The Science of MDMA & Its Therapeutic Uses: Benefits & Risks | Huberman Lab Podcast
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- Опубліковано 7 тра 2024
- In this episode, I discuss methylenedioxymethamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder (PTSD), alcohol and other substance-use addictions. I discuss the neuronal mechanisms for how MDMA elevates mood, empathy, motivation, social engagement, and reduces “threat detection” and how these effects can synergistically support talk therapy. I also explain the ongoing debate about the potential neurotoxicity of MDMA, myths about the origins and treatments for post-MDMA “crash,” the evolving legal landscape around MDMA use for clinical purposes, and I caution recreational users about the extremely dangerous additives (e.g., fentanyl) now commonly found in black market MDMA. This should be of interest to those curious about MDMA, neuropharmacology, the origins of emotional processing in the brain, empathy, PTDS, neuroplasticity, mental health and psychiatry.
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Articles
A Conserved Role for Serotonergic Neurotransmission in Mediating Social Behavior in Octopus: bit.ly/3oV8zSl
Effects of MDMA on sociability and neural response to social threat and social reward: bit.ly/3NlOYUC
The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity: bit.ly/42yMEhl
Distinct neural mechanisms for the prosocial and rewarding properties of MDMA: bit.ly/3NlNERM
Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans: bit.ly/42AF6e0
RETRACTED: Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA ("Ecstasy"): bit.ly/3J9PTVU
Science forced to retract article on “ecstasy”: bit.ly/3oRRpVM
Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs: bit.ly/3P93gcM
MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study: go.nature.com/3WqI2Zd
The effects of MDMA-assisted therapy on alcohol and substance use in a phase 3 trial for treatment of severe PTSD: bit.ly/42wqeNP
Books
PIHKAL: A Chemical Love Story: amzn.to/45ZY80w
Trauma: The Invisible Epidemic: amzn.to/45VdgfA
The Body Keeps the Score: amzn.to/3XgH5Dz
Other Resources
Multidisciplinary Association for Psychedelic Studies (MAPS): maps.org
Participate in a MAPS trial: maps.org/take-action/particip...
Huberman Lab episode on psilocybin: bit.ly/43yP80G
Huberman Lab episode on psychedelics for mental health: bit.ly/3NqC3Rz
Huberman Lab episode on dopamine, mindset & drive: bit.ly/3IqQzVb
Huberman Lab episode on leveraging dopamine: bit.ly/3P3dCuD
Timestamps
00:00:00 MDMA “Ecstasy”
00:04:37 Sponsors: Helix Sleep, ROKA, HVMN
00:08:18 MDMA History & Synthesis; Legality
00:14:45 MDMA, Methamphetamine (Meth), Dopamine & Serotonin
00:23:30 MDMA vs Psychedelics vs Ketamine
00:26:54 MDMA & Serotonin 1B Receptor, Subjective Feelings, Trauma
00:33:36 Sponsor: AG1
00:34:51 Amygdala & Threat Detection, Pro-Social Behavior, MDMA Dosages
00:45:48 Interoception, MDMA & Post-Traumatic Stress Disorder (PTSD)
00:52:36 Long-Term Effects, Threat Detection & PTSD
00:56:14 MDMA, Social Connection & Empathy; Meth, SSRIs
01:06:10 Sponsor: LMNT
01:07:22 Oxytocin & MDMA
01:16:10 Safety & Neurotoxicity; Recreational Use, Caffeine & Fentanyl
01:26:36 Is MDMA Neurotoxic?; Poly-Pharmacology, Body Temperature
01:37:07 Post-MDMA “Crash”, Prolactin & P 5 P
01:43:07 PTSD & Trauma; Talk Therapy, SSRIs
01:54:09 PTSD Treatment: Talk Therapy + MDMA
02:02:46 MDMA & Addiction; Dissociative PTSD & Empathy
02:09:47 Side-Effects?, MDMA Efficacy & Legality
02:15:22 Zero-Cost Support, UA-cam Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter
Title Card Photo Credit: Mike Blabac - www.blabacphoto.com
Disclaimer: hubermanlab.com/disclaimer - Наука та технологія
MDMA,LSD and psilocybin are amazing. I could remember several years ago, I was actually diagnosed with BPD. I also suffered severe depression and mental disorder. Not until my mom recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 8 years totally clean. Never thought I would be saying this about mushrooms.
Congrats on your recovery. Most persons never realizes psilocybin can be used as a miracle medication to save lives. Years back i wrote an entire essay about psychedelics. they saved you from death bud, lets be honest here.
Can you help me with the reliable source 🙏. I'm 56 and have suffered for years with addiction, anxiety and severe ptsd, I got my panic attacks under control myself years ago and they have come back with a vengeance, I'm constantly trying to take full breaths but can't get the full satisfying breath out, it's absolutely crippling me, i live in Germany. I don't know much about these mushrooms. Really need a reliable source!! Can't wait to get them
YES very sure of Dr.benfungi. I have the same experience with anxiety, depression, PTSD and addiction and Mushrooms definitely made a huge huge difference to why am clean today.
100% agree I used to have Psychosis and paranoid thoughts like "people thinking about me talking about me etc. Very odd behavior after getting off Adderall from 7-16. Antidepressants at 18-29. 31 now. I took way to much, but took about 20g of Gold caps (Psilocybin containing mushroom) I analyzed my entire life. The emotions that came out helped me understand behavior etc more. Wont ever need to do it again because I'm happy and contempt forever, but I wish more people did this to alter their perception of reality. Would help with healing much trauma
How do I reach out to him? Is he on insta
My boyfriend and I started taking MDMA when we went to parties but realized that we're much happier doing it at home, talking hours and hours about our relationship and play games while forgetting about the hardships of life. We felt like kids again, and it did our relationship wonders. We stopped doing any other drugs like we used to. We are married now, and still do "date night" with MDMA on occasion and we treat it with respect. It honestly feels like this is better than any couples therapy for us - as we talk about our relationship and life issues and then have a very effective time empathizing and solving all possible issues. I definitely think MDMA should NOT be used recreationally (at parties) or without some sense of responsibility or therapy involved. It's also important to know that when you buy MDMA on the streets, you might have NO IDEA what it's mixed with unless you use a test kit.
He's on Instagrams also on Telegram with the below handle as...
@@jameskim3915 what are you talking about?
This sounds identical to my experience. I agree 100% that the way to get the most potent effects of MDMA is to take it in a quiet setting with a loved one, particularly a lover, and with music, and if possible at the beach or other majestic nature setting (although back rubs on the carpet are amazing too). I don't think my wife and I would have the incredible relationship we have without those experiences.
I think people should be able to do what they want with there bodies. Maybe someone benefits from it the the way you don't at a party or just by themselves. I didn't know you had to be in a relationship to do mdma
@@terrymckensey6055 100%. This was just our experience, and of course it will be different for each person. I believe in the freedom for each individual to be able to try it however they please. I’m merely advocating that it worked wonders for us and our relationship. And I’m sure there are many other areas it can do the same if used responsibly. No one said it’s only for people in relationships, so relax 😉
I don’t recommend this but this was my experience. Both my parents became addicted to meth when I graduated high school. They became homeless and so did I. My 14 yr old sister became pregnant and I had a 3 years old little brother at the time. All the responsibility fell on me at the age of 19. It was extremely traumatic, lots of domestic violence, verbal abuse, manipulation, extreme poverty, ect.. after placing my little brother with one grandma and my little sister with another grandma I went on my on to survive. I met friends that were older and in the rave scene. These people saved my life. They tested their MDMA and after taking it at raves I have always sweared it healed somthing in me. Today I’m 29, have an amazing husband, home, career, college degree, same friends and adopted my brother and I financially help my little sister and niece. I truly believe MDMA healed/assisted my PTSD. Love this talk.
Thank you for sharing your touching story, I have a question which is, How do you take advantage of it exactly? and how does it benefit you? when it comes to your trauma, I have a life that is filled with trauma,
Do it with someone you trust and just talk! Me and my wife do mdma together and has made our already great relationship even better we just talk and have told each other secrets we would have never talked about. I suggest couples do it together a couple times a year. Just the sex alone you will have will be beneficial and will open up about sexual desires you have maybe never said out loud. And then the talks you will have will just make you so much closer and at the same time be beneficial for you personal by getting secrets, fears, desires, regrets you will voice all that and not be ashamed or embarrassed and it's very therapeutic for me
I would say she had experiences with her friends at these raves where they all felt connected and love for each other no matter what they say or have done and had some good talks and she let things out and those people supported her
Totally different drug, mdma isn't addictive like meth, although it has certain similarities, respectfully it's not the same.
Wow! Love to hear this for you, for you this made wonders. How amazing isn’t that.
Just had my first MDMA-assisted therapy session last week. The results are impressive. I was completely numb but in deep pain. I can finally feel emotions again. It's HARD, but I feel like I am finally making progress.
Good luck on your journey, brother. I truly hope it leads to healing and catharsis. :)
amazing any great insights and or visions ?
Not trynbe a doc but look into shrooms maybe
How did you go about finding a therapist that is willing to use MDMA?
Can you recommend your therapist?🙏
I can't believe i'm just discovering this guy in the last month. Thank you for your pursuit of giving free education to us
I want to reset my life and I want to inculcate things from this podcast. As a newbie can you please guide me how to adapt the changes he recommends. Because it's too much information. It's like certificate course in itself. commendable, but overwhelming.
@@aakansha353 I felt the same way. Get the news letters and go slow, one step at a time. Good luck.
I've followed him for many months now. Hehe
Too much spacing, and you're missing punctuation.
I'm*
Molly Monday on the Raverman Lab!
😂😂😂
Lulz.
69 thumbs up after I gave mine. Haha xD
:3 3.45 million subs! Hahaha. 345!
I find this comment disturbing and hilarious simultaneously
0:00: 🧪 MDMA, also known as ecstasy or Mali, is a synthetic compound with unique chemical and subjective effects.
11:40: 💊 MDMA is a synthetic compound that causes big increases in dopamine and even bigger increases in serotonin, leading to stimulant and pro-social effects.
24:26: 🧠 MDMA, also known as ecstasy, produces unique effects in the brain by increasing dopamine and serotonin levels, leading to increased energy, pleasure, and emotional warmth, as well as a desire to bond and trust.
36:42: 🧠 MDMA affects the brain in various ways, including reducing the response to threatening stimuli and increasing the perception of positive emotions.
48:25: 🧠 MDMA impacts the brain by increasing dopamine and serotonin levels, leading to changes in threat detection networks and pro-social effects.
1:01:03: 🧪 MDMA's effects on sociability and empathy are not solely due to increased levels of serotonin and oxytocin, but rather the activation of specific receptors in certain brain areas.
1:13:21: 🧪 The effects of MDMA are not directly related to the increases in oxytocin, and the neurotoxicity of MDMA is still debated.
1:25:31: 🧪 The potential neurotoxicity of MDMA is influenced by various factors such as the purity of the MDMA, the presence of other drugs, and the environmental conditions under which it is taken.
1:37:48: 💊 MDMA can cause a crash after ingestion, which is similar to crashes experienced after taking other stimulants like cocaine or amphetamines. The crash is likely due to an increase in prolactin, a hormone associated with lethargy and decreased dopamine. Some people are exploring the use of p5p, a metabolite of vitamin B6, to suppress prolactin and mitigate the crash.
1:50:41: ⭐ MDMA-assisted therapy has shown remarkable results in the treatment of PTSD, with an 88% success rate and 67% of patients achieving remission.
2:03:02: 🧪 MDMA combined with talk therapy shows promising results in the treatment of PTSD and other comorbid disorders.
2:15:05: 🧪 MDMA as a clinical tool and its importance
Recap by Tammy AI
Thanks for saving my 2hr of time! amazing summary! God bless you!
*IT'S ALREADY IN THE DESCRIPTION!!!* 🙄
I don't want to hurt Tammy AI's feelings but "Mali" is spelled "Molly"... But you did a great job regardless.
And when it's time for AI to rid Earth of humans, please give me a quick and painless dispatch. Thank you.
@@Faladaena You are right.... kinda.
Ty ❤
I lacked the courage to commit to my girlfriend who I loved very much and who wanted to get married. I took MDMA alone one day and actually saw our future together. I liked what I saw and felt like it was ordained in some strange way. I resolved to propose within weeks. We've been married 14 years. I also got rid of my judgemental attitude towards other people. In my mind MDMA properly used is a miracle.
Beautiful story of love and understanding! Enjoy!
omg iv nvr felt this much relatability youv inspired me ill marry her
@@youhavenvrfeltawomanstouch9599😅😅😅😅
Permanently lost judgemental attitude?
Please do an episode on development of babies and children. I would really like to hear more on how the brain and behavior develops and use these to raise my child in better ways. Thank you Andrew Huberman!
Yes, and the preemie brain, my sister was 3 months premature..
Yes please!
I would also LOVE to hear about how developing fetuses's nervous systems, brains, etc. can be impacted by the stress, PTSD, domestic violence ETC on the developing fetus and potential implications for that into adulthood. THANKS FOR BEING SUCH A ROCK STAR!
maybe you already listened to it but he had dr immordino yang talking about emotions and social factors impact learning also in babies
Look up Early Childhood Development, you can find lots of info on the internet👌🏽
I took Mdma in a clinical setting. [Doctor reccomend] and wow! My major anxiety disorder vanished immediately after my first visit. Its like somebody turned off a light switch. This was 7 months ago. Never had to go back. Doctor wants me to go for more sessions but I simpley don't need to. Truely a blessing. It's like Mdma healed my brains imbalances. 🧠
I’m sure you know that everyone on here wants to know where you found it and who your doctor was. Some of us are suicidally depressed and in spite of me saying that here I am 100% sure you will never respond.
Did you have to stop your treatment before you did this session?
@@weaverdreams for real. Why do people say these things and then never respond? Smh...
@@mach7rs because no one cares about anyone else. That’s the sad reality of planet earth.
@@weaverdreams very true. In this ego driven world, there are very few genuine people, let alone people that actually care genuinely for others’ well being. The best thing we can do is do our best to surround ourselves with people that do.
I am a 21 years old student and I can say with confidence that taking a huge dose of MDMA for my first time last year (1g shared by 4 approx) was by far the greatest experience of my life, providing me with a six weeks afterglow where I felt much happier than usual and ultimately helped me look deep down into parts of myself I had buried for a long time. I took it again three times after but the effects were far from being as good as the first time. I do not know what my future with the substance will be but for now I can say with confidence that MDMA is the thing that has helped me the most in terms of accepting oneself, recognizing flaws and unstable emotions, as well as having deeper compassion and understandings for my fellow others.
Your Insight is spot-on people spend an exorbitant amount of time chasing that first high and it will never be the same.
dude thank you for sharing, I had my first experience 4 days ago.(750mg between 3 ppl) My experience was so similar. It taught me to love myself.
Guys don't chase the dragon :)
How do I get this drug
Love hearing about the research for MDMA & it’s long term effects, as well as the details of the chemical compound. The part on the amygdala and heightened interoception really spoke to my situation with PTSD. Fascinating, thank you for your work.
As always a wonderfully indepth and accurate description of the studies. Having taken MDMA previously socially I am in no way addicted but found I used it to keep my energy level up only. I don't wish any neurological condition on anybody and if the therapies help just one person recover, I'm all for it. You truly are an inspiration to many and your podcasts and work show your dedication. Thanks again. To anyone struggling I hope you find your cure whatever that may be.
I want to share a story about my partner.
They suffer from serious body dysmorphia, and struggle to love themselves. They've also dealt with impostor syndrome and major depressive disorder for most of their life. And we suspect undiagnosed ADHD as well. There was a time, mid 2021, where I was guiding them through their first time in a long time taking E together. I still remember, we were listening to the Nurture Album by Porter Robinson. The song playing while this all happened was "Look At The Sky". Great song.
Once our states stabilized a bit, I took them to the mirror, and said "I love you". They said it back to me. Then, I offered them a little challenge. I asked them to say "I love you" again, but to themselves. They hesitated, but managed. I took a step back, and asked them to do it again. They did, but with more confidence. And eventually I stepped out of the room, and let them talk to themselves for a bit as the song played. I got glimpses of the conversation. They emphatically said "I love you" back to themselves. They said they were proud of themselves, and how far they had come. A lot of people are proud of them, and they're doing alright. It really was wonderful to hear them say all of this.
When they were done, I could tell they had been crying a bit. It definitely seemed like an emotional experience. But they admitted to me that they did love themselves more than they initially believed, and that they wouldn't be able to love me the way they do if they didn't have any self-love at all. They've also achieved more than they give themselves credit for in their life, and they really are doing well for themselves, in spite of what those negative voices in their head may be saying.
They obviously still have a long way to go to fully conquering these demons, but it was amazing to hear them make all of these strides.
Thank you for sharing that, and for being so good to another human. Maybe its odd to say, but I feel a lot of love for both of you just reading this. I don't really have the language to convey these personal feelings in this internet forum setting, and its somewhat patronizing to say I feel proud of you. Its odd being surprised by language's shortcomings in new ways. But I'm certainly happy, and emotional, having read this! Thanks again.
@@DishonorableDaimyo I'm glad you liked it! Frankly it is probably one of the most heartwarming things I've experienced so far.
I really like to see people do well and thrive. If I can do something to help someone be a better version of themselves, and more importantly, be good to themselves, then that's all I really need. :)
Beautiful awesome good work thank you for your service
With all respect, the "they" is making me and I'm sure many others, think you're insane and voids your otherwise beautiful message. Them/they is the dumbest thing ever imho, and I have zero hate for any sexuality, but draws the line there. You have a gender, hence also pronouns, despite whatever you seemingly identity with at the time. Just my humble opinion of-course which obviously you're free to dismiss fully, and just letting some steam out, no offence ment.
The fact that we live in a world where people think using “They” is important is indeed unfortunate, but I believe it beneficial to overlook it and allow the impact of the message to land. Clearly this person wasn’t loved properly in their formative years, leading to self-love issues, as well as the very gender issues that would result in wanting to use “they”.
I just want to say thank you so much Andrew Huberman and team for sharing all this knowledge with the world! Listening to this podcast is always a certain way to inform oneself with as non-biased a perspective as can be, the good and the bad of all subjects discussed, and all of it for free.. incredible.
Thank you for allowing non-experts like myself to learn about these topics. Always clear and concise, this is my new favorite podcast. Congratulations on the well-deserved success.
The first professor that catch all my attention despite how long the conversation is. Excellent data as usual. Never exagerated or understimated. Thank YOU for the valuable information and let me feel interested about science.
I'm grateful you devoted time and research to this treatment. For the first time I feel hopeful about my son. PTSD is a hell of its own.
YOU SAID IT SISTER!!! I feel like I am just sitting here WAITING for MDMA and psilocybin to become legalized then pray that some way I will be able to find access to them and they won't cost $$$$$$$$$$ dollars!!!
I’m posting this here, since it’s your latest episode, but my comment is not specific to this video. I want to express profound gratefulness for the positive impact you’ve made to my life. I’m the type of person that needs a framework (preferably science based) to make lasting positive changes and intrinsically motivated decisions. Thank you Andrew!
Absolutelee ground breaking. PTSD symptom free. Thank yall Pioneers and thank you Dr. Huberman for having the tests to share this information that has the potential to help so many who had lost hope.
Really wish sasha was still with us today . He would have been an amazing guest. Thank you for acknowledging his work ❤
Thank you, Dr Huberman. I know that these talks not only take a lot of time for these videos but an immense amount of time preparing for. Much love and appreciation.
Thank you for you're dedication and information. I feel I would be a good and unique candidate for an MDMA study. I only took MDMA once over 40 years ago but I remember vividly the effects it had and how it opened up my mind and enabled me to make permanent changes in the way I viewed certain people around me at the time. I've always reflected through the years how remarkable that experience was because, though very short, I realized way back then the remarkable potential that might be hiding. I was in my 20s and had just graduated from pharmacy school. I went on to open a compounding pharmacy and natural medicine (integrative medicine) pharmacy in my community during my 40s which I had for 18 years. I never forgot my experience that night on MDMA! I often wished through the years that I could once again have the support of anything close to those effects to help me work through many issues; many I recognized as early as my late teens but back then it was "taboo" if you said you needed a therapist. In recent years I've been working to overcome lifechanging events that have caused PTSD. How do I enroll in a study?
I’m an emergency physician and I’ve found your podcast invaluable for my personal life. The bipolar disorder episode was fantastic. I’d love to hear one on schizophrenia!
Me too! Very interested in learning more about schizophrenia from Dr Huberman and any guests he may have that are knowledgeable about the condition as my Mom suffers from it and has gone untreated all her life. She isolates herself now and hides it behind religion to everyone else she may rarely talk to. My Dad (now passed) and I are the only ones that know her diagnosis. Her husband of 20 plus years doesn't even know. We've had and extremely difficult relationship with periods of years where I went no contact because she and her husband are so abusive. We talk again now, but I find it extremely difficult to relate with her because she's so "out there" and uses her faith in religion as a crutch for everything, yet nothing changes or has changed for several years.
Learning about schizophrenia from someone with Dr Hubermans level of knowledge and ability to deliver it to the masses in a way we can understand could help me and others understand schizophrenia better and learn about treatments available, possibly how to get an adult with schizophrenia to get treatment, and how to relate with them when they're not receiving treatment and making no sense.
Great podcast, but as an English major, I have to point out that Dr. Huberman often uses the word 'remittance' (mainly used in finance) when he means 'remission' (many used in illness/mental illness). It's a small detail, but Dr. Huberman clearly pays attention to small details.
¡Hola Profe! I want to thank You, for all the knowledge , You bring to all of us ,on such an important subject .Your work is truly appreciated by all of us all over the world. Mental health is a really relevant and important subject in our every day life. Thank You , for all You are doing.
Hi Professor,
I am an avid listener to your podcast, and I greatly appreciate the time you are taking to post these content for everyone to listen to free of charge.
Appreciate if you could also do a series on child nutrition for brain development and health.
Thanks.
This was wonderful and it's great to know it could help so many people. I'm really excited for that Synesthesia episode you mentioned you'd have in a previous podcast. Hope that comes soon!
Love your content. Is it possible to just add some visuals on how the underlying neurophysiological processes take place to be able to better visualize what is happening?
Hi Dr. Andrew Huberman,
Firstly I would like to thank you for this insightful and comprehensive episode on MDMA. I would like to recommend a guest for your podcast, Hamilton Morris. He would be an interesting guest and contribute to an original perspective on psychoactive substances. I firmly believe that the two of you could greatly complement to each other's understanding and engage in fascinating exchanges of ideas and thoughts.
Thank you once again!
Thank you Andrew for bringing up the groundbreaking role of these molecules for finaly bringing humans to themselves again or for the first time. This work is a eternal.
Hi Andrew!
Thank you for all you are doing for us. Your work has really been a life changer for me.
I have a question about mudras. It has always been a very interesting topic, but I could never really trust the efficiency, maybe because I still can't find lots of scientific research, and I still am convinced it is only a placebo effect. It would be interesting if in the future you can talk about it in detail so we can all have clearer ideas about what they really are and if they really work! Thank you so much. Greetings from Italy :)
Amazing episode. Very cool to see a lot of promising results for treating PTSD.
Only a few minutes into the episode, yet I feel compelled to share my experiences.
I’ve never publicly disclosed my use of M.D.M.A before but I hope some good may come from doing so.
The effects of this drug are profound, I can not stress this enough. For the use in strict clinical settings it can be an almost miracle tool. Once one is under the influence of the drug, it is impossible to feel, fear, shame, or embarrassment. When I say it is impossible I literally mean, it’s impossible.
Due to this affect I can clearly see how this ‘state’ of consciousness would be extremely productive to help one face very difficult truths, and past events. All whilst being guided by a licensed counselor, or therapist. I really do believe this drug could help so many, live a better life.
However, what I felt was too blissful. I felt pure philosophical ecstasy. I am left wondering if it is even possible to feel as I did, through a life time of hard work and achievement. Now for me this isn’t causing me to suffer, at least not to my own awareness. But what if a person has a child, yet their happiest moment still remains as that time they used M.D.M.A?
Correct dosage could be a key factor in having the best long-term life outcomes with this type of therapy. I believe if the administered dosage is just enough to allow a patient to face their trauma, then real good can be achieved. If the dosage is too high and the patient experiences a level of bliss that is inconceivable. Then this could have unpredictable deleterious affects on one’s outlook on life and their relationships with others.
If your outlook on life is to chase bliss, then it is that pursuit of bliss that is the issue, not the bliss itself. There are many extremely blissful experiences I have had in my life, some as a result of drug use, others not. Achieving these states has not had a deleterious effect on me, I do not constantly compare current enjoyable experiences to them, finding my current experiences lacking. I have also had experiences without acute drug use that are just as profound and beautiful (some moreso) as those involving drug use.
"However, what I felt was too blissful. I felt pure philosophical ecstasy. I am left wondering if it is even possible to feel as I did, through a life time of hard work and achievement. Now for me this isn’t causing me to suffer, at least not to my own awareness. But what if a person has a child, yet their happiest moment still remains as that time they used M.D.M.A?"
The issue here is not a peak experience of bliss, it is the neurotic pursuit of an abstraction of the current moment. All things are impermanent, nothing will ever be as it was. In fact this brings something very important up, it is a crucial lesson. If this peak experience of bliss allows you to realise that you are and have been chasing bliss, then you can act on this knowledge and try to unravel that neurotic seeking, that dissatisfaction and rejection of the current moment. Once you can truly stop seeking abstractions of reality that can never be realised, you can allow yourself to be present in the moment (clichéd as it is), and let bliss arise of its own accord, which it will.
@@DishonorableDaimyoFantastic comment!
Like the other comment said better than me…life isn’t about chasing “bliss”. That’s where people run into problems if they take the drug with an already strong dissatisfaction, or lack of appreciation for the full spectrum of emotions. I have had some great times on mdma, but I definitely wouldn’t say they are the most blissful for me.
@@DishonorableDaimyo Hi, I do not wish to be rude but you have not understood my comment.
I chose the word ‘bliss’ as I do not wish to glorify the state of mind. I personally strive for gratitude as happiness is usually an illusion, and an addictive one.
As for deriving more deeper philosophical inferences from my brief, but to the point statement. How we ‘feel’ is nothing more than our brains neurochemistry. We have a certain number of dopamine receptors, and we have a certain number of serotonin receptors. If all those receptors have a molecule bonded to them, then that literally is our peak capacity for bliss, happiness, or whatever positive feeling you wish to attribute being experienced.
Hence why I brought attention to the importance of dosage if M.D.M.A is to be used for therapeutic reasons. If every happy happy joy joy receptor in your brain is going full throttle. You have just hit the ceiling for how ‘good’ you can feel. This isn’t philosophy, it’s science and the reality of a conscious experience.
I hope my words are not too cold, or terse. I do feel fondly of your beliefs and general ethos. This drug can do a lot of good, but it could also do a lot of harm if it isn’t handled with the greatest of care.
Be well.
@@boldandthebeautifulgimbal2881 Hello, thank you for your response. I apologise for being somewhat preachy, I just spoke from the heart after reading your comment. I apologise also if I misunderstood you, I can only respond to my subjective interpretation of your words, and there will be some degree of difference there no matter what.
Upon rereading what you said, I do not know how else to interpret it, as you are stating that a peak experience of bliss would irretrievably and negatively impact a person's ability to enjoy other things in life. To me, this points to a mindset of constantly comparing current experiences with other desired ones, hence my spiel on the dangers of pursuing abstractions chronically. How else should I interpret it? I understand that these text based public forum conversations can come across as hostile, I am trying my best to choose my words with care and compassion, please forgive me if I come across as confrontational or mean.
"Hence why I brought attention to the importance of dosage if M.D.M.A is to be used for therapeutic reasons. If every happy happy joy joy receptor in your brain is going full throttle. You have just hit the ceiling for how ‘good’ you can feel. This isn’t philosophy, it’s science and the reality of a conscious experience. "
A small thing, as I understand it if all of our serotonin receptors were activated I do not think we would feel bliss, I imagine it would be chaos, as serotonin is responsible for a massive amount of functions in the brain, not only reward systems. However I am but an interested amateur in this field, I have no formal training, so that is just my understanding of the literature I've engaged with.
My main point is that I can accept that it does hit a high intensity of joy or bliss that few things can compare with, and I understand that the experience of all states of being have their neurochemical correlate, but I don't think its a problem to experience these states intrinsically. I think it can be a problem for people who have a dysfunctional relationship with neurochemical reward systems, but that is not a problem of the blissful experience itself. I have had several peak MDMA experiences that were profoundly beautiful and truly, nothing was quite like them. But I do not experience the problem you are outlining, and I think many people would have a similar experience. Of course this is but anecdotal evidence.
I do not think you were cold or terse, thank you for respectfully responding to me. I wish you all the best in life too :)
Was waiting for this topic since your discussion with Dr. Sam Harris. I was watching that episode and was thinking it would be great if Dr. Huberman or Dr. Harris mentioned MDMA. One and half hour later you were discussing it! Then you explained why you decided to create this podcast. I felt it all by my heart. Thank you so much Dr. Huberman for all the good things you do. I've learned a lot from you. Respect.
I'll refer you to and online store where I got my own psychedelics and microdosing stuff very good reliable vendor
I get my psychedelics and microdosing stuff from an online store where I got my own his on Instagram and also on Telegram with the below handle
*Mycopete.*
Hey Andrew,
Your episodes are helping me a lot combatting against my depression. I don't have any problems with addiction whatsoever, but still I'd like to help a friend of mine who does and I noticed you got an Anna Lembke vid (which I watched) there. Maybe it would be extremely beneficial for everybody, if you would just make one about addiction (best practices, maybe a toolkit). This would help so many people!
Thank you for everything.
Felix
Never considered doing any kind of drugs, but information and education is never wasted. Listening in.
If I had Andrew as a lecturer I would've passed with flying colours. Smart, humble and jacked!! Love your work.
It is normal to overlap and to be distinctive as well thanks professor Andrew, you are the best..
Serendipity! I actually found this episode and started listening at the beginning of a large dose experiment. I love your total understanding of the subject and you make things easy to understand. I have PTSD from a near-fatal attack and epilepsy too. I like knowing the science behind things, it is just amazing that there are so many tiny chemical nteractions that compose the world we live in, and us that lives it. Thank you for your great work, now back to the trip already in progress. Be well, everybody!
hey I have epilepsy too. I wanna do assisted MDMA therapy do u think its fine for people who are epileptic?
@@grethaanderson6184 seizures vary so much in their cause and forms. hat's a decision you must read up on and decide for yourself. Even one person's experience may be irrelevant for you, I am not a doctor and can't give advice like that. And I al almost 6 years seizure-free so my example wouldn't tell anybody else much of importance. But it really helps with the depression and uncertainty that is always present.
Me,63 years old. Suffering all my life. Depression, suicidal etc. I wont even call myself a sexual assault survivor because i am barely alive. Hit rock bottom, went to get the shotgun, my grown son convinced me to try MDMA. Not a drug user other than excessive booze but what a game changer. Im 150 pounds and i took a 120 mg dose. What a trip of a lifetime. I became the man i was suppose to be. A completely different person and perspective on myself and life. Its been 2 months. Taking another dose tomorrow . Clean tested supply, no crap ecstasy. Try it, you will appreciate it.
I'd appreciate your comment!!
ON INSTAGRAM
OK I’ll go out and find some on the street tomorrow. I’ll just go ahead and take a risk that it might be fentanyl instead. Because I don’t think you’re gonna tell anyone on here how you found yours correct?
look on the internet. i wont say where specifically. other people here list contacts. whatever you get, have it tested after you get it, dont trust sellers.
U should test ur stuff if u don't know the source. Test kits are easy to get buyer beware is a good motto to live by.@@weaverdreams
I have used MDMA twice as a young man whom suffered from combat related PTSD. I pray and wish the VA used this therapy instead of filling us with SSRI’s as they make me and most veterans I talk to feel like zombies. Thanks for bringing up this discussion.
Love your podcast! I know you must get a zillion suggestions, but I have a couple I'd like to add to the pile. 1) I'd love to see a show focused on the health benefits of spending time outside. I know you've mentioned snippets on this topic (sunlight & early environment exposure to gut microbiome), but I'd love to see it expanded. I spend at least an hour or so outside every day (year round) and I always feel better. I also think it's improved my immune system. I'd love to learn more on this topic! 2) How about a show on the health benefits of owning a pet? I know there's a connection between kids and reducing their chances of allergies, but beyond that - we know pet owners may experience reduced anxiety. I think it could be a neat show.
Thanks for considering either/both!
Looking forward to this episode as I’ve been wanting to be part of an MDMA trial for awhile now. Hopefully there’s something mentioned about where to go for that. My psychiatrist has let me know about the psychedelics i could try as their approved for treatment assuming I could afford them but MDMA is the one I believe could help… and if a trial, more affordable to me.
As a person who likes to take mdma couple times a year, I was hoping for such an episode of the HLP. I actually made up a title for it: The science of MDMA and how to offset withdrawal😂
Yeah, couple times a year is also my sweet spot 😛
@@FedeJack-li5li Hi there....I would like that store reference please? Thanks in advance...
If you take the right dose you won’t have withdrawal 🤦♂️🤣
@Fede Jack no one cares scammer
You should be dosing correctly. Bad withdrawals is a sign of maybe doing too much.
Hi Andrew, I love your podcast and appreciate hearing about your own challenges and personal story when you have been on other podcasts.
Would you consider doing a show(s) covering the following topics: developmental complex trauma and the impact it has on the nervous system and ways to re-regulate the nervous system in adulthood, mindfulness techniques, distress tolerance, expanding the window of tolerance, dialectical behavioral skills, parts work, acceptance and commitment strategies, somatic techniques, grounding, Polyvagal Theory, and engagement in rhythmic behaviors (dance, chanting, passing a ball), etc. as interventions for re-regualating the nervous system?
Many people have been exposed to chronic abuse of some type or emotional neglect or dis-attunement during their formative years and a discussion of the impact of this on the developing nervous system and ways to re-regulate it now would be so helpful. I think this is something that could be very useful and powerful. Would you do a show on these topics? Thank you!
Great podcast, it’s very informative and very clear, thank you so much for sharing this great educational information !
Love your podcasts! I’m pursuing neuroscience for my PhD and your podcasts have helped me get a great head start in my field.
Imagine discovering MDMA and being the first person on the planet to have tried it and then noticing the insane effects it had.
He must have thought he found the best drug in the world and the secret to life or something.
Thats basically what Alexander Shulgin did.
Great episode Dr.Huberman, i dont miss any episodes every monday. I was wondering can we get some new merch in the store for hubermam lab, specifically hats? Also could you include an episode with Dr. Michio Kaku, his demeanor is amazing.
Hi Andrew ! Thank you very much for your educational and well rounded content, I listen to it all the time. I have a request for a future episode to explore how nueronal activity actually translates to perception, feeling - i.e. how does one go from electrical signals in a complex graph to actual perception, such as feeling cold, smelling a rose, seeing red. Thank you!
Funny story: I did MDMA for the first time 2 months ago. No one told me the appropriate dosage, so I broke the 1g shard in half, and down the hatch with 500mg!! I’m 6’3” 240lbs and it was quite the ride! After this podcast I now know what dosage I should have taken: 100-150mg. Anyways, I took it on Saturday night and it was still in my system the next morning while I was playing the pipe organ for Anglican Worship. Everyone was amazed at my musical improvisation that morning. 🤪😇
That’s a huge dose for the first time (even for your size). Glad you had a good time and are ok. Phew.
I don't find that a funny story... more an incredibly dangerous one. Were you on your own? Couldn't you have asked whoever you bought it from what would be a reasonable dose? Or looked it up on your phone? I'm glad you're alright, but you could've died.
so you played it with no past experience
@@AliHamzaAliHamza that’s generally what musical improvisation is. Of course I have to preface that by saying to be good at improvisation, one must first be a master of the instrument in legitimate form, and have a fairly deep understanding of musical theory. So it wasn’t like I had never played the pipe organ before and suddenly I was a genius at it. What I’m saying is that the MDMA opened doors to unsuspecting places in my musical experiences and education and that is what I was able to draw upon when improvising, taking the music in directions I previously would’ve not thought about.
that tab was probably not pure mdma but etacy with plenty of filler
Thank you for the detailed explanation! So important!
Good morning, Mr. Huberman. I recently discovered your channel and it's become an addiction. Maybe a topic for a future video. I've explored a lot of information towards mental performance in a quest to improve my pool game. It's often said that at higher levels, pool is 90 percent mental. Problem being that most information is provided by those only relaying information or their own personal experiences. Your information is highly professional and proven. I'd like to challenge you to look into the game of pool and discover the many aspects of mental preparations and executions during high level competition. Thank you for your dedication.
Good morning class, have a wonderful learning week.
I used sometimes MDMA recreationally, and allow me to give people some advice.
I do not recommend taking big doses in one go, that is usually a mistake, because it makes you go extremely high, sometimes to almost uncontrollable levels, depending on your personality it may cause you to go into a state of panic because you feel like you are about to explode. Also in my experience big doses in one go may cause severe hangover from 1 to 3 days, and when I mean severe I mean much much much worse than alcohol hangovers. This happened to me, and even I which I am quite calm and pragmatic, had a small panic attack, breath and just take it in if it happens, walk around, smile, it goes away quite fast.
My advice is to take a small dose, and eat something, 45min later take another small dose and eat something, doesnt need to be a meal, just something like a fruit. Its important to eat because if your digestive system is on stand-by the MDMA may become kinda stuck in your stomach, you start to think that the MDMA is not working, so you take more, then more, and all of a sudden when your digestive system starts working, all that MDMA goes in one go into your blood, and that's how you can get an overdose at worst. This happened to me the last time I took, I had a very high manageable peak.
Small doses allows you to regulate how high you are, just remember that from the time you take it to the time it starts to make effect it can go from 30min to a hour and a half.
I generally take it between 1 hour and 2 hours before I want it to make effect, small doses. The high follows in my opinion a sudden rush, then it stabilizes on an intense high, then it gradually goes down, but there's a moment when it stabilizes on a level where you still feel quite well but its not that intense, when you feel this is the case it may be a good time to take another small dose.
What is a small dose and what isn't is very much up to each person, so it takes some experience, still this is the safest way in my opinion to take MDMA, and another piece of advice, taking MDMA is not a rush to see which one of your friends take more, just be confident on yourself and your instincts, you don't have anything to prove to anyone.
You're not really supposed to redose and you need a strict dosage and timing control. I don't think your advice is good. You take one dose up to 80-150mg (150 is strong) instead of redosing mdma even once you should bump ketamine to keep it going, much safer and healthier.
But 2cb after a roll is the best, 10-15mg taken once the roll begins to level out, ca 3 hours after dropping M. This can give you afterglow for weeks. It's much better than 2cb on its own. And definitely safer than redosing mdma. The easier way is ketamine tho because you can bump tiny amounts.
The 2cb mdma combo works so well that I'm sure it'll be part of standard procedure, Shulgin said it himself and I have no objections to that after trying this.
@@randomguydoes2901 my advice is based on my anecdotal experience and what works for me and how I seen things working and not working for friends.
Thanks for the knowledge
Thank you so much for your interview with Dr Robert Sapolsky which led me to his lecture series. Amazing! Looking forward to listening to your latest installment and hoping in the future that you will interview Dr Sarah McKay.
Thank you Andrew for making this amazing content regarding The future of psychiatry !
Please make videos about The other psychedelic substances, If i can request DMT or 5-meo DMT. There is so much research out there on DMT atleast. The world needs to know about this substances potential for healing. Love, Raymond, psychologist.
The other day I was thinking to myself about PTSD and how MDMA can help with that and now here you are talking about it.
Thank you, Andrew Huberman and his team for all the effort! 🙏❤️
Saved my soul 🎉 i love that feeling when my PTSD overworked amygdala is off, put the music on and enjoy the moment , a pure therapy 🎉
Hello Dr. Hubermann, I'm a big fan and first of all I want to thank you for making all this wonderful knowledge accessable. Please excuse my English it's not my first language.
I want to ask you to make a review regarding a topic I don't often see spoken about - connective tissues.
I happened to fall into a rabbit hole of research regarding correlations between neurodiversity (ASD, ADHD) and hypermobility, connective tissue and gastrointestinal issues, hypermobility and fibromyalgia and much more.
I have a hunch you might find that unexplored territory fascinating. Thank you once again, and have a lovely day 🥰
First of all, I would like to say that we are all different and that each body has a very unique way of reacting to any substance. I only tried Mdma for 5 years of my life within which for 3 months I was consuming small amounts every day. I just wet my finger and sucked on it. I did it because it allowed me to socialize and have a good mood, even though inside I was very depressed all the time. This happened and I only used it recreationally. Since that moment I have not felt happy again, I have been living in thoughts of continuous suicide for years, everyday is dark, i find my self with not value at all and I feel like i cannot enjoy anything at all, I feel empty. Before knowing the ecstasy I was not so well but at least somethimes i could found happiness and enjoyment in certain things. I'm sure that episode of mine with mdma changed something forever in my brain. I regret it a lot, I would like to feel beautiful and nice things again. Please be careful. If you need to feel good, first ask yourself where your depression comes from and why it is there. Before covering up the symptoms, please focus on finding the cause, even if it is difficult. Love for everyone. Sorry for my English.
I have heard that it damages/ destroys your dopamine receptors if you take it for a long time! I wonder if there is a supplement you can take that can rebuild those parts of your brain! So sorry that happened to you!
I'm really sorry that happened to you, and I can't tell you how happy I am to know that you are still here
Please don’t give up hope. Our bodies can cure themselves little by little, slowly but surely. Maybe not fully, but you should feel at least a little bit better. Have you tried going to therapy? Maybe some antidepressant medication may help?
@@shadouge333 Thanks!!! i think the same, I stop doing drugs, includ alcohol and trying to sleep more, doing some more sports. I feel kinda better sometimes so i think thats good :) Def gonna try therapy, dont want to take more pills, but im open to try herbs and just maybe talk more about this with kind people. I just want to enjoy the simple things in life again :)
I went through something very similar. Did MDMA soo hard I started stuttering, I started worrying thinking I permanently fried myself. That goodness I was playing rugby and exercising quite regularly at the time. I then learned about neuroplasticity and literally clawed my way back. I started playing guitar and video games to build back the neurons coze I read that the use of your hands and improving hand eye coordination were the most effective at promoting new neuron growth. So I got myself back so a relatively base level (let's face it, I'll never be the same , just because it's am experience that shaped me). I then did LSD and coke for a while, nothing too regular , but more than 7 times a year, maybe once a month. I've since then stopped for almost 3 years and I definitely find that things that I used to get excited for or happy about seem empty to me. Finding motivation outside for things I enjoy is hard. But I found that I needed to stop drinking and exercise more, it's slow but I'm getting there again.
I'm still
I used MDMA recreationally a lot when I was at college. Afterwards, the way I experienced the sensation of happiness changed. Ever since, I have felt the tingles of happiness delivered in the same way as if I were on MDMA. I was wondering if there's any scientific explanation for this. Thanks for all the great work
I'll refer you to and online store where I got my own psychedelics and microdosing stuff very good reliable vendor
*Mycopete.*
Lol, for sure. I can watch a video of a rave or something and I'll start grinding away like nothing.
@@davidkymdell452 Also the beeps of the traffic lights get me bopping
Alot of memories are linked to the feelings you had while you were on mdma. I used it frequently when i was younger and still get tingles when certain songs or feelings of joy come. I believe that MDMA helps us RECOGNIZE when we have active serotonin long after the effect wears off.
Thank you for giving Shulgin credit, he was a great mind and ahead of his time. Much respect!
hello Dr. H! i wonder if there might be a liver episode in the works or at least a planned episode in the future? great episode as per usual 🧠🥂
MDMA potentiates the mystical effects of other psychedelics. It appears that when therapeutic doses of MDMA and, for instance, psilocybin, are taken together the heightened states of energy and pleasure can behave like a sort of "fuel" for the visionary and mystical experience, allowing one to spend more time in the mystical state, and have deeper, clearer visions in that state, but brings with it it's own quality otherwise absent in those mystical experiences.Telepathic like phenomena also seem to happen when done in a group setting. I would love to see the research get to this point in the near future. I believe the most radical discoveries in this field won't start to be uncovered until combination research begins in earnest.
tried both at the same time once.. they did not compliment each other. I felt the effects of both, but each was hindered by the other. It was kind of boring
Been there. Only with pure MDMA and liquid sunshine with my boyfriend and we had the same trip I'll never forget it and that's a combo I want if I'm ever dying in pain and afraid.
Thank you Dr Huberman! I live in downtown San Fran, and the fentanyl epidemic is very real and present, as I'm sure you are aware. On the topic of promising drug-assisted treatments, please do a full episode on ibogaine!
Agreed, ibogaine is fascinating.
Thanks for this interesting topic Dr Huberman!!
Hi!! Long time listener first time commenter 😄 as a licensed mental health professional in the state of California and mental health advocate, I wanted to just say a few things and offer some feedback around the way you discuss suicide. As a general rule in the land of psychology and psychiatry, we are shifting our language away from the phrases. “committed suicide” and “successful completion of suicide.” The language that the field prefers to use currently is “someone died by suicide” as a way of being more sensitive with the subject and shifting away from the concept of suicide as a crime that has been committed and towards a deeper understand that it is often death caused by a psychiatric/medical condition. Just wanted to share that. Thank you so much for all your great work!!
As always Thank you.
Hi Andrew. I just hope you see this comment.
Please do a series on children & teenagers suffering from psychiatric conditions like intellectual disability, autism, dyslexia etc and how we as parents can ensure maximum neuroplasticity in their learning.
I second this recommendation
Thank for another incredible episode! I'm a massage therapist and would love to see an episode on massage therapy and the effects it can have on the body.
A therapeutic massage on MDMA would be something else lol
Dr. Hubermann, could you please at some point in the future include information about Psychedelics related diseases such as HPPD, visual snow, etc. because I’ve been dealing with them for some time and would love to hear from you, if there was some remedies to help deal with this condition or help the brain heal itself.
Thank you very much!
Wow caught this one early! I am now supplementing creatine and fish oil. It has helped me with pain and inflammation. Thank you so much for the work that you do You have educated a dumb truck driver like myself. To the point where sometimes I am more educated than the people treating me on certain issues lol
Why fish oil and not algae oil. You get the beneficial fatty acids without the heavy metal contamination 😊
Truck driver here too. Please don’t diminish yourself or this great profession. More than often the most uneducated and inexperienced people are those that manage this world we live in, from behind their boring desks. Best regards mate ! Keep on trucking 🤙🏻
@@Carglouche. thank you I do understand that and do not treat people differently based on their profession. However my fellow truck drivers rob my truck when I'm not there. Start fights with customers and embarrass the company often. I often have been treated differently because of my profession. I definitely agree with you and understand where you're coming from.
@@PizzlesTechTime You're welcome. Indeed there are a few bad apples in the industry, but gotta stay proud. Hope you'll find a better company to work for, that is more professional and rewarding. Cheers !
Hi Andrew! It would be really cool if you could do you podcast about grounding (walking barefoot on grass) benefits. Recently it has become really popular, because of the like of Gary Brecka. Was wondering if it really has as much benefit as they say it does and what does the data tell us
Wonderful, thank you for picking up this subject! A small correction though.. at around 22:20 you mention ppl under the influence looking at pictures if faces and interpret them als `less fearful´ as they would normally do. But its not like that. Its that they ´feel less fearful´looking at pictures they would normally find slightly unfriendly or threatening. So the perception and interpretation of other people change towards positive . I had heard the same paper being discussed by Dr. Carter- Harris.
I really appreciate you, Andrew. Thank you!
Ya'll be safe.
Know why your taking a substance. Know where your going to take it
Know who if anyone your going to take it with
And my advice, don't hold on to tightly but don't lose yourself go too far.
Let’s take a moment to appreciate his sucking/puking sound effects. I have cptsd. I was SA’d growing up by my brother. I’m 33 now and of course he still tries to dominate and control me to the point I’ve even abandoned my mother because she will give him my location… and she knew about the SA. I recently discovered he also did the same to my little sisters. Re opening a wound like this just sent me down hard.. I know I should get back in therapy. I did 2 years of trauma therapy: best tool I got was to meditate. But I need help. I’d be a perfect candidate for mdma therapy.
Look into ashwaganda .. sorry to hear about your trauma.. should report him especially if he has children of his own he could be victimizing others.. family members that don’t care for you will cause you recurring trauma if you don’t cut them off . Take care of yourself..
This episode mentions adderall having some kind of isolationist or anti-social side effect and refers back to the previous episode a couple episodes ago on Adderall and other adhd drugs; however, that episode doesn’t talk about this side effect. Will you please tell us more about it? Thank you. You are so generous and helpful. Truly life-changing. Keep up the great work!!!
As far as I remember the episode it wasn't about Adderall being anti social. It was more about making a case that it's not the meth-amphetamine part of MDMA that is responsible for the empathetic, social side of the drug, as the same is not felt in Adderall (an amphetamine)
One of the most brilliant but at the same time never straight to the point man!
Sooo much fluid words with small to no meaning for the general public!
Definitely need someone to summarize it for a dummies like myself
mycotripper1
On instagram
…,¿
started microdosing mushrooms in place of my prescriptions and the difference is night and day in my mental health and my anger i feel like ive become a better person best decision ive ever made wish it was more accessible to those that need
I guess everyone arrives to mushrooms with different expectations. For me it was my eternal search for answers.
mycotripper1
On instagram
……?¿
They have the best shrooms lsd dmt and other psychedelic edibles and ships discreetly.
This is gonna be very interesting. Would love to see one about psilocybin or LSD
We did an episode on psilocybin hubermanlab.com/how-psilocybin-can-rewire-our-brain-its-therapeutic-benefits-and-its-risks/
@@hubermanlab I am a regular viewer of your podcasts and it has immensely helped me.But it is really alarming to see profiles which advertise their psychedelics in comment section and as you know,you don't want this great initiative to take blame on leading clueless teenagers to try it out and go astray.
@@Pompeii123 They don't have control over UA-cam's bot problem. This is a poorly phrased and positioned message if you have legitimate concerns and should be directed at the owner of the service. It is the job of the person reading the comments who sees malicious posts to report so they are removed, until such a time where youtube can handle this issue.
@@Pompeii123 What is he supposed to do? Every YT channel's comments are flooded by bots and scammers, and they make more accounts every time they're deleted.
Thank you Dr.Huberman !!!
I tried MDMA 3 times in the last year, both as pure MDMA crystals and as XTC-pills. Talking only from my own personal experience, it's an amazing drug that has so many beautiful results. The only problem is that it's being abused so much. If you take it responsibly (right doses, right time between doses) and most importantly optimize your recovery after taking it (rest, nutrition, and supplements like 5HTP), I think more people should try it. I don't condone or encourage the use, make the decision for yourself.
Don’t you think you the sole attribution to 5HT1B receptors for MDMA's empathogenic effects is a little dodgy and cherry-picked? Malenka’s 2020 study indeed showed 5-Ht1b antagonism in the NAc abolishes the pro social effects of MDMA in mice. But you seem to dismiss the other serotonin receptors rather directly. However, Kenada’s 2023 study (10.1016/j.ejphar.2023.175653) in mice shows that systemic 5-HT1A antagonism, but not 1B, 2A, 2C, nor 4 antagonism had any effect on MDMA-induced prosocial effects. Specifically, they point to 1A receptors in the basolateral amygdala. This result is well-established in rodents by other papers they cite. However, these models do not translate well across species. Howell's 2017 study (10.1038/npp.2017.80) shows evidence of a dependence on 5-HT2A receptors for MDMA's prosocial effects in primates, with 2C providing the opposite effec, but no effect of 1A. In humans, 1A and oxytocin is seen to have no effect (10.1371/journal.pone.0100719 and 10.1371/journal.pone.0040187), but 2A seems to be indicated. Ketanserin (mixed 2A/2C antagonist) blunts "positive affect" and "emotional excitation," but not "extroversion" or "positive mood" (10.1016/S0893-133X(00)00126-3). In fact, we have 5HT1B agonists used clinically ('triptans') that penetrate the blood brain barrier to high degrees like zolmitriptan (10.1007/s10928-005-9001-1), yet there's no subjective side effect profile of this vs. non-centrally acting triptans. Therefore, don't you agree 5HT1B as a target for MDMA's prosocial effects seems scant? Keep in mind this is just a cursory 15 minute review, but it apparently much more complex than just 1B as you mention. If you were going to just gloss over one serotonin receptor, 2A seems most indicated, at least in humans and primates. Or do you have more counter-evidence to these points that aren't published? I'd love to hear a more in-depth analysis by you/an amendment to this video.
I cannot thank you enough for this incredible resource. As a responsible MDMA user, using it for PTSD and to heal developmental trauma, my previous source of information came from Reddit, which as you know is all anecdotal and mostly bs
As always thanks for your interest in our health 💫
Im all for psychedelics and their potential, but huberman can't promise to discuss risk in the title and only discuss risk for 2 min. Go into some detail please.
I love this podcast it's really informative. I would love for you to cover disc health. My husband and I know many others who have either ruptured, slipped or otherwise have disc degeneration and there seems to be so little one can do to help heal themselves. Too often we seem only to be recommended surgery which I understand has pretty poor outcomes. I would love a toolkit on how to help heal his back, rather than only to treat pain.
I mean he is a neurobiologist so while this topic is interesting, I'm not sure it is his expertise. I would recommend the podcast Drive by (med) Dr Attia for general health questions, he might have an episode on back/spine
Dr. Huberman, I have been listening to your podcast for quite a while now and enjoy everything you put out. Given your domains of expertise, I thought an episode featuring Photic Sneeze Reflex "ACHOO Syndrome" would be incredibly interesting. All of the males on the paternal side of my family have this unique reflex. I would love to hear your thoughts on the mechanisms that make this happen.
Thanks so much for what you do!
I didn't know this was a thing my high school boyfriend used to sneeze every time he went in to kiss me. I thought it was something like the soap I was using.
Very interesting!! So excited you're discussing this. We are so behind in psychiatric medicine. Really sad...Have you seen the recent paper on the theory in depression and how instead of the insula sending signals to the amygdala, it's reversed, going from the amygdala to the insula. Is this new or just another redundant paper with new signatures??❤
Looking foward to the Episode on Ayhuasca! 😄
I smell the spirit of Joe Rogan
You are a very good UA-camr. ❤
Many thanks for giving me hope. Hope is the difference between the awful ideas in my mind and being able to tell those thoughts to f&ck off. Conventional meds for bipolar and trauma were ineffective and the depressive episodes are brutal.
Thank you for this podcast and all your work. Do we know anything about the dependancy of the drug and whether it could, in any case, become an addictive substance?
Pure MDMA never had me feeling bad after. Was always better than before. Whether or not it works, i take 5htp after a roll. Never crashed
same
Never take 5htp without egcg (green tea extract)
@@thefbat5847 whats 5htp?
As someone who’s dealt with some extreme narcissists and the destruction caused by their lack of empathy, I have to wonder if that personality type could benefit from this therapy.
Allows them to actually feel for a few hours? Makes sense to me!
Wow, just Wow! 😍 Thanks Andrew, for this and all of your podcasts. 🥰🤘🏼☀️💖🌸
Neuroscience supported by legitimate consumer mattress advice. Thank you Huberman! I can sleep well and finally my mind is also healthy thanks to this new mattress! Thank you!
Huberman bends over backwards in all these drug episodes to mention he never tried or does them. When he gets to the coke episode he's gonna be like, "Now let me be clear, I LOVE cocaine. I enjoy a nice slug whether it's after the gym, after eating a steak dinner that's high in protein, or when I'm simply just edging for 4 hours straight. It keeps me alert, makes me feel rewarded, and gives me a nice glow all the next day. I can't stress it enough, I love it."