Platelet Plug Formation - Mechanisms

Platelet Plug Formation is an important part of hemostasis. Watch the video and see how platelets become "sticky" to one another and form a plug to stop blood flow.

[@musukabrian2260]

this video has saved me long hours of reading text.

[@cloudsgamezz]

I'm not a medical student but I watch this type of videos to admire the complexity of the creation of GOD. Such a small thing that is invisible to the eyes has such a giant functionality with multiple phases. Greatly explained btw

[@SJs0705]

This is what i was looking for...other videos are tooo confusing

[@sander1099]

Very clear explanation and I like your animation style + summary. I was baffled that your videos are not nearly as much viewed as I expected. You deserve more viewers/subscribers!

[@physiopathopharmaco4190]

Thank you so much Sander for the comment- yes we are hoping for more subscribers - I think they will come as we continue producing the best quality videos we can.

[@brokebhutaneseartist8620]

i like your way of explaning, it is simple and wonderful, less headaches

[@bikrantguragain5012]

this is the best video i have ever seen.....short and sweet and of enough content

[@aninditadevasarmah4373]

This simplified the process so much, it's gonna stay in my brain forever 😍 didn't understand so well even after slides in class and textbook. Thank you so much 🙂

[@saeedanwar2622]

Oh man we love your videos you deserve more subscribers and views now i knew why the diamonds are hard to find❤

[@sachinchikku89]

Best video about platelet in UA-cam...
Thanks a lot man !!

[@ahmedmohamed-lh7hb]

مفيد جدا و وفرلي وقت كتير , متشكر ياباشا والله

[@pragyabiswas1562]

Summary:
1. Vessel damage + vWF secretion
2. vWF binds to collagen
3. Circulating platelets bind to vWF via GPIb receptor
4. Platelet activation (conformational change in platelet shape+ expression of GPIIb receptors)
5. Release of alpha and dense granules to release vWF, PDGF; ADP, TXA2 respectively.
6. Fibrinogen binds to GPIIb/IIIa receptors
7. Platelet aggregation

[@debigdogk9563]

Awesome teaching, your videos are always helpful, thank you ❤❤❤❤❤

[@taqwasabri4329]

thank u helped a lot, loved the question part at the end too

[@physiopathopharmaco4190]

Thank you for the feedback, glad it helped 🙂

[@rapstartwagi9397]

Wow,I felt brilliant learning from this video and answering the questions right.Thank you!!

[@miranabubakr5844]

Thank you for your simplified lecture, it helps a lot! 😍

[@parhamvatankhah2609]

It was great, from an engineer working on blood flow and litteraly knowing nothing ;)

[@Doctr_dope]

Love you brother. This video helped me understand this difficult mechanism.

[@emanarif5248]

Thank u sooo much u saved our time

[@kainatgul4063]

Too glad to see this vedio...thank you very much for making this topic soo easy for us

[@rachellarson7543]

Thank you for simplifying this process. It's a lot harder to understand in the book :(

[@physiopathopharmaco4190]

You're very welcome - Very glad it helped!

[@ayeshanaseem9953]

This video made it Much easy to understand ❣️Thankyou

[@عزالدينالشيخسليمان]

1. C
2. D
3. C
4. A
thanks a lot

[@noxusfumes3628]

Extremely helpful! Keep up the good work man

[@Alchemist_171]

Worderful. Simple and neat, just as I needed it! Thanks so much!

[@bhavishapatel8459]

Exactly what I wanted I got her!! Thankyou 👍

[@pranavireddy1884]

Thank you so much it's really very helpful ❤️ and also questions at the end are also interesting .

[@physiopathopharmaco4190]

So glad it was helpful

[@wem3121]

Thank you!! I absolutely needed that for my finals! >_< you are a life saver

[@ndhart3213]

We M,
Cells at work might help...

[@vi....6124]

متشكر اوي يباشا 🥹🤍

[@josephcoon5809]

3:00 Question about endothelial damage.
Spike proteins that attach to ACE-2 receptors on cell membranes. Since spike proteins produced by mRNA vaccines are not covered by sugar, I assume there are more active sites on the spike proteins which your immune system will generate antigens for.
Wouldn’t this create a thrombus-like growth composed of spike proteins and antigens?
If so, wouldn’t blood flow create increase stress upon endothelial cells which could tear the membrane resulting in conventional thrombosis on top of the spike protein/antigen pseudo-“thrombosis”?
Also, basic fluid dynamics would predict a higher velocity of plasma through smaller blood vessels creating higher stresses on endothelium cells. This would contribute to endothelial damage triggering conventional thrombosis.

[@javierfongzuluaga2054]

Amazing explanation, thank a lot

[@masumrabbani9996]

Just awesome sir...want more

[@patch0789]

This was extremely helpful thank you 🙏

[@physiopathopharmaco4190]

You're so welcome!

[@devanshimehta7416]

Thanku so much..for your wonderful effort.

[@stricklandfamily928]

Wow! Just what I needed. Thanks! 🔥

[@freedaboyoung3722]

Excellent video thanks

[@tavishg]

Awesome videos.. keep up the good work.god bless

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great clarity and simple presentation.how did you make it? Interested in making such videos .Am also a teaching faculty in a medical school..Wud appreciate if you cud give a hint abt the software or app used in making this.

[@murukeshtimetvm4119]

Thank you ❤️

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Thank you so much sir 🙏🙏🙏

[@ayachb3563]

Thank you so much.. Very helpful

[@physiopathopharmaco4190]

Awesome- you’re very welcome

[@정두릅]

it helps a lottttt thank you :)!!!!

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Thank you very much

[@muhammadsaad124]

Best video❤

[@qasimzia8842]

Made it very easy.

[@rawanabdullah3026]

Thank you very helpful

[@nagatsatti8426]

Thank you so much doctor

[@pratibharajbhandari7919]

Thank you

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brilliant work

[@MarYam-ei2vx]

Thank u 🌼

[@physiopathopharmaco4190]

You’re welcome 😊

[@immadisarojini2775]

Nice 👍

[@doctorsuze5731]

‏‪what is the function of thrombin for platelet adhesion?
Please answer me .

[@vijaylaxmimishra4449]

Thank u

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Nice video

[@asmaaaboalmagd792]

Thanks for video

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❤

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[@user-ec1uy8jl3i]

Wow ! Thanks ♥️

[@drmisha2814]

It helped a lot

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You're awesome

[@vedataslan6121]

Thank you so much. Did you made this in MS PowerPoint?

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Goodddd 👏🏻🤟🏻

[@nerd_nafis]

thank u so much.that was really helpfull..

[@physiopathopharmaco4190]

You’re very welcome, thanks for the comment.

[@jas9art]

Thanks!!!

[@physiopathopharmaco4190]

You bet!

[@yasminmeirelles6184]

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[@physiopathopharmaco4190]

You’re welcome glad it was helpful

[@bluepoop7365]

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[@straightforward8928]

Thnks

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is that a course for med students or nuses students ?

[@physiopathopharmaco4190]

It’s for both, thanks for watching

[@jaleelbarnes7142]

Love yall

[@devanshimehta7416]

Can u pls tell me what is the difference between secondary hemostatic plug, clot and a thrombus?

[@عزالدينالشيخسليمان]

mostly the word thrombus describe something pathological although it might be the same as clot

[@devgahlot]

What about the role of GP6?

[@geocacheguy6736]

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[@bio366geethasankar7]

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