Penicillin and Antibiotic Resistance (from PDB-101)

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  • Опубліковано 7 лют 2025
  • Since its discovery in 1928, penicillin and penicillin-related antibiotics helped save countless lives from bacterial infections. However, in the face of overuse and misuse of antibiotics, bacteria evolved resistance mechanisms that allow them to proliferate even in the presence of the newest antibiotics. Watch this video to learn how penicillin and penicillin-related antibiotics disrupt the bacterial life cycle, and what molecular mechanisms bacteria employ to evade the action of these drugs.
    Learn more about antibiotic resistance from PDB-101 pdb101.rcsb.org...
    Story by: Stephen K. Burley, David S. Goodsell, Maria Voigt
    Animation and Video Editing: Maria Voigt
    Narration: Brian Hudson

КОМЕНТАРІ • 86

  • @RCSBProteinDataBank
    @RCSBProteinDataBank  6 років тому +11

    To contribute subtitles to this video in your language, use this link: ua-cam.com/users/timedtext_video?v=m0V6DRJBBGY&ref=share

    • @ivanbombana9481
      @ivanbombana9481 6 років тому

      Very beautiful video!! I amo a chemist 😊.... are You looking for a new chemist in your team? 😊

    • @RCSBProteinDataBank
      @RCSBProteinDataBank  6 років тому +1

      We are looking for a Biocurator at Rutgers. Have a look:www.rcsb.org/news?year=2019&article=5ba8f79f6078e948d6421758

    • @RCSBProteinDataBank
      @RCSBProteinDataBank  6 років тому +1

      Sorry, this link is better: www.rcsb.org/pages/jobs

  • @shihyonseo7314
    @shihyonseo7314 2 роки тому +21

    The video made so much sense. The graphics and the sound effects made it so much easier to understand how penicillin works. Thank you for a great video!

  • @geoggernaut
    @geoggernaut 4 роки тому +46

    the squishy sounds really made me realize the importance of antibiotic resistance in a molecular level

  • @desireemartin3303
    @desireemartin3303 4 роки тому +16

    I am so grateful to share the animation with my students, so they may see the mechanics of macromolecules in action through bonding.

  • @kummer45
    @kummer45 4 роки тому +12

    This work is of institutional proportions. From these new scientists will understand problems faster due to the detailed explanations with the animations.

  • @adabujiki
    @adabujiki 4 роки тому +7

    Seriously this is mind blowing .. i could watch 3 hours of this. How did they find out these details ??? This is bleeding edge bio chemistry.. and this guy and his voice drive this home!!! The detailed explanations, graphics OMG!! Imma fan

    • @raplopez4258
      @raplopez4258 3 роки тому

      I know, thank God for his American accent

  • @srgkzy1294
    @srgkzy1294 6 років тому +21

    Underrated channel !

  • @jamesdean1074
    @jamesdean1074 6 років тому +27

    Top-notch AV work. Thank you very much.

  • @ideoformsun5806
    @ideoformsun5806 5 років тому +11

    I hope we can learn to use bacteriophage therapy more. It's targeted to a specific bacterium, and leaves the rest of the microbiome.
    I wonder if then we could cycle antibiotics in and out of use to retain their novelty.
    I wonder if antibiotics affect mitochondria.

  • @jamiek6471
    @jamiek6471 5 років тому +2

    This channel is priceless

  • @PocketGlobalHealth
    @PocketGlobalHealth 6 років тому +32

    The WHO recently listed antibiotic resistance as a leading threat to global health in 2019!

    • @lessalazar9068
      @lessalazar9068 4 роки тому +1

      Well... look at where we are now

    • @tucker2074
      @tucker2074 4 роки тому +4

      @@lessalazar9068 This is a "Plandemic" not a "Pandemic"

    • @Fallenangel_85
      @Fallenangel_85 3 роки тому +5

      @@lessalazar9068 A virus pandemic, unrelated to antibiotic resistance.

    • @tomato-v8x
      @tomato-v8x 2 роки тому

      @@Fallenangel_85 Can be related if people take antibiotics for viral infections. One of the contributing factors to antibiotic resistance.

    • @tomato-v8x
      @tomato-v8x 2 роки тому

      @@tucker2074 You live a sad, misinformed life.

  • @muhtesemaksoy
    @muhtesemaksoy 6 років тому +2

    A very good and educational video

  • @reneecardoso6400
    @reneecardoso6400 4 роки тому +1

    Esse canal é excelente.
    Parabéns!!!!!!!

  • @pharmaseraj
    @pharmaseraj 6 років тому +3

    Very good

  • @I_am_AmanSingh
    @I_am_AmanSingh 2 роки тому

    So what is more effective penicillin G or penicillin V??

  • @xpossed
    @xpossed 4 роки тому +4

    "oh.... That wasn't so bad"
    "That was penicillin"
    *_"BRUH"_*

  • @ShivaBioTechnical
    @ShivaBioTechnical 3 роки тому +1

    विख्यान बहुत अच्छा है धन्यवाद

  • @Kubra-fy7df
    @Kubra-fy7df 3 роки тому

    ga ik gebruiken tijdens mijn lessen, merci!

  • @abeeraftab9410
    @abeeraftab9410 4 роки тому

    Such a helpful video.

  • @rosesiano1173
    @rosesiano1173 2 роки тому

    Absolutely incredible fantastic and amazing.

  • @LadyWendy_50
    @LadyWendy_50 4 роки тому

    Explained very well!

  • @devendrakhandelwal5468
    @devendrakhandelwal5468 3 роки тому

    Thank you so much sir 🙏🙏🙏

  • @williamdoherty4727
    @williamdoherty4727 3 роки тому

    This is really great

  • @緑の小道
    @緑の小道 3 роки тому

    Thank you.. incredibly useful

  • @mcdonnell-douglasdc-1032
    @mcdonnell-douglasdc-1032 3 роки тому

    Excellent.

  • @lintangkawuryan4587
    @lintangkawuryan4587 3 роки тому

    amazing video thankss!

  • @tilak231
    @tilak231 5 років тому

    Awesome explanation!!!

  • @------country-boy-------
    @------country-boy------- 5 років тому +1

    god i love these videos

  • @augusto256
    @augusto256 5 років тому

    Wonderful videos

  • @HighxHat88
    @HighxHat88 5 років тому

    Wow, that was fantastic

  • @ashleen6985
    @ashleen6985 4 роки тому +1

    Brilliant

  • @AcuarionAdenine
    @AcuarionAdenine 5 років тому +4

    Ah Cat and mouse games , i love those

  • @chrisp8168
    @chrisp8168 2 роки тому

    Marijuana killed my MRSA after months and months of failed antibiotics and if and when I ever get another infection that's exactly what I will use!

  • @sharosepp8277
    @sharosepp8277 5 років тому

    awesome..
    thanks a lot

  • @kseniaershova3818
    @kseniaershova3818 5 років тому +2

    Thank you very much! Very cool video!!

  • @inesreardon3265
    @inesreardon3265 3 роки тому +2

    Please make sure to make it clear that "bacteria does NOT develop resistance in order to fight antibiotics" as implied in the video. Mutations are random, not driven by the organism's need! The mutation "pops" up which provides positive selection when the bacterium is in an environment with antibiotic present. This bacterium survives and reproduces.

  • @jayashridoddamani7659
    @jayashridoddamani7659 5 років тому

    Please let me know the difference between penicillin and antibiotics

    • @arqamzahid1821
      @arqamzahid1821 4 роки тому

      Penicillin is just a type of antibiotic. There are many other groups of antibiotics available.

    • @Weezechargedup
      @Weezechargedup 3 роки тому

      Does it work for sexual transmitted things ?

  • @iliketurtles6777
    @iliketurtles6777 3 роки тому

    Could phage viruses be effective against these super bugs?

  • @jeewan1985
    @jeewan1985 6 років тому

    Sir i understand completely and all world is know about drug Resistant Typhoid in Pakistan XDR typhoid Extremely drug Resistant also meropenim Sir here is my one question many Medicine companies selling there Antibiotics one just 05 rupees than other same are 50 rupees why ....If i am not wronge low power medicine or not completely distroy the Bacteria when the 3rd generation Antibiotics is powerful but patients are not treated...

  • @magellanaa
    @magellanaa 4 роки тому

    someone knows how to synthesize penicillin by chemical in vitro process? (No biochemical, no biotechnology)

    • @josoghurt5192
      @josoghurt5192 3 роки тому +1

      Yes! For years I have waited to share my scientific research. The only way to synthesize Penicillin in a lab is by [ redacted ]

    • @magellanaa
      @magellanaa 3 роки тому

      @@josoghurt5192 how funny

  • @brandonkelley6500
    @brandonkelley6500 5 років тому +2

    Those sound effects tho

  • @Meleeman011
    @Meleeman011 4 роки тому

    Why not just let mold and mrsa battle it out?

  • @peakhead7087
    @peakhead7087 5 років тому +1

    Wherever we go there is war.

  • @nagendrarao3147
    @nagendrarao3147 4 роки тому

    👍👍👍

  • @malvinderkaur4187
    @malvinderkaur4187 4 роки тому

    why is bacteria named New Delhi? that is not fair.

  • @PrettyPlease2001
    @PrettyPlease2001 4 роки тому

    niceee

  • @jirayurchonmanat6887
    @jirayurchonmanat6887 2 роки тому

    Begine of the world

  • @thug.shaker931
    @thug.shaker931 4 роки тому +1

    I am allergic to this medicine

  • @Caktusdud.
    @Caktusdud. 4 роки тому +1

    Hhhmmmmm oo I know we one that penetrates the membrane and then explode

  • @josepablolunasanchez1283
    @josepablolunasanchez1283 4 роки тому +1

    Alexander Fleming was not a pioneer and he did not invent penicilin. It was a Nicaraguan named Clodomiro Picado Twight.
    * 1923 Clodomiro "Clorito" Picado published a paper titled "Sobre la acción fitopatógena de los hongos a distancia" where he discovered penicilin effects on plants.
    * 1927 He published the paper "vacuna curativa no específica" described clinical data on how penicilin helped people with several infectious diseases.
    * 1929 Alexander Fleming published a paper on British Journal of Experimental Pathology on Penicilin.

    • @hwanglee3330
      @hwanglee3330 4 роки тому

      Do you have its paper in English? I am curious. Thanks

  • @shianeharris1340
    @shianeharris1340 3 роки тому

    .🦁

  • @Weezechargedup
    @Weezechargedup 3 роки тому

    Does it work for sexual transmitted things ?

  • @dianetheone4059
    @dianetheone4059 Рік тому

    *****

  • @poulomi__hari
    @poulomi__hari 4 роки тому

    Why is an enzyme named after New Delhi?

  • @hwanglee3330
    @hwanglee3330 4 роки тому

    So greeny fungus lol

  • @jeepz669
    @jeepz669 3 роки тому

    Wow, how could these geniuses screw up so bad and allow super mutant bugs to potentially develop and destroy masses of people??

  • @bb-ig4kk
    @bb-ig4kk 4 роки тому

    💉