I realize this is meant to be an introductory video, but I think it would be worth noting that VWF is present in multiple components of the blood and the vessel wall in multiple forms. It is present in both the Weibel-Palade bodies of endothelial cells as well as platelet granules. On top of that, large VWF multimers flow freely within the plasma. Immunostaining has also shown VWF is stored in the subendothelium (presumably bound to collagens), which further primes the exposed vessel wall to be pro-adhesive. Lastly, fibrin tends to accumulate closest to the vessel wall and decreases toward the lumen, effectively preventing total vessel occlusion by the hemostatic plug.
Alex, thank you for your comments. You are right, it is difficult to get all the science across and still create a good narrative of the processes for the student who is new to the subject. I think clotting is particularly challenging in this regard!
I think its "Gp 1b ix-v" receptor on the platelets which binds von willebrand factor and "gp IIb/IIIa" receptor which binds fibrinogen! Any correction will be appreciated!
It is both actually. Vwf binds Gp 1b ix v and helps in cell adhesion to vessel wall. Gp 2b 3a, is in resting state, when Vwf binds to it, it gets activated and vwf forms a bridge between two gp2b3a receptors on two platelets. This helps in aggregation ( along with fibrinogen)
Those who are confused:
Adhesion = vWF - Gp Ib
Aggregation = vWF - GpIIIa/IIb
this video is veyr clear and informative, very easy to understand. thank you so much
Is it not the glycoprotein Ib that binds to vWF and IIb-IIIa that binds to fibrinogen?
noticed too
Daniel Caamaño no. He is right.
No, he is not right. Gp IIb/IIIa is a receptor for fibrinogen. Gp Ib is a receptor for vWF.
GP Ib => VWF
GP IIb/IIIa => fibrinogen
yeah you're right. i was freaking out cuz i thought i memorized it wrong.
Incredible 🌹🌹🌺🌺🌺🌺🌺🌺
❤
Thanksss💕💕💕
nice video, thanks a lot
merciii
Does paracetamol also inhibit cox pathway...I think it doesn't...it is centrally acting drug
I realize this is meant to be an introductory video, but I think it would be worth noting that VWF is present in multiple components of the blood and the vessel wall in multiple forms. It is present in both the Weibel-Palade bodies of endothelial cells as well as platelet granules. On top of that, large VWF multimers flow freely within the plasma. Immunostaining has also shown VWF is stored in the subendothelium (presumably bound to collagens), which further primes the exposed vessel wall to be pro-adhesive. Lastly, fibrin tends to accumulate closest to the vessel wall and decreases toward the lumen, effectively preventing total vessel occlusion by the hemostatic plug.
Alex, thank you for your comments. You are right, it is difficult to get all the science across and still create a good narrative of the processes for the student who is new to the subject. I think clotting is particularly challenging in this regard!
I think its "Gp 1b ix-v" receptor on the platelets which binds von willebrand factor and "gp IIb/IIIa" receptor which binds fibrinogen! Any correction will be appreciated!
von wilibrand tip 2b
It is both actually.
Vwf binds Gp 1b ix v and helps in cell adhesion to vessel wall. Gp 2b 3a, is in resting state, when Vwf binds to it, it gets activated and vwf forms a bridge between two gp2b3a receptors on two platelets. This helps in aggregation ( along with fibrinogen)
The background music was distracting.
very distracting!!!
This is genius! Thanks❤
HOW COME VWF IS NEVER BROUGHT UP WITH ENDOMETRIOSIS PATIENTS?
🙏
Brown Shirley Anderson Edward Lee Sarah
Why don’t you have a billion followers? The world is mad
Clear as distilled water!!! Thank you!!
it was very useful!! thank you sir! 😊👏
Great video and a great addition to my notes, but please get rid of the music in the background!!
Thanks mate
What a nice explaination Sir ❤
This is a great video, but the music is too loud and distracting, making it harder to follow.
Awesome 👍👍👍👍👍👍
Great video! Thanks!
great👍👍👍👍
Thank you for the excellent explanation.
mint
thanks
thanks
this guy is HOT
nice
I couldn't understand the accent because of loud music