5 most promising anti-aging compounds (for 2021)
Вставка
- Опубліковано 15 лип 2024
- There are more than 200 different geroprotective compounds. Some of these are already available as supplements, some are in clinical trials and some have FDA approval. Which are my top 5 that I think i most promising in terms of their anti-aging effects (so focusing more on healthspan than lifespan). And note the use of "promising" - there is still much work to be done to better investigate the long-term safety, dose and timings of different supplements which you should always bear in mind.
Anyway, I made this video more for a bit of fun and to make a longer summary video to pull ideas together from multiple previous videos with some new info too! So hope you like it!
Do my top 5 match yours?
#aging #anti-aging #supplements #nmn #akg
TIMESTAMPS:
Intro & useful resources - 00:00
Pick #1 - 03:10
Pick #2 - 06:14
Pick #3 - 08:52
Pick #4 - 11:24
Pick #5 - 12:54
Round-up - 15:28
Bonus #1 - 16:10
Bonus #2 - 16:25
References;
Check out @LifespanIO rejuvenation road map;
www.lifespan.io/road-maps/the...
Nature comment - www.nature.com/articles/d4158....
AKG news - www.buckinstitute.org/news/a-...
TAME trial - www.afar.org/tame-trial
Table I showed - Partridge, L., Fuentealba, M. & Kennedy, B.K. The quest to slow ageing through drug discovery. Nat Rev Drug Discov 19, 513-532 (2020). doi.org/10.1038/s41573-020-00...
eLife rapamycin - doi.org/10.7554/eLife.16351.001
Suggested Brian Kennedy interview (rapamycin)- www.lifespan.io/news/brian-ke...
Rapamycin Opinion article - Aging (Albany NY). 2019 Oct 15; 11(19): 8048-8067.
Published online 2019 Oct 4. doi: 10.18632/aging.102355
Previous videos of use;
NAD - • NMN experiment
Icons in intro; "www.freepik.com/free-photos-v..."Background vector created by freepik - www.freepik.com - Наука та технологія
I made this video more for a bit of fun, these are just my opinions, *not recommendations* and to make a longer summary video to pull ideas together from multiple previous videos with some new info too! So hope you like it!
Do my top 5 match yours?
Matches most of mine. I’ve been following spemidine and it’s found in concentration wheat germs. However would it be safe to take a small mg dose 2-3mg from this? Spermidine Free Base, 25 Grams smile.amazon.com/dp/B0771PZQ62/ref=cm_sw_r_cp_api_glt_fabc_NHJ2FbKHX9G2D
1-rapamycin dosed weekly
2- metformin
3- CaAKG
4- spermidine
5-GDF-11
Tried nr and nmn, neither showed effect on my bio markers
What are your views on Berberine as a substitute for prescription Metformin?
What do you think of red algae?
Could be because they only are 25% bioavailable. I take 600 mg of NR and 1g of nmn because of this. I know it’s expensive but it works.
These are the supplements I take;
-NAD
- Resveratrol
- Glutathione
- alpha lipoic acid
- D3-K2
- Turmeric-Ginger compound
- Multi-vitamin
- Vitamin C 1000 mg
- CoenzymeQ10 200 mg
I'm 68 years old and bench press 36kg+36kg dumbbells 3 sets 12 reps.
This formula is working quite well for me.
Turmeric is pretty much a liver poison, isn't it?
@@bluellamaslearnbeyondthele2456 I think the dosage is the key factor. Too much of every supplement is harmful for the body. I have my liver functions checked now and then. I personally didn't come across any problem.
Turmeric ginger compound nedir curcumin mi?
@@karga9014 ZADE VİTAL Curcumin Forte
Nmn?
My Top Five Anti-Ageing Supplements
1. Sirolimus (Rapamycin)
2. NR + Niacinamide (Not MNM)
3. Lithium Orotate
4. Melatonin
5. Resveratol
(Regular exercise is by far the most proven healthspan extender. Number 2 is time-restricted eating.)
The reason Metformin does not make the list is that while an excellent supplement for younger people it is very problematic for older people. I am 80 yrs. old and do not take it.
I think melatonin is an extremely underrated and underappreciated healthspan and life extension supplement. I have been using it for 40 yrs and long before I started taking the other supplements. I am in excellent health and epigenetic age tests claim my epigenetic age is 64.
I go to the gym 3 to 6 times a week. My BMI is 22.
Congrats dude :)
I’m 24 and looking to stay healthy for the rest of my life
I feel lucky to be on the bio-hacking train already :)
Reservatol doesn't do anything.
1. AKG
2. Metformin
3. Nad+ (nmn)
4. Resveratrol
5. Rapamycin
I’m 64.....My top 5....bio-identical HRT, marine collagen, biotin, NAD, vitamin D. What I don’t consume......sugar, omega 6 oils, artificial sweeteners flavours and colours, refined carbohydrates. Love from Australia 🇦🇺
@pr k You need to be consistent. It takes a month to feel better and a year to look younger
@pr k Some for years, marine collagen and NAD for 6 months so far. They need time so make them part of what you do EVERY day 😊
You are a GILF.
Ur hot for a 64 year old.
1. lack of compound, see calorie restriction/fasting 2. berberine 3. garlic, 4.sulforaphane 5.ubiquinol
Fasting for sure and eating right all year around (recommend getting a dietitian), lyft weights, sunscreen and max 10 minutes a day out in the sun.
Good to see that you added sulforaphane.
@@GuidetteExpert "Sunscreen and max 10 minutes a day out in the sun." Er, no. You are confusing sunshine and sunburn. Sunshine has cardiovascular benefits - and these quite apart from vitamin D3, and cardiovascular benefits that are not trivial. Remember the principle advised by natural medicine cardiologist Dr Jack Wolfson of "Sunshine good, sunburn bad" and you can't go far wrong. Also, sunscreens have chemicals that are not part of humans' natural environment, for which there is no physiological requirement or known deficiency disease, and which could be toxic; a few of these are. The foregoing stated without frivolity or vexatiousness.
Epitalon and Thymalin
@@JahreadyKnow Sad truth is that humanity evolved within the shelters they built. Their DNA got corrupted by false environment. If humans never stayed inside homes and always outside and let the environment decide their evolution, then they'd be genetically superior species today. Skin would've evolved protective layers to screen from harmful radiations as well.
So much quality, I'm in love. All the books I've read summised in one vid
I'd say she's already taken.
Epitalon and Thymalin
#1 Epitalon
#2 Thymalin
#3 Emoxypine
#4 SS-31
#5 Maritime Bark Extract
newer and probably better choices than hers
@@Holypikemanz I thought it was a good list. Just passing on info I've learned. Thanks for the reply
@@BryanHocking reliable source for epitalon? benefits of Emoxypine?
Thanks!
Dosing, synergistic response (with other compounds, supplements, medication, diet, etc), medical pre-conditions, , age at which administered, etc, are among key issues if one chooses to go the compound route,
1: AKG
2. Metformin
3. NAD+ precursors
4. Resveratrol
5. Rapamycin
Great Video. I'd definitely think about adding Urolithin A to the list due to it's ability to induce mitophagy. Plus maybe Nobiletin as it's a potential clock enhancing molecule and circadian dampening is highly associated with ageing and disease progression.
Epitalon and Thymalin
Thank you, epic content ! Keep it coming! "On" brocolli / avos / fish / berries for years now, never felt better, occasional NR / resveratrol... Let's see where this is going :D
Epitalon and Thymalin
Enjoyed you video and took notes. Thank you for doing the research for me.
Thanks for making this video. Appreciated!
Awesome video as always!
yes, but she sounds 12 or 13 years old. she should not see any real aging till she is 45 years old. just saying
Wow, this was a great video. Thanks Sheeky!
Great content thanks for the concise information.
Hey Sheekey! wOw I love your content. I have been looking for this sort of thing for a while and thought it just might not exist. As someone who is trying to get into cellular therapies and the field of aging I really appreciate you following the science and not jumping to conclusion or making exaggerated claims!!! Please keep up the good work.
Great upload! Tip for the future though, always do Top 5s or 10s starting at the bottom and working your way up to the Number 1 ( best thing ) last. It keeps people hooked and builds excitement ; - )
Lifespan is the key to a good retirement, never heard of akg interested
Cheers for the video it really helps with research towards improving my health, you deserve a shit tonne more subs!
And I’ll get them for her. Super star 🌟
amazing content as allways) ty!!
I'm glad you mentioned ND38, this might become more and more important as a precursessor
I take nmn sublingual 750mg, trans resveratrol, TMG, parsley flakes, olive oil for anti-aging. And intermittent fasting as well
I follow all the main people involved in anti aging and after seeing Dr Nichola Conlon speak at the main anti aging conference (RAAD I think) two years ago , I was looking forward to the NAD+ product Time , which I now use. The data is on the website, but they appear to have boosted NAD levels 4x over the other NMN and NAD products. There are many great NAD , NMN products so I am not trying to sell lol, it just should be looked at by anyone looking for the best boost without IV infusions !
@pr k in short yes for sure; energy and focus heightened and skin nails are outward youthful improvements
is it working
where do you get the sublingual trans resveratrol? I have allergies to the pill form.
Thanks so much!
Excellent video packed with highly valuable and well supported statements
my top 5.
1. Nac.
2. niacin.
3. resveretrol
4. apigenin
5. D3 & C
Great needed that 💖💖💖💖💖💖
2. NmN ? A particular type of niacin kept in fridge cold. Should be white powder as if brown oxidated to nicamidide and isnt NMN??💖
Also need amounts in Grams pls 💖
@@jimtempleton4312
This is just my stack and not what you should be taking for example Nicain B3 with flush, I increased slowly.
1. Nac. --> 3000mg per day in 2 doses
2. niacin. --> 500mg per day and every few days 750mg in 500mg + 250mg
3. resveretrol --> 500mg trans resveratrol in yogurt with olive oil
4. apigenin --> from dried parley added to Yogurt. 2 table spoons in a cup of yogurt
5. D3 & C --> D3 is combined with K2-MK7 --> that I use once a week 5000UI of D3 and 200 mcg this is every few days loosely every 3'd day or so.
C I take 2 times a day 500mg each.
Great list. Im learning alot about Nac and niacin.
Thank you very much for the very interesting video.
Great information 👍
Really excellent video. Possibly the best I've seen on this subject so far (and I've watched loads!!). Thank you, you have a new subscriber!
Thank you!! 😊
So much great info!
Yes, I would like to ask you what are your thoughts on Epitalon?
you are awesome, please keep on doing this :)
Love it!
Sheekey keep up yr informed analysis. With regard to healthspan do u have any views on proteolytic enzymes and/or proresolving mediators to reduce inflamtion and repair. Also AKG supplements are mostly not calcium but arginine based. Does this make a difference. (I'm an ageing engineer not biochemist).
Very complete...good job
Metformin is difficult to obtain without a prescription, even on the Internet. An alternative is berberine ("poor mans" metformin) which can be purchased.
I think that the TAME study will change all that. Nils Barzilai predicts that in a few years once you turn 60/65 metformin will automatically be given out by gps.
I bought a lot of metformin OTC in Colombia and Mexico
Lots of Indian pharmacies on the internet that will send you metformin. Had good luck with alldaychemists. The online order from will ask for a prescription, but as long as you make a valid payment, they will send your order anyway.
I’m in Thailand now stocking up on metformin 18 months supply
@@APBCTechnique Careful about recalls - www.fda.gov/drugs/drug-safety-and-availability/fda-updates-and-press-announcements-ndma-metformin
Thanks for the video!
Any insights on berberine vs metformin? The former seems to have the edge in the supplemental space, no? Kind regards
Great job!
Thanks. I take some of these like fisetin episodically. Likewise, with apigenin as a senolytic and CD38 modulator. Very true, dose matter, as well as duration.
What is a CD 38?
@@BK-dy8jk a NAD+ depletor that is overexpresed on a proaging enviroment
I absolutely love this channel
Please make this video a habit? Maybe once or twice a year? or whenever you feel their are changes worth updating? TY for all your excellent videos :-)
Great video thank you! 😎
Another cool science show! :)
What do you make of the GSK research from roughly 2012 and the most recent 2020 paper using CRISPR which both seem to show that resveratrol does not activate Sirtuin pathways?
Wow, you really do your homework, really in-depth stuff.
Epitalon and Thymalin
just stumbled on your channel and instant subbed, keep it up :)
Great . please keep the good work .
Great info. Anything on car t and cancer? Cure?
Great videos! Where can you purchase these? Such as reversatrol that will not be fake and have actual potency ? Is Berberine ok to take if you can’t get a prescription for metformin? Thank you :)
EXCELLENT !
great work, in an interesting field. for human trials i think the socioeconomic confounding should be but into consideration for longevity studies
What do you think of Pterostilbene vs Resveratrol? Elysium uses Pterostilbene in their NR supplement (Basis) instead of Resveratrol. They do a pretty good job of explaining why on their site.
Great list and info as always, Eleanor! Glucosinolates also come to mind. Are you familiar with DR Jed Fahey's work? I know Rhonda Patrick is a huge fan!
definitely nrf2 activators such as sulforaphane as well as other isothiocyanates should be mentioned. I love Rhonda.
What is the best NAD+ precursor - NR or NMN?
Do you think that using streptomyces hygroscopicus the bacteria that produces rapamycin as a yogurt probiotic would have similar or better results?
Brilliant, thanks for the info. My Top 5: NR, Fisetin, Quercetin, Tumeric, Gamma E and as a bonus: C, D3-K2 ;) p.s. Intermittent fasting and I HIGHLY recommend reading The Phoenix Protocol Dry Fasting for Rapid Healing and Radical Life Extension: Functional Immortality it's an eye opener. Would love to get your take on it.
Epitalon and Thymalin
I think TMG should be used to counter the negative effect of sulforaphane+niacinamide reaction . What do you think ?
I subscribed just because you are so close to 100,000
Sheekey, what is your take on the best diet for a human ? I understand there are many variables, just out of interest what would be your idea for the best diet ?
Can you substitute rapamycin (sirolimus) with tacrolimus? If so, any suggestions on the optimal dose
So how do you prevent all the benefits for healthy cells working for cancer cells as well?
would you be likely to do a video on Creatine because i have suspicion it also has an anti aging affect
side note i have not looked too deep into Creatine I've just looked into its affects on muscles and i seems to have and effect on the brain but i don't know
Yes.Ive heard ot helps slow brain aging
Excellent.
Thank you for your work. Please is there any research regarding the foxOgene or telomere regulating gene? I believe the answer to health and longevity is there, but who am I to say this hehe
What about sulforaphane for anti-aging? isn't Nrf2 activation better than taking anti-oxidants directly?
Epitalon and Thymalin. Peptides baby
I agree, the list can change so quickly now, the exponential growth in computing power is coupled with an ever increasing number of people researching year after year and it now seems like there's always something new being announced. A very exciting time to be alive...
Are C-AKG and A-AKG basically the same compound attached to a different salt? Any indication they’ll work the same?
I've heard cakg for anti aging only
Thanks 🙏
how about telomerase activators such as cycloastragenol come to mind
Love your channel. You do fantastic work. Thank you.
i made a recent video on telomeres, thanks
What about pure NAD+ by injection, Patch or Nasal Spray? Curious why precursors would rank, but the real-deal wouldn't?
Is it worth supplementing AKG if a person already consumes a high protein diet?
Consider Pterostilbene as an analog of Resveratrol that is more bio available and less expensive.
My top 5: Benfotiamine(fat-soluble B1), Niacin, PQQ, Astaxanthin, Phospholipids(Antarctic Krill)...
2nd category list
@@juliontrump7539 what's your first category list? Please kindly elaborate.
Very interesting. You may find yoga study touches on aging too. Hatha yoga, very ancient teaching, serious studies are mostly avoided in the west at least.. Inverted postures slow the aging process. As do slow breathing. Great benefits for hormonal system. How about fo-ti? Gives greater energy in 2 weeks. And shilajit from high altitude mountains. (15,000' ft+)
Why didnt you include senolytic combination as anti aging approach together with what you already mentioned. such as fiestin or quercetin combination with dasatinib. Also quercetin with theaflavins.
No particular reason, there are many things i didnt include!! 😊
Since I cannot get metformin without a prescription, I searched for an alternative supplement…
My research showed that Berberine has been found to assist in lowering glucose levels and to help regulate as well as assist in preventing Type 2 Diabetes.
Is this a good substitute?
Does this supplement have the potential to have the same effect upon our bodies as Metformin and its role in anti-aging??
Yeah, I think it interrupts MPC1 pathway in mitochondria also and activates AMPK so it is a calorie restriction mimetic
What is your opinion of Aubrey de Grey predictions? (Robust mouse rejuvenation could be by 2022)
i get asked this a lot, will make a video later this year! :)
I have robust mouses but don't
brag about it. 😆
Must we have AKG on empty stomach or with food?
what if you combined NMN and Icariin ? Could well condens the list of 5 to 2 ?
Is there a direct link to buy the supplement? Without reading 500 pages to get to the purchase?
1. “Mediterranean Keto” Diet. 4 liters EVOO, fiber, green veggies, fatty fish, eight cloves garlic, polyphenols, Italian spices, Natto,
2. Six hour time restricted eating window and quarterly 48 hr fasts
3. Berberine taken with milk thistle.
4. Theracummin or Longvida Curcumin
5. HITT and resistance training
If you aren't pre-diabetic or diabetic drop berberine/metformin. Recent studies have shown no benefit over excercise alone and in fact they reduce exercise performance.
I would ask if the Niacin for NAD+ precursors, was Niacin flush or non flush. I do do Niacin flushes. The supplements I take are AKG, Resveratrol, and NR. I gotta switch to CaAKG because I accidentally just bought 60 days of regular AKG.
I couldn’t find akg in your store. Do you have a brand that you recommend?
Can't recommend as not something i currently take, sorry - you may find some answers in the comments section of a previous akg video i made!! ua-cam.com/video/3I7TxBT8FmI/v-deo.html
Does NAD+ increase immflamation in Crohns , Colitis or IBD.
Full flush/regular Niacin is a LOT cheaper as a precursor to NAD than NMN supplements. Is it as effective as NMN? Can you take both?
Unfortunately NMN is blocked by CD38. Niacin isnt.
@@ew2886 is that a good thing?
Man, check out Ford Brewer md he takes megadoses of regular naicin..just build up to it..To me nmn and nad are proven on a cellular level but not long term ingestion by humans..too expensive for me until it is proven.Niacin may even be more effectatious..
@@geraldfriend256 thnx. ✌i watcjed that dude. Never knew his name. He turned me on cinnamon. Also, Rhonda Patrick. All this stuff works together. I can vouch for it. Im 49 and i have abs and i dont work out at the moment. I see overweight men/coworkers my age with land nad cars and property but in such poor health, overweight with one foot in the grave. But people are so clueless and uniformed and dont want to listen because its just too much info and they are too far gone.
Sorry for my slow reply. I can't say it is a good thing. You can watch Brad Stanfield, Rhonda Patrick etc.
NAD+ precusor NMN/NR/NA is very hot compound right now, however, there will be many side effect too, Metformin also show around 1/3 effectless for human, I suggest trial period shall be less than 3 month for taking these compound, otherwise side affect will be more than benifit.
What would be the food sources of those 5 ?
What do you think about Sulfurophane?
For skin anti aging, I would say sunscreen and vitamin A. And for hair, I would say 5-alpha-reductases and minoxidil. Pterostilbene may be another honorable mention.
Minoxidil is life commitment
@@mostafa202023 so is everything else...
I have followed much of these anti aging trials and like the research in metformin and the anti aging benefits. My first try with this was under and It bother my stomach. Dosage is important
Is berberine as good as metformin?
I take these at the moment: Hydrolyzed collagen peptides, Hyaluronic acid, NR, AKG, Apigenin, Quercetin, DHEA, Ubiquinol
good stuff. you could have tossed in a few CD 38 inhibitors :)
I've divided my anti-aging/bio-hacking into three levels. Level 1. Lifestyle such as IF, CR, sleep, HIT/HIIT ie. Level 2. Hormon level. Level 3. Pathways and cells. My number one go to is dr. Khavidson protocol on Epitalon. Then d3/K2, B12, C, Magnesium, GlyNAC, DHEA/7-keto DHEA, Omega-3, fermented broccoli sprouts - some...
Wow .. I had to listen more than once just for the accent !
Thanks for the vid. I know this is dated but j also know you update your info on these vids.
Resveratrol dietary supplements IMO are a waste of money. The compound has 3 hydroxyl groups and is metabolized very quickly as a result, resulting in poor absorption. I believe most of the RCTs for resveratrol are either done in vitro, ex vivo, or done IV. Correct me if I'm wrong on that last part.
Its methylated analog, pterostilbene, is FAR SUPERIOR, and I find it works best when paired with an NM supplement, even if research on dietary NM is also conflicting.
Video starts at 3:10
My top 5 is PQQ, NAC, NMN, DHEA an B vitmins.
What are some great biology books (or articles) on the processes and hallmarks of aging?
search "books" on my channel page - have covered a few!
@@TheSheekeyScienceShow Thanks! I really appreciate your work.