NAC & Glutathione: Health Benefits + Testing Explained
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- Опубліковано 15 лип 2024
- Let's discuss some new research re: NAC and glutathiione.
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----------------------------------------Show Notes-------------------------------------
----------------------------------------Show Notes-------------------------------------
0:00 Intro
0:44 New paper
1:07 what NAC does in the body
1:44 Infection raise free radicals in the body
2:26 Clotting
3:08 D-dimer
4:40 Dose to consider
5:15 Glycine and sleep
6:00 NAC Dosing
8:00 GGT and Glutathione testing
9:50 Oral glutathione
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Isn't it interesting that the FDA warned about NAC during C19, and then Amazon stopped selling it. BUT, when the plandemic was over, Amazon began offering it again.
Explain😊
Yes i remember lol
Just “trust the science” and CDC head Rochelle (((Walensky))).
They took NMN off the market too. W.H.O. also attacked many independent health focused UA-cam channels by labeling their videos as "misinformation."
Matrix of treachery
When using garlic in a recipe; chop fine, add fresh lemon juice leave for 10 minutes and add in the last minute of cooking to your food. This enhances the allicin and sulphur compounds...which in turn will help your system to make NAC and Glutathione. Protein rich foods plus any sulphur rich foods plus Vit C will enhance NAC and Glutathione naturally. Thanks Mike. Happy everything folks. 🥳
There is a lady who knows her stuff!
I'm making Pico de Gallo all the time now lol. Heavy on garlic
NAC breaks down mucus. Really helpful
Thank you Mike. I’ve been taking NAC since I was given last rites in ICU from Covid 2020. Somehow I pulled through with many many terrible issues. I started taking glycine for diabetes and found out it worked well with NAC for lungs and many other health issues.
Did the glycine help much along with NAC for diabetes? We take NAC and vitamin C for years, not glycine. Is it worth adding?
@@tossyv I think it has. For diabetes and lung issues. I also take C and Berberine for diabetes.
@@debracappiccille6485 May I ask what strength berberine? My husband had very bad diabetes, high doses of insulin, which is now in remission. Only one tablet to get off now. He was thinking of adding berberine.
Hi did it make you feel "odd" first dose? I tried it during the day, made me feel odd 700mg. After watching this maybe I'll take it at night
Hi did it make you feel "odd" first dose? I tried it during the day, made me feel odd 700mg. After watching this maybe I'll take it at night
I have suffered with a condition called Trichatillomania (eyelash pulling) since the age of 10. I am now 55. I have been treated with everything under the sun for this condition. NAC has cured this issue. I take 1300 mg twice a day.
Great content! Regardless of the reasons given I think NAC being temporarily pulled during the “pandemic” as more people were purchasing it was no accident. They knew it had multiple benefits.
It was still available via companies not a part of or influenced by the ruling class
@@mamandapanda185 Very interesting.
I actually use Nac pre pandemic and I used it more during pandemic because in our local hospital they prescribed this to COVID patients and they have good progress…and my friends who have COVID I told them to take this and they do it well…by the way I am a nurse was assigned in COVID ward during pandemic and I did not get the virus even i only used regular mask while on duty…
@@marvinjuliusmag-aso1137
Did they force you to take the jab?
UA-cam conspiracy theorists strike again
I take 600 mg in the morning on an empty stomach. It has cured my gut issues pretty much. Unreal! So happy I ran across this.
We have been using cysteine since the 1990s when my 7 yo son, who was poisoned with pesticide, had an amino acid test. Both blood and urine were low in cysteine, taurine, and phosphoethanolamine. L-cysteine supplements raised his cysteine and taurine levels to normal and decreased his ongoing symptoms by about 70%. NAC also in Merck Manual for Tylenol poisoning and in NEJM 2006 article for gadolinium induced kidney damage from the contrast for angiograms. Thanks for spreading the information about this most important supplement.
I take NAC and magnesium glycinate at bedtime. Helps my muscles unravel and great sleep
I've been taking NAC for well over a decade. Originally for osteoarthritis requiring bilateral hip replacements at a fairly young age. It's beneficial effects have been masked by the other upgrades I've made like like low carb, autoimmune diet. But what I'm reminded of every day is what a great bronchodilator/expectorant low dose NAC taken 3-4 times a day can be. A higher dose taken once a day can cause a little bronchial congestion, but a 300-400 mg dose with meals and at bedtime is better than any inhaler I've tried! All of NAC's beneficial effects are appreciated, but nothing reminds me of it more than being able to breathe easily. I rarely come across any info on NAC that I didn't already know, but I watch every video Mike makes about NAC because I need constant reminders to keep me from taking it for granted. (I watch every video Mike makes no matter the subject, and I learn an immense amount). Thanks, Mike.
Milk Thistle works great with NAC as it increases glutathione levels too and improves liver function and protects the liver . Milk Thistle research is coming out now it helps the lungs too
@@theancientsancients1769I have been taking milk thistle everyday for many years. Do you just add the NAC as needed for illness or do you take it everyday?
I just saw a YT video by a doctor that said NAC is best taken on empty stomach
@@HappyLife-wv5ms You can take NAC daily at 600mg up 1200mg , usually when I need a boost I take 1200mg . You cycle too and maybe decide not to have it every month . But if you have liver issues its best to take it regularly. Tudca if you look up has really good reviews too for the liver. Dandelion is good for the liver and Artichoke as herbal supplements.
If you want a product with Immune boosting ingredients that is good for the liver all in one ingredients that my sister uses who has very high liver enzymes is Immune Stay by Xtend-life . That company makes very high quality products and can cover many health issues using scientific research and they manufacture their own products unlike most supplements companies and are FDA and GMP register and have third party quality test.
The liver is the only organ that is regenerative so could heal Itself. I have dealt with my sister and late dad liver issues .
My best wishes!!
Something to consider is that the powdered form of NAC has a shelf life of around 2 months while the capsules have a shelf life of 2 years. I researched this because some NAC bottles I have are nearing the expiration date. Unless you're going to consume all your NAC powder in 2 months the capsules may be a better option.
I had been taking NAC, glutathione, and glycine every day for months and my levels were ZERO. Turns out, mold toxicity and zero enzymes are being made by my pancreas. I was prescribed antidepressants for 20 years without knowing I had mold toxicity the whole time... I have MTHFR and HLA gene mutations making it impossible for me to methylate and excrete certain biotoxins.
have you tried coffee enemas?
@@inthehouse9062 nope. Lot of mold in coffee.
@@2010kgurlDave Asprey claims that his bulletproof coffee is free of mold. I don’t know how true this is, but maybe worth looking into
did you follow Advanced Nutrient Therapy by William J Walsh
Instant coffee....
Would love to see you talk about Nitric Oxide production Mike. I watched an amazing interview between Jesse Chappus and Dr. Nathan Bryan and it blew my mind how connected Nitrates/Nitrites/Nitric Oxide are to virtually all chronic diseases.
I’ve been taking 3 nac tablets a day since 2020. 1 morning 1 afternoon , 1 night, each at 1g. and I haven’t had any major sicknesses. Even the cold and flu, even while being around people who have the flu, I feel like it’s boosted my immune system.
Can you take 3 a day ? Mmm I only take one bit always wondered if I could I take more
Started taking NAC yesterday. Had the best sleep of my life that following night.
I started using NAC when I was diagnosed with NAFLD during C19 lockdown and was offered no treatment options. I read a few papers and decided to try it. I hadn’t considered buying NAC in powdered form. NAC was never unavailable here in Canada despite the supply chain issues during C19. The capsules are still pretty cheap, especially once you weigh in the benefits. I use magnesium bisglycinate capsules too. I think I have a good combo going on now. I’m 70+ years old and living young and well with self-managed autoimmune conditions. My rheumatologist tells me I should never stop the NAC and lauds it as a great supplement for seniors. He also encourages the use of cannabis as a wellness adjunct among seniors. This young guy calls it going old school. He’s now also teaching at our closest med school.
Thanks, Mike. I'm 70 yrs old and (after 3 vaccinations) I caught the plague in the summer of '22, mild symptoms but had serious respiratory and energy issues well into 2023. Started taking nac and glycine this summer before getting hit with the same virus at Thanksgiving. Again, relatively mild symptoms, BUT I bounced back completely within two weeks with no residual after effects. Makes me wonder if those with long covid wouldn't benefit from NAC. Merry Christmas to you and your family!
It has been a study by doctors that it does. Check it out on UA-cam
Could you please share which brand of nac and glycine did you take? Greatly appreciated 🙏
Not telling anybody else to do this, but I take about 3 grams of NAC daily and supplement with 2 grams of glycine for liver health (and milk thistle) , AST and ALT levels both extremely good at 26, even though taking acetaminophen daily for back injury (ex- competitive bodybuilder) for about 6 years now. I am an endovascular guy, NAC is amazing, actually when patients present to the ER for acetaminophen poisoning, NAC I.V. is first line defense and started to detox liver. Also, I'm a Factor-V, great video BTW
Thank you Mike. Very informative.
Great presentation Mike.
Thanks for the info man, God bless you.
Thank you for putting out helpful information to keep your tribe healthy🙏🎄
Thanx for all your hard work, Mike! Now if I could get my loved ones to take this. Happy Holidays! ☃️🌲✨
Thank you SO much Mike!! No doubt from everyone who loves you. We can’t say it enough for all your hard work. Merry Christmas Everybody!!
I originally started taking NAC at the advice of my therapist to control my trichotillomania. It worked after one week. The added benefit of taking NAC was that it helped with my asthma symptoms and stopped my yearly bronchitis
Good stuff. Thanks for the information, I appreciate it.
Mike, I just want to wish you a very Merry Christmas!
I am grateful for you and I am incredibly thankful for your solid work in support of my health and wellbeing. I was able to share this knowledge with my loved ones as well.❤
Great info on sleep!! I’ll try switching from morning NAC/ glycine to before bed .
Thanks for posting the recommended dose and time of day ! I bought 2.5 lbs of NAC in2020 when I found out the FDA told retailers to stop selling it. I just need to get back in a regimen with it.
Love this! What do you think about ground/earthing bed sheets & standing mats that are being advertised everywhere? Can you do a video?
I know we're not talking about it but NAC cleared my lungs that got crazy congested from covid. It definitely treated my lung congestion, no doubt!! I was able to get off my couch without fainting thanks to NAC.
I was using Glutaryl, a transdermal (not liposomal) Glutathione, and my doctor suggested I stick with NAC fearing that taking straight glutathione would down regulate my body's ability to make it. The Glutaryl has some good data but is expensive
Thanks Mike, another excellent and informative vid - my MSc research is on chronomedicine and fasting and also yielded some insights for myself into oxidative stress and inflammatory processes in re circadian rhythms. fascinating topics!
In the UK we can get a month's worth of liposomal GSH for around $50 with B6 and Se in the formulation too. Sometimes difficult to get hold of NAC powdered here tho
Hi Mike been subbed to your channel for years. Can't remember when you first mentioned glutathione, but it sparked my interest and remember someone said it improved blood flow. Well I used to get very cold fingers in winter - sometimes they would go white. I bought some glutathione tablets and was shocked. Completely cured this. So much so that my hands and fingers are always warm. So thanks.
Iodine helps this too.
Interesting trivia 👍
Glutathione helps warm the body? This would be good if so. 🤞🏼🤞🏼
This helps with depression, anxiety, and also preventing COVID.
Never got sick or 'the product' and was taking this for 2 years. Oh and I broke the rules. It helped with the constant inflammation of my bladder and tendency to infection, too. Apparently it attacks biofilms. After about 3 months, I also noticed things like mood swings and lifelong rumination mellowed considerably. I took 700mg powder/day.
Biofilms?.?.?. I need to look into this as I have long standing sinus infection I suspect biofilm and can’t kick it.
@@treasuresabound0062 I found that biofilm bit first on PubMed after searching "n-acetylcycsteine urinary tract." 700mg/day powder swallowed using water took away that nagging, deep ache I had for decades. I didn't start taking it for that. I started taking it because what was discovered about using it for SARS-coV1, also on PubMed.
@@treasuresabound0062 How did it go?
@@treasuresabound0062 look into serrapeptase with that too
Thank you for this interesting information. I love your clever wording to get around the YT overlords. Good job!👍🏻 I started taking NAC and Glycine about a month or two ago. It does seem to help my sleep. I usually take it late at night.
Same combo, started recently and it does help a little bit with sleeping from the very beginning which is not bad, add a bit of taurine before workout and that also seems to help a little. Plan to cycle all the suplements but firs want to boost my system a little
Yes, timing and dosing do matter. Thank you.
I take NAC for neuropathy symptoms. It certainly doesn't cure it or take away the pain. It does reduce to pain to an almost manageable level though. I stopped taking it for a while and the pain got much, much worse. I started taking it again and the pain is reduced. I started giving it to my 2 autistic kids when they were sick. Not sure if it helped them feel better sooner or not but it has improved their moods significantly so they still take daily.
Very helpful video, thank you :D
Top class information 👏
Thank you Mike your truly bad ass !
THANK YOU ❤
I’ve been taking 600 mg NAC PROB FOR AT least 10 years .
Started taking for my Hashimoto And I Never looked back .Hands down my Favorite Supplement next to Creatine .❤❤❤
Energy Health strength skin Love it !!!
excellent content
I've had a pretty bad case over the last few days. Made a cocktail of Kalmegh (indian echinacea), L-Glutathinone, Aspirin and potassium citrate+calcium ascorbate+magnesium bisglycinate and it made a night and day difference.
Can't say it helped me get better faster, but it makes me feel normal instead of miserable. Though it definitely warded of periods of deathly-feeling weakness.
I don’t take NAC regularly but do take it. I have to be careful and not take it close to times that I have bloodwork or anything where I might bleed because it is a blood thinner. It is minimal but I try not to take it a few days prior. I must admit, I have been able to avoid illness with the use of it as well as electrolytes and a low carb diet. 🎉
This is reassuring. I’ve been taking glynac every night before bed. Thanks Mike
Thanks for useful information. I gonna try taking NAC + glycise
Thanks, Mike. I’m currently taking NAC along with magnesium glycinate hoping it helps with overall health and diminishes panic attacks and health anxiety. Wishing you and everyone here a Merry, Merry Christmas. Feliz Navidad desde México
If you have panic attacks and over anxiety I highly recommend you research Serene Saffron by Xtend-life! Also taking high dose omega 3 fish helps . Other than that walking is a good therapy for anxiety. I know what panic attacks are like too well and hope you will find something that is not pharmaceutical that helps as they tend to get addictive. Counseling is good too . I know when people have these things they just see doom and gloom only but trust me there is a way out!
Avoid caffeine while you have this too . Best wishes 🤞🏻
@@theancientsancients1769 thank you! On my last visit to the doctor he asked if I wanted a prescription for my anxiety and I said NO. Feeling better lately anyway 🙏❤️🌸
@@laurahinojosa2742 Oh glad you avoided that! Glad you are feeling better too. What I learned over the years is the longer the state of panic attacks or anxiety continues the longer the recovery is! Which is why it's important to take action fast whenever you notice it . Often stress is the culprit, but what most people don't realise is that stress builds overtime and doesn't happen overnight to cause anxiety unless something really spooked you .
Get plenty of daylight which will help you sleep better and stay active walking etc . Healthy foods can help too , and omega 3 and magnesium. If you do ever feel it's not enough having Serene Saffron just in your drawer alone is comforting as it is the best thing for this out there in my experience since 2007!
Stay strong and positive and keep the momentum
@@theancientsancients1769 🙏❤️🙏
Did you improve with nac?
Liposomal Glutathione seems far superior in my experience. Never have been sick since starting it.
Thank you so much, my take from this video is to take glynac in the evening, thanks a bunch!
Very good 👍 thank you ❤
Much like calcifediol can ramp up D3 in 4-5 hours instead of days (as was used for Covid in Spain) Liposomal GSH is in the marketplace for those who are in dire straits, or who don't process NAC into GSH for whatever reason(s).
I took NAC when I had covid and it really cleared out my congestion. I was able to find it at the vitamin shoppe and I've kept taking it because of its health benefits. I also have had a pulmonary embolism many years ago. I was prescribed a daily aspirin a day but I think the NAC is a better choice! Thank you for this information!
Been using injectable (subq)glutathione 100mg, 50mg nac, glycine 5x week. Made a huge difference in how my skin looks. Dont need gram amounts of dosing subq.
Great video, here is a summary
NAC and Glutathione Overview:
The video discusses the health benefits of N-acetylcysteine (NAC) and its role as a precursor to glutathione.
Glutathione is emphasized as crucial for overall health, particularly in the context of infections, including its antioxidant properties and potential benefits during viral infections like COVID-19.
Mechanisms of Action:
NAC is highlighted for its ability to increase glutathione levels by providing cysteine, the rate-limiting amino acid for glutathione synthesis.
The discussion includes the role of glutathione in neutralizing oxidative stress and its potential impact on the clotting cascade during infections.
Benefits During Infections:
The video presents evidence suggesting that NAC treatment can reduce mortality in severe COVID-19 cases, improve blood oxygen ratios, and decrease markers of inflammation and clotting.
Dosage and Timing Recommendations:
Recommended NAC dosage ranges between 800 and 1600 milligrams, preferably taken at night.
Timing considerations include post-infection periods, after prolonged sitting or travel, and evenings, aligning with the concept of chrononutrition.
Comparison with Glutathione Supplements:
The video compares the cost-effectiveness of NAC as a precursor to glutathione against direct glutathione supplements, suggesting potential savings with NAC while achieving similar results.
It's a shame he still has to tip toe around NAC. Edited because of UA-cam's
censorship.
Thank you
Interesting regarding timing. If take them before bedtime my sleep is restless. Take in the Morning, I sleep great and my asthma is lessened.
This is common and it's better to take NAC in the morning.
Its also the precursor for ceruloplasmin, which is the primary mobilizer of copper. Half of more of the general population is copper toxic ( JOM ) and so NAC + mild zinc supplementation will slowly drop copper toxicity in tissues.
There is no blood test that can detect this. You have to get a hair mineral analysis. Most doctors don't knew anything about this, FYI.
Oglioscan is good too. I had a hair mineral analysis test but sometimes they don’t tell what’s in the tissues like mine. But the scan did. I have mercury, aluminum and cadmium
@@zachp419 NAC, ALA and silica rich water will handle all of those elements, as long as you stop eating any processed food and start drinking clean water. Fiji water is the most easily obtained, but you can search "silica rich water" for other brands with higher amounts. Good luck!
Taking a scoop every night on month three now! Thank you.
For me, I noticed that if I take it before bed, it keeps me up. It’s like electricity running through my system. So I take it with breakfast and at lunch.
Best on an empty stomach upon waking up is how I was instructed.
Same!!! NAC upon waking and glycine before bed is what I practice
I have been taking NAC and I never want to stop. It is good. I appreciate this video because sometimes I forget and skip a day or a few days, and I don't want to let it slip. So this is a good reminder. I like the tip about buying the powder form. Good idea.
It destroyed my tendons
@@mark2073 That is deeply disturbing. My tendons seem ok, and I have been taking NAC for two years. Your condition seems serious and please seek qualified medical advice.
@@blahblah6725I'm OK, I just stopped taking it and 6 months later they are rebuilt. It was possibly from resveratrol since I was intermittently taking it at the same time but I'm pretty sure it was from NAC. Same thing happened with macadamia nuts. It can shut down the inflammatory reaction needed to repair tissue after damage from workouts. They did a study on this and found that it significantly reduced recovery of athletes. Be careful and be aware. Apparently this doesn't happen to everyone.
I read that NAC is most effective on an empty stomach so right after waking up is when I take it. And glycine before bed. Any proven studies on timing?
I just came across your channel. Your videos are the most in-depth, so thank you!
Quick question; you mention that antioxidants taken during the day is bad for the body (vs at night). Does this also apply to antioxidants from food? I drink a 64oz smoothie (water + frozen berries) during the day😬.
Let me know! Thank you!
Thank you!! I didn't know we should take NAC at night instead. I've taken it sporadically and randomly, to try and stymie colds, and had mixed results. I will become a smart hummingbird and try taking it just before going into torpor and see if it makes the difference.
I can't take it after noon or it keeps me awake all night. I'm at 600mg per day which seems optimal for me. We're not one size fits all so it's important I think that we use discernment when choosing what is helpful, prioritizing paying attention and listening to our bodies.
Hi Mike, hope You're doing great. Do you take glutamine to go with nac and glycine? Thank you sir
Remember the L-Glycene (glynac) and the Serine!!! Also, 5 htp for serotonin production (5 hydroxytriptophan).
Have you looked into GlyNAC before? Very interesting research on it.
I take NAC and glycine pre work out for Engery
Well. Common antioxidants talked about ate vitamin A and vitamin E which are recommended to take in the morning. Are they good to take in the morning?
I actually think clove, lemon balm and many other herbs and spices are better antioxidants than vitamins. I might try my clove at night now.
Above 2g daily dosing it is effective as an antidepressant. I didn’t know this until I tried to suddenly stop taking it.
I find the time to take it interesting b/c it seems to work better for me if I take it in the evening.
Thx
NAC is a dose dependant Mtor inhibitor. That’s why glynac dose is so high imo .
one lady said her dad was being treated in the hospital for bacterial pneumonia and he tested positive for fungal infection. she said he was never treated for fungus. I read that Nac can help keep a person with covid out of the hospital.
Cysteine is a much cheaper supplement. The NAC will be broken down into cysteine and acetic acid in the digestive tract anyway, so I doubt consuming the NAC is an advantage. Acetic acid is in vinegar
What is difference between NAC and TUDCA?
Hey Mike is there a benefit to taking the form ethyl ester?
Seems like you could augment the Zelenko Protocol with NAC and GSH
1:00 👌👌👌
2:45 Clotting
5:10 Antioxidants at Night
6:05 Dosing
6:25 Glycine
8:30 Glutathione turnover
10:00 Oral Glutathione
Thanks for this. I take half my dosage in the morning and the other half before bed. Is that ok?
You could have talked a little more on Glycine such as dose to be taking with the dose of NAC
00:20
"Nutritional support"
Riiight 😉
I thought there was an issue with NAC causing a problem if you take it after drinking? That it is protective if fully metabolized before drinking? I have no doubt that you are correct - but a clarification would be helpful, thanks!
BUMP- as I want to know the answer to this too...Maybe with enough comments, he'll see this.
You are correct although mice model study - pubmed.ncbi.nlm.nih.gov/16439183/
I was always told to take NAC on an empty stomach so I’ve been taking it first thing in the morning.
I notice my stomach works better! And less acid and better digestion
I read L-Alanyl-glutamine injectable is a stable version, but is a dipeptide composed of alanine and glutamine, and is what is sold mostly in Asia. Will this have the same effect as taking "pure" L-Glutamine injection?
Is taking Vitamin C with NAC(Glutathione) helpful or hurtful? GSH being mother of antioxidants, taking Vit C can be bad? Another question is NAC is OK to take with DHEA with no adverse effects? For people over 50. TIA.
Hmm what does it mean if GGT is low ( 4 IU/L)? I would think treatment would be different than if levels were elevated? My naturopath put me on NAC and explained my body is using up glutathione; does that sound correct? I was also fighting a virus at the time. What are prime levels because on my lab test is says normal range is 8-61.
Thanks for all the knowledge you share! 🙏🏽
Do you sale both of these Mike ?
Mike , the dosage you recommend seems a little bit off compared to what was shown to work in recent studies which said to take glynac @ 100 mg / kg of weight. Which runs into 6.5 g of Nac + 6.5 g of glycine for a 65kg person. That's way higher than the 800 mg to 1600 mg you recommend. Care to clarify plz ? Thanks.
My mother had blood clots and heart damage from the Covid V.
What about injectable glutathione? Can it me taken subq and is there a lot of pip?
When should you take it?
NAC took 5 weeks stop my "illness". Had another two months well after that (feb this year) then got Anhedonia on two occasions which shut mind and body down for 24 hours each time. Started taking it 30 to 36 hours apart which worked for a couple of weeks. Then had a massive reaction to it leading to massive inflammation and infection markers on blood tests, 10 days of delirium, lost 11 KG (what muscle I had retained)Symptoms of bronchial infection, but definitely triggered by NAC. Am devastated. Made such a difference to my life. Now am back to feeling terrible all the time. This has gone on for decades. No one knows whats wrong with me. Blood tests come back "normal"- lost my spleen at 21, am 68 in October. Desperate for some wellbeing. Terrified of taking NAC again-got huge supply in fridge as thought I'd found a remedy. . . .
NAC can become moldy, were you taking powdered or capsules?
caps@@droneswfh
So sorry to hear. My best wishes.
Is glutathione injection good ??
I take magnesium glycinate....this contains glycine ...is there an optimum dose of glycine you could recommend to take with the NAC?
Do we need the Glycine on top of NAC or can I just get NAC by itself?
What dosages are often used in these studies?