If your kidney function GFR has low numbers putting you in stage 3 or 4 kidney disease, many have gone on 5 day fast, started eating clean and were able to elevate their GFR numbers back to normal.
I've always been suspicious of the TMAO argument and from Science news 11/6/2018 " "it seems that a fish-rich and vegetarian diet, which is beneficial or at least neutral for cardiovascular risk, is associated with a significantly higher plasma TMAO than red meat- and egg-rich diets, which are considered to increase the cardiovascular risk," researchers from the Medical University of Warsaw in Poland and the Polish Academy of Sciences wrote."
I am confused by the choline TMAO issues. I have a liver issue and am now concerned about eating eggs at all. Does TMAO go away if you eat clean after eating something high in choline?
Thanks Dr. Brewer, I just wanted to say that Deuterium isn't radioactive, so it isn't for radioactive labelling but still useful in organic chemistry because of its differences (compared with Protium) in spectroscopy techniques. Thanks for the information!
Great topic that the media in general blurted out danger warning headlines/articles without the nuances adequately being discussed. I have never had a doctor say anything to me about kidney function from blood test results for yearly physicals, and I wonder if you look at eGFR and/or the results of an MACR or SDMA test to help quantify whether a patient is experiencing lower kidney function than might be expected due to age, sex, etc. People with lower kidney function are prone to hypertension and heart disease. It seems like IR/diabetes, lower kidney function and hypertension are all bound together in a bad set of negative feedback loops.
Very true. And you evidently haven’t taken our CV Inflammation course. ua-cam.com/video/zC3eU0iiNno/v-deo.html Here’s a pop quiz question: why do I consider MACR the most important of the CV Inflammation tests?
Dr. Brewer, Valter Longo is recommending eating a plant-based diet most of the time with some occasional fish added for people who need extra protein to maintain muscle mass. It seems to me that using the longevity diet protocol our microbiome would be tilted toward a population of gut flora that does not favor the production of TMAO. Combined with good kidneys clearing TMAO from the bloodstream it would seem that the whole food plant based diet with occasional fish would be a pretty good idea. While a keto leaning diet rich in TMAO might be metabolically preferable, overall due to the atherosclerotic risk it might have some issues that have not been addressed. As far as I know, there are no long-lived populations that have a keto type diet. What are your thoughts on these comparative risks? Does fish produce less TMAO?
@@PianoPatterns123 However, it appears that Fresh Water fish don't seem to have the same problem. Specifically Trout and Walleye but I don't know about other Fresh Water fish. Cleveland Clinic study
I'm guessing it comes down to gut dysbiosis as the culprit. There's substantial evidence on both sides of the fence. When you have that, I tend to look at the quality of the study, whether there is other evidence to support the findings, then the variables. Improper digestion, leaky gut, inflammatory issues are all value of that have to be considered. I have yet to read the study, but when the pendulum swings to extremes, this is what I suspect.
Thanks for appreciating our content. Here’s a reminder of things you can do to help us fight heart attack & stroke. They’re quick, easy & free: 1. Subscribe to the UA-cam channel - and click the Bell icon to get notifications when we publish a new video; 2. Share the videos with others using your email social media: FaceBook, Twitter, & LinkedIn. These shares tell the UA-cam algorithm that this is information worth sharing. It will do the same; 3. Comment & Like lots of videos, preferably early. Again, this tells the algorithm to suggest the videos to others. (Even Dislikes increase video suggestions - the algorithm likes debate; 4. Join The PrevMed community mailchi.mp/1224fb9e00e7/prevmed_community Coming soon - Volunteer to translate a video caption for those that speak your language. Not everyone understands English, especially with my Southern US drawl. I’m still working on setting this up.
I use the common and descriptive terms of "good" and "bad" concerning heart disease all the time. "Good" is being able to exercise, work and enjoy life without heart related pain or disability. "Bad" is being on a hospital gurney kissing your spouse goodbye as you head towards the double doors of the coronary surgical unit. ;-)))
@@akbarshoed Well....that's my question also but right now, until I hear more that's definitive.....I don't think they really know. According to the National Institutes of Health...... "It requires more research." Arrggh!!!!!!
Bottom line - a lot of people worry about TMAO. But not me. If your kidney function is good - TMAO doesn’t matter. If your kidney function is bad, you’ve got bigger problems. So, in the end, it’s kidney function- not TMAO.
I did not understand how this is connected to the title, I presume TMAO affects coronary risk and you are saying the vegans may have a point. Or are you saying that if you have impaired kidney function you may be more sensitive to specific diets. P.S. Vegans are never right, they are mostly left(joke)
Spoken like a true Vegan. Choline is an essential nutrient in our bodies. There is a lot of I believe and here... there is obvious logical fallacy here of correlation equals causation.
Sooo, Dr. Brewer (who forgot to introduce himself in this video), do you sit right down and eat all those eggs and bacon as shown in this video? I'm guessing not.
I can’t say I’ve had 6 eggs & bacon for breakfast. These days, I’m not eating any breakfast. But yes, I’m not concerned about TMAO. I’m concerned about kidney function.
If your kidney function GFR has low numbers putting you in stage 3 or 4 kidney disease, many have gone on 5 day fast, started eating clean and were able to elevate their GFR numbers back to normal.
I've always been suspicious of the TMAO argument and from Science news 11/6/2018 " "it seems that a fish-rich and vegetarian diet, which is beneficial or at least neutral for cardiovascular risk, is associated with a significantly higher plasma TMAO than red meat- and egg-rich diets, which are considered to increase the cardiovascular risk," researchers from the Medical University of Warsaw in Poland and the Polish Academy of Sciences wrote."
Not to mention a study of older women who got levels up 10x for 24 weeks, no inflammation.
I am confused by the choline TMAO issues. I have a liver issue and am now concerned about eating eggs at all. Does TMAO go away if you eat clean after eating something high in choline?
Waiting for my TAMO test results now. Thanks!
Great. Thanks. Good luck.
Great visuals...major improvement. Love that you get into this topic from various points of view.
Thanks Dr. Brewer, I just wanted to say that Deuterium isn't radioactive, so it isn't for radioactive labelling but still useful in organic chemistry because of its differences (compared with Protium) in spectroscopy techniques. Thanks for the information!
Doesn't garlic consumption eliminate the rise in TMAO ?
@John Lorscheider Much appreciation for your concise and enlightening reply. I will pursue the understanding re: kidney function as you point out.
Great topic that the media in general blurted out danger warning headlines/articles without the nuances adequately being discussed. I have never had a doctor say anything to me about kidney function from blood test results for yearly physicals, and I wonder if you look at eGFR and/or the results of an MACR or SDMA test to help quantify whether a patient is experiencing lower kidney function than might be expected due to age, sex, etc. People with lower kidney function are prone to hypertension and heart disease. It seems like IR/diabetes, lower kidney function and hypertension are all bound together in a bad set of negative feedback loops.
Very true. And you evidently haven’t taken our CV Inflammation course.
ua-cam.com/video/zC3eU0iiNno/v-deo.html
Here’s a pop quiz question: why do I consider MACR the most important of the CV Inflammation tests?
Dr. Brewer,
Valter Longo is recommending eating a plant-based diet most of the time with some occasional fish added for people who need extra protein to maintain muscle mass. It seems to me that using the longevity diet protocol our microbiome would be tilted toward a population of gut flora that does not favor the production of TMAO. Combined with good kidneys clearing TMAO from the bloodstream it would seem that the whole food plant based diet with occasional fish would be a pretty good idea. While a keto leaning diet rich in TMAO might be metabolically preferable, overall due to the atherosclerotic risk it might have some issues that have not been addressed. As far as I know, there are no long-lived populations that have a keto type diet. What are your thoughts on these comparative risks? Does fish produce less TMAO?
Of all the foods you can eat, Fish has the highest level of pure TMAO, plus mercury.
@@PianoPatterns123 However, it appears that Fresh Water fish don't seem to have the same problem. Specifically Trout and Walleye but I don't know about other Fresh Water fish. Cleveland Clinic study
Thanks for the video, looking forward to the next one 👍
Thanks.
I'm guessing it comes down to gut dysbiosis as the culprit.
There's substantial evidence on both sides of the fence. When you have that, I tend to look at the quality of the study, whether there is other evidence to support the findings, then the variables.
Improper digestion, leaky gut, inflammatory issues are all value of that have to be considered. I have yet to read the study, but when the pendulum swings to extremes, this is what I suspect.
That’s a good thought. We have another coming up. Here’s a hint; it’s kidney function more than TMAO.
Good video. Thanks for including the paper.
Thanks
wow, that's a great video!
thanks!
Thanks for appreciating our content. Here’s a reminder of things you can do to help us fight heart attack & stroke. They’re quick, easy & free:
1. Subscribe to the UA-cam channel - and click the Bell icon to get notifications when we publish a new video;
2. Share the videos with others using your email social media: FaceBook, Twitter, & LinkedIn. These shares tell the UA-cam algorithm that this is information worth sharing. It will do the same;
3. Comment & Like lots of videos, preferably early. Again, this tells the algorithm to suggest the videos to others. (Even Dislikes increase video suggestions - the algorithm likes debate;
4. Join The PrevMed community
mailchi.mp/1224fb9e00e7/prevmed_community
Coming soon - Volunteer to translate a video caption for those that speak your language. Not everyone understands English, especially with my Southern US drawl. I’m still working on setting this up.
Please please please use the words, "Good" and "bad".
I use the common and descriptive terms of "good" and "bad" concerning heart disease all the time. "Good" is being able to exercise, work and enjoy life without heart related pain or disability. "Bad" is being on a hospital gurney kissing your spouse goodbye as you head towards the double doors of the coronary surgical unit. ;-)))
@@zift18 is TMAO good or bad?
@@akbarshoed Well....that's my question also but right now, until I hear more that's definitive.....I don't think they really know. According to the National Institutes of Health...... "It requires more research." Arrggh!!!!!!
Bottom line - a lot of people worry about TMAO. But not me. If your kidney function is good - TMAO doesn’t matter. If your kidney function is bad, you’ve got bigger problems. So, in the end, it’s kidney function- not TMAO.
I did not understand how this is connected to the title, I presume TMAO affects coronary risk and you are saying the vegans may have a point. Or are you saying that if you have impaired kidney function you may be more sensitive to specific diets. P.S. Vegans are never right, they are mostly left(joke)
Good joke. I don’t think TMAO is really an issue, like vegans may think, unless there is a major kidney problem.
Spoken like a true Vegan. Choline is an essential nutrient in our bodies. There is a lot of I believe and here... there is obvious logical fallacy here of correlation equals causation.
?? I’m not a vegan. Low carb.
Please actually watch his videos. This channel is easily the most neutral I've seen when it comes to bias.
Correlation does not mean causation :)
True.
Easy EAT GARLIC or GARLIC supplements
Sooo, Dr. Brewer (who forgot to introduce himself in this video), do you sit right down and eat all those eggs and bacon as shown in this video? I'm guessing not.
He eats salmon on daily basis...
Clean up your kidneys and you won't have to worry about it. The body seems to take care of itself when all is in order.
@@robrae14 - clean you kidneys?
@@robrae14
Yup, i don't worry about that as dr. brewer explain in the video...
I can’t say I’ve had 6 eggs & bacon for breakfast. These days, I’m not eating any breakfast. But yes, I’m not concerned about TMAO. I’m concerned about kidney function.