All found benefit.
There are also reviews of collagen for osteoarthritis, the best probably being Larder, Iskandar, and Kubow 2023.
One thing that needs testing re the joint connective tissue effects of collagen are specific types of collagen...i.e., type II.
“I don’t know why you WOULDN’T take collagen peptides.” I do! Every time I take them I get a crashing migraine. 😢 It is very upsetting.
Thank you for your contributions to our health and happiness. Merry Christmas to you and your family.
NMN-has there been a good study with only 60+ year olds? If NMN levels reduce with age, perhaps the aged should be the population that is examined.
I would still watch the 5 hrs of quilting..My experience with NMN is to pair it with Betaine to give my liver methyl groups and glycine to help methylate away the excess amount of it. The other aspect of it is that I take it only if I do a draining workout during cutting phases. I seem to tolerate it better than Niacin, I feel However, that this is because I have G6PD deficiency, and it has been seen that niacinamide and niacin tends to reduce the g6pd enzyme production.
I like garlic, green leaves, legumes, veggies and fish...
Interesting… I’ve always wondered if GlyNAC supplements would benefit someone who has a G6PD deficiency. Any thoughts?
Regarding collagen pepties - it contains quite a bit of glycine. The usual amounts of glycine in typical meat/whey protein cannot provide the amount provided in collagen. Personally, I just take glycine.
@24:00- Dr. V. is correct about collagen peptides being bioavailable, and being signalling molecules for fibroblasts. But it's mostly di-peptides. Tri-peptides may get absorbed into serum, but the evidence is not as good. It's even possible that oligopeptides made up of 4 or more aminos make it into serum. But I haven't seen good evidence (e.g. radio tagging) of that.
My 2 fav health gurus!! :)
I would love to take collagen but as a kidney stone maker I must admit I'm a bit afraid to. I haven't seen solid evidence one way or the other though.
a good argument for collagen peptides is the ratio of glycine, by taking collagen peptides along side whey protein, you get a much better balance of glycine to cysteine.
Another interesting subject aside from Photomodulation (mitochondrial Melatonin?! Collagen generation? Interesting!!!) I would like to mention the usage of sublingual Carnosine or, the oral precursors of it.
For some years I used Carnosine sublingually to avoid the stomach, then later switched to cheap beta-alanine.
Once again another interesting and cheap anti-glycation supplement.
I would also advocate for not only suppletion, but depletion as well.
For example, a friend of mine is now totally obsessed by transfats. And thus, he is a vegetarian now, only allowing chicken now and then. My opinion is, transfats can have different origins, generated in the own cells, then, from animal origin and also synthesised forms. I cannot imagine these transfats have a similar effect. I told my friend it may be more beneficial to focus on the origin of the meat, grass fed/ organic and most of all, avoiding all seed oils, rather than simply cutting red meat.
Early man, never had red meat on a daily basis. Intermittently fasting was daily routine for the simple reason, the hunt was not always successful. This makes meat-transfat research less useful I think bc, having it daily was never part of our early man routine. And this puts our whole nutrition habit in a different perspective.
But this meat-vegan discussion is a pretty heated one. More like a war on social media.
Btw, bacon contains an awful high amount of carnosine 😁. I just don't think a lot of it will be digested. That is why I'm adding beta-alanine.
Your friend has a point. Most people consume too much protein from animal sources and not enough fiber (aka plants).
I take collagen for bone 81 yrs do Taurine , l-leucine, creatinine . A Dexa pronounced osteoporosis after hit Greater Trochanter broke stem of femur had hip replacement in July had just done 9 miles step racing. I want improvement of bone doing therapy for walking without cane. Hair has thicken fingernails strong can’t see bones. Also on Alendronate prescription. Doing weight resistants upper and lower body with free weights and machines.
As someone who has just turned 70, I believe NMN has made a difference.
When you say you take collagen, in what way do you mean? I use Vital Proteins chocolate mixed in with skyr or Greek yogurt with some blueberries, sometimes. Mix it together and it’s like eating a healthy chocolate pudding.
Happy Festivus!
For the rest of us… no airing of grievances unless you hands are touching the pole
Knitting a quilt now thats clever
Drives me crazy. I see the virtues of so many supplements being extolled on youtube, but whenever I try them, even from reputable manufacturers like Do Not Age, my liver enzymes go up (from the teens to 50-100). This includes collagen peptides, NAC and glycine. With creatine, my eGFR drops to the 50s. So for me, it does seem to have an effect on kidney function.
So I'm happy to have a healthy diet, cardio and RT exercise, and as much sleep as I can manage. Along with Vit D/K2.
Thanks. I am thinking about creatine. Now I think I will not take it.
Creatine is worth giving a go. It improves muscle strength and cognition. @@joeextraknow2854
NMN does raise NAD levels though, you can test it yourself. Question is if there's any benefit to that
I am not a scientist nor am I a doctor. Needless to say, I have over 20 years experience in the fitness industry, working with and utilizing various hydration techniques, fasting, diets and supplements. I have also lost count of the number of doctors that I have talked to that have never used any supplements, never prepared for any type of fitness or sports competition, are in poor physical condition but have convinced themselves that they are the experts. Whatever pays the most counts.
Oxidative stress => antioxidant properties
What is the best way to consume creatine?