That comment spoke volumes to me. "We don't want to encourage people to take supplements because theoretically anything that increases GABA, Glutamate, Serotonin etc because that system is so delicate that even small changes make a difference in the way our body functions and can easily throw the system even further out of whack so it's better to look at what's causing the imbalances Eg. Chronic stress etc." Replace supplements with antidepressants and after 31 years of chemical intervention and dependency, I would show that statement to anyone thinking of using a chemical crutch first. Pity that wasn't taught to psychiatrists and doctors before they hastily get their prescription pad out.
Thank you. I have neurofibromatosis, TBI due to brain tumor removal surgery as a child, and am 45 with a neurology appointment in 6 hours and I am always teaching the specialists from everything I learn from all of you on here and I have been researching NF since I was around 12-13 years old at the library from the books medical students couldn't even check out, then onto college in 1999 and studying the books there and borrowing from other universities as well.
You’re so welcome. Thank you for your kind words and for watching the video. Remember, you can use DocSnipes.com/Clones for more tips, tools and in-depth information on all things mental health.
When I listened to this I heard sooo much that reflects some of the health issues I’ve been having. I’d already researched and tried a lot of these supplements over the last two years but the way you explained it made it much easier to understand and apply. It may help to understand what’s going on in my body and how to get myself back into balance. Thank you for making this video.
I wish it was that simple to me. Find simplicity like this. I started GABA today. My wife felt asleep from it. i stayed up all night worrying. Glutamate sending signals and GABA shuts em down. Got my blood work today. It was a shock. In one year. My thurood gone 250% up. Never had a problem. My liver gone up 100% in enzymes. I dont drink or smoke. Take 40 vitamins aday. I know I will die. I got hold of Bromantane and NSI-189 plus 9MBC. Took some. My kidney is better. So is my cholesterol and triglyceride bit my liver and thyroid suddenly falling. Found out old doctor lied. Had inflammation for 3 years. From what? Cancer or liver. I started MK-677 recently and its a HGH and I know it can decrease T4 and increase T3 ("controversial) wjt eoild that destroy liver. My glucose is fine. 34mol A1C and 5.7 average glucose. My father was psychologist. Died from Parkinsons on my birthday. I feel the pain in my brain last 3 years are coming from somewhere. I took 750 mg gaba. 37 mg B6 while taking B6 in strongest B complex there exist to buy from Germany. Look into the shutdown of Choline when people take devils breath like scorpolamin. It drcresses choline and explains the infant behavior. Know a guy who got robbed. Suffered still brain damage and memory problems. There is a link there in memory with devils breath and choline. Funny how vomitory medicin shuts down Choline also. No one thoight of this. I experimented with most medicines. I taken up to 20 x 10 mg zolpidem at once. I csn still stay awake for days naturally. Tried to stsy awake 210 hours once. Hallucinations. Drinked 2 glas water only. I was still muscular and lost no real mass. 4-7 kg. Almost died. I wonder if the 2-3 units per night HGH are doing something to me. I even take NAC 800 mg. Didnt work on blood work. Was fine last teo years. Got worse after NAC and MK-677. Xanax feels more light than Rivotril lets say. Thr voice id hypnotic. I should sub. I sm on old phone. Can barely see what I am typing here. Tiny 2 cm writing box. Interesting about amfetamine. I listen to all words and store it while thinking. I have anxiety but is it really? Fear mostly myself. Not others. Just their judgement. This is twisted. What is your take on atypical SSRI like Mirtazipin. Not just serotonin but Nassa. What about glutamate and L-Glutathione? Hence NAC to form it. Glutarhione cycle shapes Synaptic glutamate activity. I am Danish and cant write here. Rare I come across this smart lady talking. Screen is black. Rely on memory when writing. Only hear voice. Sorry my convoluted manifest. Sure Ketamin is zombie drug. Like speed and coke and ecstacy mixed. Keeps going on nothingness. My father had this tremor. Lack of hereof. I believe peoole can think themselves to deterioration. I also thought that Lysine shut down Arginine in building. I think i will get Boron for SHBG and lower E. Then max out T. Already higher T with dutasteride. I take 50 mcg D aday for 20 years and still law low in Scandinavia. No sun. Just darkness here. Aswaganda is slowing and make me pissed. Cant take Ginseng neither. Too much energy. I also taken pure CBD oil. I despise junkies with needles and wounds. I believe however its natural to enhance yourself and biohack. Psychologically self engineering. I lost my creativity as musician. Was famous once. I have no desire for years. Maybe my drive. Yet i am strong and muscular. Alot of anger. Who knows what it is. Maybe this tumor or HG I've started topped original problem. Loved the lecture
Thank you for sharing-it sounds like you’re dealing with a lot of stress, and setting boundaries with your sister Jane might be an important step for your mental health. Family dynamics can be incredibly complex, and it’s not always easy to recognize when distance or limits are needed to protect your well-being. I’m glad the video resonated with you and provided some clarity! If you found it helpful, please consider sharing it-it might help someone else recognize how stress and relationships impact their mood and mental health. Have you thought about specific steps you can take to reduce stress while navigating this situation? Even small actions, like grounding exercises or practicing self-compassion, can make a big difference. You deserve to prioritize your peace!
@@DocSnipes I really want to find a simple study guide that allows me to understand and memorize the neurotransmitters in your chemicals and how they interact with each other so that I can memorize this kind of neuropsychology or neuronomy. Do you have any suggestions on any kind of study guides or material that could help me do so?
Epilepsy is also B6 deficiency. Babies who has epilepsy when bom are B6 dependent. I read a study about.the best way im to correct is B6 B6 suplement. Also pregnant woman who has epilepsy after giving birth are B6 deficiency
This is an amazing video, thank you so much! My sister was taking gabapentin for many years. It then started making her suicidal as each dose wears off so it's extremely difficult for her to discontinue use even with tapering down. She's tried antidepressants without any success, this makes me hopeful that ketmine may assist her in discontinuation.
High levels of glutamate can cause epilepsy seizure, that is why Lamotrygine (epi drug) blocks the overdose of glutamate level that could enter neurons (also ions of Calcium), and modulate sodium channels to balance the neurotransmission... So direct influence of GABA on neurons is not enough to prevent the seizures... sorry but the authority of doctors are questionable and it is good to address it in every suplement/drug recommendation. Xanax is the real dangerous killer if doctors prescribe and recommend it frequently it shows their lack of knowledge or ignorance... sorry but this is a fact. I recommend lamotrigine the best drug that was developed so far for EPI.... Gabapentin is not enough ....
GABA is readily available in health food stores in USA. I was suffering from depression earlier this year and started taking GABA with L- theanine from my health food store. My research showed it takes 2 weeks for the full effect to kick in. Sure enough 14 days later I woke up feeling so much better. I was approved by my Dr. to qualify for counseling from a MFC licensed professional who was also a female and the two combo therapy and supplements got me back on track. It takes 2 full weeks for the supplements to build up in your system but it’s much better than prescription medication which I’ve been on going through a divorce after a 40 year marriage. I highly recommend going through the supplement route VS the prescriptions. Gentler on your system and not addictive as some prescribed medications can be.
Thank you so much Belfast Ireland 🇮🇪 😎 This is really good How you break it down.. It's only right That Gabba It's only right one Positive and negative The Neurons and nervous system are like a plug Belfast Ireland 🇮🇪 😎
How do we find out why certain neurotransmitters are out of whack. It seems like experimenting at small doses of different supplements is the only way to figure it out through trial and error. Your explanations are great, thank you. It's shame not all doctors are as well spoken as you.
Well it depends what your dealing with but fish oil and taurine/b6 are probably the most important supplements for a healthy brain anyone can benefit from them.
Hello Doc. I was a defence counsel of 25 years experience. I had a lot of 'regulars' ie clients who would keep returning - repeatedly. How 'bout this: At the age of 24 - not 23, not 25 - I NEVER saw them again! Also when visiting The Netherlands I spoke with a Probation Officer. She told me that their information that was that the brain only stopped growing at the age of 24. I was surprised but it matched my experience. So very gratifying to hear that again. As an aside I find it gratifying that you focus on the cause, rather than the symptom. Thank you for insights and best wishes from New Zealand.
Great, great, great video. Thank you. So, patients of ALS, have the problem of NOT enough GABA, or too MUCH Glutamate, and therefore, the nerve cell are always in a condition of "exitment" till they get destroied, which causes that the muscles don't get the message from the brain to function. I was wondering why not take GABA supplements and solve the problem? But appatently, it does not go through the brain barier, and the liver destroys the "extra" GABA in the body. Also, the medication that ALS patients receive, is to decrease part of the Glutamate. But, I am wondering, if GABA is made from Gutamate, then destroing the Glutamate, is it not causing the body to produce even less GABA? Then the medication, not only does not help, but causing damage. Am I wrong?
Thank you for watching the video. If the body is destroying or using up glutamate excessively, it can indeed lead to reduced production of GABA. This can result in anxiety and other mood disturbances due to the imbalance between excitatory and inhibitory neurotransmitters. It's important to address the underlying causes of glutamate dysregulation, whether they be stress, nutritional deficiencies, or other factors, to help restore balance and support mental health.
I heard that as neurons are destroyed the contents of the neuron (glutamate) “spill” into the area which destroys more neurons that in turn spill their contents which destroy more neurons and do the cycle continues. If correct that would mean there are chronically elevated levels of glutamate creating an environment of excitotoxicity and this neuro inflammation causes oxidation
Check for Calcium magnesium deficiency. Good supplement by New Roots called Strong Bones. Also hypoglycemia will wake u up. Be sure to eat 3 meals a day. A smoothie with whey protein pop in two caps strong bones spinach or kale (i keep frozen) blueberries, bananas, psyllium fiber and a T collagen plus 1 tsp progressive greens (good taste not fishy). Brown Rice salad with veggies, boiled egg few walnuts avocado fresh lemon olive oil. 2 caps strong bones. Hearty turkey soup toast. Ginger cookie with molasses good bone broth and minerals. Helps make serotonin. Vit D 5000 is perday in divided amts based on location to sun. First 10 min no sunscreen. I hour before bed order Melatonin plus Ltheanine and 5HTP. Chewable by weber naturals. If over 40 take 1 Weber B12 Vit 6 and Folic Acid. Combo. at noon. I am a Holistic Nutritionist. Hope this helps you.
Hey, I was wondering if I could ask you a question: I feel like my glutamate and or GABA system is very, very out of balance as I don’t feel right, and I also can’t feel the psychoactive effects of drugs *whatsoever* and I’m talking prescriptions or recreational drugs regardless of dose. The only drugs that work are other GABA drugs, and partially some of the physical side effects of others, but no mental effect at all. This issue occurred after taking phenibut daily for 3 years (3G a day). phenibut is a VGCC blocker, and a GABA-B agonist. Think of it as essentially gabapentin combined with baclofen. I tapered off phenibut verrrrry slowly to 500MG, then swapped to 300MG of gabapentin, and I’ve now been on the gabapentin for a year, and it’s nearly impossible for me to taper off it. If I try to reduce the dose I become very depressed, lethargic, sleep in all day long, feel sick, just really awful. My thought here is that my glutamate system was inhibited for far too long, and that’s why other prescriptions or psychoactive drugs have no effect on me. The only drugs that work are other GABA drugs, however that’s it. I cannot feel any of the psychoactive effects of any other drugs, and I believe the same reason that is occurring is also why I don’t feel good. You could give me 50MG of morphine or 100MG of adderall and I wouldn’t feel any mental effects from it despite having no tolerance. I might feel some physical effects / side effects, but nothing mentally. Do you have any idea why taking phenibut would cause this problem? I’ve never heard of anyone else experiencing this. Can you lead me in the right direction for where I could learn more about how this could be occurring? I’ve done countless hours trying to learn more, but I can’t find anything. I’m thinking about getting on the keto diet as I hear it can significantly help regulate the GABA system, and hopefully that will help me get off gabapentin as I assume it’s the gabapentin that’s screwing me up. It appears the gabapentin is almost giving me a paradoxical effect. I feel kind of OK when taking it, but if I were to take any more than 300MG it will make me feel worst.
Nice video, at 16:03 Magnesium, is a macro mineral, not a vitamin. It is not found in sufficient levels particularly with people consuming a Group 4, UPF diet. I have had great success with hundreds using both Mg. GABA and also key amino acids, also HTMA to find tissue levels are affordable and put the power back in my client's hands. Cacao is less processed than cocoa.
I have been tested positive with a Babinski sign. I do have a celiac disease disease and a neurodegenerative one which affect the pyramidal tract. Is there any way that I can be tested for these neurotransmitters?
addiction(mainly alcohol ) increases GABA and then after effects get over your body will crave for it again ! and ultimately you fall in the loop and will lower your GABA
@@DocSnipes your not well versed in that but you advised against taking it earlier? I think i have everything wrong with me lol. Thanks for the video. It does help me better understand SOME things. Still dont know wtf is wrong with me though lol
None. I've just finished a diazepam taper. I had to reinstate after seven months of hell. Then a seven month taper from 20 mg of diazepam. There is a list of herbal products and medications to avoid. You can obtain the list online. It's quite extensive and traumatic..
@@waynegrow hi thanks for thecreply I have 0.25 to go yes they tell me I can jump but just going to be sure so stay on .25 valium few days then jump... can ya tell me what to Google I take taurine l - theaine glycine vit c.. - Now I am a client of Dr Cain and she a big fan of avena sativa .. so but I understand stand Hiw you deal with sleep issues thanks
@@garysimone4977 I would stay on that dose of diazepam for at least two weeks then jump. I handled the 1 mg drops from 8mg down to 2mg then I went half mg drops every two weeks. Every is different though. You've made it though and we'll done. You're through the worst. I do advise any surgical procedures need to be analysed. Like any thing that acts on gaba. Which is most things. I need dental surgery in the near future gases like propofol and midazolam will act on gaba and other gases. Just warning people that need general anesthesia beware. Do your homework and seek professional advice from an anesthetist.
@@waynegrow yes I saw that list but that was 30 yr old list .. it gets confusing Dr Cain uses avena sativ l -theanie glycine inositol in her protocol as reports of dhea and more recently a report out of England list 5 herbs i never heard off so Doescanyone really know since we are all so different ?? All I know is I have no answers ..
@@DocSnipes I suspect that's what happened to me, I took some and am now dealing with terrible symptoms. How long do you think it takes for gaba and glutamate to naturally normalize?
Systematically evaluating the system. Start with sleep hygiene for example and begin checking off potential issues. ua-cam.com/video/2ixWgVYMWKw/v-deo.html
I am sorry about that. What was the cause of his neurotransmitters imbalance? Here are the videos on dopamine: ua-cam.com/users/DocSnipessearch?query=dopamine
Amazing performance and presentation. I'm interested to know your insight on this, I've experienced increases in calmness and less movements and tics when I purposefully focus on trying to calm myself down, my question is, can we increase the levels of gaba and other neurotransmitters by our thougts alone? Like feeling gratitude for serotonin too?
Fermentation is hugely important & missing from the modern diet both in the foods we eat & the gut. Traditional diets fermented or sprouted grains & legumes before eating. Hominy instead of plain corn. Legumes can chelate essential minerals from the body. Gut bacteria are destroyed by many things in the modern world: chlorine in water, pasteurized foods, antibiotics. Grass fed meats are needed.
Gabapentin after some times taking it causes long term memory lapses like PIN for ATMs. This is disturbing & be prepared. Not only this happened to me but also to my doctor of 35 years. I had to stop Gabapentin .....
Just a clean diet . There is a list online tells you what to avoid. Herbals and medicinals. Just eat clean. Your receptors are downregulated they don't need gaba supplements they need to unregulate naturally. You could introduce some products down the line but not recommend at the early stages.
Valproic acid is often used as a mood stabilizer, particularly in the treatment of conditions like bipolar disorder and certain types of seizures. It works by affecting neurotransmitters, especially by increasing the levels of GABA (gamma-aminobutyric acid) in the brain, which is an inhibitory neurotransmitter. By boosting GABA, valproic acid helps to calm overactivity in the brain, which can be particularly helpful for stabilizing mood and reducing manic or hypomanic episodes. At the same time, valproic acid also impacts glutamate, which is the brain’s main excitatory neurotransmitter. By balancing these two neurotransmitters-GABA, which calms the brain, and glutamate, which excites it-valproic acid can help manage mood swings and prevent the overstimulation that might lead to episodes of mania or other mood disturbances. If you’re considering this medication or are curious about it, it’s always a good idea to consult with a healthcare professional to understand how it fits into your treatment plan and how it might interact with other neurotransmitter systems. Thanks for your question!
Question for the Gaba and taking amfetamines in before developing brain,24, as GABA is an excitatory chemical. 1. It still is produced from glutamate, but then what is the calming chemical that works to balance things out? I remember I was taking melatonin to fall asleep for many years And if the endocannabinoids system is not working because of no adequate diet of omega 3 and 6 fatty acids (anorexia and bulimia ) from 15 to 23 years of age, then clear depression, anxiety and anger ...happening because many of the main chemicals are not happening ? Ps. Can the endocannabinoid system be recovered fully?
"During early brain development, GABAA first acts as an excitatory neurotransmitter due to a higher intracellular than extracellular Cl− concentration, and subsequently changes its action to inhibitory due to a reduction of intracellular Cl− levels after the first postnatal week (Cherubini et al., 1991; Rivera et al., 1999)."
At the beginning she said not enough GABA is bc there's not enough Glutamate which is made from L Glutamine. I'm sure there are other causes but I know she said that.
Vitamin B3 probably wouldn't do much for Glutamate as Glutamate dehydrogenenase only really makes Glutamate when ammonia levels are too high. Most Glutamate is produced from glutamine through the enzyme Glutaminase.
Do we know if gray matter correlates with orientation dispersion of neurites? Does gray matter reduce arborization and prune dendritic clusters oriented between brain nodes, in-turn causing a direct more lawful one to one connection between brain nodes - with less dispersal? Or does gray mattet make this happen less?
The relationship between gray matter and the orientation dispersion of neurites, as well as its influence on arborization and dendritic pruning, is a complex topic that intersects with various aspects of neuroscience. Gray matter in the brain is primarily composed of neuronal cell bodies, dendrites, and unmyelinated axons, along with glial cells and capillaries. It plays a crucial role in processing information in the brain. Orientation dispersion refers to the variation in the alignment of neurites (axons and dendrites) in the brain's white matter. It's a measure used in diffusion MRI to assess the complexity of brain tissue microstructure. Gray matter's role in this context is less direct, as orientation dispersion is more commonly discussed in relation to white matter. Regarding arborization and dendritic pruning, these are processes that occur during brain development and throughout life as the brain adapts to experiences. Arborization refers to the growth and branching of dendrites, which increases the number of synaptic connections. Dendritic pruning is the process by which extra neurons and synaptic connections are eliminated over time, which is essential for the brain's maturation and the development of efficient neural networks. Gray matter is not typically described as reducing arborization or pruning dendritic clusters in a way that would cause a more direct, one-to-one connection between brain nodes. Instead, gray matter density and cortical thickness can reflect the balance between processes like neurogenesis, synaptic formation, and pruning. These processes are influenced by a variety of factors, including genetics, environmental influences, and overall brain health. It's important to note that the brain is highly plastic, meaning it can reorganize itself by forming new neural connections throughout life. This plasticity allows the brain to compensate for injury and adjust to new learning and experiences. Factors such as stress, hormones, and lifestyle can impact neurogenesis and the health of neurons, potentially affecting the brain's structure and function over time. If you're interested in a deeper understanding of how various factors influence brain health and neuroplasticity, l discuss these topics in my videos, such as "Trauma Related Brain Damage Glutamate and Neurotoxicity" and "How Trauma Reprograms the Vagus Nerve & Orienting Reflex | Healing from Trauma." In summary, while gray matter is essential for processing information in the brain, its relationship with orientation dispersion of neurites and its direct effect on arborization and dendritic pruning is complex and influenced by a multitude of factors. Understanding these processes requires a multifaceted approach that considers the dynamic and interconnected nature of brain development and function. You can search for the videos I recommend or learn more for FREE at allceus.com/AskDocSnipes.
Low Glutamate and GABA together could have a negligible effect on blood pressure. I would look at other potential causes rather than focus specifically on the Glutamatergic cycle here, unless you have other evidence to suggest severe issues with your Glutamatergic cycle.
Hi Boris Remove MSG (Monosodium Glutamate) from your diet. Since I see your name and surname I believe, that you are from Adriatic region of the Europe. So do not eat artificial MSG E-numbers from E-620 to E-625 To help you a bit more, Podravka Vegeta and Maggi Wurtze are not for you anymore. Wish you all the best in the future. Br, M
Do you do private consultations? I am in rock bottom since taking L glutamine for a few days. I'd love to talk to you and ask you some questions. Please message me if you can
I wonder if too much serotonin can cause a GABA deficiency. I take Prozac [40 mg] and it seems it increases my anxiety. I.E. I have to take more Klonopin.
What if you see addiction in your direct family as well as previous generations, and anxiety disorders in siblings and generation above? There seems to be possibly neurotransmitter related issues in both my parents’ bloodlines including myself now. What kind of possible “leak” would there be in such a case?
@@lexsea98I just picked up some glutamine and for the first time in my whole life, I’m alert 30m after waking. Typically I slowly woke up. About 11 it felt like I was fully awake. I’m shook, this is amazing.
You'd have to know that your levels of glutamine are fine, which as she said they probably are. In which case, there may be a mutation preventing natural production of Glutaminase, the enzyme responsible for converting glutamine into Glutamate. Adding additional glutamine to such a system could have some effect, but I've found amphetamines (legally prescribed as part of ADHD treatment) work well for boosting natural production of Glutamate. Unfortunately, due to the blood-brain barrier, there really aren't any supplemental options for Glutamate, if your body just doesn't produce the glutaminase.
Olanzapine destructs Krebs cycle. So GABA becomes even more non adequate. Solution? To improve your Oxydation. High pressure (sea level) and dense oxygen level (rural areas). We have two strong cellular mechanisms: 1- is mithocondrial 2- lysosomal. By applying Keto diets for ex (fat diets) you target fatty acids and those acids are used for lysosomal destruction (of bad stuff). Evolution will lower the shift from GABA to Glutamate eventually, but we still need to prevent auto-immune to corrupt GAD conversion to stay sane and safe. Good video but unsatisfactory ending.
Its interesting that you mention sex hormones at the beginning of this video. Male sex hormones are almost totally ignored when dealing with males and mental health issues. Actually many health organizations around the world seem to be pushing hard against any use of testosterone at all for man, when optimal testosterone levels in men have many health benefits not just in mood but also preventing diabetes, improving cardiovascular health to name just a few. Greatly overlooked in men but of great benefit. Too much ignorance and scare mongering when it comes to testosterone as its commonly believed but false that testosterone causes heart attacks, cancer, lowers immunity etc but if one digs into the research they will find the opposite. Out of all the treatments in reguards for neurotransmitters and hormones, testosterone should ne top of the list for many men and will help fix a multitude of problems before even considering many psychiatric drugs.
@@StardropSmoothie if testosterone is bad for a mans health why isnt there high rates of heart disease and cancer in younger males with high testosterone levels. The increased rates of heart disease and cancer are in men with lower testosterone and increasing levels of estrodiol who are 40 yo or older. Their hormone levels drop and health issues increase. Similar to women, when they hit menopause their risks of heart disease increase. It would be safer for a man to going on TRT then not to put them on cholesterol meds, antidepressants, pain killers and sleep meds. So many health people confuse testosterone with steroid such as cortisone. Because cortisone decreases immunity doesnt mean testosterone replacement to a healthy level is immunosuppressive, if that was the case young men would have suppressed immune function and catching many infections. Increased Cholesterol is another myth about using physiological doses of testosterone. A smart cardiologist realises low testosterone is a big cardiac risk, increasing it to normal range is beneficial and cardio protective. Testosterone and anabolic steroids are what kept many hiv pts alive before anti retroviral drugs were available, they had very compromised immune system and theres research showing increased immune function after steroid treatment.
I couldn't agree more. In fact my own experience of depression stemmed from quite an extreme drop in T levels between 43 and 45 years of age, although i didn't know it and spent 2 anxiety and angst-ridden years trying to figure out what the hell happened to me. My mood and my sense of well-being went over a cliff! It almost wrecked my life. After many attempts to pyscho-analyse myself back to 'normality' i eventually read something about Testosterone and mood and went to have it checked with a good endocrinologist. However she said your T is about 350 so quite good for a man your age. I had no hypogonadism, so in her opinion it wasn't T deficiency. She was wrong. The range for men for normal T is approx 250 -1100 which is a very wide range and when I took some natural supplements and a couple of other key actions to boost T and reduce oestrogen also [which reduces your available T levels] like magic my mood, optimism, sense of vitality returned me to where I was before my two years of hell. And when I got my T measured three months later it was at 850. So all of this info is available elsewhere on UA-cam, however my small addition to this gradually building folk knowledge, and which I haven't seen elsewhere is this: One of the major challenges in someone who was mentally [relatively] healthy all their life and is suddenly in deep anxiety and depression is the huge shock that the change causes which in turn can then lead to a vicious cycle downwards. So it's not just the descent, it's the speed and strength of the decent, that can really traumatise us. In short, 'normal' levels of T are different for everyone and mine was clearly around 850 approx [as at 850 i feel exactly the same as I did at 42 years old - not stronger, not more positive - just the same] so then a drop to 250 would've been huge and had a huge impact on my psyche and sense of self, much more than if it had gradually gone down by the expected average of 1-2% per year. Why it went down by so much and so quickly is another story for another time, but it went over a cliff and almost brought me over the cliff with it. If this reply is for you I'm glad - if not, let it pass... PS. There is no conspiracy to lower T in males - in fact females need T also. Rather it is the oestrogen saturated environment we now live in, which at the same time has produced and stored more food so that more people can stay alive, which is depriving us of our essential T. To take one small step to counteract that, consider eating a lot of cauliflower and broccoli, or take a DIM supplement to help metylate estrogen and maintain a strong detoxed liver [even with alcohol consumption you can do that if you are careful] and watch what happens. Good luck
It's not testosterone that's being downplayed by the medical profession. Its hgh. Essentially everything has to be in balance. But you can't pill pop your way to a healthy life. I'm 36 now my experience is excercise and strengthening the body has a drastic positive impact on the body and mind. You increase testosterone naturally, especially with lower body excercises like squats. You don't need a gym membership or expensive equipment. I got ripped and healthy from my own home. Utilizing my own body weight. Nutrition and exercise is the foundation. Consistency the key. You'll soon notice you don't need half of these supplements that you THINK you need.
Good things I learned from you doctor.Mediterranean diet is the key of our health no vegans or keto good for us moderate is the key away from supplements
In my subjective experience, if your nervous system leans more to glutamatergic firing rather than GABA, I’d be very observant in regard to norepinephrine and dopamine re-uptake in SNRI medication. NE and DA promote more glutamatergic firing.
@@DocSnipes LOVE your videos. I’m sure nicotine increases GABA. I use it for my ASD and I like it. High doses I get sensory overload, which probably decreases GABA (FOR ME). I use the vape… Also, ashwagandha ;)
Glutamic acid in foods is important for everyone to eat it does not cause excess glutamate in the brain as it does not cross the blood brain barrier and the body regulates how much glutamate it needs the rest is excreted. To Make GABA we need to eat foods HIGH in gluatamates so bring on the proteins, parmesan cheese, mushrooms and everything high in glutamic acid.
Doesn't food high in gluten excite the brain? Ice recently tapered off diazepam and had a pizza the other day and my sleep was non existent. My gaba receptors are still downregulated therefore any foods high in gluten would affect the upregulation of my gaba receptors..
Amazing seminar....the complexity and coherence of neurotransmiters has been clearly described. Please extend the role of glutamine and influence of sensory neurotransmission (lack of sense of touch). Great video. . But it was not mentioned that; High levels of glutamate can cause epilepsy seizure, that is why Lamotrygine (epi drug) blocks the overdose of glutamate level that could enter neurons (also ions of Calcium), and modulate sodium channels to balance the neurotransmition... So direct influence of GABA on neurons is not enough to prevent the seizures... sorry but the authority of doctors are questionable but it is good to address it in every suplement/drug recommendation. Xanax is the real dangerous killer if doctors use this frequently it shows theit lack of knowledge or ignorance... sorry but tis is a fact. The interactions of drugs should be focused on balancing and indirect effect.
Anti nutrients cause alot of issues, 99% of nutrition books and courses hardly touch this topic. You never mentioned how ms and spasms can be the cause of mental issues.
wow... @Gary Simone you didn't even ask a specific question earlier. I see her responding just not to you. Your question said..."can 'this' be used..." without saying what the 'this' is lol.... this video wasn't about any 'one' thing. That said, my recommendation would be to taper down followed up with ketamine treatment and supplementation.
That comment spoke volumes to me. "We don't want to encourage people to take supplements because theoretically anything that increases GABA, Glutamate, Serotonin etc because that system is so delicate that even small changes make a difference in the way our body functions and can easily throw the system even further out of whack so it's better to look at what's causing the imbalances Eg. Chronic stress etc."
Replace supplements with antidepressants and after 31 years of chemical intervention and dependency, I would show that statement to anyone thinking of using a chemical crutch first. Pity that wasn't taught to psychiatrists and doctors before they hastily get their prescription pad out.
What about valproic acid ?
Thank you. I have neurofibromatosis, TBI due to brain tumor removal surgery as a child, and am 45 with a neurology appointment in 6 hours and I am always teaching the specialists from everything I learn from all of you on here and I have been researching NF since I was around 12-13 years old at the library from the books medical students couldn't even check out, then onto college in 1999 and studying the books there and borrowing from other universities as well.
You’re welcome. I am sorry you are struggling with NF and I appreciate you watching the video
One of the most useful videos on the internet. Much thanks.
You’re so welcome. Thank you for your kind words and for watching the video. Remember, you can use DocSnipes.com/Clones for more tips, tools and in-depth information on all things mental health.
I did enjoy the realistic approach of Gaba, and other Siblings .Great video!!!
Thank you!
@@DocSnipes Welcome!
When I listened to this I heard sooo much that reflects some of the health issues I’ve been having. I’d already researched and tried a lot of these supplements over the last two years but the way you explained it made it much easier to understand and apply. It may help to understand what’s going on in my body and how to get myself back into balance. Thank you for making this video.
You are so welcome. 😀😀
I wish it was that simple to me. Find simplicity like this. I started GABA today. My wife felt asleep from it. i stayed up all night worrying. Glutamate sending signals and GABA shuts em down. Got my blood work today. It was a shock. In one year. My thurood gone 250% up. Never had a problem. My liver gone up 100% in enzymes. I dont drink or smoke. Take 40 vitamins aday. I know I will die. I got hold of Bromantane and NSI-189 plus 9MBC. Took some. My kidney is better. So is my cholesterol and triglyceride bit my liver and thyroid suddenly falling. Found out old doctor lied. Had inflammation for 3 years. From what? Cancer or liver. I started MK-677 recently and its a HGH and I know it can decrease T4 and increase T3 ("controversial) wjt eoild that destroy liver. My glucose is fine. 34mol A1C and 5.7 average glucose. My father was psychologist. Died from Parkinsons on my birthday. I feel the pain in my brain last 3 years are coming from somewhere. I took 750 mg gaba. 37 mg B6 while taking B6 in strongest B complex there exist to buy from Germany. Look into the shutdown of Choline when people take devils breath like scorpolamin. It drcresses choline and explains the infant behavior. Know a guy who got robbed. Suffered still brain damage and memory problems. There is a link there in memory with devils breath and choline.
Funny how vomitory medicin shuts down Choline also. No one thoight of this. I experimented with most medicines. I taken up to 20 x 10 mg zolpidem at once. I csn still stay awake for days naturally. Tried to stsy awake 210 hours once. Hallucinations. Drinked 2 glas water only. I was still muscular and lost no real mass. 4-7 kg. Almost died. I wonder if the 2-3 units per night HGH are doing something to me. I even take NAC 800 mg. Didnt work on blood work. Was fine last teo years. Got worse after NAC and MK-677. Xanax feels more light than Rivotril lets say. Thr voice id hypnotic. I should sub. I sm on old phone. Can barely see what I am typing here. Tiny 2 cm writing box.
Interesting about amfetamine. I listen to all words and store it while thinking. I have anxiety but is it really? Fear mostly myself. Not others. Just their judgement. This is twisted. What is your take on atypical SSRI like Mirtazipin. Not just serotonin but Nassa. What about glutamate and L-Glutathione? Hence NAC to form it. Glutarhione cycle shapes Synaptic glutamate activity.
I am Danish and cant write here. Rare I come across this smart lady talking. Screen is black. Rely on memory when writing. Only hear voice. Sorry my convoluted manifest. Sure Ketamin is zombie drug. Like speed and coke and ecstacy mixed. Keeps going on nothingness. My father had this tremor. Lack of hereof. I believe peoole can think themselves to deterioration. I also thought that Lysine shut down Arginine in building. I think i will get Boron for SHBG and lower E. Then max out T. Already higher T with dutasteride. I take 50 mcg D aday for 20 years and still law low in Scandinavia. No sun. Just darkness here. Aswaganda is slowing and make me pissed. Cant take Ginseng neither. Too much energy. I also taken pure CBD oil. I despise junkies with needles and wounds. I believe however its natural to enhance yourself and biohack. Psychologically self engineering. I lost my creativity as musician. Was famous once. I have no desire for years. Maybe my drive. Yet i am strong and muscular. Alot of anger. Who knows what it is. Maybe this tumor or HG I've started topped original problem. Loved the lecture
Beautifully explained thanks for sharing madam blessings
My pleasure 😊
Thanks!
You’re most welcome! Thank you!
Some great takeaways from this. Thank you for posting this presentation. Extremely well explained 👍
You’re most welcome. Thanks for watching
This is SO much easier for me (a patient) to grasp. Ty
Very clear explanation, with relevant examples! Thank you for your work!
You're very welcome!
14:08 to 14:28 sums up what everyone needs to do. Extremely important
Thanks for watching. Other videos you might be interested in can be found at ua-cam.com/users/DocSnipessearch?query=neurotransmitters
You’re such a great explainer! Thank you for your work!
You’re so welcome. I am grateful to be of help and I appreciate you watching the video. What did you find most useful from it?
Getting away from my sister Jane will be the best thing ever!! Soooo Stressed!! Thanks for your advice! Spot on!!!!
Thank you for sharing-it sounds like you’re dealing with a lot of stress, and setting boundaries with your sister Jane might be an important step for your mental health. Family dynamics can be incredibly complex, and it’s not always easy to recognize when distance or limits are needed to protect your well-being. I’m glad the video resonated with you and provided some clarity!
If you found it helpful, please consider sharing it-it might help someone else recognize how stress and relationships impact their mood and mental health.
Have you thought about specific steps you can take to reduce stress while navigating this situation? Even small actions, like grounding exercises or practicing self-compassion, can make a big difference. You deserve to prioritize your peace!
I have two sisters that I stay away from….😂😂😂
This is the perfect lecture subject. Thank you!
You’re most welcome. I appreciate you watching
@@DocSnipes I really want to find a simple study guide that allows me to understand and memorize the neurotransmitters in your chemicals and how they interact with each other so that I can memorize this kind of neuropsychology or neuronomy. Do you have any suggestions on any kind of study guides or material that could help me do so?
Epilepsy is also B6 deficiency. Babies who has epilepsy when bom are B6 dependent. I read a study about.the best way im to correct is B6 B6 suplement. Also pregnant woman who has epilepsy after giving birth are B6 deficiency
Thanks for watching.
Really appreciate this it is extremely informative and easy understandable to a layman
Great to hear! Thank you for watching
After years of trying tons of supplements, etc. weight lifting and some biking fixed it all.
That’s awesome news! I appreciate you watching :)
Can you please explain how to get out of benzo medications and handle withdrawal symptoms , without damaging the brain nerve ?
Good question. Have same question for alcohol withdrawal
@@mattjones6323 Exercise and sleep will do wonders.
15:15 You forgot Taurine necessary for glutamic acid decarboxylase required for the GABA-glutamine cycle
this is helpful, thank you. Taurine seems to be the only one that works for me in this regard. B6 helps somewhat.
Delicate balance in Neurotransmitters is essential for wellbeing and to overcome depression.
Thanks for watching.
What kind of a doctor would you see to find these brains levels?
This is an amazing video, thank you so much! My sister was taking gabapentin for many years. It then started making her suicidal as each dose wears off so it's extremely difficult for her to discontinue use even with tapering down. She's tried antidepressants without any success, this makes me hopeful that ketmine may assist her in discontinuation.
You can stop anything with ketamine
@@billydamnit you can't with benzodiazepines. Can only get off a benzo with a benzo. Not sure even Black tar heroin and alcohol will suffice.
High levels of glutamate can cause epilepsy seizure, that is why Lamotrygine (epi drug) blocks the overdose of glutamate level that could enter neurons (also ions of Calcium), and modulate sodium channels to balance the neurotransmission... So direct influence of GABA on neurons is not enough to prevent the seizures... sorry but the authority of doctors are questionable and it is good to address it in every suplement/drug recommendation. Xanax is the real dangerous killer if doctors prescribe and recommend it frequently it shows their lack of knowledge or ignorance... sorry but this is a fact. I recommend lamotrigine the best drug that was developed so far for EPI.... Gabapentin is not enough ....
@@konradzlu5h 100% correct
zinc picolinate, magnesium help
Great video
Very comprehensive!
Thank you so much for watching. What is your favorite tip from the video?
Excellent presentation.
Thanks for watching
Super informative, thanks!
I appreciate you watching
At 15:06, ive read that hops and barley grass can boost gaba too. Now Foods has a gaba supplement, but those supplements are illegal in the UK.
Thanks for watching
GABA is readily available in health food stores in USA. I was suffering from depression earlier this year and started taking GABA with L- theanine from my health food store. My research showed it takes 2 weeks for the full effect to kick in. Sure enough 14 days later I woke up feeling so much better. I was approved by my Dr. to qualify for counseling from a MFC licensed professional who was also a female and the two combo therapy and supplements got me back on track. It takes 2 full weeks for the supplements to build up in your system but it’s much better than prescription medication which I’ve been on going through a divorce after a 40 year marriage. I highly recommend going through the supplement route VS the prescriptions. Gentler on your system and not addictive as some prescribed medications can be.
But if you have a Methylation problem then Glutamate won’t be converted into GABA
Thank you so much
Belfast Ireland 🇮🇪 😎
This is really good
How you break it down..
It's only right
That
Gabba
It's only right one
Positive and negative
The Neurons and nervous system are like a plug
Belfast Ireland 🇮🇪 😎
I appreciate you watching the video :)
How do we find out why certain neurotransmitters are out of whack. It seems like experimenting at small doses of different supplements is the only way to figure it out through trial and error. Your explanations are great, thank you. It's shame not all doctors are as well spoken as you.
So welcome! Thank you for watching!
Well it depends what your dealing with but fish oil and taurine/b6 are probably the most important supplements for a healthy brain anyone can benefit from them.
@@agentbertmacklin9880 I'm pretty sure taking too much B6 is not always safe?
@@M_K_M_K_M_K can be… sometimes the difference between medicine and poison is the dosage
@@agentbertmacklin9880 True! Just a little warning for people who want to just throw in a supplement without realizing this :).
Is it safe to take gaba everyday everyday
thank you
so much
Welcome!
How about your gut-health and how it controls your brain
What if somebody has polymorphisms on glutamate genes that predispose them to high glutamate and feels a lot better taking L-theanine for the GABA?
It in matcha green tea natually
Hello Doc. I was a defence counsel of 25 years experience. I had a lot of 'regulars' ie clients who would keep returning - repeatedly. How 'bout this: At the age of 24 - not 23, not 25 - I NEVER saw them again! Also when visiting The Netherlands I spoke with a Probation Officer. She told me that their information that was that the brain only stopped growing at the age of 24. I was surprised but it matched my experience. So very gratifying to hear that again.
As an aside I find it gratifying that you focus on the cause, rather than the symptom.
Thank you for insights and best wishes from New Zealand.
Thanks for watching from NZ.
Great, great, great video. Thank you. So, patients of ALS, have the problem of NOT enough GABA, or too MUCH Glutamate, and therefore, the nerve cell are always in a condition of "exitment" till they get destroied, which causes that the muscles don't get the message from the brain to function. I was wondering why not take GABA supplements and solve the problem? But appatently, it does not go through the brain barier, and the liver destroys the "extra" GABA in the body.
Also, the medication that ALS patients receive, is to decrease part of the Glutamate. But, I am wondering, if GABA is made from Gutamate, then destroing the Glutamate, is it not causing the body to produce even less GABA? Then the medication, not only does not help, but causing damage. Am I wrong?
Thank you for watching the video. If the body is destroying or using up glutamate excessively, it can indeed lead to reduced production of GABA. This can result in anxiety and other mood disturbances due to the imbalance between excitatory and inhibitory neurotransmitters. It's important to address the underlying causes of glutamate dysregulation, whether they be stress, nutritional deficiencies, or other factors, to help restore balance and support mental health.
I heard that as neurons are destroyed the contents of the neuron (glutamate) “spill” into the area which destroys more neurons that in turn spill their contents which destroy more neurons and do the cycle continues. If correct that would mean there are chronically elevated levels of glutamate creating an environment of excitotoxicity and this neuro inflammation causes oxidation
Great work! Thanks Dr!
very nice lecture
Thank you. I appreciate you watching the video
Amazing video thank you so much.
Welcome
I tried Gaba, but not sure yet, I just seem to wake up at between 12.30am to 3am fully awake 🙏🙏Help me Lord
Check for Calcium magnesium deficiency. Good supplement by New Roots called Strong Bones. Also hypoglycemia will wake u up. Be sure to eat 3 meals a day. A smoothie with whey protein pop in two caps strong bones spinach or kale (i keep frozen) blueberries, bananas, psyllium fiber and a T collagen plus 1 tsp progressive greens (good taste not fishy). Brown Rice salad with veggies, boiled egg few walnuts avocado fresh lemon olive oil. 2 caps strong bones. Hearty turkey soup toast. Ginger cookie with molasses good bone broth and minerals. Helps make serotonin. Vit D 5000 is perday in divided amts based on location to sun. First 10 min no sunscreen.
I hour before bed order Melatonin plus Ltheanine and 5HTP. Chewable by weber naturals.
If over 40 take 1 Weber B12 Vit 6 and Folic Acid. Combo. at noon. I am a Holistic Nutritionist. Hope this helps you.
Go to the your medical doctor 🏥
I am now on Melatonin and works fantastic... Praise God 🎼 🎶 👏
Hey, I was wondering if I could ask you a question: I feel like my glutamate and or GABA system is very, very out of balance as I don’t feel right, and I also can’t feel the psychoactive effects of drugs *whatsoever* and I’m talking prescriptions or recreational drugs regardless of dose. The only drugs that work are other GABA drugs, and partially some of the physical side effects of others, but no mental effect at all.
This issue occurred after taking phenibut daily for 3 years (3G a day). phenibut is a VGCC blocker, and a GABA-B agonist. Think of it as essentially gabapentin combined with baclofen.
I tapered off phenibut verrrrry slowly to 500MG, then swapped to 300MG of gabapentin, and I’ve now been on the gabapentin for a year, and it’s nearly impossible for me to taper off it. If I try to reduce the dose I become very depressed, lethargic, sleep in all day long, feel sick, just really awful.
My thought here is that my glutamate system was inhibited for far too long, and that’s why other prescriptions or psychoactive drugs have no effect on me. The only drugs that work are other GABA drugs, however that’s it. I cannot feel any of the psychoactive effects of any other drugs, and I believe the same reason that is occurring is also why I don’t feel good. You could give me 50MG of morphine or 100MG of adderall and I wouldn’t feel any mental effects from it despite having no tolerance. I might feel some physical effects / side effects, but nothing mentally.
Do you have any idea why taking phenibut would cause this problem? I’ve never heard of anyone else experiencing this. Can you lead me in the right direction for where I could learn more about how this could be occurring? I’ve done countless hours trying to learn more, but I can’t find anything.
I’m thinking about getting on the keto diet as I hear it can significantly help regulate the GABA system, and hopefully that will help me get off gabapentin as I assume it’s the gabapentin that’s screwing me up.
It appears the gabapentin is almost giving me a paradoxical effect. I feel kind of OK when taking it, but if I were to take any more than 300MG it will make me feel worst.
Hi there. Would this work for pssd
Nice video, at 16:03 Magnesium, is a macro mineral, not a vitamin. It is not found in sufficient levels particularly with people consuming a Group 4, UPF diet. I have had great success with hundreds using both Mg. GABA and also key amino acids, also HTMA to find tissue levels are affordable and put the power back in my client's hands. Cacao is less processed than cocoa.
Thanks for watching
Great! Thanks
You’re most welcome. Thanks for watching the video
I have been tested positive with a Babinski sign. I do have a celiac disease disease and a neurodegenerative one which affect the pyramidal tract. Is there any way that I can be tested for these neurotransmitters?
Does addiction lower gaba levels ?
addiction(mainly alcohol ) increases GABA and then after effects get over your body will crave for it again ! and ultimately you fall in the loop and will lower your GABA
Yes alochol and caffeine and porn and nicotine
For gaba supplements should I start if. With 100 mg or go to a higher dose like 500mg right away
Thanks for watching! I don't feel well versed enough in the subject to give that particular advice.
@@DocSnipes what do you mean I’m confused on what are you talking about
@@DocSnipes your not well versed in that but you advised against taking it earlier? I think i have everything wrong with me lol. Thanks for the video. It does help me better understand SOME things. Still dont know wtf is wrong with me though lol
What possible supplements can help with Benz WD ???
None. I've just finished a diazepam taper. I had to reinstate after seven months of hell. Then a seven month taper from 20 mg of diazepam. There is a list of herbal products and medications to avoid. You can obtain the list online. It's quite extensive and traumatic..
@@waynegrow hi thanks for thecreply I have 0.25 to go yes they tell me I can jump but just going to be sure so stay on .25 valium few days then jump... can ya tell me what to Google I take taurine l - theaine glycine vit c.. - Now I am a client of Dr Cain and she a big fan of avena sativa .. so but I understand stand Hiw you deal with sleep issues thanks
@@garysimone4977 benzodiazepine information coalition. This list comes from Heather Ashton herself. The list is extensive .
@@garysimone4977 I would stay on that dose of diazepam for at least two weeks then jump. I handled the 1 mg drops from 8mg down to 2mg then I went half mg drops every two weeks. Every is different though. You've made it though and we'll done. You're through the worst. I do advise any surgical procedures need to be analysed. Like any thing that acts on gaba. Which is most things. I need dental surgery in the near future gases like propofol and midazolam will act on gaba and other gases. Just warning people that need general anesthesia beware. Do your homework and seek professional advice from an anesthetist.
@@waynegrow yes I saw that list but that was 30 yr old list .. it gets confusing Dr Cain uses avena sativ l -theanie glycine inositol in her protocol as reports of dhea and more recently a report out of England list 5 herbs i never heard off so Doescanyone really know since we are all so different ?? All I know is I have no answers ..
Good information.
Thank you! I am grateful to be of help and I appreciate you watching the video.
Do you think taking L glutamine could throw this balance off?
Yes, it could. Thanks for watching
@@DocSnipes I suspect that's what happened to me, I took some and am now dealing with terrible symptoms. How long do you think it takes for gaba and glutamate to naturally normalize?
@@DocSnipesI take it with tarurine
How does someone decrease turrets syndrome?
How I know my gaba and glutamate levels. I was taking gabapentin but I have to stop it because make me feel worst with my fybromalgya síntoms
So how do we go by finding where the leaky pipe is are what's causing the leaky pipe?
Systematically evaluating the system. Start with sleep hygiene for example and begin checking off potential issues. ua-cam.com/video/2ixWgVYMWKw/v-deo.html
What about organic acid testing?
my husband has high glutamate, super low gaba and on the lower side dopamine...
I am sorry about that. What was the cause of his neurotransmitters imbalance?
Here are the videos on dopamine: ua-cam.com/users/DocSnipessearch?query=dopamine
Chinese medicine doctor
Amazing performance and presentation.
I'm interested to know your insight on this, I've experienced increases in calmness and less movements and tics when I purposefully focus on trying to calm myself down, my question is, can we increase the levels of gaba and other neurotransmitters by our thougts alone?
Like feeling gratitude for serotonin too?
Yes, we can. Thank you for watching the video
Fermentation is hugely important & missing from the modern diet both in the foods we eat & the gut. Traditional diets fermented or sprouted grains & legumes before eating. Hominy instead of plain corn. Legumes can chelate essential minerals from the body.
Gut bacteria are destroyed by many things in the modern world: chlorine in water, pasteurized foods, antibiotics.
Grass fed meats are needed.
I also take Gabapentin. I'm scheduled to see a neurologist.
Gabapentin after some times taking it causes long term memory lapses like PIN for ATMs. This is disturbing & be prepared.
Not only this happened to me but also to my doctor of 35 years. I had to stop Gabapentin .....
Going through benzo withdrawals. Insomnia has been tough. Which supplement would be good?
You need to talk to your medical doctor about that.
Can this be used during benzo withdrawal to help
Thanks for watching
@@DocSnipes thank you but you did not answer my question Nor addressed benzo wd issues and gabba etc... that would be so helpful to millions.
Just a clean diet . There is a list online tells you what to avoid. Herbals and medicinals. Just eat clean. Your receptors are downregulated they don't need gaba supplements they need to unregulate naturally. You could introduce some products down the line but not recommend at the early stages.
Great video, thank you! :)
Thanks for watching! Wishing you peace, health, and, happiness.
What about valproic acid?
Valproic acid is often used as a mood stabilizer, particularly in the treatment of conditions like bipolar disorder and certain types of seizures. It works by affecting neurotransmitters, especially by increasing the levels of GABA (gamma-aminobutyric acid) in the brain, which is an inhibitory neurotransmitter. By boosting GABA, valproic acid helps to calm overactivity in the brain, which can be particularly helpful for stabilizing mood and reducing manic or hypomanic episodes.
At the same time, valproic acid also impacts glutamate, which is the brain’s main excitatory neurotransmitter. By balancing these two neurotransmitters-GABA, which calms the brain, and glutamate, which excites it-valproic acid can help manage mood swings and prevent the overstimulation that might lead to episodes of mania or other mood disturbances.
If you’re considering this medication or are curious about it, it’s always a good idea to consult with a healthcare professional to understand how it fits into your treatment plan and how it might interact with other neurotransmitter systems. Thanks for your question!
Then mixing Gaba with Tramadol is not a good combination?
Amazing info!!
Ty
Thank you
You're welcome
Question for the Gaba and taking amfetamines in before developing brain,24, as GABA is an excitatory chemical. 1. It still is produced from glutamate, but then what is the calming chemical that works to balance things out? I remember I was taking melatonin to fall asleep for many years
And if the endocannabinoids system is not working because of no adequate diet of omega 3 and 6 fatty acids (anorexia and bulimia ) from 15 to 23 years of age, then clear depression, anxiety and anger ...happening because many of the main chemicals are not happening ?
Ps. Can the endocannabinoid system be recovered fully?
GABA is inhibitory starting one week after birth. Developing brain here is restricted to early development.
"During early brain development, GABAA first acts as an excitatory neurotransmitter due to a higher intracellular than extracellular Cl− concentration, and subsequently changes its action to inhibitory due to a reduction of intracellular Cl− levels after the first postnatal week (Cherubini et al., 1991; Rivera et al., 1999)."
Why there is no reason mentioned in the video about why a brain is experiencing GABA deficiency?
At the beginning she said not enough GABA is bc there's not enough Glutamate which is made from L Glutamine. I'm sure there are other causes but I know she said that.
where can I locate some of your research?
I would say, right here on her channel via rt here on Utube!! She's pretty astute n insightful, isn't she??
Vitamin B3 probably wouldn't do much for Glutamate as Glutamate dehydrogenenase only really makes Glutamate when ammonia levels are too high. Most Glutamate is produced from glutamine through the enzyme Glutaminase.
I appreciate you watching the video. What did you find most useful from it?
@@DocSnipeswhole lotta npc
Do we know if gray matter correlates with orientation dispersion of neurites?
Does gray matter reduce arborization and prune dendritic clusters oriented between brain nodes, in-turn causing a direct more lawful one to one connection between brain nodes - with less dispersal?
Or does gray mattet make this happen less?
The relationship between gray matter and the orientation dispersion of neurites, as well as its influence on arborization and dendritic pruning, is a complex topic that intersects with various aspects of neuroscience. Gray matter in the brain is primarily composed of neuronal cell bodies, dendrites, and unmyelinated axons, along with glial cells and capillaries. It plays a crucial role in processing information in the brain.
Orientation dispersion refers to the variation in the alignment of neurites (axons and dendrites) in the brain's white matter. It's a measure used in diffusion MRI to assess the complexity of brain tissue microstructure. Gray matter's role in this context is less direct, as orientation dispersion is more commonly discussed in relation to white matter.
Regarding arborization and dendritic pruning, these are processes that occur during brain development and throughout life as the brain adapts to experiences. Arborization refers to the growth and branching of dendrites, which increases the number of synaptic connections. Dendritic pruning is the process by which extra neurons and synaptic connections are eliminated over time, which is essential for the brain's maturation and the development of efficient neural networks.
Gray matter is not typically described as reducing arborization or pruning dendritic clusters in a way that would cause a more direct, one-to-one connection between brain nodes. Instead, gray matter density and cortical thickness can reflect the balance between processes like neurogenesis, synaptic formation, and pruning. These processes are influenced by a variety of factors, including genetics, environmental influences, and overall brain health.
It's important to note that the brain is highly plastic, meaning it can reorganize itself by forming new neural connections throughout life. This plasticity allows the brain to compensate for injury and adjust to new learning and experiences. Factors such as stress, hormones, and lifestyle can impact neurogenesis and the health of neurons, potentially affecting the brain's structure and function over time.
If you're interested in a deeper understanding of how various factors influence brain health and neuroplasticity, l discuss these topics in my videos, such as "Trauma Related Brain Damage Glutamate and Neurotoxicity" and "How Trauma Reprograms the Vagus Nerve & Orienting Reflex | Healing from Trauma."
In summary, while gray matter is essential for processing information in the brain, its relationship with orientation dispersion of neurites and its direct effect on arborization and dendritic pruning is complex and influenced by a multitude of factors. Understanding these processes requires a multifaceted approach that considers the dynamic and interconnected nature of brain development and function. You can search for the videos I recommend or learn more for FREE at allceus.com/AskDocSnipes.
Really great. Ty!
You're very welcome!
I have very low BP but don’t see how I could possibly have low GABA I’m suspecting it’s high. Can you have low GABA and low bp?
Low Glutamate and GABA together could have a negligible effect on blood pressure. I would look at other potential causes rather than focus specifically on the Glutamatergic cycle here, unless you have other evidence to suggest severe issues with your Glutamatergic cycle.
Great video.
Ty
My memory is horible... And i have to learn ALOT because of my job.
It is so frustrating.
I am at the point of being ready to try anything.
Thanks for watching. Wishing you peace, health, and happiness.
Hi Boris
Remove MSG (Monosodium Glutamate) from your diet. Since I see your name and surname I believe, that you are from Adriatic region of the Europe. So do not eat artificial MSG E-numbers from E-620 to E-625
To help you a bit more, Podravka Vegeta and Maggi Wurtze are not for you anymore.
Wish you all the best in the future.
Br,
M
Do you do private consultations? I am in rock bottom since taking L glutamine for a few days. I'd love to talk to you and ask you some questions. Please message me if you can
Can down regulated gaba a and glutamate imbalance cause heart rhythm issues?😂
Yes. It can. Thank you for watching the video.
Superclear tnx!!
thanks
I wonder if too much serotonin can cause a GABA deficiency. I take Prozac [40 mg] and it seems it increases my anxiety. I.E. I have to take more Klonopin.
High levels of serotonin on their own can cause anxiety.
There both down regulating your dopamine that why
What if you see addiction in your direct family as well as previous generations, and anxiety disorders in siblings and generation above? There seems to be possibly neurotransmitter related issues in both my parents’ bloodlines including myself now. What kind of possible “leak” would there be in such a case?
I think it’s glutamate, a deficiency. Figuring this out now for myself and my addict family.
@@lexsea98I just picked up some glutamine and for the first time in my whole life, I’m alert 30m after waking. Typically I slowly woke up. About 11 it felt like I was fully awake. I’m shook, this is amazing.
You'd have to know that your levels of glutamine are fine, which as she said they probably are. In which case, there may be a mutation preventing natural production of Glutaminase, the enzyme responsible for converting glutamine into Glutamate. Adding additional glutamine to such a system could have some effect, but I've found amphetamines (legally prescribed as part of ADHD treatment) work well for boosting natural production of Glutamate. Unfortunately, due to the blood-brain barrier, there really aren't any supplemental options for Glutamate, if your body just doesn't produce the glutaminase.
Amazing, thank you so much.
Welcome
Perfect
Thank you. I appreciate you watching the video
Olanzapine destructs Krebs cycle. So GABA becomes even more non adequate. Solution? To improve your Oxydation. High pressure (sea level) and dense oxygen level (rural areas).
We have two strong cellular mechanisms: 1- is mithocondrial 2- lysosomal. By applying Keto diets for ex (fat diets) you target fatty acids and those acids are used for lysosomal destruction (of bad stuff). Evolution will lower the shift from GABA to Glutamate eventually, but we still need to prevent auto-immune to corrupt GAD conversion to stay sane and safe. Good video but unsatisfactory ending.
Its interesting that you mention sex hormones at the beginning of this video. Male sex hormones are almost totally ignored when dealing with males and mental health issues. Actually many health organizations around the world seem to be pushing hard against any use of testosterone at all for man, when optimal testosterone levels in men have many health benefits not just in mood but also preventing diabetes, improving cardiovascular health to name just a few. Greatly overlooked in men but of great benefit. Too much ignorance and scare mongering when it comes to testosterone as its commonly believed but false that testosterone causes heart attacks, cancer, lowers immunity etc but if one digs into the research they will find the opposite.
Out of all the treatments in reguards for neurotransmitters and hormones, testosterone should ne top of the list for many men and will help fix a multitude of problems before even considering many psychiatric drugs.
An integrative approach is essential. So many people on psychotropics when the real cause is an imbalance somewhere in the physical system.
@@StardropSmoothie if testosterone is bad for a mans health why isnt there high rates of heart disease and cancer in younger males with high testosterone levels. The increased rates of heart disease and cancer are in men with lower testosterone and increasing levels of estrodiol who are 40 yo or older. Their hormone levels drop and health issues increase. Similar to women, when they hit menopause their risks of heart disease increase.
It would be safer for a man to going on TRT then not to put them on cholesterol meds, antidepressants, pain killers and sleep meds. So many health people confuse testosterone with steroid such as cortisone. Because cortisone decreases immunity doesnt mean testosterone replacement to a healthy level is immunosuppressive, if that was the case young men would have suppressed immune function and catching many infections. Increased Cholesterol is another myth about using physiological doses of testosterone. A smart cardiologist realises low testosterone is a big cardiac risk, increasing it to normal range is beneficial and cardio protective.
Testosterone and anabolic steroids are what kept many hiv pts alive before anti retroviral drugs were available, they had very compromised immune system and theres research showing increased immune function after steroid treatment.
There is a political agenda to lower male testosterone.
I couldn't agree more. In fact my own experience of depression stemmed from quite an extreme drop in T levels between 43 and 45 years of age, although i didn't know it and spent 2 anxiety and angst-ridden years trying to figure out what the hell happened to me. My mood and my sense of well-being went over a cliff! It almost wrecked my life. After many attempts to pyscho-analyse myself back to 'normality' i eventually read something about Testosterone and mood and went to have it checked with a good endocrinologist. However she said your T is about 350 so quite good for a man your age. I had no hypogonadism, so in her opinion it wasn't T deficiency. She was wrong. The range for men for normal T is approx 250 -1100 which is a very wide range and when I took some natural supplements and a couple of other key actions to boost T and reduce oestrogen also [which reduces your available T levels] like magic my mood, optimism, sense of vitality returned me to where I was before my two years of hell. And when I got my T measured three months later it was at 850. So all of this info is available elsewhere on UA-cam, however my small addition to this gradually building folk knowledge, and which I haven't seen elsewhere is this: One of the major challenges in someone who was mentally [relatively] healthy all their life and is suddenly in deep anxiety and depression is the huge shock that the change causes which in turn can then lead to a vicious cycle downwards. So it's not just the descent, it's the speed and strength of the decent, that can really traumatise us. In short, 'normal' levels of T are different for everyone and mine was clearly around 850 approx [as at 850 i feel exactly the same as I did at 42 years old - not stronger, not more positive - just the same] so then a drop to 250 would've been huge and had a huge impact on my psyche and sense of self, much more than if it had gradually gone down by the expected average of 1-2% per year. Why it went down by so much and so quickly is another story for another time, but it went over a cliff and almost brought me over the cliff with it. If this reply is for you I'm glad - if not, let it pass... PS. There is no conspiracy to lower T in males - in fact females need T also. Rather it is the oestrogen saturated environment we now live in, which at the same time has produced and stored more food so that more people can stay alive, which is depriving us of our essential T. To take one small step to counteract that, consider eating a lot of cauliflower and broccoli, or take a DIM supplement to help metylate estrogen and maintain a strong detoxed liver [even with alcohol consumption you can do that if you are careful] and watch what happens. Good luck
It's not testosterone that's being downplayed by the medical profession. Its hgh.
Essentially everything has to be in balance. But you can't pill pop your way to a healthy life. I'm 36 now my experience is excercise and strengthening the body has a drastic positive impact on the body and mind. You increase testosterone naturally, especially with lower body excercises like squats. You don't need a gym membership or expensive equipment. I got ripped and healthy from my own home. Utilizing my own body weight. Nutrition and exercise is the foundation. Consistency the key. You'll soon notice you don't need half of these supplements that you THINK you need.
Good things I learned from you doctor.Mediterranean diet is the key of our health no vegans or keto good for us moderate is the key away from supplements
Thank you for watching the video
In my subjective experience, if your nervous system leans more to glutamatergic firing rather than GABA, I’d be very observant in regard to norepinephrine and dopamine re-uptake in SNRI medication. NE and DA promote more glutamatergic firing.
Thanks for watching and commenting.
@@DocSnipes LOVE your videos. I’m sure nicotine increases GABA. I use it for my ASD and I like it. High doses I get sensory overload, which probably decreases GABA (FOR ME). I use the vape… Also, ashwagandha ;)
Glutamic acid in foods is important for everyone to eat it does not cause excess glutamate in the brain as it does not cross the blood brain barrier and the body regulates how much glutamate it needs the rest is excreted. To Make GABA we need to eat foods HIGH in gluatamates so bring on the proteins, parmesan cheese, mushrooms and everything high in glutamic acid.
Doesn't food high in gluten excite the brain? Ice recently tapered off diazepam and had a pizza the other day and my sleep was non existent. My gaba receptors are still downregulated therefore any foods high in gluten would affect the upregulation of my gaba receptors..
@@justincarrillo12626 Eat foods in glutamic acid forget synthetic supplements.
"That was an awesome display of excitatory knowledge."
Thanks for watching. 😀
Can THC or smoking marijuana increase Glutamate levels?
Amazing seminar....the complexity and coherence of neurotransmiters has been clearly described. Please extend the role of glutamine and influence of sensory neurotransmission (lack of sense of touch). Great video. .
But it was not mentioned that; High levels of glutamate can cause epilepsy seizure, that is why Lamotrygine (epi drug) blocks the overdose of glutamate level that could enter neurons (also ions of Calcium), and modulate sodium channels to balance the neurotransmition... So direct influence of GABA on neurons is not enough to prevent the seizures... sorry but the authority of doctors are questionable but it is good to address it in every suplement/drug recommendation. Xanax is the real dangerous killer if doctors use this frequently it shows theit lack of knowledge or ignorance... sorry but tis is a fact. The interactions of drugs should be focused on balancing and indirect effect.
Thanks for watching.
Why is Xanax dangerous?
B6 toxicity is a real thing...everything has b6 in it these days
Thanks for watching
Its water soluble, you’d have to be taking like a gram of pyridoxine
I am hypotensive.
I wonder if doctors take GABA into consideration?
Anti nutrients cause alot of issues, 99% of nutrition books and courses hardly touch this topic. You never mentioned how ms and spasms can be the cause of mental issues.
Thank you so much for watching. Have an awesome day. What did you find most helpful from the video?
Deciding whether to become a brain scientist? If you prefer simplicity, study the cosmos instead LOL
Haha totally.
drink kava from gods place fiji.this is the best for bad days
Nachos and wine...
Those sound yummy. Thanks so much for watching. Have a great day
No one reply save your time
Thanks for watching
wow... @Gary Simone you didn't even ask a specific question earlier. I see her responding just not to you. Your question said..."can 'this' be used..." without saying what the 'this' is lol.... this video wasn't about any 'one' thing. That said, my recommendation would be to taper down followed up with ketamine treatment and supplementation.
@@timarmstrong7627 I tried ketamine 5x did nothing
@@timarmstrong7627 I asked what supplements can be used for benzo wd... you know of any
Is avena sativa good for WD is is inositol l - teaming Dhea are they any good ..