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Parkinson's disease "The importance of the gut-brain axis in Parkinson's" by Dr Filip Scheperjans
We are delighted to be able to share with you our latest interview with
Dr Filip Scheperjans who shared with us his fantastic work on "The importance of the gut-brain axis in Parkinson's" which was followed by an excellent Q & A session.
More about our expert:-
Dr. Filip Scheperjans is a leading expert in neurology, specialising in treating Parkinson’s disease and focusing on advanced methods and gastrointestinal symptoms.
He earned his Licentiate of Medicine from the University of Düsseldorf in 2006 and completed his Neurology specialisation at the University of Helsinki in 2013. In 2008, he received his Doctor of Medical Science, focusing on neuroanatomy, and became Associate Professor in 2020 at the University of Helsinki.
Dr. Scheperjans investigates the relationship between gastrointestinal symptoms and the microbiome in Parkinson’s disease, exploring novel treatment strategies. His work includes advanced therapies like drug infusions and deep-brain stimulation, supported by major organisations such as the Academy of Finland and the Michael J. Fox Foundation.
He was the first to describe gut microbiota changes in neurodegenerative diseases and received the Young Researcher of the Year Award in 2019 from the Finnish Neurological Society.
You can find out more here:-
www.hus.fi/en/person/filip-scheperjans
www.michaeljfox.org/researcher/filip-scheperjans-phdmd
www.vjneurology.com/video/vpykfw5ps-e-microbiota-targeting-agents-for-parkinsons-disease/
Brain or body first Parkinson's www.vjneurology.com/video/agjjmdetii-brain-first-and-body-first-parkinsons-disease-are-there-subgroups-of-prodromal-patients/
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www.paypal.com/donate/?hosted_button_id=WMV6D8DD7CVYU
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Переглядів: 4 158

Відео

Parkinson's Disease:- "Finding the energy: What happens to mitochondria in PD?" by Prof Sonia Gandhi
Переглядів 8 тис.2 місяці тому
Prof Sonia Gandhi joined us to share her expertise on how Mitochondria affects PD with an excellent presentation followed by a very probing Q&A by our well informed audience. Prof Gandhi is a leading expert in the process of protein misfolding, in which smaller proteins, monomers, join together to form larger proteins, oligomers, and how this process may drive organellar dysfunction and cell to...
What have I learned from speaking to 30 Parkinson's researchers?
Переглядів 5 тис.2 місяці тому
Beatrice Zatorska, Founder and CEO of the PD Buddy App, recently spoke with Michel Planquart, co-founder of the Parkinson's support group No Silver Bullet 4PD, about his insights from conversations with dozens of Parkinson's researchers over the past few years. The interview, originally conducted for the Young Onset Parkinson's Network newspaper, highlights Michel's journey in becoming a genera...
"Why I am optimistic that we might now have a Silver Bullet for PD" by Dr Jonathan Sackner-Bernstein
Переглядів 45 тис.3 місяці тому
We had the pleasure of a presentation by Dr Jonathan Sackner-Bernstein, MD, on the topic of "Why I am optimistic that we might now have a Silver Bullet for Parkinson's", followed by a Q&A session of almost 50 probing questions from our audience. Dr. Jonathan Sackner-Bernstein is transforming the treatment of Parkinson’s disease (PD). First, he discovered that the brain cells (dopaminergic neuro...
"Inflammation and Parkinson's"- a discussion hosted by Cure Parkinson's
Переглядів 4,5 тис.4 місяці тому
We are delighted to share this discussion on "Inflammation and Parkinson's" that was held by Cure Parkinson's in partnership with the University of Edinburgh and the Journal of Parkinson’s Disease, with Edinburgh University’s Professor Tilo Kunath as chair. This hour-long webinar is for the Parkinson’s community and allows the opportunity to hear first-hand from experts in the field, to learn m...
Advancing Inclusivity Efforts in Parkinson's Research by Anaya Navangul
Переглядів 3514 місяці тому
We are delighted to share this recording, the 4th of a series of 4, that one of the world's leading PD Charities, Cure Parkinson's, hosted recently in Central London. Parkinson's affects patients across all ages, racial, ethnic, socio-economic, geographic, and gender demographics; despite this, promoting equality, diversity, and inclusion (EDI) remains a challenge in Parkinson's research. In th...
Cure Parkinson's Research Update Spring 2024 presented by Dr Simon Stott
Переглядів 2 тис.4 місяці тому
We are delighted to share this recording, the 3rd of a series of 4, that one of the world's leading PD Charities, Cure Parkinson's, hosted recently in Central London. In this talk, Dr Simon Stott, Cure Parkinson's Director of Research, gives an update on new and ongoing research projects, as well as a look at what is to come over the next year. Originally from New Zealand, Simon has more than 2...
LixiPark (lixisenatide) trial results by Prof Olivier Rascol
Переглядів 1,3 тис.4 місяці тому
We are delighted to share this recording, the 2nd of a series of 4, that one of the world's leading PD Charities, Cure Parkinson's, hosted recently in Central London. The results of the Cure Parkinson's co-funded phase 2 clinical trial of lixisenatide (LixiPark study) were published in the New England Journal of Medicine. The researchers reported that the trial had met its primary outcome, indi...
Montpark (montelukast) trial results by Prof Per Svenningsson
Переглядів 1,2 тис.4 місяці тому
We are delighted to share this recording, the 1st of a series of 4, that one of the world's leading PD Charities, Cure Parkinson's, hosted recently in Central London. Cure Parkinson's Linked Clinical Trials (iLCT) programme aims to repurpose existing drugs that have shown promise in other diseases and test their effectiveness in people with Parkinson’s. Now in its 12th year, the iLCT initiative...
"Practical strategies for a happier life with Parkinson's"- an interview with Dr Michael Okun
Переглядів 8 тис.4 місяці тому
We had the pleasure of interviewing Dr Michael Okun on the topic of "Practical strategies for living a happier life with Parkinson's". Dr Okun is a worldwide recognised leader on Parkinson’s disease, is the distinguished Professor of Neurology and Director of the Norman Fixel Institute for Neurological Diseases at the University of Florida Health. The UF institute he co-founded with Kelly D. Fo...
"How can medical cannabis help people with Parkinson's" by Dr. Michelle Sexton
Переглядів 3,2 тис.5 місяців тому
We were delighted to host Dr Michelle Sexton who presented on the topic of "How can medical cannabis help people with Parkinson's" and here is the recording of the event. About the speaker:- Dr. Sexton is an integrative medicine specialist and respected pioneer in the field of medical cannabis. She has over thirty years of experience as a midwife, herbalist, and naturopathic doctor. She complet...
"The importance of genetics in finding a cure for Parkinson's" by Prof Christine Klein
Переглядів 1,4 тис.6 місяців тому
We were delighted to host Prof Christine Klein who talked to us about "The importance of genetics in finding a cure for Parkinson's". It was a really interesting presentation and followed by a very good Q&A with excellent questions from you our audience, so thank you. It is now a very worthwhile video to understand more about this important topic. About the speaker:- Christine Klein is a profes...
“The role of Focused Ultrasound in the management of PD" presented by Dr Raul Martinez
Переглядів 2,4 тис.7 місяців тому
We are excited to share our latest interview with you all, in which Dr Raul Martinez- Fernandez explains the therapy of Focused Ultrasound, a therapy that offers appropriate candidates with an alternative to the more intrusive DBS. It is of course not a replacement for DBS, simply an alternative offering a solution for those with differing symptoms. More about Dr Martinez-Fernandez:- Dr Raul Ma...
"PD research takeaways from 2023 & research to be looking for in 2024" presented by Dr. Simon Stott
Переглядів 7 тис.8 місяців тому
We are delighted to host Dr. Simon Stott again in what is becoming our regular start to the year's presentations. And what better way than to hear Dr. Stott's main PD research takeaways from 2023 and research results he will be looking for in 2024. For those of you who are unfamiliar with Dr. Stott's work, Dr Stott is the Director of Research at Cure Parkinson's. The trust is an international s...
Merry Christmas and a Happy New Year
Переглядів 5439 місяців тому
A very Merry Christmas and Happy New Year
Prof Bas Bloem presents "The importance of nutrition in managing Parkinson's disease"
Переглядів 26 тис.9 місяців тому
Prof Bas Bloem presents "The importance of nutrition in managing Parkinson's disease"
Dr Matthew Phillips presents "Neurodegenerative Disorders as Metabolic Icebergs"
Переглядів 4,2 тис.10 місяців тому
Dr Matthew Phillips presents "Neurodegenerative Disorders as Metabolic Icebergs"
The "UP-study" phase 2 trial of UDCA Co funded by Cure Parkinson's led by Prof Oliver Bandmann
Переглядів 7 тис.10 місяців тому
The "UP-study" phase 2 trial of UDCA Co funded by Cure Parkinson's led by Prof Oliver Bandmann
"Light therapy for Parkinson's":- Dr Wayne Markman CEO SYMBYX
Переглядів 9 тис.10 місяців тому
"Light therapy for Parkinson's":- Dr Wayne Markman CEO SYMBYX
"In the Shoes of a Woman living with Parkinson's" by Dr Annelien Oosterbaan & Richelle Flanagan
Переглядів 3,6 тис.11 місяців тому
"In the Shoes of a Woman living with Parkinson's" by Dr Annelien Oosterbaan & Richelle Flanagan
Dr Lorraine Kalia "Drug repurposing for Parkinson's therapies"
Переглядів 6 тис.Рік тому
Dr Lorraine Kalia "Drug repurposing for Parkinson's therapies"
Parkinson's disease:- CUE1, a wearable device to reduce slowness & stiffness in Parkinson's
Переглядів 15 тис.Рік тому
Parkinson's disease:- CUE1, a wearable device to reduce slowness & stiffness in Parkinson's
Dr P Tass "The Parkinson's glove & Vibrotactile fingertip stimulation to ease Parkinson’s symptoms"
Переглядів 11 тис.Рік тому
Dr P Tass "The Parkinson's glove & Vibrotactile fingertip stimulation to ease Parkinson’s symptoms"
Parkinson's disease "What do successful people do to slow down PD progression?” Dr. Laurie Mischley
Переглядів 104 тис.Рік тому
Parkinson's disease "What do successful people do to slow down PD progression?” Dr. Laurie Mischley
Parkinson's disease:- Julie Jones Exercise & Physical activity; Getting started & staying active
Переглядів 3,9 тис.Рік тому
Parkinson's disease:- Julie Jones Exercise & Physical activity; Getting started & staying active
The ASPro PD phase 3 clinical trial of Ambroxol by Cure Parkinson's.An update and panel discussion
Переглядів 10 тис.Рік тому
The ASPro PD phase 3 clinical trial of Ambroxol by Cure Parkinson's.An update and panel discussion
Dopamine cell replacement therapies for Parkinson's:- Where are we now by Prof Roger Barker
Переглядів 13 тис.Рік тому
Dopamine cell replacement therapies for Parkinson's:- Where are we now by Prof Roger Barker
Parkinson's Disease:- Dr Rick Helmich "Managing Stress with Parkinson's Disease"
Переглядів 5 тис.Рік тому
Parkinson's Disease:- Dr Rick Helmich "Managing Stress with Parkinson's Disease"
Parkinson's Disease - Dr Matthew Phillips: Intermittent Fasting & Keto & Diet Strategies
Переглядів 89 тис.Рік тому
Parkinson's Disease - Dr Matthew Phillips: Intermittent Fasting & Keto & Diet Strategies
Parkinson's Disease:- Dr. Simon Stott's research highlights from 2022 & what's in store for 2023
Переглядів 11 тис.Рік тому
Parkinson's Disease:- Dr. Simon Stott's research highlights from 2022 & what's in store for 2023

КОМЕНТАРІ

  • @alexd7466
    @alexd7466 2 дні тому

    Even though I hear lots of good advice, his lack of knowledge about nutrition worries me. He says that in order to prevent malnutrition, one simply has to increase calories. How can an expert say something silly like that? And also, since Parkinsons is a metabolic disease related to high insulin levels in the brain (which can't be used by the cells), the best way is to replace carbs by fats, so the brain is able to use ketones, and the gut microbiome can start to heal. High fiber is only required on a high carb diet, so replace carbs and the fiber isnt an issue anymore. The are thousands of studies about the effects of keto on parkinsons, so very strange that he could only cite one pilot study. Looks like he didnt do his homework well enough.

  • @jderucki
    @jderucki 6 днів тому

    Those are two great men . thank you for your contributions to the Parkinson’s community.

  • @roseogundo9323
    @roseogundo9323 8 днів тому

    Where do i get the book i live Kenya. Dr

  • @geoffreysayer4073
    @geoffreysayer4073 8 днів тому

    Thank you. Just catching up on PD science, as a recently diagnosed patient, and this was by far the clearest and most helpful analysis I have seen.

  • @ClareBoyd-f8c
    @ClareBoyd-f8c 8 днів тому

    Young Amy Jones Jennifer Allen John

  • @ClareBoyd-f8c
    @ClareBoyd-f8c 10 днів тому

    Anderson Edward Thompson Deborah Anderson Karen

  • @janetfuchs7565
    @janetfuchs7565 10 днів тому

    This is one of the most fascinating and helpful presentations I've ever seen. Thank you so much for posting it. I follow all your episodes and trust your scientific integrity.

  • @symbyxbiome
    @symbyxbiome 11 днів тому

    If we have a look at the number of people who report experiencing constipation and other gut issues prior to their PD diagnosis (even decades before), the importance of the gut in Parkinson's becomes clear as day. It's EXACTLY why we look at treating the gut here at SYMBYX. This message is so important - thank you for sharing this.

  • @p.a.93
    @p.a.93 11 днів тому

    Many report keto diet and carnivore diet have solved PD. Start with ua-cam.com/users/live_FsuO_dOR4M?si=ac6iblHZCFQrX6VZ

  • @YogaatAUMhOMeShalaMiami
    @YogaatAUMhOMeShalaMiami 12 днів тому

    Fabulous! Thank you for sharing your important work.🙏

  • @valmajames1556
    @valmajames1556 12 днів тому

    If you transplate faetal matter from one person to another. How do this impact on the gut DNA?

  • @kevink9720
    @kevink9720 12 днів тому

    Neurologist Matthew CL Phillips promotes fasting & ketogenic diet; Much less carbs (and grains) than indicated in the Western "Food Pyramids", and Mediterranean diet.

  • @JLH63
    @JLH63 13 днів тому

    Interesting that paléo medecina in Hungary is researching the ´leaky gut’ problems for years now and are succesfull treating this as the the health problems it gives Little to no interest from the scientific world for their work,even to get their case studies published Worth looking closer ICMN as it is called nowadays I believe…

  • @janetgies8698
    @janetgies8698 13 днів тому

    I learned about the intestines/gut-brain (hence “leaky bowels”) connection. I keep things flowin’. 😉Kids in high school need to learn about the Proper Human Diet.

  • @raulikarkulahti9669
    @raulikarkulahti9669 13 днів тому

    Interesting 👌

  • @julieolson2272
    @julieolson2272 13 днів тому

    I've had parkinson's for 25 years. And I'm in a wheelchairbut I can talkand luck a little bitand. Walk a little bitand I have no problems with my speech so I don't think I'm in level 5..

  • @peterraymond1853
    @peterraymond1853 18 днів тому

    METAMUCIL... Loaded with ASPARTAME

  • @peterraymond1853
    @peterraymond1853 18 днів тому

    DAIRY.... Bad But is Fermented dairy such as L.Reuteri "Better"

  • @davoodazarangi6986
    @davoodazarangi6986 20 днів тому

    information about frequency of alpha , beta , and theta was wrong.

  • @donnarichardson2888
    @donnarichardson2888 29 днів тому

    Maybe go to Michael J Fox for grant money!

  • @juliaorpheus
    @juliaorpheus 29 днів тому

    I LOVE your show, so informative and helpful. I especially appreciate the alternative medicine topics and the critical, yet open-minded approach your show has to looking for answers for people with Parkinson’s.

  • @lisettecadottegiroux2414
    @lisettecadottegiroux2414 Місяць тому

    May we have the document in French, please? Thank you!

  • @coryarts
    @coryarts Місяць тому

    Been using the Duo Coronet on my toe and my toe nail fungus is clearing up, tried for two years to get rid if it , also noticed other minor changes in my books that is my stools are softer before they were harder, So I guess RLT is working but I will have to notice a major change. Started my Mom on RLT last week 8/18/24, she has Alzheimer hope it helps her.

  • @janedouglas2991
    @janedouglas2991 Місяць тому

    see: YT: Dr. Matthew Phillips: "Parkinsons and Mitohormesis". Just connecting the dots re: Mitrochondrial function

  • @mariannelittleford2044
    @mariannelittleford2044 Місяць тому

    Hi, how can I purchase one of your hats and how much will it cost, please 🙏

  • @neilslade
    @neilslade Місяць тому

    The web is full of testimonies from people who have reversed and even totally eliminated symptoms, with supporting documentation. What planet are these people on? (I am talking about doctors taking the conventional line on the cause/treatment for PD) For myself, my PD number was 37 in Dec of 2019, today July 2024 it's 22. My personal feeling is that "Parkinson's" is nothing but a catch all phrase for a situation and symptoms that have a wide variety of causes, all different and individual rather than a single cause that all PD patients have in common. I can see symptoms dramatically differ within a 24 hour period, simply a result of changing other unrelated meds I am taking for pain and/or sleep, which I am working to eliminate completely.

  • @DailyDoseOfImbeciles
    @DailyDoseOfImbeciles Місяць тому

    Why don’t the manufacturers (looks like Bausch) of the drug RB190 want to back a trial…?

    • @RickinICT
      @RickinICT 6 днів тому

      If it's been around since the '70s, it's long since off-patent.

  • @davidbarrett8348
    @davidbarrett8348 Місяць тому

    The Q&A demonstrated how near we are to a cure. Answer: NOT EVEN CLOSE!

  • @Dreamopticsredlightglasses
    @Dreamopticsredlightglasses Місяць тому

    Amazing conversation, thanks both, I'll be back to listen to the second half 👍

  • @paulochaves1687
    @paulochaves1687 Місяць тому

    Hippocrates already stated that diseases begin in the intestine. The basis of treatment begins with modular the intestinal microbiota, decreasing its permeability and cutting out inflammatory foods. The purpose of this is to prevent Alpha Syneclein from traveling up the vagus nerve and feeding the deposits of this substance in the brain. Despite not being able to avoid a total blockade, It is achieved through reducing substances such as antioxidant vitamins and some amino acids such as N-Acetyl-cysteine, N-Acetyl-Carnitine, Coenzyme Q10, among others, including all B complex and omega 3 with three main objectives: Increase the level of Glutathione beyond PQQ to reduce this oxidative stress. at the brain level to reduce oxidation, substantially improve the production of ATP by mitochondria and produce from amino acids such as L-Tyrosine, a non-oxidized dopamine. And by associating Levedopa/Cardidopa as auxiliaries, there is a result shown very promising. The key substance in the whole process is NADH, as it is the best substance for mitochondrial activation, especially in the form of an implant, Vitamin B2 protects Glutathione from oxidation and is used in injectable form as it combines Glutathione itself which has a short life in the system. The treatment does not aim to reduce alpha Synuclein, since the glalia no longer suffer from the inflammation process. This is due to a healthy feedback that inhibits the presence of harmful substances such as excess glucose, oxidative stress and bad fats, among others. In this aim, we seek to treat the patient and not just the disease.

    • @paulochaves1687
      @paulochaves1687 Місяць тому

      This is an opinion. My mother has PSP and I use this conduct tô help her. This disease is terrible.

  • @MiltBrewer
    @MiltBrewer Місяць тому

    Michel purchased TENS for my partner. He has not used it on his hands but I’ve used it on his back many times and he loves it. Last night I put it on my back as well and must say it’s very relaxing. I seem to notice that stress and overextending himself seems to aggravate his symptoms. So we’ll keep using the TENS and extend it to his hands…

    • @nosilverbullet4pd998
      @nosilverbullet4pd998 Місяць тому

      Great. Please let me know how it goes!

    • @MiltBrewer
      @MiltBrewer 2 дні тому

      @@nosilverbullet4pd998 Michel, my partner has been using TENS for about a month now. He uses it on his hands for 30 minutes in the morning and his back for 30 minutes in the morning and at night. We haven't noticed a difference in his symptoms but it certainly relaxes him. He really enjoys the quiet time that it allows. He is also on high dose B1 therapy and has been for about 8 months. We have noticed a difference in his handwriting, gait and arm swing. We do believe he's found his "sweet spot" and his dosage is going to remain the same. We went very slowly increasing the B1. Thank you for time and I'll keep watching you.

  • @markprana
    @markprana Місяць тому

    Here is a very informative interview with Prof. Glen Jeffrey that gives grest insight and helps connect the dots with the potential benefits of this approach with PD: ua-cam.com/video/yllNLJi1S0Q/v-deo.htmlsi=Ph5BUmZ6nInMTKly

  • @mylifecoach163
    @mylifecoach163 Місяць тому

    This is exciting information!

  • @robertschrum5496
    @robertschrum5496 Місяць тому

    My goodness, a doctor who advises taking a Calcium supplement? That's something expected from a third grader. Maybe she slept during nutrition class. Calcium supplements are an absolute no.

  • @annb5610
    @annb5610 Місяць тому

    How do you explain all the healthy athletic people who get this disease.?

    • @supersport22
      @supersport22 Місяць тому

      Probably a history of neck injury, concussion, whiplash etc. These injuries can crimp the jugular vein which drains the cerebrospinal fluid. A disruption can cause a detoxification impairment in the brain. This is probably what happened to Michael j fox and Muhammad Ali both of whom had head trauma earlier in life. Either that or EMF

  • @gavinmogan9467
    @gavinmogan9467 Місяць тому

    Great interview! Mastery of both the content and its application.

  • @coffee_5647
    @coffee_5647 Місяць тому

    The idea that an egg in the morning can ruin meds for the entire day is new to me. So far, the most conservative advice I've come across is to wait 2 hours after consuming protein before taking levodopa. (Of course, this timeframe would have to work with the individual's medication needs overall.)

  • @sandraarchuleta6991
    @sandraarchuleta6991 Місяць тому

    Iwas told that diabetes was a part of Parkinson’s by a dr

  • @robert9248
    @robert9248 Місяць тому

    Is anyone out there using Ambroxol as I am for their Parkinson’s and at a much lower dose than Clinical Trials

  • @tomkeresztes3210
    @tomkeresztes3210 Місяць тому

    This was tip top - great speaker (thank you Dr. Ghandi) and fantastic presentation.

  • @anitajugwanth9524
    @anitajugwanth9524 Місяць тому

    Thank U for the HOPE

  • @ngana8755
    @ngana8755 Місяць тому

    It would have been helpful if the title for this video stated that Dr Jonathan Sackner-Bernstein has a hypothesis that Parkinson's Disease is caused by too much dopamine, not too little. I had to watch 20 minutes of this before finding that out. People these days don't have the time to watch an hour or an hour and a half of video to have scientific knowledge that can be summarized in nuggets that are 5 minutes long.

  • @coffee_5647
    @coffee_5647 Місяць тому

    Interestingly, there is research that suggests that exposing the eyes to certain wavelengths of red light improves eyesight, allegedly by "charging" the mitochondria.

    • @kathrynmathews4654
      @kathrynmathews4654 Місяць тому

      It's interesting that Professor Glen Jeffrey, also at UCL, is researching into the effects of red light on the eyes with Moorfields Eye Hospital . He also refers to using using photobiomidulation with good effect on children with mitochondrial disease - it's intriguing

  • @normanrubenzer
    @normanrubenzer 2 місяці тому

    not enough doctors believe in red light.

  • @steveh1460
    @steveh1460 2 місяці тому

    Very informative .! Thank you

  • @doriscorr334
    @doriscorr334 2 місяці тому

    Sonia Gandhi keep on searching. You are a great hope for us with PD.

  • @RDZimmerman-m8u
    @RDZimmerman-m8u 2 місяці тому

    Such an excellent presentation, clear and informative. I have the PINK1 mutation, so I found this particularly interesting.

  • @audreyboyle52
    @audreyboyle52 2 місяці тому

    You would think a ketogenic diet would have a positive effect on a number of levels from reducing insulin resistance in the brain to damping inflammation and boosting mitochondrial function

  • @gerbrandkomen5674
    @gerbrandkomen5674 2 місяці тому

    A surplus of free dopamine in the cytosol of dopaminergic neurons and a shortage of packed vesicular dopamine in these cells hints in my opinion at a failure in the dopamine packaging mechanism. In fact several studies have shown that a reduction in VMAT2 expression or function in Parkinson's disease leads to impaired dopamine packaging. Targeting this failure seems a better therapeutic strategy then reducing dopamine production. Any comments on this idea?

  • @audreyboyle52
    @audreyboyle52 2 місяці тому

    A beautifully clear presentation. So in addition to exercise it would be worth a shot at supplementing TUDCA (a supplement similar to UDCA which is about to enter P3) NR or GLP1 agonists to help our ailing mitochondria!