Medical School Pathology: Introduction to Lymphoid Neoplasms

Hematopoietic neoplasms are HARD! This video will provide a framework for understanding lymphoid neoplasms and set you up for the Boards and the Wards.

[@moshesadofsky9429]

Amazing intro to a subject that is difficult for many students. A couple of comments. When Dr. Deyrup says Flow Cytometry sends a laser beam through the cells and can determine features of the cells, she is using a shorthand description. The beam can directly determine some features of the cells, like how granular or how transparent they are (“forward scatter, side scatter”) but more typically the beam can “read” whether a fluorescent marker is attached to a cell, by means of an antibody to a particular protein. So “CD-5 + T-cell” means that an antibody against CD-5, coupled to a fluorescent marker, is bound to that cell, and glows when hit by the laser.
Hematopoietic and Immune cell lineages are the best studied cells in the body. We can culture them in vitro and have studied their patterns of development. As a result, we are able to give names to all those stages of developement and varieties of cells that form the lineages. It is not so surprising that every one of those normal cells has a malignant counterpart. I would surmise that the same would be true of every other lineage of cells in the body, if we knew as much about them.

[@PathologyCentral]

Thank you for your additional comments, Dr. Sadofsky. Techniques used for diagnosis in hematopathology are fascinating: flow cytometry, FISH, immunohistochemistry, cytogenetics, next Gen sequencing. They do it ALL!

[@edlamasfaw7880]

Tnxs professor this is really helpful 🙏

[@PathologyCentral]

You are welcome. Thanks for the feedback!

[@radiologydarkroom7709]

I love ur effort

[@PathologyCentral]

Thank you! This was a tough one. Hemepath is hard!!

[@blackwhite5879]

Is CD5 positivity in B cells an abnormal finding?

[@PathologyCentral]

There's usually a small polytypic subset of CD5+ B-cells in lymph node, bone marrow, and peripheral blood. This subset can be expanded but should still be polytypic in some infectious and autoimmune disorders.
When you have a suspicious neoplastic population that shows CD5 expression and you determine it is clonal, that's when you start looking through your list of CD5+ neoplasms.
I hope this helps!
Andrea

[@blackwhite5879]

Thanks a lot.