Parkinson's Disease:- "Parkinson's and the B1 Therapy" with Daphne Bryan
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- Опубліковано 17 лип 2022
- An excellent interview with Daphne Bryan, Author of the book "Parkinson's and the B1 therapy", explains this very interesting treatment.
In 2011, the Italian neurologist Dr. Antonio Costantini began treating his Parkinson’s patients with high doses of vitamin B1. As a result, he saw many of their symptoms improve, with no obvious progression in the disease over the five years he worked with them.
Daphne Bryan outlines the research and the theories in her book ‘Parkinson’s and the B1 therapy’ and will talk about the therapy’s protocol, its difficulties, and its successes.
Daphne Bryan is a musician and a teacher and has a doctorate in music psychology. In 2010, she was diagnosed with Parkinson’s. Her first book “Music as Medicine, particularly in Parkinson’s” explores how music can be used to reduce symptoms.
In 2017 she read of Dr. Costantini’s work and decided to try the B1 therapy herself. Within a few months, she realised that she had lost most of her Parkinson’s symptoms. The improvements have remained to the present day.
After advising people on how to adopt the therapy on a FaceBook group, she decided to bring together all the information Dr. Costantini had left and write a book which would explain the available research and provide a handbook on the protocol.
Daphne lives in Scotland with her husband.
We do not usually plug products however will take exception with Daphne's book as proceeds go to the "go fund me" page to raise money for a comprehensive trial into B1
So here is a link to Daphne's book on Amazon www.amazon.co.uk/gp/product/B...
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We started the B1 therapy after having read your book. Didn't think too much about it but made sure he got his dose three times a week (1/2 tab). That was six months ago. Yesterday we had my husband's six-month checkup and the doctor remarked that he could find no muscular stiffness in my husband at all. We reminded him we had started the B1 therapy six months before because we discussed it with him before starting the therapy. His doctor had approved it six months ago. The doctor was so impressed with my husband's exam here six months later that he said for us to continue it and increase it as we saw fit. Thank you, Daphne! We have not increased his original dosage but now are considering adding a fourth day as his increase. We are not going about this in any rush.
3 x day maybe ??
That’s amazing!!
I know it worked for me ! Amazing. I’d even wonder if I really had Parkinson’s !
@@susanedghill6597can you specify what is the medicine name? Did you had Parkinson
What is the dose you took.? I can’t remember for sure but I think it was every day for me. . Don’t know why I stopped but getting back on it now
This is brilliant! I started my husband on 100mg a day. Within 2 weeks, the shaking and nightmares stopped! However, he had to have a minor surgical procedure. In the hospital they didn’t give him his B1. When he got home, his shaking and nightmares started again, I had to give him 200 mg a day and he no longer has any symptoms. I have purchased the book and it’s a must read. Also, prior to giving him his first dose, I had him call his neurologist to see if okay. They said it’s fine, but they don’t expect anything. Well, at his next appointment, he took the book with him. They noticed no symptoms and asked to borrow the book. I never got it back lol. So, I’m purchasing a 2nd book.
100mg sublingual tablet?
Brilliantly done Daphne! I read your book a month ago, began high-dose B1 therapy right away. It took a couple weeks to dial in my dose. I think I've got it now - about two weeks on what seems to be the right dose for me. I'm looking forward to positive results. The book and protocol are mandatory for anyone with Parkinson's - IMO.
how much are you on? Benfotiamine?
I'm going to give it a go nothing to lose after being diagnosed with PD 18 months ago.
😊
@@annegordon6725o88
Any updates on your B1 therapy? My husband may have Parkinson’s.
Thank you so much for sharing your knowledge on this important subject ..
Thank you very much for this interview.
Thank you very much everyone for your very nice and encouraging comments. I am delighted that this session was of interest and am excited about the other great sessions we have already scheduled for after the summer. Stay tuned for more details! Michel
So grateful to you for this!!! You give me hope for my father!! Eternally grateful!! 💛💛💛🙏🏼☺️✨
Thank you very much Sabine for your very nice message!
In July last year, I started on Parkinson’s disease TREATMENT PROTOCOL from Natural Herbs Centre (ww w. Naturalherbscentre. com). One month into the treatment, I made a significant recovery. After I completed the recommended treatment, almost all my symptoms were gone, great improvement with my movement and balance. Its been a year, life has been amazing
Thanks for a very helpful interview.
Thank you so much for this....
Thank you so much for this information and very helpful interview xx*
Daphne and Michel. Thank you so much for your very informative and useful talk that I would share. Thank you for giving informed hope to so many !
Great work, Daphne!
Thank you Daphne. I will order your book…
Thank you to you both for your advocacy. You are both inspirational for how you are using your situation to perpetuate good. I hope to do the same. I’m enjoying this talk very much. Thank you
Fabulous Informative and giving a WORLD of hope , to them who feel hopeless. God Bless U richly ,Madam. Stay well and remember ,you are a very great INSPIRATION.
BUT i reqest watchers/viwers to not ask repetitive questions. We must have respect for this Great Lady and not waste her energy and time.
Thank you!
Thank you so there’s hope 😊
Excellent interview, easy to keep listening to the end. Book bought.
Thank you so much for sharing your wisdom and knowledge🙏
Started EZ Melts B1 under the tongue last night. Came same day from Amazon. Not bitter. We will go slow as in the book. You've given us Hope and that is a precious commodity with advanced Parkinsons.
EZ melts are not sublingual…they are absorbed just like capsules…which are much cheaper.
@@debp.2599 So what’s this EZ Melts B1 25MGs non-capsules that have been melting nicely under my tongue and have been helping these last few weeks?
Dallas GA USA
@@scottmerrell4337 Although those melt they are not considered sublingual because they are not absorbed directly into the blood through the membranes under your tongue...Those actually go through your digestive tract.
@@debp.2599 That does not make sense. Do you know something about the formulation that would make it not work under the tongue? Seems to work for me😁
Great interview. Well done.
Thank yo Daphne and Michel! Great interview and very inspirational! I am looking forward to begin the protocol,
What dose of b1 to start with
@@salwashenouda783 It was mentioned in the video
Thank you both of you, very clear interview.
For anyone that hasn't looked at the Studies. Vitamin d3 and omega 3 also had miraculous results in many conditions. The dose was 2000 iu of d3 and I think 1 gram of omega 3 daily.
measure cholecalciferol levels. my patients often need 20,000 u D3 /day x 3 months and MEASURE because too much, level over 80, is dangerous. NO calcium while on high D3 as can cause kidney stones or hardened coronary artery plaque
@@glenliesegang8935 True and always measure. K2 can also balance it.
@@glenliesegang8935how can you get rid of artery plaque,
D3 must *always* be taken with K2 to push it into bones and teeth, otherwise it clogs arteries.
I think it's generally very important but in Dr Laurie Mishley's large scale PD surveys it is nowhere near as effective as gingko biloba.
K2 mk7 seems important to take to transport the increased calcium into bone storage, so ask your doctor.@@theluckyman74
Daphne I’d like to get your book my wife has parkensons and would like to know so we can start the B1
Bravo Cuz!
Finding the correct dosage
20:16
31:30
Just to echo Michel's comments. It was a pleasure creating the interview and we have some very exciting speakers lined up in the coming months and hope they all help in someway
Where do i get the book i live in trinadad
In this video I mention EZmelts B1 in connection with it possibly being a sublingual tablet. We now know EZmelts is NOT a sublingual tablet. It does NOT pass through the mucous membrane under the tongue, but travels through the digestive system. This means that if you use it for high dose thiamine therapy you would need between 20-160 tablets a day!
try a more bioavailable form like benfotiamine or ttfd. these need to be used in high dose, like 1000mg a day. Also adding magnesium and a B-complex vitamin will help (very important)
@@landmarcmusicdotcom More is not necessarily better in this therapy. You have to find the right dose for the individual. Too much and Parkinson’s symptoms worsen. There are little or no cases of individuals finding their Parkinson’s symptoms reduce using benfotiamine or TTFD. There are several cases known to me of people shooting into overdose symptoms on these derivatives even on a far smaller dose than 1000mg a day. One overdosed on 25mg! More bioavailable can make it just too strong for this therapy.
@@daphnebryan4578 stop increasing at effective dose, else high cost and no more benefit.
@@daphnebryan4578 how does one recognise their sweet spot given it may take weeks to identify benefits?
Is oral B1 dosage the same as Sublingual B1 ?
You need to use a more bioavailable form such as: benfotiamone or ttfd. Also, make sure you are taking magnesium and a b-complex vitamin as these nutrients become much more needed now that the body is using thiamine.
Hi, I had exactly same reflexion as yours since a couple of days I discovered this treatment method but then I told myself that Dr Costantini was naturally also aware of the other forms of thiamin, like the sulbutiamin and if there was an added value, he would have told it. I order the Daphne Bryan's book and maybe it contains some explanations. There is probably a reason why he didn't talked about the other alternatives, I would appreciate to know if somebody found real added value with other than natural Thiamin. Also if somebody tried NADH remedy It would be interesting to know about. Father of the inventor of NADH is the one who proposed levodopa to manage Parkinson, according to videos I found about.
Thks
alternatives very expensive esp on 4000 mg/day. NOW brand by Swanson $8.50 for 100, so much less costly.
L😊
Methylated B vitamins absorb better.
What is the name of the book
Can B1 deficiency be important right in the gut environment, as well as in the CNS later, for pathogenic initiation?
I see you’ve asked several questions. I’m afraid my understanding of the action of B1 comes from the only research into B1 and Parkinson’s. There is yet no research out there to answer your questions and it’s definitely beyond my qualifications to enter into a discussion on it I’m afraid. The research we have from Dr Costantini suggests that high doses of thiamine can influence cellular energy metabolism which has been disrupted or inhibited by other factors. The theory is that by using high doses of thiamine, certain enzymes involved in energy metabolism are stimulated and metabolic function in the cells is restored, so they can work efficiently once more.
@@daphnebryan4578 Yes, there seems to be quite a bit of research on some of these questions, but the more I read, the more questions I have, I guess that is good. You certainly have brought a lot of B1 questions to the fore, thanks, i'll be reading a lot of related papers.
Most likely, Check out youtube videos from EONutrition, Elliot Overton talks about the role of thiamine in digestive function. Also check out a video interview of Chandler Mars about thiamine deficiency. She wrote a book with Dr. Lonsdale called: High Calorie Malnutrition; You need to use a more bioavailable form either: benfotiamine or ttfd, regular thiamine-hcl is only absorbed about 3-6% Also, be sure to add magnesium and a b-complex vitamin as well, as these help the body utilize the B-1 better
@@landmarcmusicdotcomhow much benfoitamine and ttfd is absorbed orally
13:42 placebo effect: remarkable answer however
I did however hear Dr. Costantini's nurse express that her doc told her personally (as a patient) that she was going to feel better soon. I thought that was problematic tbh.
I am astonished that the supplement of vitamin B1 is not known to most doctors...so very sad...
I took vitamin B1 for a month following this video. There was no improvement at all with my Parkinson's. Probably that's why neurologists don't automatically prescribe it. I've now bought some mannitol which somebody told me improves the brain and relieves Parkinson's symptoms. Here's hoping.
@@ziontours5893 My husband too with parkinson, took vitamin B1 and nothing really changed...
@@ziontours5893Did the mannitol work?
You mention needing to also use magnesium and B complex but what form of magnesium? I take magnesium threonate…is that sufficient?
Must measure blood levels. certainly stop if diarrhea. no more than 400 mg bid x 2 months w/o measuring.
Currently, I take both Mg threonate and glycinate. There is some research about threonate better getting into brain. But, apparently not much of what you take stays in the body long. Glycinate.
How do I get B1 vitamin sublingual? I have tried amazon, I couldn't find the sublingual B1. Where could I find or purchase this vitamin.
You can ask Daphne via this Facebook page
facebook.com/groups/512119977204633/?hoisted_section_header_type=recently_seen&multi_permalinks=798435068573121
Parkinson disease is a very terrible illness, my Dad suffered from it for 19 years until we finally got a help and a medicine that truly works that helped treat, cure and reversed all his symptoms totally 💯. My Dad is well again…
Please tell us what medicine you used for your dad!!!
Please tell us the medicine and treatment that worked for your dad as I have parkinsons
When they make posts like this but do not state anything about the miracle cure….. it is usually a fake post.
Hello, why would you make a statement like that, then not tell everyone what worked for your Dad. We are all put on this earth to love and help one another, as Jesus said. So, please comment on what his regimental that, " he took. You might just bring relief and joy at being able to get back some of their former life. Praying you do the right thing. Just look inside your own heart and ask the question "should I help these people". Then do what your heart tells you to. From a daughter whose mother has parkinsons and desperately needs help.
Be Blessed.
@@donnarichardson2888 if you need the treatment you should contact Dr Madida on UA-cam
Anyone have the correct dose? I just got diagnosed at 39 with PD I’m devastated I’m very scared about my future I have young kids I need to find some hope 💔💔💔💔💔
Start slow at 50mg multiple times a day with mag citrate ,nutritional yeast ,and 10000 iu vit d....
I can imagine I was diagnosed at 35, 2019 my daughter was 4. I lost my job lost my ability to drive and worse her mom left me. I just stumble into this interview. I'm definitely getting a book and I'm going to try this. All I can saying to you is be strong don't be afraid to try...
Hi Daphne As I think you already know I am a new Parkinsonee and am keen on B1 and trying to see what else is available as treatment.
I have just watched a presentation on red light therapy which impressed me considerably. I had seen references previously in my research and thought can this be real but there is a much more believeable evidence
I am interested in your view or anyone who has tried the treatment. Dick
Dick, we have Dr Catherine Hamilton talking about Red light therapy in a couple of wks, so you may want to join us and ask the question directly
www.eventbrite.co.uk/e/update-on-red-light-therapy-and-its-potential-benefits-for-people-with-pd-tickets-413654430537
Quantum biology discussions of near infra red light, especially from daylight, CAN benefit mitochondrial function, which appears in the literature to be approaching the 'root cause'. Now, many things can increase that dysfunction, so reading as much of the research as possible is important, to find ways of improving those energy problems. Find doctors that are looking specifically at this research, and find one that knows more adequately about quantum biology. IMHO
Daphne what’s the name of your book my wife has Parkinson’s and we’d like to buy it
Unbelievable but have to believe because it is a fact that has been working with several hundred folks. I have read the book mentioned in this session.
One basic question is can human body absorb such a high dose of B1 or any other vitamin or nutrient for that matter, and still won't have any side effects ? I am not an expert in this domain but the general knowledge is that daily dose of most of these vitamins is few milligrams and excess intake esp. synthetic or artificial ones is flushed out by the human body.
So what happens in case of B1 therapy wherein you take multiple times higher dose than required by the human body ? Is that converted into new cells of various types which includes dopaminergic ones ? If part of the higher intake is converted, where goes the remaining ? If remaining quantity is stored by the body in some form, will that stock build-up not cause any problems in the body in future, may be after some years ?
A good question and one perhaps best to address to Daphne via her Facebook group that she monitors closely facebook.com/groups/parkinsonsb1therapy
In theory surplus B vitamins get excreted in urine but B6 for sure can cause neuropathy in its most common (cheapest) form at high doses over time.
How many mg should one take per of vitamin B1?
Hi, if you would like Daphne to reply then best to post the question on her Facebook group
facebook.com/groups/512119977204633
Dr Costantini recommended taking vitamin B1 by intramuscular injection
What is the recommended dose of B1
Daphne will probably not see this comment. She does run a Facebook group that she comments on daily so suggest asking the question there. This is the link facebook.com/groups/parkinsonsb1therapy
Hi good evening. I would like to know is B1 and BeOne the same
B1 is the proper name for Thiamine.
Good afternoon. To get the vitamin B1 dosage adjustment, we started with 500mg. But how much can we safely increase this dosage? Can you reach up to 2 g, for example, without major risks?
Daphne will probably not see this comment. She does run a Facebook group that she comments on daily so suggest asking the question there. This is the link facebook.com/groups/parkinsonsb1therapy
Is there any verified B1 sublingual tablet? Please provide name and source. Thank you
Daphne recommended this www.pureformulas.com/no-shot-b-1-100-mg-100-dissolvable-tablets-by-superior-source.html
Not sure where in the world you are but hope it helps
Will b complex 100 work as well?
Dr. Stasha Gominak has clinical evidence that B100 can become problematic, and B50's seemed far better to her point of view. Goggling her, or YT, brings her comments up.
If B1 level is important in normal gut environment, and in the vegas nerve pathway to the brainstem, is it also important physiologically in the dopamine-producing cells in the brain tissue? Is it important in mitochondrial functioning? If the brain volume shrinks as cells die, and near infrared light passing into the brain from the sun can help restore mitochondrial optimal function and numbers in such brain cells, does B1 play a vital role in this strengthening? Is B1 making its way through the BBB to be present there, and can a deficiency from normal levels there be overcome by increasing it? Is it additive, or synergistic, with melatonin produced in mitochondria by the NIR light? Does it help in Nitric oxide production to dilate capillaries to facilitate erythrocyte passage through to provide more O2 for ATP production?
Does a-synuclein mis-folded protein form fibrils that obstruct erythrocyte passage? Do these tangles limit O2 supply too much? Is melatonin level in mitochondria enough to deal optimally with the ROS production? Does B1 help in all of this, as well as in the gut?
Well, yes, a short Pubmed search brings up ample research suggesting importance of B1 levels in brain tissue: (eg.Mol Cell Neurosci
. 2013 Jul;55:17-25. doi: 10.1016/j.mcn.2012.09.001. Epub 2012 Sep 13.
Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes
Gary E Gibson 1 , Joseph A Hirsch, Rosanna T Cirio, Barry D Jordan, Pasquale Fonzetti, Jessica Elder
Glycation of the erythrocytes must also add to difficulty of maintaining good flow through small vessels, complicating the problem of the fibrils, and if the nitric oxide is not adequate?
If so, do we have 'erectile dysfunction of brain'?
And, for ATPase turbine 'lubrication' deuterium-depleted water Exclusion Zone water, increasing spin of the turbine and safeguarding ETC functionality? Can many 'hibernating' dopamine-producing neurons (under-fueled by glycation of supply system), and starving mitochondria into having to ration suboptimal ATP to more essentially needed neurons than those that produce dopamine, can hibernating but undead ones be refueled by use of exogenous ketone ester use?
Constantini essentially rediscovered the same mechanism of action as Dr.Derrick Lonsdale
Benfotiamine and L-tyrosine in my coffee with cream (they're both lipophilic)
I am really interested in trialling B1 but would this interfere with other medicines.
If PD starts in the gut, with a-synuclein, and 'normal' form of it mis-folds before it begins moving into the vegas nerve, to move up toward the brainstem via retrograde axonal transport, is it likely that a b-vitamin1 suboptimal presence in the gut allows increased mis-folding? Some observers of sleep dis-orders, and daily headache suggest that it takes enough vitamin D3 to allow the four symbiotic bacteria species (or genera) to be producing and sharing each other with the eight B's between them, for a 'healthy' bacterial assemblage to be present. What might the D3 level need to be to provide this ecology of gut? Given D3 being so commonly deficient in populations, can a B1 deficiency, because of aberrant gut bacterial assemblage, be causative? Is a-synuclein (with its 'normal' form actually doing some important function in gut not known yet), but under less supportive bacterial gut assemblage (with sub-optimal D3), have increased mis-folding to yield a dysfunctional protein, or even a more aberrantly-toxic protein to enter the vegas? Does the mis-folding process begin with deficiency of a metal such as zinc in zinc finger, or similar metal substitution by the toxic metal lead? Or, an amino acid sequence that includes adjacent placement of glycine/glycine near either end of the chain, where it can be readily subject to glycine replacement by glyphosate? Or, is there research currently that shoots holes in these suggested possible mechanisms? Both metal/metal substitutions, and glyphosate/glycine substitutions have some supportive evidence as real mechanisms. IMHO
In ayurveda India its told by Charak aacharya and give treatment like basti - anal enema n other
Ray, it seems you are well researched in this. Following your thinking
RAY KINNEY WHAT A BRILLIANT COMMENT !
Listen up everyone … everything he says is very significant …
IGNORE RAY AT YOUR PERIL
👍
Ray Kinney 👈🏿
BRAVO ….
Best comment here.
🤗🌟✅👍
@@snowyowl6892 Or, follow him at your peril, I'm ' just some guy on the internet', no alphabet soup following my name. And, probably more wrong than right.
😊😊😊 24:12 😊😊
What dose of vitamin B1 is best?
Did she take levadopa also?
Yes. It is not a substitute to it.
I take 600mg benfotaimamine. That is fat soluable does it work getting B1 that way. It is meamt to get into the cells easier.
Have you seen improvement with the benfotamine?
@@marcismiles I stopped taking benfotamine because it doesn't get into the brain. I take 1600mg of B1, 200mg thiamine B1, 1200mg TUDCA. A Dr is doing stage 2 clinical trials on UDCA for Parkinson's with promising results. UDCA is converted by the body to TUDCA, protects the neurons by stopping the mitochondria from telling the cell to die. TUDCA has loads of other health benefits. It is a bile acid salt. I take 2400mg of NAC, is converted into glutathione the body's main antioxidant, NAC gets into the brain to boost brain levels of glutathione. I take 900mg Alpha Lipoic acid, protects the neurons and mitochondria, stops the mitochondria from telling the neurons to die when under stress. They all help. You can research TUDCA, and search UDCA for Parkinson's. You van research NAC, and you can research ALA. Everything I do is aimed at protecting the neurons. I do a keto diet as well. That helped me lose 3 stone in weight. They all help. Hope this helps. I spend many hours looking for supplement that protects neurons. ALA is very good for Type 2 diabetes.
@@marcismiles I replied to you but it disappeared. Take 1600mg B1 and 200mg Thiamine B1 With TUDCA, NAC, and ALPHA LIPOIC ACID. Keto diet and they all work.
@@marcismilesI try to reply to you but the reply disappeared.
Love your show. I wish you would talk much slower so we can understand what you are saying.
11:48 Fatigue
interesting if true!
Benfotiamine is good for neuropathy, but only accumulates in the peripheral and does not cross the BBB as it is not truly lipophilic. Sulbutiamine and all allithiamine arr better for getting into the brain.
This protocol doesn’t work for everyone with Parkinson’s. I have Parkinson’s and Celiac. Celiac disease can inhibit absorption of vitamins and nutrients.
This will work...with Celiac you need to go carnivore...then after few days add b,1....quit dairy d gluten and sugar
Does benfotiamine (another form of B-1) have the same effect? I believe it has an affinity for the nervous system.
She seems to have answered my question.
Can't get rich selling Vitamins
It certainly seems to work two benfotamine and a magnesium threeonate my tremors are gone for at least 8 hours ,,,
What dose is each tablet
How many mg for each tablet?
In Parkinsons there is calcium buildup in the brain. To remove it use EDTA. Then to address the issue, try Vitamin K2 MK4 type because that is what our cells need. Vitamin K2 opens calcium ion channels, and may prevent the calcium buildup by getting the calcium where it is intended to go. Calcium is what sends the signal for neurons to release neurotransmitters. If the calcium ion channels begin opening and taking the calcium in properly, your condition may improve.
The α7 nAChR subtype has one of the highest permeabilities to calcium, the activation of which can raise cytoplasmic calcium levels and trigger a series of calcium-dependent intracellular processes. Calcium ions are one of the most versatile intracellular messengers known, and impacts almost every aspect of cellular life, including excitability, exocytosis, motility, apoptosis, and transcription; this is achieved by interacting with thousands of proteins and their downstream effectors9, 10. Calcium influx through nAChRs, particularly through the α-bungarotoxin-sensitive α7-containing nAChRs, is a very efficient way to raise cytoplasmic calcium levels. Here we will present a brief summary of the calcium signals initiated by the activation of neuronal nAChRs, and its possible physiological relevance.
www.ncbi.nlm.nih.gov/pmc/articles/PMC4002362/
Another thing to try is a Nicotine Patch or other form, gum, lozenge, pouch, etc.
Nicotine is a super agonist for the activation of neuronal nAChRs. Nicotine is present in all Nightshade Vegetables, Eggplant having the highest amount. It is in celery, potatoes, tomatoes, and more. So you see plain nicotine is not addictive. Tobacco products have many additives that make them addictive. Don't use them.
Yes, but I'd like to know why K2mk7 is not also helpful, by getting increased Ca into bone?
Yes mk7 is the most effective form.
Yes, some of the questions sparked by this presentation, listed below, are also clarified in significant research In Pubmed:
(e.g. Mol Cell Neurosci. 2013 Jul;55:17-25. doi: 10.1016/j.mcn.2012.09.001. Epub 2012 Sep 13.
Abnormal thiamine-dependent processes in Alzheimer's Disease. Lessons from diabetes
Gary E Gibson 1 , Joseph A Hirsch, Rosanna T Cirio, Barry D Jordan, Pasquale Fonzetti, Jessica Elder
So, deficiency of B1 can definitely play important roles in brain pathogenicity.
𝐩𝐫𝐨𝐦𝐨𝐬𝐦