Dr Sinclair Newest Study A Chemical Approach To Reprogram Cells To A Younger State
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- Опубліковано 1 жов 2024
- Dr David Sinclair's new paper reports on experiments to see if partial reprogramming of cells is possible with small molecules rather than by gene therapy.
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#davidsinclair #yamanaka #reprogramming
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Honestly, when I see Sinclar never smiling, it's clear to me that his entire face is Botoxed, and he's afraid his skin might crack. He barely moves his lips, and that's it... when the camera catches him a bit harsher and directly in the eyes, you can see his age. David, I don't believe you, but everyone has the right to believe what they want.
I mean, it could fizzle out, but there’s a lot of work in this direction. It’s more than one paper more than one group having similar results. Also, maybe judging the fate of scientific papers by reactions on Twitter is not the best.
Hi Joe, thanks for sharing. It could all fizzle out, but I did see that other groups had also used chemicals to create iPSCs so hopefully a critical mass is reached.
Thanks, Richard! Good balance of optimism and reality. This work is an indication that there may be something usable and enables a good research plan to be put together going forward, but the fact that it's a divergent direction from using 3 of the Yamanaka factors, as Sinclair has touted for years in his eye-health research, indicates that that other path might not be playing out as expected. Regardless, the known barriers to using Yamanaka directly - primarily how to evenly distribute it to every cell in the body and how to turn it on and off at a desired age, still need to be solved whatever the final chemical solution is.
From my understanding, I think he wants to make it as a pill because it would be significantly cheaper and more accessible to the general public. And might even have the potential to rejuvenate more of the body at once. Atleast thats what im getting from it...
@@Kongstrong519 Here's hoping! Personally, if it impacts even one organ to make it younger, I'm taking it.
@@KenOtwell oh absolutely me too!
Hi Ken, thanks for sharing. One thing I think is different between Yamanaka factors and chemicals is that the chemicals will get cleared from the body, so the same kind of off/on control that Yamanaka factors need is not required. Kind of like fisetin. It can be taken once a month, remove some of the senescent cells, but then it is cleared and the senescent cells come back.
As a note, gene therapy also has its benefits. When Dr Noah Davidsohn was on the channel the talked about a gene therapy for dogs which embeds in the liver and continues to produce a protein which goes down with age (I forget which one). One treatment is good for 12 years.
@@ModernHealthspan When senescent cells are cleared by a senolytic (like fisetin), they don't come back. Some new ones may form from previously healthy cells, but the ones that were removed should be gone for good. Senolytics allow them to undergo apoptosis, and that takes them out permanently.
I just posted ona bunch of Facebook pages where Sinlcair says it might come down to a single pill.
This is the same guy who let the FDA regulate NMN
@@benv.5170NMN is not regulated or banned as a supplement
Hi Thanks. I have seen comments to that effect. I have mostly stuck to reporting what the paper said.
@@ironmaidenfitness654 in the US it is
I don't know how I feel about this paper. It got hammered on Twitter. It feels like one more paper that makes the headlines but then disappears never to be heard from again. Salk Institute put out a similar discovery article about an arthritis breakthrough back in 2019. I recently reach out to them for an update and got a snarky reply that they were a research institute and it was up to industry to develop any new products. All I ask for was an update on their follow-on work. I don't know if their reply means the follow-on work was a bust, the original work not reproducible, etc. I think a lot of these guys publish and then quietly disappear when it's all crap.
I know how you feel about this paper. I know because the very first thing you say is that it got hammered on Twitter maybe Twitter is not the best place to go to forecast the result of scientific research?
And yeah, things do fizzle out, but there is a lot of research in this direction. It’s not just one group or one result.
@@RandomGuy-qg9xf I mean the paper itself is not hype. It’s a paper with results. Hype comes from interpretation. Don’t think the paper can stop itself from being interpreted. Also bear in mind to the extent that Sinclair is excited he’s excited because of the results he’s seeing now which results are further along in the process than anything, published now just because of them just because of the delay that naturally occurs between doing an experiment beginning to see results and actually publishing them. So the experiments that this paper describes probably started the couple years ago which means that in the intervening couple years they’ve made more progress and he’s excited about it and if you’re making progress reversing aging, it’s pretty legit to be excited about it.
Hi Scott, thanks for the comment. A couple of thoughts on this. The paper itself just says that they reduced the age of the cells in vitro with chemicals and that is what I stuck to in my review. This seems a valid statement. There did seem to be comments on twitter etc. about rejuvenation in a pill which is a big leap from what the paper says.
In terms of translation, I agree. However the hit rate of discoveries from the lab to usage is low so should be expected and also takes a long time (which hopefully can be shortened).
But again, it may turn out that it is not possible to get this mix of chemicals to the cells in the right concentrations in vivo or they do and it does not work and the research does not proceed!
@@RandomGuy-qg9xf What wasn't previously known was that Yamanaka factor like reprogramming could be achieved with these particular small molecules. Which if true could have implications for how feasible and affordable these treatments could be. To say that a new more convenient way to do something is not significant is to basically say that air travel added nothing significant to the world since after all, modes of travel already existed. Convenience matters.
Something got hammered on Twitter? Well, you must take that as gospel then! 😆
Thanks Richard for great video keeping us updated on the latest news in anti-aging field
Hi thanks! I hope that you find our videos helpful!
Excellent summary!
Hi Thanks for your kind comment!
More and more we approach the bottom rung of the longivity escape velocity ladder. Just don't die from anything silly in the next decade.
Hi Thanks! That is my thinking too.
This information was amazingly clear and forthright in understanding how the cells work.
Very good presentation of Yamaka factors rejuvenation.Good news that there re might be easier and eventually cheaper ways to achieve cellular reprogramming.
I m about to enter my first year at Pharrmaceutical Chemistry University in my country.
Hope in future I could work on such pils
Hi Andre, thanks for your comment and good luck in your studies!
interessted informations 😊😊😊😊
Human clinical trials is what is important. Whenever that would ever start.
Hi thanks for your comment. This is true and they are a long way off I would guess. We also look at up coming technology on the channel.
This is fantastic. I feel there are multiple ways that lead to the goal of full body rejuvenation. Imagine what is going on at Altos Labs where Yamanaka works now!
Hi thanks for sharing. It is good to see multiple paths towards the same goal. Who knows which will work, be first or be most affordable. We certainly do not want one company which owns the only method that works!
Sinclair said in a recent interview that the cost for this pill is a thousand times cheaper to produce, and that _"it's surprisingly simple to reset the age of tissues and organs once you know how to do it. I would put it to you that any highschool student can do it in their kitchen"._
If it's that simple, then that means that pretty much all of us have the ability to do it right now, yes? What could it possibly be?
Hi thanks for your comment. I do not know to what Dr Sinclair is referring to in this case. I don't think that the ingredients in the cocktails are available to the average high school student and the paper showed only changes in cell culture not any form of rejuvenation of organs.
@@ModernHealthspan Yes, he's probably speaking from theory or expectation on some of it... knowing what he knows about it, and projecting forward from that. He seems very confident and relaxed about it.
Hey bro you rock! You deserve alot more subs
Thanks Mr. Modern! This one is very exciting!!❤❤
Hi Thanks for your kind comments!
One of the questions you didn’t address in your summary and I was wondering if it’s in the paper is what is telomere length and kilometer race activity restored in the rejuvenated cells? Obviously, senescent cells typically have destroyed telomeres. Also, if you don’t restore, telomere length, it seems like a healthy cell with short telomeres is potentially a profound, breeding ground for cancer, because it will only take a couple replication cycles for that so population to completely exhaust any telomere protection
Telomerase activity. Sorry voice recognition creates weird typos.
Also, when they discussed using senescent cells as a proxy, which I think is probably a pretty robust proxy, the idea being that senescent cells are pretty deeply malfunctioning and thus if you can rescue them, you can rescue any merely aged non-senescent cell short of cancer. But did they discuss what sort of senescent cells are used because senescent cells are very different in different parts of the body. Sorry to be asking you questions. I guess I should just go read it. This was just a couple things that popped in my head overall great presentation and thank you for the summary you do great work.
Good question
One would expect regenerated telomeres but it has to be investigated to know for sure
@@RandomGuy-qg9xf it might be another hallmark of aging. That's the point if you were truly rejuvenating, you're going to affect many of them.
I'm fairly sure Yamanaka rejuvented cells have perfect telomeres. Would have been nice to get telomere length results here.
Thank you Richard, very well explained! Have safety studies for these small molecules already been done in humans? Are animal studies necessary? Humans often don't react the same way as animals and the dosage conversion is not really simple to do anyway.
Hi Thanks for your question. The main ingredients of the cocktails are unfamiliar to me and I did not investigate there safety with humans. It seemed premature based on only an in vitro study. They did include some in the cocktails which are available, alpha-ketoglutarate, sodium butyrate and forskolin.
I think they are going to test these cocktails on mice next.
Will be interesting to see how long the mice live. Another lab used AAV gene therapy to double the remaining life span of old mice.
Will be interesting to see if the chemicals are as good as or better than the gene therapy
i heard on a video if its correct that david sinclair is releasing a product sometime in 2024 at least that's what it sounded like so i thought can you find out that information for me if you can also i want to know what were the other chemicals that they found besides the 6
I hope they figure this out befire s spike kills
is there a combination of supplements that can do potentially do this?
Imagine, if you will, every few years going to a clinic and receiving an intense, 2 day treatment that costs $10,000 but rolls your age back by 3 years.
Now, imagine this same treatment only it cost $1.000,000.
Only the rich get to live forever.
Same old story.
So, make sure you're rich before that time. It's that easy.
Hi Jack, thanks for the comment. This is of course a concern. My thinking is that if you look at history all new technologies start off only for the rich but become more affordable with time.
thank you for sharing this information.
Hi Mark, thanks!
Great stuff Richard I saw some other scientists were berating Sinclair on twitter the other day but it appears he has patented his findings.
Hi Thanks for sharing. It is a good point, I should always review the Funding and Conflict of Interest statements when I go through a paper. And in this case it does mention that Dr Sinclair has patent applications.
When can we expect the pill?
This is the recent David Sinclair news, right?
Yes
Hi thanks for the question. Yes, this paper came out on July 12 2023
If this works governnent will be able to cut out the old age pension.
I find this very useful and helpful for the future is hopeful and we all will win
David makes some wrong he looked I the newest videos older than before
Fascinating. I hope it all works out in future research.
Summary was pretty good thanks for putting this together. I know how much time it takes. I did find it helpful in clarifying it how this works. Super excited! :-)
Hi Will, thanks for your kind and supporting comments!
Thank you so much for the video. You are awesome!
Excellent information
will see if these would be helpful in the future
Hi Olya, thanks for your comment. Yes, there is a lot to be done. To me cellular reprogramming is a very exciting technology as it does seem to genuinely rejuvenate the cells and this is a great proof of concept.
Very exciting! Thank you!
Hi Robyn, thank you. Yes, I really hope that this moves forward
Thanks Richard.
Hey Ron, thanks!
Which chemicals?
Hi Eric, thanks for the question. The main chemicals are on the slide (and in the paper). The supplementary data includes the 80 other chemicals that they considered and the details of each cocktail are reported in the text. The chemicals are quite obscure (at least to me, with names like CHIR-99021, Tranylcypromine and E-616452) so it did not seem worth diving into them in detail.
Thank you!
Hi Milena thanks!
exciting stuff
Hi Josh, thanks! Yes it is.
@@ModernHealthspan i like david sinclair he is great
@@ModernHealthspan do you know if they started the clinical trials on humans with these chemicals yet please let me know
Unless someone comes with an FDA approved and proven data of disease and age reversal, all these discussions are useless. 😅
immunofluorescence is a method prone to error. I will have to read the paper to see how they got around that.
Hi Charles, thanks for your comment. Please let us know what you find.