No powerpoint. No notes. Straight memory. One drawing using organized multi-colored markers. One slide telling the whole scientific story. This Ninja Nerd is mastery on a level I've never seen. Might have to buy a t-shirt.
This video has some errors that should be reviewed. In order for the intrinsic pathway to work properly you need calcium (Ca2+) not just for factor X activation, but from the start at factor XII. Nitric oxide prevents platelet aggregation not adhesion by blocking GP2b/3a. If the platelet is binding to the endothelial lining (adhesion) and you want to prevent this, vWF or GP1b would have to be blocked, typically a heparin drug is used. Not only is protein C needed to keep blood from clotting but so is Protein S. They both inhibit factor V & VIII. Overall hemostasis and coagulation is broken down into 3 steps not 5; Primary hemostasis: formation of platelet plug due to damage, Secondary hemostasis: formation of fibrin clot and repair, Tertiary fibrinolysis: breakdown of clot.
@@xavierxrcYeah there are so many mistakes here that this video has actually made it harder to study. Even more than what you listed. TPA is not streptokinase, steps are missing or numbers or pathways are wrong. If you're trying to study for a test, watch this once for the big picture at most, and then use your book and study materials for the foundational details before you start to solidify mistakes and have to unlearn them.
I never in my life had a professor as good as you, they "tried" to explain this in weeks what you clearly did in 40 min. Amazing content for all the medical students out there!!!!
I am simply amazed at the fact you collected this vast amount of medical knowledge and thorough understanding which enabled you to explain in simple language even a child can understand. The multitude of subjects you have covered is usually in medical text books in hundreds of pages of several chapters. How in the world were you able to absorb that knowledge? With people like you, pretty soon every human being will become his own doctor! They just have to view Ninja Nerd Science videos on UA-cam!
I just want you to know that 7 years later and this video is still helping medical students throughout the world. I love you! Thank you for sharing your knowledge and love of teaching free of charge for us to consume. Thank you a million times!
I am a "way-older" adult returning to school after 30 years and having trouble understanding many concepts in my Patho 1 course. I actually cried cause your info and teaching-style allowed a light bulb to go off in my dusty brain. Thank you.
they do it purposely... srsly.. i have realized this... a lot of PHD's do not want to teach but they have to teach for money ofcourse and because they had shit dng the phd they purposely make stuff look confusing and hard for students because their very intent is not to teach... I know what i said is v harsh but this is what i noticed in most of the PHD Professors... they some how miraculously want you to just know everything ALREADY. Then why do we even need the degree or why do we even need to be in school if we knew stuff already ...
You mic dropped, with your stare, at 31:27ish - as you were unlocking a key to teaching the next generation. I’ve listened to this lecture 5 or so times in the car, first time watching and taking notes, and you are a great teacher who has worked hard to develop this.
People at my school literally go to your channel before watching the lectures here or even looking at the ppt slides, and I think I'm going to follow their footsteps. You made something so complicated so easily understandable. Quit making med school look like a piece of cake man!!
Holy crap I cannot thank you enough for 32:00-32:45! That is SUCH an easy way to remember the pathways! That outline really helped me scaffold the whole thing. That's wonderful.
ANyone reading this please find a way to make up a way to memorize everything. Maybe I am just lucky that I am creative but idk how anyone survives without making up weird memorization tricks for everything, apparently it's a talent or you haven't tried yet. no matter what it will all be goofy sounding if you make it up but it just has to work for you
This is my first UA-cam comment, and I just wanted to thank you for making this along with the rest of your videos. I’m an M1 and have been having a rough time with how competitive medical school is with constant exams being thrown at you. It’s been overwhelming to say the least. I have a biochem exam tomorrow and I’ve been freaking out over the material and I almost want to cry because you made me finally understand it! You’re better than Lecturio! Lol.
Hi.... I don't usually comment on youtube videos but this time I did to just tell you how amazing you are. You're the type of teacher that actually shows the why and the how instead of projecting information without reasoning!
You are the best physiology teacher you know I watched this video in class because my lecturer is explaining and I couldn’t understand 😭🥺then I remembered I have NINJA 🥷 NERD and I watched...God bless you
I am not a native English speaker, and study this process from books is really tiring. You make it so simple and easy to understand. Thank you Ninja Nerd!
I'm brazillian and i have to say that i understand more about all these complex subjects with you, than i do when i watch classes in portuguese, even though being my mother language. The way you teach, the passion you transmit when you are speaking, it can surpass even the language barrier, it makes us feel comfortable to learn more. So, i hope you keep up with this good work. 🤝
I honestly cried after watching this. I loved it and i think i will never forget this ever. You are literally the best teacher ever and yo should be recognised even more !
you did what my professor couldn't do for months in 50 minutes , you're the best physiologist PROF .that I've ever seen in my life . thanks million ninja much respect for you from me and from all medical students in Yemen . { Sana'a University Faculty of medicine
+Koustav Supriya Thank You so much for your kind words, I cant express how much that means to all of us here from Ninja Nerd Science. Your comment is greatly appreciated and I hope that these videos helped.
@@NinjaNerdOfficial hi sir thanks for ur video but can u give me a reference from which i can get more details and drogs and please tell me where do u bring ur information from
Bro the way of ur teaching is another level we can understand subject easily in your videos that we didn't understand at the classroom thank you buddy u made me understand the subject with grief ur amazing to convey the concept we're greatful to watch ur video's u can deserves millions of views
I feel like I comment this a lot but from the bottom of my heart 1) You are the main reason I'm passing vet school 2) Your enthusiasm is one of the most important things that keeps me excited about learning about medicine. I truly, TRULY cannot thank you enough!
Every time I watch you videos, I’m amazed by three things. Firstly your amazing knowledge, secondly the amazing complexity of the body and thirdly the amazing ability of man to figure all this complexity out.
My professor taught us a great trick to remember the intrinsic pathway coagulation factors. Work 8 to 12 and take a break at ten to go to the common. Great video! It was very helpful to review the whole process step by step. Definitely following and checking out more of your videos!
Dr from the UK here coming to remind myself of haemostasis. Used to watch you all the time in med school and you're just as amazing now as you were then!
I was in my first year of senior high school when I found this channel. It was easier for me to learn it from here than any teacher that capable of teaching this detailed yet understandable material for me... and I amazed how your channel can make me memorize such complex system and understand it better. Thank youu
Perhaps scientists and professors receive awards for describing the entire process, but Zach and the NN team receive as a reward the gratitude and love of all the hearts of medical students❤
I never post comments but I have a coagulation exam coming up and you explained almost two entire PowerPoint lectures!! You explained it in such simple terms that even I was amazed at how simple coagulation can be if it is explained properly! idk your background since this is the first video of yours ive watched but damn youre good Thank you!!!!
Im speechless. This is by far the best video I have ever seen in my life. Such light headed explanation of smth that is written on 100smth pages in Guyto. If I pass my physio exam in 4 days, its going to be all you man. Thank you so much and just keep up with this
Your youtube channel is such a gem! You explained everything concisely. This really helped me in understanding hemostasis in just one sitting. Currently studying for my midterm exam on Hematology, and this video became my supplemental notes. Please keep on educating the community, you are making a difference. Thank you thank you!
Hey man i know its been 6-9 years since you made a lot of these videos, but just wanna say thank you from a current paramedic student and wanted to lyk that this is still reaching and helping people 🙏
Bro we all think you're even able to teach those university professors how they must get the attention to the students! Great work, just keep killing it
This video made my day. I am preparing for SH(ASCP). I am studying 6 different hematology books and you have just covered everything about hemostasis which I have been reading for the last 3 weeks. Thank you very much
Seriously! Thank you for making this video. I'm a biomedical lab science student, we're having a course on hemostasis and the tests dealing with it. Our lecturer tried to explain this to us. Success rate was very so-so. I'm only 12minutes in to this video and I'm already raving "why couldn't they just explain it like this?!"
These videos have helped me so much in med school, especially during coved and online classes. They brings these concepts that can seems so overwhelming and make them clear and actually 100X more fun and engaging.
I don't know if it was the visual way you used to explain this, but I got more from you than listening to my lectures from school over 15 times. This is what people need sometimes, and you do an amazing job. Thank you so much I your knowledge is outstanding!!
Im a layperson. Mind is BLOWN! By...how well designed the body is....and equally by your powerful combo of raw knowledge, clear explanation, and superb presentation skills!
Honestly, thanks to the whole NINJA NERD TEAM !! i honestly dont think you guys know the impact you have. Thanks to you guys, there will be a lot of more Dr , or ' better' Drs out there in the world. If you look at the big picture, how many people you guys help indirectly its HUGE !!!! You guys have so my respect ! for real
After all the lectures I have attended on coagulation and the clotting cascade you finally helped it click! I love your teaching method of saying then drawing and repeating the information with review at the end. Never stop! We need the Ninja Nerd like the smallville needed Superman!
I have a mechanical engineering background and currently pursuing a Ph.D. in modeling the coagulation kinetics. I must say the information disseminated here is sth you'd only get after going through hundreds of book and scientific papers. Great job guys!
Wow, your videoed lecture is a comprehensive masterpiece. By making this subject more understandable you will personally help save many lives because there will be more people to apply this knowledge in helping patients and in advancing this field. Respect.
I am a retired Chem Engineer . I designed the heat treat to viral inactivate HIV in blood plasma that contain FVIII. Before rFVIII is available. You are a wonder kid. Now I learn how the complicated cascading Factors that convert fibrinogen to fibrin. I also listen and understand how the COVID virus work through your presentation. I am now retired. How I wish I discover you earlier when I was a practicing chemical engineer.
I cannot stress how much this picture is ingrained into my head. I constantly find myself mentalling referencing this diagram during exams because it just makes sense and makes everything seem logical. Ive watched this video at least 40 times. Thank you so much.
Your videos are amazing, you deserve sooo much more recognition! Please never stop making them they're so great! I plan on watchin' them all over summer ahah. Keep up the good work!
Come teach our professors how to teach. Wow 😮. This material felt impossible after sitting through 2 lectures from my biochem professor. You sir have made it possible. Amazing. Thank you thank you thank you. You have a gift
you'are amazing I understand you more than in my class although in my country I learned in Frensh it's so easy in English I love it and you deserve millions of likes 👏👏
You r amazing 🤩❤️❤️❤️thank u so much!!! Our professors just make it harder & harder! But u make it easier! U make me love the subject ‘❤️ Even if I didn’t answer in my exam ,I’m happy that I watched these 43:13! No regret!❤️thank u again😍
Being a medical student had a lot of stress for the topics to get to be throughly understood. However, professors like Ninja Nerd 🤓 just comes to our rescue and make not only our study easy to grab but also interesting. Blessed to have you sir.😇 Kindly keep uploading such videos for us.👍 A big shout out to you and your team.🏆🎖 Amazing efforts ❤ You really are like a NINJA for us who just easies our life smartly 🥳
Thank you for the best explanation ever! I have watched your biochemistry videos too and you handle it quite professionally yet fun at the same time. That is a true predagogical approach to students and scholars. Keep it up my favourite Ninja Nerd. I can't wait for the new videos! ♥
You're literally one of the best teachers out there ,wayyyyy better than my college professors who just likes to use some stupid slides which only helps us to get confused even more ,lots of thanks sir !
Whenever I have to study a hard lecture in med school ,I search ninjanerd videos and if you have covered that topic I become sure that I could understand that topic with every single detail… thanks for making our life better prof.. maybe you can’t imagine how much you are magically wonderful for me and many medical students
In addition to your great lessons, you even surprised me to another level that you enjoyed the cupping therapy. Just saw the cupping marks on your back neck in this video.
(Text wall ahead, very long comment, don't press read more if you don't want to read this) This is my way of remembering the coagulation cascade: I treat them like a family. Before starting, remember that factor four and six are forsake (pun intended, four six--> forsake), they are forsaken, they are left out from this cascade. I start with intrinsic pathway first. The regulation of clotting factors are mentioned at the start of the video. The clotting factors regulated are 2, 9 and 10 by anti-thrombin 3, 5 and 8 by thrombin. If you notice, if we exclude extrinsic pathway, every clotting factor mentioned(2 ,5 8 ,9 ,10) are included in the intrinsic pathway till the end of cascade, while those not mentioned are not present, other than that larger than 10, and factor 1, because he is the head of the family, and nothing gets past the head of the family. This might be more complex than the one mentioned in this video, but I use this method because find this effective for me to remember which clotting factor are the ones being regulated along with the cascade together in one go by relating them together. It also helps me remember which part of the pathway requires PG3 and Ca2+. We start from factor 12. Factor 12 calls and activates the one member older, factor 11. But when factor 11 calls out factor 10, factor 10 is the lazy one, and says nah, you're not convincing me just by yourself.(X marks the spot also helps you remember which factor is the common pathway). So factor 11 calls and activates the one member older of factor 10, factor 9. But even the older factor 9 can't activate factor 10 by himself because that's how lazy factor 10 is. Instead, factor 9 calls one member older, factor 8. Factor 9 together with factor 8(with PG3 and Ca2+), they are finally able to get factor 10 into work. Remember factor 10 is the lazy one? He says, I don't wanna do all the work myself. So he seeks help. Which factor would factor 10 find? Ask yourself, which clotting factors are the ones regulated? 10, 9, 8, 5 and 2. 10, 9 and 8 already appeared in this cascade, so which one is next? Clotting factor 5. Factor 10 and 5 activates the next regulated factor, factor 2(prothrombin). But due to the lazy nature of factor 10, even after seeking help from factor 5, factor 10 is like, meh, let somebody else do the job. So instead factor 10 activates prothrombin activator, not factor 2 itself. And the laziness of factor 10 doesn't stop here, he will get all the help he needs, so he will also take in PG3 and Ca2+ to activate prothrombin activator. Finally, factor 2 is activated(thrombin), he is factor 2, factor TWO, he will do two things. One is to call and activate the head of the family, factor 1(fibrinnogen) into factor 1a(fibrin). The other one is to call factor 13. Factor 13 is like Goku in Dragon Ball Z. He doesn't show up until the very last moment. Factor 2 activates factor 13, with the help of Ca2+ (Goku eats a lot, he needed that energy. But hey, at least PG3 is not involved, unlike the lazy factor 10). As the Goku of the family, factor 13 gives a powerful effect. He creates cross bridges between factor 1a(fibrin) and stabilizes the mesh. Intrinsic factor cascade is finished, now we go onto extrinsic factor. Just remember, which member are not yet mentioned beside the forsaken factor 4 and 6? Factor 3 and 7. The older factor 3 calls and activates the younger factor 7 to help 9 and 10 out. Which part of this cascade requires PG3 and Ca2+? It circles around the factor I gave names to, the lazy factor 10, and Goku, factor 13. Factor 10 is so lazy that activating him requires PG3 and Ca2+, and him activating something else also requires both chemicals. Goku, factor 13, needs Ca2+ because he eats a lot, but he don't need PG3 cuz he's not as lazy as factor 10. And which are the factors regulated by endothelial cells? Intrinsic pathway factors of the cascade, those less than 11, not forsaken and not the head of the family, who are 10, 9, 8, 5 and 2.
I GENUINELY enjoy watching your videos. Even though you teach difficult subjects, you have this way of communicating with your viewers. It feels like you are having a casual conversation with us, like the comments you throw in every so often whenever you are perplexed by something: "I know! Such horrible stuff, it's crazy!". You just make the info stick and you allow it to make so much sense. Thank you!!!!
Very nice video, however you're incorrect about how the coagulation cascade is initiated in vivo. Tissue factor derived from endothelial cells and fibroblasts forms a tenase complex with activated factor VII which cleaves factor X and IX. The thrombin produced here when factor X cleaves prothrombin kickstarts the intrinsic pathway by activating factor XI (among other things) but also drives fibrinogen cleavage through initiation of the common pathway. The intrinsic factor is of little importance in vivo but used in vitro for analysis of aPTT.
You’re so amazing and smart! Thank you so much for making this videos and helping me understand hard concepts. I really appreciate it!! I enjoy watching your videos
I was hoping you could capture the whole lecture in the end to look at the whole white board for some of us to draw it too and be able to explain it ourselves in the future💓
This is incredible! Your video was recommended in my hematology class by my Medical Lab Science program director, and I was so pleased to have already found it the night before while I was studying! You're helping my entire cohort remember coagulation and I can't say thank you enough!
legend and a gift to medical community! Einstein once said if you cannot explain a concept in few sentences, you never understood it. you explain it in one slide with few sentences
The GOAT in medicine 🐐 I dont care if there are some errors , this video helped me understand things we have been studying and memorizing for years but not really knowing whats going on . Every video from ninja nerd makes me go DAMNNNN Well done sir , absolutely incredible work👌✌️
No powerpoint. No notes. Straight memory. One drawing using organized multi-colored markers. One slide telling the whole scientific story. This Ninja Nerd is mastery on a level I've never seen. Might have to buy a t-shirt.
This video has some errors that should be reviewed. In order for the intrinsic pathway to work properly you need calcium (Ca2+) not just for factor X activation, but from the start at factor XII. Nitric oxide prevents platelet aggregation not adhesion by blocking GP2b/3a. If the platelet is binding to the endothelial lining (adhesion) and you want to prevent this, vWF or GP1b would have to be blocked, typically a heparin drug is used. Not only is protein C needed to keep blood from clotting but so is Protein S. They both inhibit factor V & VIII. Overall hemostasis and coagulation is broken down into 3 steps not 5; Primary hemostasis: formation of platelet plug due to damage, Secondary hemostasis: formation of fibrin clot and repair, Tertiary fibrinolysis: breakdown of clot.
Gicgux
true
Lol there’s really well timed cuts, so there’s some notes mixed in!
@@xavierxrcYeah there are so many mistakes here that this video has actually made it harder to study. Even more than what you listed. TPA is not streptokinase, steps are missing or numbers or pathways are wrong. If you're trying to study for a test, watch this once for the big picture at most, and then use your book and study materials for the foundational details before you start to solidify mistakes and have to unlearn them.
I never in my life had a professor as good as you, they "tried" to explain this in weeks what you clearly did in 40 min. Amazing content for all the medical students out there!!!!
What kind of medical school is spending weeks on coagulation cascade
@@lachyt5247 mine has repeated this topic 4 times and each time it went over my head. Ninja nerd literally is an angel
@@lachyt5247 For us it was literally one day before they posted new learning material.😂😭
@@daniedeklerk1914 Same for me, "Any part of coag factors will be on the exam" was about the extent of depth for our lectures.
Not in med school...have to learn this and I'm do grateful this guy posted this.
I am simply amazed at the fact you collected this vast amount of medical knowledge and thorough understanding which enabled you to explain in simple language even a child can understand. The multitude of subjects you have covered is usually in medical text books in hundreds of pages of several chapters. How in the world were you able to absorb that knowledge? With people like you, pretty soon every human being will become his own doctor! They just have to view Ninja Nerd Science videos on UA-cam!
IKR
Our professors should watch his videos rather than just dictating in lecture halls.
The coagulation cascade is not "hundreds of pages of several chapters" LOLL.... a very hyperbolic statement my guy. relax.
@@snekjuce he wanted to say in general I think...not just the coagulation cascade
Yea I also agree
I just want you to know that 7 years later and this video is still helping medical students throughout the world. I love you! Thank you for sharing your knowledge and love of teaching free of charge for us to consume. Thank you a million times!
1- Vascular Spasm 7:10
2- Plug Formation 10:55
3- Coagulation Cascade 17:55
(Coagulation Cascade recap 30:00)
4- Clot Retraction & Repair 33:18
5- Fibrinolysis 36:15
Summary 39:30
Drugs:
Heparin 40:00
Clopidogrel (Plavix) 40:58
Abciximab 41:34
Prodaxa 42:02
Warfarin 42:17
Bless you
Thank you so much
Thank you
Thanks so much!!!❤
Been watching this guy over the last week due to having severe anemia and being diagnosed with a dvt…easier to understand and I’m a qualified nurse!
Thank you for doing more in 20 min than my professor in an entire semester
broo you should have your own university
Anyway we all consider him as our university dont we😀😀
Right ?
Yes broo new ninja med schools
I would enroll in a heart beat
I would obviously definitely take admission there ASAP
I am a "way-older" adult returning to school after 30 years and having trouble understanding many concepts in my Patho 1 course. I actually cried cause your info and teaching-style allowed a light bulb to go off in my dusty brain. Thank you.
Ninja Nerd is saving my education during this pandemic!
sooo truuuee!!!!
I 100% agree
my teacher with a PhD degree in hematology couldn't get any close to teaching like you, THANK YOU
Very true
I'm in a med school still...never got these concepts
Are you from Kurdistan?
they do it purposely... srsly.. i have realized this... a lot of PHD's do not want to teach but they have to teach for money ofcourse and because they had shit dng the phd they purposely make stuff look confusing and hard for students because their very intent is not to teach... I know what i said is v harsh but this is what i noticed in most of the PHD Professors... they some how miraculously want you to just know everything ALREADY. Then why do we even need the degree or why do we even need to be in school if we knew stuff already ...
@@ahmedmuhammed1028there is no place called kurdistan lmao
I am an ICU doc, and this provided me more knowledge and understanding than medschool and my professional training combined.
Awesome!
You mic dropped, with your stare, at 31:27ish - as you were unlocking a key to teaching the next generation. I’ve listened to this lecture 5 or so times in the car, first time watching and taking notes, and you are a great teacher who has worked hard to develop this.
People at my school literally go to your channel before watching the lectures here or even looking at the ppt slides, and I think I'm going to follow their footsteps. You made something so complicated so easily understandable. Quit making med school look like a piece of cake man!!
Holy crap I cannot thank you enough for 32:00-32:45! That is SUCH an easy way to remember the pathways! That outline really helped me scaffold the whole thing. That's wonderful.
ANyone reading this please find a way to make up a way to memorize everything. Maybe I am just lucky that I am creative but idk how anyone survives without making up weird memorization tricks for everything, apparently it's a talent or you haven't tried yet. no matter what it will all be goofy sounding if you make it up but it just has to work for you
This is my first UA-cam comment, and I just wanted to thank you for making this along with the rest of your videos. I’m an M1 and have been having a rough time with how competitive medical school is with constant exams being thrown at you. It’s been overwhelming to say the least. I have a biochem exam tomorrow and I’ve been freaking out over the material and I almost want to cry because you made me finally understand it! You’re better than Lecturio! Lol.
Continue it
lecturio is like a robot talking, here is a human talking
my professors can't handle zoom
meanwhile: this guy educates people all over the world in less than a 1h video.
Hi.... I don't usually comment on youtube videos but this time I did to just tell you how amazing you are. You're the type of teacher that actually shows the why and the how instead of projecting information without reasoning!
dude bless your heart! this is something my professor couldn't teach in a two hour lecture! thank you!!
You are the best physiology teacher you know I watched this video in class because my lecturer is explaining and I couldn’t understand 😭🥺then I remembered I have NINJA 🥷 NERD and I watched...God bless you
I am not a native English speaker, and study this process from books is really tiring. You make it so simple and easy to understand. Thank you Ninja Nerd!
I am MD, and I watched many videos about hemostasis , really this one is the best. good job.
I'm brazillian and i have to say that i understand more about all these complex subjects with you, than i do when i watch classes in portuguese, even though being my mother language.
The way you teach, the passion you transmit when you are speaking, it can surpass even the language barrier, it makes us feel comfortable to learn more.
So, i hope you keep up with this good work. 🤝
This guy is so awesome! I learn more and retain more from these videos than I do from attending my actual class. Thank you, Good Sir!!
+Tiffany Selrick LOL!!! I'm so glad these videos are helping!! Thank you for your super kind words!!
I don't think I've ever commented on youtube in my life, but you GOATED on this one. well done
I honestly cried after watching this. I loved it and i think i will never forget this ever. You are literally the best teacher ever and yo should be recognised even more !
you did what my professor couldn't do for months in 50 minutes , you're the best physiologist PROF .that I've ever seen in my life .
thanks million ninja
much respect for you from me and from all medical students in Yemen .
{ Sana'a University Faculty of medicine
Bro, your videos are too great. your videos deserve over a million veiws. your's way of teaching is different still amazing. Great. Keep up buddy. :D
+Koustav Supriya Thank You so much for your kind words, I cant express how much that means to all of us here from Ninja Nerd Science. Your comment is greatly appreciated and I hope that these videos helped.
@@NinjaNerdOfficial hi sir thanks for ur video but can u give me a reference from which i can get more details and drogs
and please tell me where do u bring ur information from
Bro the way of ur teaching is another level we can understand subject easily in your videos that we didn't understand at the classroom thank you buddy u made me understand the subject with grief ur amazing to convey the concept we're greatful to watch ur video's u can deserves millions of views
It now has over a million views!
I feel like I comment this a lot but from the bottom of my heart 1) You are the main reason I'm passing vet school 2) Your enthusiasm is one of the most important things that keeps me excited about learning about medicine. I truly, TRULY cannot thank you enough!
Every time I watch you videos, I’m amazed by three things. Firstly your amazing knowledge, secondly the amazing complexity of the body and thirdly the amazing ability of man to figure all this complexity out.
WHAO! this dude is in a class of his own... saying this is fantastic will just be a gross understatement
My professor taught us a great trick to remember the intrinsic pathway coagulation factors. Work 8 to 12 and take a break at ten to go to the common. Great video! It was very helpful to review the whole process step by step. Definitely following and checking out more of your videos!
Dr from the UK here coming to remind myself of haemostasis. Used to watch you all the time in med school and you're just as amazing now as you were then!
I was in my first year of senior high school when I found this channel. It was easier for me to learn it from here than any teacher that capable of teaching this detailed yet understandable material for me... and I amazed how your channel can make me memorize such complex system and understand it better. Thank youu
You are a blessing to us.. God bless you sir🙏
I know this video was created 7 years ago… but this man deserves his flowers! Absolutely amazing job, and right off the dome! You are my hero!
Dude I’m in a pathophysiology class and we’re reviewing this for an exam and you saved my life!
Perhaps scientists and professors receive awards for describing the entire process, but Zach and the NN team receive as a reward the gratitude and love of all the hearts of medical students❤
I never post comments but I have a coagulation exam coming up and you explained almost two entire PowerPoint lectures!! You explained it in such simple terms that even I was amazed at how simple coagulation can be if it is explained properly! idk your background since this is the first video of yours ive watched but damn youre good
Thank you!!!!
Crying I thought I'll never understand 😭 this the best teaching than I previously watched
Im speechless. This is by far the best video I have ever seen in my life. Such light headed explanation of smth that is written on 100smth pages in Guyto. If I pass my physio exam in 4 days, its going to be all you man. Thank you so much and just keep up with this
This man saved atleast 3 of my semesters. Truly one of the best educational channel out there. Keep up the good work
Your youtube channel is such a gem! You explained everything concisely. This really helped me in understanding hemostasis in just one sitting. Currently studying for my midterm exam on Hematology, and this video became my supplemental notes. Please keep on educating the community, you are making a difference. Thank you thank you!
Hey man i know its been 6-9 years since you made a lot of these videos, but just wanna say thank you from a current paramedic student and wanted to lyk that this is still reaching and helping people 🙏
Bro we all think you're even able to teach those university professors how they must get the attention to the students! Great work, just keep killing it
This video made my day. I am preparing for SH(ASCP). I am studying 6 different hematology books and you have just covered everything about hemostasis which I have been reading for the last 3 weeks.
Thank you very much
Finally, I found someone who was able to make me understand the coagulation cascade......
Many thanks.....really loved and enjoyed your lecture
Seriously! Thank you for making this video. I'm a biomedical lab science student, we're having a course on hemostasis and the tests dealing with it. Our lecturer tried to explain this to us. Success rate was very so-so. I'm only 12minutes in to this video and I'm already raving "why couldn't they just explain it like this?!"
These videos have helped me so much in med school, especially during coved and online classes. They brings these concepts that can seems so overwhelming and make them clear and actually 100X more fun and engaging.
I don't know if it was the visual way you used to explain this, but I got more from you than listening to my lectures from school over 15 times. This is what people need sometimes, and you do an amazing job. Thank you so much I your knowledge is outstanding!!
Ninja nerd, u did what my paid uni professors could not do. Thank you so much. God bless u 🥰
Im a layperson.
Mind is BLOWN!
By...how well designed the body is....and equally by your powerful combo of raw knowledge, clear explanation, and superb presentation skills!
I feel like a new man after watching this, thank you so much.
Honestly, thanks to the whole NINJA NERD TEAM !! i honestly dont think you guys know the impact you have. Thanks to you guys, there will be a lot of more Dr , or ' better' Drs out there in the world. If you look at the big picture, how many people you guys help indirectly its HUGE !!!! You guys have so my respect ! for real
Hey Man, your videos are awesome. I really appreciate your effort. You are better than our lecturers :-)
So glad we could help out!
After all the lectures I have attended on coagulation and the clotting cascade you finally helped it click! I love your teaching method of saying then drawing and repeating the information with review at the end. Never stop! We need the Ninja Nerd like the smallville needed Superman!
You are saving my life!!! Biochemistry and now blood clotting finally makes sense to me! Thank you, and keep up the good work!
i have no doubt that you are the best medical speaker i have ever watched in my entire carrier since 33 years... Thanks alot
thank you for saving me from another mental breakdown! hands down better than my professor's recorded lecture video! very very very comprehensive!
I have a mechanical engineering background and currently pursuing a Ph.D. in modeling the coagulation kinetics. I must say the information disseminated here is sth you'd only get after going through hundreds of book and scientific papers. Great job guys!
17:53 coagulation
25:56 intrinsic
29:58 trick
33:24 clot retraction
36:22 fibrinolysis
No words to express that feeling of satisfaction after viewing your lectures....
Wow, your videoed lecture is a comprehensive masterpiece. By making this subject more understandable you will personally help save many lives because there will be more people to apply this knowledge in helping patients and in advancing this field. Respect.
I am a retired Chem Engineer . I designed the heat treat to viral inactivate HIV in blood plasma that contain FVIII. Before rFVIII is available. You are a wonder kid. Now I learn how the complicated cascading Factors that convert fibrinogen to fibrin. I also listen and understand how the COVID virus work through your presentation. I am now retired. How I wish I discover you earlier when I was a practicing chemical engineer.
Thank u so much, Mr. Ninjaaa! Im literally shedding tears of happiness...
thank you for saving life with your lectures!
You have covered the basic so nicely, everything explained in a easiest way. I just loved it. Great job.
I cannot stress how much this picture is ingrained into my head. I constantly find myself mentalling referencing this diagram during exams because it just makes sense and makes everything seem logical. Ive watched this video at least 40 times. Thank you so much.
Your videos are amazing, you deserve sooo much more recognition! Please never stop making them they're so great! I plan on watchin' them all over summer ahah. Keep up the good work!
+Nina Kal thank you so much for your kind words. I am so glad that you like them and I hope that they helped.
Come teach our professors how to teach. Wow 😮. This material felt impossible after sitting through 2 lectures from my biochem professor. You sir have made it possible. Amazing. Thank you thank you thank you. You have a gift
you'are amazing
I understand you more than in my class although in my country I learned in Frensh it's so easy in English
I love it and you deserve millions of likes 👏👏
I confused about the people who dislike this video, how can they dislike this amazing video??, Thank You for the video, it really helps me study
39:39- Quick Recap.
Came back to this video for a quick revision, looked for the time stamp comment and found this. Thankyou.
Ninja Nerd content is the real deal. Top notch and deserve all the recognitions.
You r amazing 🤩❤️❤️❤️thank u so much!!!
Our professors just make it harder & harder! But u make it easier!
U make me love the subject ‘❤️
Even if I didn’t answer in my exam ,I’m happy that I watched these 43:13!
No regret!❤️thank u again😍
Being a medical student had a lot of stress for the topics to get to be throughly understood. However, professors like Ninja Nerd 🤓 just comes to our rescue and make not only our study easy to grab but also interesting. Blessed to have you sir.😇
Kindly keep uploading such videos for us.👍 A big shout out to you and your team.🏆🎖 Amazing efforts ❤ You really are like a NINJA for us who just easies our life smartly 🥳
Thank you for the best explanation ever! I have watched your biochemistry videos too and you handle it quite professionally yet fun at the same time. That is a true predagogical approach to students and scholars. Keep it up my favourite Ninja Nerd. I can't wait for the new videos! ♥
+Øna V. awesome I'm so happy we were able to help!
You're literally one of the best teachers out there ,wayyyyy better than my college professors who just likes to use some stupid slides which only helps us to get confused even more ,lots of thanks sir !
University faculty are the only ones that could possibly dislike this lol
Whenever I have to study a hard lecture in med school ,I search ninjanerd videos and if you have covered that topic I become sure that I could understand that topic with every single detail… thanks for making our life better prof.. maybe you can’t imagine how much you are magically wonderful for me and many medical students
In addition to your great lessons, you even surprised me to another level that you enjoyed the cupping therapy. Just saw the cupping marks on your back neck in this video.
(Text wall ahead, very long comment, don't press read more if you don't want to read this)
This is my way of remembering the coagulation cascade: I treat them like a family.
Before starting, remember that factor four and six are forsake (pun intended, four six--> forsake), they are forsaken, they are left out from this cascade.
I start with intrinsic pathway first. The regulation of clotting factors are mentioned at the start of the video. The clotting factors regulated are 2, 9 and 10 by anti-thrombin 3, 5 and 8 by thrombin. If you notice, if we exclude extrinsic pathway, every clotting factor mentioned(2 ,5 8 ,9 ,10) are included in the intrinsic pathway till the end of cascade, while those not mentioned are not present, other than that larger than 10, and factor 1, because he is the head of the family, and nothing gets past the head of the family. This might be more complex than the one mentioned in this video, but I use this method because find this effective for me to remember which clotting factor are the ones being regulated along with the cascade together in one go by relating them together. It also helps me remember which part of the pathway requires PG3 and Ca2+.
We start from factor 12. Factor 12 calls and activates the one member older, factor 11. But when factor 11 calls out factor 10, factor 10 is the lazy one, and says nah, you're not convincing me just by yourself.(X marks the spot also helps you remember which factor is the common pathway). So factor 11 calls and activates the one member older of factor 10, factor 9. But even the older factor 9 can't activate factor 10 by himself because that's how lazy factor 10 is. Instead, factor 9 calls one member older, factor 8. Factor 9 together with factor 8(with PG3 and Ca2+), they are finally able to get factor 10 into work.
Remember factor 10 is the lazy one? He says, I don't wanna do all the work myself. So he seeks help. Which factor would factor 10 find? Ask yourself, which clotting factors are the ones regulated? 10, 9, 8, 5 and 2. 10, 9 and 8 already appeared in this cascade, so which one is next? Clotting factor 5. Factor 10 and 5 activates the next regulated factor, factor 2(prothrombin). But due to the lazy nature of factor 10, even after seeking help from factor 5, factor 10 is like, meh, let somebody else do the job. So instead factor 10 activates prothrombin activator, not factor 2 itself. And the laziness of factor 10 doesn't stop here, he will get all the help he needs, so he will also take in PG3 and Ca2+ to activate prothrombin activator.
Finally, factor 2 is activated(thrombin), he is factor 2, factor TWO, he will do two things. One is to call and activate the head of the family, factor 1(fibrinnogen) into factor 1a(fibrin). The other one is to call factor 13. Factor 13 is like Goku in Dragon Ball Z. He doesn't show up until the very last moment. Factor 2 activates factor 13, with the help of Ca2+ (Goku eats a lot, he needed that energy. But hey, at least PG3 is not involved, unlike the lazy factor 10).
As the Goku of the family, factor 13 gives a powerful effect. He creates cross bridges between factor 1a(fibrin) and stabilizes the mesh.
Intrinsic factor cascade is finished, now we go onto extrinsic factor. Just remember, which member are not yet mentioned beside the forsaken factor 4 and 6? Factor 3 and 7. The older factor 3 calls and activates the younger factor 7 to help 9 and 10 out.
Which part of this cascade requires PG3 and Ca2+? It circles around the factor I gave names to, the lazy factor 10, and Goku, factor 13. Factor 10 is so lazy that activating him requires PG3 and Ca2+, and him activating something else also requires both chemicals. Goku, factor 13, needs Ca2+ because he eats a lot, but he don't need PG3 cuz he's not as lazy as factor 10.
And which are the factors regulated by endothelial cells? Intrinsic pathway factors of the cascade, those less than 11, not forsaken and not the head of the family, who are 10, 9, 8, 5 and 2.
Amazing amazing no words to Express my happiness 🤩🤩 Love from India 😍😍
pharmacy student here struggling with pathology.... just wanted to say u are a SAVER!!!!
Sir..can u plzz focus the whole board at last in ur videos for a screen shot...or is the picture available anywhere?...that vl b of grt help..
I GENUINELY enjoy watching your videos. Even though you teach difficult subjects, you have this way of communicating with your viewers. It feels like you are having a casual conversation with us, like the comments you throw in every so often whenever you are perplexed by something: "I know! Such horrible stuff, it's crazy!". You just make the info stick and you allow it to make so much sense. Thank you!!!!
Very nice video, however you're incorrect about how the coagulation cascade is initiated in vivo. Tissue factor derived from endothelial cells and fibroblasts forms a tenase complex with activated factor VII which cleaves factor X and IX. The thrombin produced here when factor X cleaves prothrombin kickstarts the intrinsic pathway by activating factor XI (among other things) but also drives fibrinogen cleavage through initiation of the common pathway. The intrinsic factor is of little importance in vivo but used in vitro for analysis of aPTT.
It really feels wasting of time when watching medical videos on other channels when you have ninja nerd... SIR you just built different ❤️
You’re so amazing and smart! Thank you so much for making this videos and helping me understand hard concepts. I really appreciate it!! I enjoy watching your videos
+Cinthya Larios absolutely! I'm so happy that we were able to help you!
I thought I was smart after explaining Harrison medical book! This guy is super Awesome!!!
I was hoping you could capture the whole lecture in the end to look at the whole white board for some of us to draw it too and be able to explain it ourselves in the future💓
Thank you so much Ninja Nerd. You saved my medical education.
Thank you! Would be better if you have subtitles for the hearing-impaired. :)
youtube has auto-generated subtitles, they're like 90% accurate probably less so with the medical terminology though lol
Best professor ever..!!! I didn't understand what my professor said for 10 days but I got in 40min can't believe 🙏
Excellent thank you! Love your energy and really easy to understand
This is incredible! Your video was recommended in my hematology class by my Medical Lab Science program director, and I was so pleased to have already found it the night before while I was studying! You're helping my entire cohort remember coagulation and I can't say thank you enough!
You saved my life
legend and a gift to medical community! Einstein once said if you cannot explain a concept in few sentences, you never understood it. you explain it in one slide with few sentences
Bro this is amazing.saved me as usual thanks❤️❤️
I am really really admiring the way you simplify things i can't get over how grateful I am that we have you prof...
God bless you !!
+Thomas Eyob thank you so much!!!
The GOAT in medicine 🐐
I dont care if there are some errors , this video helped me understand things we have been studying and memorizing for years but not really knowing whats going on . Every video from ninja nerd makes me go DAMNNNN
Well done sir , absolutely incredible work👌✌️