Once again, Richard, you have hit the nail on the head. I'm just learning about exosomes. I did an artificial intelligence search of the internet and found 6 different ways to purify or extract exosomes. Each method had their pros and cons. It would be interesting to know which one they were using. This comment sounds so pretentious but doctor Katcher is one of our world's foremost experts, and It would be such a loss to read about him dying. I respectfully submit that he needs to go ahead and try this, not just on his hand but on his whole body. Richard and Doctor Katcher, please keep up the good work. It is so good to hear about someone being concerned that even the poor people in this world would have access to an advance like this.
Hi Alan, thanks for your kind comments. We talk about human trials in the next section and Dr Katcher says that he is going to volunteer in the first batch. Really hope he get the opportunity to try it soon.
Well done, Richard. Dr. Harald katcher really likes your style of interview as do I. Your only focus is getting at the truth of the research. Harald, of course, is a genuine genius he reminds me a lot of Frank Whittle, who found it extremely difficult to get people on board with his ideas because his ideas were like Harold's ideas just to much for "normal" sensible people to comprehend. I also enjoy Harold's wicked sense of humour what a breath of fresh air he really is. I think he is our man to get us a huge decisive victory in this ageing war.
Hi Anthony thanks for your comment and support. It is always a pleasure talking with Dr Katcher. He seems to be able to see what the results mean so clearly. I am also impressed by his persistence in moving the research forward with so few resources. I hope things can accelerate from here!
I hope Katcher publishes the exact method he used to purify and extract e5 from blood! This is super exciting! Also kind of dangerous considering zoonotic diseases and the filthy, stressful conditions of a factory farm... Tbh I think all that is happening here is that cells are being supplied with signals to build the correct things to repair themselves. If enough stem cells are lost or degraded, I think the effect will be diminished. As the doc says, if you want anti aging without applying external stuff, we have to fix the DNA somehow, which I think means osk activation. Still, I want to see how long a rat or worm can live if it is continually dosed with e5. Can it stay young forever if it keeps getting regular doses? Why is no one testing for this? For every one of these anti aging treatments, the test seems to be to measure the effect of one dose... beagles live much too long for this kind of test!
As far as a time goes, an article I read recently said there be another lab working on something like E5 and making progress and so the E5 folks are pushing a bit harder to get to human trials. GOOD. I do not know which of the various treatments will be first, I just want any or all of them to hurry up. I'm 52.
Indeed. This whole saga has been like pulling teeth. Delays, delays and more delays. And maybe they got complacent, as they were the only ones doing this at first. But no longer. Also, GOOD. They need a kick in the ass and to get their act together as a company. I don't blame Harold for his meandering, as he is 80 years old and seems 100. But the company's CEO is nowhere near Harold's age and doesn't have the same excuse. I'm 45, so I'm coming up right behind you. And I want more time, goddamn it! At least, more time spent being younger! Even getting half the results in humans that they got with these rats would be incredible.
Wow, imagine solving the feral hog problem here in the US with E5. Incredible how porcine/pig blood exosomes/nano-particles work for rats and humans without rejection. Mind-blowing stuff...
Perhaps as this plays out the word "problem" will no longer be associated with feral hogs, as they will be more valuable alive than any crops or livestock they disrupt. Catch, bleed, release, live long, cash in. As the blind-man said, "We shall see."
Hi Armando, thanks for your comment. I was surprised that the cross species exosomes produced no immune response. Interestingly Dr Duncan Ross mentioned the lack of immune response as one of the main benefits of exosomes in comparison to stem cells.
Water buffalo is not the same as a cow in terms of "holiness" in India is because ancient Indians domesticated only cows and the cows provided them a lot of help in their farming. Their rationale is we took so much from the cows so lets not kill them and eat them. Simple as that and makes sense. Don't force western templates on ancient non-western cultures. Also the word "yuvan" (in Yuvan Research) is a Sanskrit word for youth and is a root term. Makes sense since Sanskrit (ancient Indian language) is one of the or the only mother of Indo-Germanic family of languages. Another example is the name "Seema" given to the rat and the Dr. explained how it means "boundary".... It is another Sanskrit word that is used in English - seam like the seam of a dress which also loosely translates to "boundary".
Thank you for another great interview Richard. Will there be a part 2 to this interview? It seems to end quite abruptly. I'm wondering if you asked Harold or if he spoke about a timeline where he expects E-5 to be commercially available wether as a topical application first or as the full blown injectable therapy. Things seem to be progressing very slowly with E-5 and I would think that Harold would want to receive the full benefits sooner rather than later. Here's hoping!
Hi Daniel, thanks for your question. I saw your other comment, so you saw that it is part 1. We talk about trials and next steps in the next part with some reference to timelines. However some of it seems to be more in the hands of Akshay Sanghavi (the CEO).
It is still early times but I would be curious about what the following 4 therapies put all together could do in one´s body. 1* Life style intervention 2* Rapamicine 3* Sinclair new cocktail pill based in Yamanaka factors 4* E5 from Dr Katcher both plasma and topical applied Very exciting times ahead!
I don't think any of the other stuff is necessary. E5 is all we will need. I imagine once this is seen in dog trials and then humans. A huge field of research will focus on nano particles.
@@anthonymason385 regarding total health span, apart from SIMA the results were limiited, that is why I think until this technology improves and matures we should combine different therapies being lifestyle the main one for now in my opinion.
Hope this works out. What about risk of zoonotic infections since there is at least theoretical possibility as well as an in vitro study suggesting viral infection can occur via exosomes (the 'Trojan horse hypothesis')?
Outstanding interview. What I don't understand is why these foreign porcine proteins don't induce an immune response. It was brought up quickly, but the answers weren't satisfying. One way one could explain the effects are miRNA that bind to conserved mRNA sequences. Perhaps you should ask him in a future interview.
On Dr. K's skin, how many years was the age reversed? E5 seems to work on skin, by topical application. Therefore, I would expect that it might be practical to introduce it sublingually but I don't know how to do this with dogs. Another great series so many thanks.
This is really fascinating and sounds very promising. There are a couple of other studies that point to a conserved mechanism across species. . One question I have is what does the 'youthening' look like. Is it just a return to a younger cellular phenotype or is it true rejuvenation, which would would put me in mind of Dr Michael Levin's work.
Hi thanks for your comment. It is a good question. What is the difference between a "younger cellular phenotype" and "true rejuvenation" though? To me they sound very similar. In the rat experiments all the markers they measured moved back to a younger state, as did the epigenetic clocks. However the rats weight remained the same (it increases with age and E5 did not reverse this) so the reversal seems not complete. Also in the lifespan experiment the rats died. It would be interesting to know what the cause was. Did it point to one area which was not rejuvenated while the rest of the rat was or were the causes the normal distribution for rats? Perhaps I should have asked!
@ModernHealthspan Could you please reply, Richard? Some time ago you published a video on a study showing that a component of ginger (gingerenone A) can increase NMN absorption. Do you have a link for that video or know what is that study? Many thanks.
Thanks for the interview (Katcher videos are a rarity). I think they're about to start a beagle experiment: is there anything about that in the next videos?
Hi thanks for the question. We do talk about trials in the next episode and the beagle experiment is still on, but I don't think he gave a concrete date.
I was wondering the same. It might be to compare and see how long the effect last. And it last more than a year. I wonder why they don’t commercialize already the treatment with a very expensive price. I could not afford it but there is people who can. Money could boost the rest of the research ?
Hi thanks for the question. It is a good point, I think partly it is that they manufacture of E5 is in India at the moment (we talk about that a bit later) and partly that there still is not a lot of it available.
@ModernHealthspan Hi Richard, hope you are fine. Some time ago you published a video on a study showing that a component of ginger (gingerenone A) can increase NMN absorption and therefore generate more NAD. Do you remember which is that video or that study? Many thanks.
Is there a more simpler shorter way with fewer processes that Incubating young blood plasma fraction with polyethylene glycol (PEG), centrifuging the sediment into a pellet, then a size exclusion chromatography matrix (concentrating the eluted fractions) for chronokines ?
Chinese people use pig blood, tofu, and vegetables to make a healthy soup. This soup has a reputation as a healthy and tasty meal in China. In Hungary when a pig is slaughtered in the morning, the blood is fried with onions and served for breakfast.
Hi Ryan, thanks for your question. A couple of thoughts. From what Dr Katcher said, yes, cow blood would work, and could be harvested without hurting the cow. However, it has not been tested so this is only in theory at the moment. With respect to dose, we talked about it a bit in this interview and do touch on it again later. Dr Katcher said 4 times the number of exosomes as the rat naturally has. So assuming that cows and humans have the same number of exosomes per liter of blood. Human's have 5 liters so it would require 20 liters of cow blood (4 times as much blood to get 4 times as many exosomes). A quick search shows a cow has 31 liters (though that would be fully grown and we would want an adolescent calf). I am not sure what the volume of exosomes would be after extracting them from the blood.
Would be great if you can ask if there is a particular reason why Harold believes that there may be a ”kill switch”, superior to E5. Seems to me a lot of research is needed in determining weather or not E5 is distributed to all cells, especially in the brain. Also, why he has not tried E5 on his other hand…? Many thanks for the interview otherwise, much appreciated.
It is odd that he has not applied E5 to the more damaged hand. I'm not convinced by a small patch on one. Dr. Katcher's credentials are not in dispute. I just worry about his age and reliability at this point. He doesn't even seem 79, he seems 89, in other interviews he speaks slowly and his mind wanders. That's what concerns me. I will believe in this when Dr. Katcher injects himself and shows signs of rejuvenation. It would actually be a much more convincing display of the effectiveness of E5 if it could rejuvenate someone of his age and seeming frailty than someone 20 years younger. It would make international headlines, even with all the crazy stuff happening right now. I'm puzzled as to why the good doctor hasn't already injected himself. I know he wants to follow the gold standard method for trials, but I worry he will die before he gets a chance to reach his goal.
Many thanks for the interview. If the rejuvenating particles would be identified precisely and they are for eg exosomes, would it be possible to expand them in vitro artificially?
Hi Bernhard, thanks for your comment. It would be have been good to have got better sound. Hopefully Google autogenerated subtitles will work. Figuring out a way to autogenerate the transcript is in our plan.
Hi thanks for the question, as @unutilisateur4729 said it is because that is where Akshay was based. In the book Dr Katcher goes through some of the story of getting sufficient funding to perform the first trial and why it ended up in India. Yuvan Research is also based in Mountain View California, but the research is done in India.
Katcher has old people brain syndrome; you can adjust the speed of the video by clicking on the little gear at the bottom right corner of the player and then selecting "playback speed" (I do that on most interviews).
@@unutilisateur4729 yes… I find that feature very useful and use it all the time, thank you. But this is still way too many words to describe what is going on… We need information density on these videos… There is a lot to know at their end information needs to be presented concisely.
Hi thanks for your comment. Dr Katcher goes into some detail on what he thinks is the mechanism. If you do not want the details, perhaps watching our summary of the paper would be a better bet.
Interesting. However what he shows with regards to his hands is what he showed in the past which is the ghk-cu treatment and it is basically unrelated to the other part in relation to exsosomes transfusion.
@@unutilisateur4729 You rationalize. (This assumes you're not jesting.) While we're all aware of the fact that there are many variations in pronunciation when it comes to the many strains of English, this isn't one of them. More than a single option 'exists' as you say, because the second is a mispronunciation. It's a point Richard himself recently came up against, and graciously acknowledged, as he'd assumed not only a long i but also a hard c. It may be that you're following the same insistent, somewhat presumptuous form of 'logic' another viewer advocated for, that is, thinking that modifiers like feline and canine make it certain por-seen can be dispensed with. In any event, you've managed to miss the point. Even if the version you entertain HAD managed to wend its way into the language (as mispronunciations often do), por-seen would still remain the preferred form in academe ...thus the surprise here.
@@thomasraywood679 Language is a living thing and you might as well be complaining about why english suddenly started to use vowels, instead of being the incomprehensible droning slurry of a drunken englishman that it originated as.
@@thomasraywood679 The word "porcine" itself is a butchered version of the French word "porcin(e)", which is itself derived from a latin word (and so on). Language didn't come down from heaven, it's the result of people pronouncing words however they want; there's nothing you can do about it, and if Katcher et al succeed (which is the point of the video/channel, in case you missed it), you'll have a lot more "mispronunciations" to cry about in the future.
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Thank you Richard for bringing us more from the elusive Dr. Katcher. I'm so very interested to see how this story plays out.
Hi David, thanks. We will certainly keep an eye on his activities and report what we find.
Once again, Richard, you have hit the nail on the head. I'm just learning about exosomes. I did an artificial intelligence search of the internet and found 6 different ways to purify or extract exosomes. Each method had their pros and cons. It would be interesting to know which one they were using.
This comment sounds so pretentious but doctor Katcher is one of our world's foremost experts, and It would be such a loss to read about him dying. I respectfully submit that he needs to go ahead and try this, not just on his hand but on his whole body.
Richard and Doctor Katcher, please keep up the good work. It is so good to hear about someone being concerned that even the poor people in this world would have access to an advance like this.
Hi Alan, thanks for your kind comments. We talk about human trials in the next section and Dr Katcher says that he is going to volunteer in the first batch. Really hope he get the opportunity to try it soon.
Well done, Richard. Dr. Harald katcher really likes your style of interview as do I. Your only focus is getting at the truth of the research.
Harald, of course, is a genuine genius he reminds me a lot of Frank Whittle, who found it extremely difficult to get people on board with his ideas because his ideas were like Harold's ideas just to much for "normal" sensible people to comprehend.
I also enjoy Harold's wicked sense of humour what a breath of fresh air he really is.
I think he is our man to get us a huge decisive victory in this ageing war.
Hi Anthony thanks for your comment and support. It is always a pleasure talking with Dr Katcher. He seems to be able to see what the results mean so clearly. I am also impressed by his persistence in moving the research forward with so few resources. I hope things can accelerate from here!
This has all taken so long that I'll believe it when I hear dog trials have actually started. Everything has been continually postponed since 2020.
Looks like Dr. Katcher could use some NMN.
Get that brain running on all 8 again.
Interesting interview. Will need to keep an eye on E5 research.
I hope Katcher publishes the exact method he used to purify and extract e5 from blood! This is super exciting! Also kind of dangerous considering zoonotic diseases and the filthy, stressful conditions of a factory farm...
Tbh I think all that is happening here is that cells are being supplied with signals to build the correct things to repair themselves. If enough stem cells are lost or degraded, I think the effect will be diminished. As the doc says, if you want anti aging without applying external stuff, we have to fix the DNA somehow, which I think means osk activation. Still, I want to see how long a rat or worm can live if it is continually dosed with e5. Can it stay young forever if it keeps getting regular doses? Why is no one testing for this? For every one of these anti aging treatments, the test seems to be to measure the effect of one dose... beagles live much too long for this kind of test!
As far as a time goes, an article I read recently said there be another lab working on something like E5 and making progress and so the E5 folks are pushing a bit harder to get to human trials. GOOD. I do not know which of the various treatments will be first, I just want any or all of them to hurry up. I'm 52.
Thanks. I am with you; competition is good and nearly always helps push progress forward.
What is the name of the competing lab?
Indeed. This whole saga has been like pulling teeth. Delays, delays and more delays. And maybe they got complacent, as they were the only ones doing this at first. But no longer. Also, GOOD. They need a kick in the ass and to get their act together as a company. I don't blame Harold for his meandering, as he is 80 years old and seems 100. But the company's CEO is nowhere near Harold's age and doesn't have the same excuse.
I'm 45, so I'm coming up right behind you. And I want more time, goddamn it! At least, more time spent being younger! Even getting half the results in humans that they got with these rats would be incredible.
Wow, imagine solving the feral hog problem here in the US with E5. Incredible how porcine/pig blood exosomes/nano-particles work for rats and humans without rejection. Mind-blowing stuff...
Perhaps as this plays out the word "problem" will no longer be associated with feral hogs, as they will be more valuable alive than any crops or livestock they disrupt. Catch, bleed, release, live long, cash in. As the blind-man said, "We shall see."
Hi Armando, thanks for your comment. I was surprised that the cross species exosomes produced no immune response. Interestingly Dr Duncan Ross mentioned the lack of immune response as one of the main benefits of exosomes in comparison to stem cells.
Water buffalo is not the same as a cow in terms of "holiness" in India is because ancient Indians domesticated only cows and the cows provided them a lot of help in their farming. Their rationale is we took so much from the cows so lets not kill them and eat them. Simple as that and makes sense. Don't force western templates on ancient non-western cultures. Also the word "yuvan" (in Yuvan Research) is a Sanskrit word for youth and is a root term. Makes sense since Sanskrit (ancient Indian language) is one of the or the only mother of Indo-Germanic family of languages. Another example is the name "Seema" given to the rat and the Dr. explained how it means "boundary".... It is another Sanskrit word that is used in English - seam like the seam of a dress which also loosely translates to "boundary".
Thank you for another great interview Richard. Will there be a part 2 to this interview? It seems to end quite abruptly. I'm wondering if you asked Harold or if he spoke about a timeline where he expects E-5 to be commercially available wether as a topical application first or as the full blown injectable therapy. Things seem to be progressing very slowly with E-5 and I would think that Harold would want to receive the full benefits sooner rather than later. Here's hoping!
For sure, and 3, 4, 5…
Hi Daniel, thanks for your question. I saw your other comment, so you saw that it is part 1. We talk about trials and next steps in the next part with some reference to timelines. However some of it seems to be more in the hands of Akshay Sanghavi (the CEO).
It is still early times but I would be curious about what the following 4 therapies put all together could do in one´s body.
1* Life style intervention
2* Rapamicine
3* Sinclair new cocktail pill based in Yamanaka factors
4* E5 from Dr Katcher both plasma and topical applied
Very exciting times ahead!
5* Taurine
6* Melatonin
7* Fisetin/Geraldol
8* Quercetin
9* Astaxanthin
10* L-Selectin inhibitors
11* Sulfur rich Fucoidans
12* Deuterium restriction
13* Fructose, alcohol elimination
14* Carnosine
15* Phytosterol restriction
I don't think any of the other stuff is necessary. E5 is all we will need. I imagine once this is seen in dog trials and then humans. A huge field of research will focus on nano particles.
@@anthonymason385 regarding total health span, apart from SIMA the results were limiited, that is why I think until this technology improves and matures we should combine different therapies being lifestyle the main one for now in my opinion.
@@anthonymason385 mRNAs being instructions will probably have better leverage, you're right
Outstanding, great to see Katcher again. Thank you for the new interview series. Looking forward to the next one.
Hi thanks!
Strange, when Richard asked him why they stopped the treatment on the long lived rat he said he doesn’t know. How could he not know??
Hope this works out. What about risk of zoonotic infections since there is at least theoretical possibility as well as an in vitro study suggesting viral infection can occur via exosomes (the 'Trojan horse hypothesis')?
*Edit....I just saw that this was Part 1, just answered my own question! Cheers Richard
His hand is much younger even with the camera quality is poor you can definitely tell is treated hand is much younger that's amazing.
Outstanding interview. What I don't understand is why these foreign porcine proteins don't induce an immune response. It was brought up quickly, but the answers weren't satisfying. One way one could explain the effects are miRNA that bind to conserved mRNA sequences. Perhaps you should ask him in a future interview.
On Dr. K's skin, how many years was the age reversed?
E5 seems to work on skin, by topical application. Therefore, I would expect that it might be practical to introduce it sublingually but I don't know how to do this with dogs.
Another great series so many thanks.
Definitely our man!
1:30 "small molecules, proteins" ... lots of exosomes contain exactly this
why He only fixed his hand ? Looks to me He needs to go further. :)
This is really fascinating and sounds very promising. There are a couple of other studies that point to a conserved mechanism across species. . One question I have is what does the 'youthening' look like. Is it just a return to a younger cellular phenotype or is it true rejuvenation, which would would put me in mind of Dr Michael Levin's work.
Hi thanks for your comment. It is a good question. What is the difference between a "younger cellular phenotype" and "true rejuvenation" though? To me they sound very similar. In the rat experiments all the markers they measured moved back to a younger state, as did the epigenetic clocks. However the rats weight remained the same (it increases with age and E5 did not reverse this) so the reversal seems not complete. Also in the lifespan experiment the rats died. It would be interesting to know what the cause was. Did it point to one area which was not rejuvenated while the rest of the rat was or were the causes the normal distribution for rats? Perhaps I should have asked!
@ModernHealthspan Could you please reply, Richard? Some time ago you published a video on a study showing that a component of ginger (gingerenone A) can increase NMN absorption. Do you have a link for that video or know what is that study? Many thanks.
Not really its pretty much one older gentleman driving this forward. He is getting zero support from anyone except the Indian businessman.
Very interesting. I look forward to hearing more about this! Thank you!
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Hi Chris, thanks! We will release the rest in the next couple of days.
Thanks for the interview (Katcher videos are a rarity). I think they're about to start a beagle experiment: is there anything about that in the next videos?
Hi thanks for the question. We do talk about trials in the next episode and the beagle experiment is still on, but I don't think he gave a concrete date.
I wonder why he hasn't treated his other hand, given the results from the first test.
I was wondering the same. It might be to compare and see how long the effect last. And it last more than a year. I wonder why they don’t commercialize already the treatment with a very expensive price. I could not afford it but there is people who can. Money could boost the rest of the research ?
If I were him I’ll be taking baths with it.😅
Injecting both hands make the experiment useless, you must compare to the untreated hand and see how long the effect lasts
He wouldn’t be able to demonstrate the difference in interviews if he did
Hi thanks for the question. It is a good point, I think partly it is that they manufacture of E5 is in India at the moment (we talk about that a bit later) and partly that there still is not a lot of it available.
@ModernHealthspan Hi Richard, hope you are fine. Some time ago you published a video on a study showing that a component of ginger (gingerenone A) can increase NMN absorption and therefore generate more NAD. Do you remember which is that video or that study? Many thanks.
Is there a more simpler shorter way with fewer processes that Incubating young blood plasma fraction with polyethylene glycol (PEG), centrifuging the sediment into a pellet, then a size exclusion chromatography matrix (concentrating the eluted fractions) for chronokines ?
Chinese people use pig blood, tofu, and vegetables to make a healthy soup. This soup has a reputation as a healthy and tasty meal in China. In Hungary when a pig is slaughtered in the morning, the blood is fried with onions and served for breakfast.
What is E5 ?
So this would theoretically work with cow blood as well? How many liters would you need?
Hi Ryan, thanks for your question. A couple of thoughts. From what Dr Katcher said, yes, cow blood would work, and could be harvested without hurting the cow. However, it has not been tested so this is only in theory at the moment. With respect to dose, we talked about it a bit in this interview and do touch on it again later. Dr Katcher said 4 times the number of exosomes as the rat naturally has. So assuming that cows and humans have the same number of exosomes per liter of blood. Human's have 5 liters so it would require 20 liters of cow blood (4 times as much blood to get 4 times as many exosomes). A quick search shows a cow has 31 liters (though that would be fully grown and we would want an adolescent calf). I am not sure what the volume of exosomes would be after extracting them from the blood.
I just started that next video and found that the 4 times statement is in part 2 not part 1. Sorry about that.
@@ModernHealthspan We won't complain about having a "preview" of the next video ;)
Would be great if you can ask if there is a particular reason why Harold believes that there may be a ”kill switch”, superior to E5. Seems to me a lot of research is needed in determining weather or not E5 is distributed to all cells, especially in the brain. Also, why he has not tried E5 on his other hand…? Many thanks for the interview otherwise, much appreciated.
It is odd that he has not applied E5 to the more damaged hand. I'm not convinced by a small patch on one. Dr. Katcher's credentials are not in dispute. I just worry about his age and reliability at this point. He doesn't even seem 79, he seems 89, in other interviews he speaks slowly and his mind wanders. That's what concerns me.
I will believe in this when Dr. Katcher injects himself and shows signs of rejuvenation. It would actually be a much more convincing display of the effectiveness of E5 if it could rejuvenate someone of his age and seeming frailty than someone 20 years younger. It would make international headlines, even with all the crazy stuff happening right now. I'm puzzled as to why the good doctor hasn't already injected himself. I know he wants to follow the gold standard method for trials, but I worry he will die before he gets a chance to reach his goal.
Forget his other hand how about his face. Joking aside, I think injection is the way forward as that will affect bone and muscles under the skin.
Pro Tip: Watch at 1.25X or 1.5X speed. I like the interview but the Dr. a while to get his words out. Not being critical. The guy is very sharp at 79.
Many thanks for the interview. If the rejuvenating particles would be identified precisely and they are for eg exosomes, would it be possible to expand them in vitro artificially?
Why did Dr Katcher stop at his hand?
Very nice interview. Sound is so so. For not native English speakers it would have been nice to get the under title.
Hi Bernhard, thanks for your comment. It would be have been good to have got better sound. Hopefully Google autogenerated subtitles will work. Figuring out a way to autogenerate the transcript is in our plan.
Too bad he doesn't thrust his treatment so much as to treat his entire body with it. Just put E5 in his blood.
What's the protein that is an exception? "Lamin A"? 2:00
It's the protein that is botched in children born with progeria, basically part of the shell or envelop of the cell's nucleus.
Thanks Richard.
Hi Ron, thanks!
Why is he based in India?
Because the guy who funded the research at the very beginning is Indian (Akshay Sanghavi). Now they are in India and in the US.
Hi thanks for the question, as @unutilisateur4729 said it is because that is where Akshay was based. In the book Dr Katcher goes through some of the story of getting sufficient funding to perform the first trial and why it ended up in India. Yuvan Research is also based in Mountain View California, but the research is done in India.
Lord that is a LOT of words to say very little ... need to start getting AI concise summaries
Katcher has old people brain syndrome; you can adjust the speed of the video by clicking on the little gear at the bottom right corner of the player and then selecting "playback speed" (I do that on most interviews).
@@unutilisateur4729 yes… I find that feature very useful and use it all the time, thank you. But this is still way too many words to describe what is going on… We need information density on these videos… There is a lot to know at their end information needs to be presented concisely.
I can imagine you commenting on an interview with Albert Einstein... "oh, just some twaddle about events and clocks".
Hi thanks for your comment. Dr Katcher goes into some detail on what he thinks is the mechanism. If you do not want the details, perhaps watching our summary of the paper would be a better bet.
Please post if you've got any made
Interesting. However what he shows with regards to his hands is what he showed in the past which is the ghk-cu treatment and it is basically unrelated to the other part in relation to exsosomes transfusion.
No, it's not GHK-Cu; he applied some E5 to one of his hands when he visited the Indian lab a while back.
GHK-CU is not powerful enough to do that as quickly as described and I doubt it's effect is gonna last that long in one treatment
Hi Yuval, thanks for your comment. As mentioned this was E5 not the ghk-cu Blue Gel based cream.
Please stop the mid video advertising. I pay UA-cam for no ads.
Tough. He’s allowed to negotiate his own sponsors.
Hi Thanks for your comment. We have our own sponsors who help to pay for the costs of running the channel.
How remarkable that so accomplished a scholar mispronounces porcine.
I don't know if you're joking but both pronunciations exist, that's just the usual divide between American English and, uh, English English.
@@unutilisateur4729 You rationalize. (This assumes you're not jesting.) While we're all aware of the fact that there are many variations in pronunciation when it comes to the many strains of English, this isn't one of them. More than a single option 'exists' as you say, because the second is a mispronunciation. It's a point Richard himself recently came up against, and graciously acknowledged, as he'd assumed not only a long i but also a hard c. It may be that you're following the same insistent, somewhat presumptuous form of 'logic' another viewer advocated for, that is, thinking that modifiers like feline and canine make it certain por-seen can be dispensed with. In any event, you've managed to miss the point. Even if the version you entertain HAD managed to wend its way into the language (as mispronunciations often do), por-seen would still remain the preferred form in academe ...thus the surprise here.
@@thomasraywood679 Language is a living thing and you might as well be complaining about why english suddenly started to use vowels, instead of being the incomprehensible droning slurry of a drunken englishman that it originated as.
@@thomasraywood679 The word "porcine" itself is a butchered version of the French word "porcin(e)", which is itself derived from a latin word (and so on). Language didn't come down from heaven, it's the result of people pronouncing words however they want; there's nothing you can do about it, and if Katcher et al succeed (which is the point of the video/channel, in case you missed it), you'll have a lot more "mispronunciations" to cry about in the future.
@@unutilisateur4729 Also, I observe that the correct pronunciation accents the second syllable, not the first.