We seniors are counting on you and your collegues for a longer, healthier life.... and you're doing it! It's obvious to the lay-observer that longevity research has reached a critical mass. I'm hearing David Sinclair's words about treating aging as THE causal factor in nearly all common morbid diseases coming from labs all over the world now. Thank you so much for taking on this challenge!
Brilliant explanation of the ISR and ISRIB! Cheers. And what a beautiful molecule: suppressing the high baseline ISR activity seen in ageing without affecting the spikes in the ISR needed to fight viruses etc.
Excellent. Have been following aging issues for years (as a layman) and don't recall coming across ISR. Reminds me a bit of hormesis. Really appreciate the amount of work and level of detail which goes into your presentations. Thank you!
Your channel is very unique and interesting. Thank you for the time that you've invested in these videos and for your interest in making information about things like this available in a way that is easy to understand. You seem to have a lot of passion for educating. I wonder if being a teacher is in your future? Regardless of what you decide to do; I really hope that you will continue to produce content like this! Kind regards! Skyler R - BSW RSW, Canada. BC.
Last question, I'm not sure if you're familiar with Cerebrolysin, but if you are could you shed some light on whether prion disease, brain cancer, and other purported risks are serious concerns?
I was curious about this too - haven't managed to probably look into it yet... But as as i mentioned in the video, the ISR is an important process and although the stresses are "integrated" through the pathway it could be that inhibiting ISR when its induced by PERK (unfolded proteins) like in neurodegen is more beneficial than inhibiting ISR when induced by GCN2, but yeah, good question!!
Thanks, Eleanor! You make me wish I had a bigger brain … maybe I need ISRIB. The multiple layers of negative feedback (X inhibits Y which inhibits Z) seem like the submerged platform problem adapted for humans. I always feel smarter after one of your videos.
this is my favourite youtuber.
Cool. So i kinda missed the part of dosage for this stuff . Would you be so kind to tell me how much i need for 75 kg lab rat ? Ty very much
We seniors are counting on you and your collegues for a longer, healthier life.... and you're doing it! It's obvious to the lay-observer that longevity research has reached a critical mass. I'm hearing David Sinclair's words about treating aging as THE causal factor in nearly all common morbid diseases coming from labs all over the world now. Thank you so much for taking on this challenge!
As a 70 year old I agree.
I'm continually amazed at how you're able to explain the complex in a most accessible way, and with humor.
Thank you!! 😊
Brilliant explanation of the ISR and ISRIB! Cheers. And what a beautiful molecule: suppressing the high baseline ISR activity seen in ageing without affecting the spikes in the ISR needed to fight viruses etc.
Awesome video as always Eleanor!
there are people taking it right now in the nootropic community.
Where from?
I had spent 5 years studying yeast eIF2B (GCD6 and GCD7) and eIF2 (GCN3 or SUI2). It was a very interesting field. Thanks, Dr. Scheekey!
ISRIB seems promising! Nice analysis!
Excellent. Have been following aging issues for years (as a layman) and don't recall coming across ISR. Reminds me a bit of hormesis. Really appreciate the amount of work and level of detail which goes into your presentations. Thank you!
Thanks, glad it was helpful! :)
💯%
Great job Eleanor!
Thank you, great explanation! Amazing stuff going on in our cells all the time.
Lots of great details in this video! Thanks
Awesome vid!
Send me some of that ISRIB please!
How do I get this?
Please make more videos on nootropics! 💖💖💖
Great lecture! I really enjoyed it, as I am beginning to dig into ISRIB Thank you!
I am a researcher new to this pathway, thanks for this excellent resource, very helpful !
This person makes me feel like an idiot. Subscribed.
ditto
Your channel is very unique and interesting. Thank you for the time that you've invested in these videos and for your interest in making information about things like this available in a way that is easy to understand. You seem to have a lot of passion for educating. I wonder if being a teacher is in your future? Regardless of what you decide to do; I really hope that you will continue to produce content like this! Kind regards! Skyler R - BSW RSW, Canada. BC.
So, what about natural sources of ISRIB? Is this basically something that fasting can trigger? Are we talking about inhibiting mTor?
Not natural!
Hexarelin, and si wu tang extract can also affects mTOR pathway according to my findings!
15:21, It can be beneficial in diabetic patients because the glucose is needed to convert protein into IGF-1
Liponacid and Olive leafextract Melatonin ist helpful as well
Excellent job explaining the process.
Hey.. love from India 🥰
Are there any experiments of ISRIB generalized for general cognative tests? (Perhaps IQ tests)
Last question, I'm not sure if you're familiar with Cerebrolysin, but if you are could you shed some light on whether prion disease, brain cancer, and other purported risks are serious concerns?
so can calorie restriction activate ISR through activating GCN2?
I was curious about this too - haven't managed to probably look into it yet... But as as i mentioned in the video, the ISR is an important process and although the stresses are "integrated" through the pathway it could be that inhibiting ISR when its induced by PERK (unfolded proteins) like in neurodegen is more beneficial than inhibiting ISR when induced by GCN2, but yeah, good question!!
❤️
It was my understanding that lower level integration of our stress response is supposed to keep cells young...
Ordered some custom synthesis ISRIB to try, thinking to dose 1mg, the slowly increase to say 15mg.
let us know how it goes. My dad's memory is going done with age and I want to see how this can help
Ярослав, принимали уже ? Как чувствуете себя?
После того как машина сбила с концентрацией сильно хуже, хотелось бы помочь себе.
@@user-wq4cw7ej1n Да, принимал, рабочая вещь, залетай в дискорд, там народ пробует и делится опытом - discord.gg/QzKrHDnq8E
@@vineets It's working, I use it for ME/CFS, there is a discord group where people share their experiences - discord.gg/QzKrHDnq8E
How’d it go?
yes, it's "cool' :-)
:-)
do you think it's safe to take?
Thanks, Eleanor! You make me wish I had a bigger brain … maybe I need ISRIB. The multiple layers of negative feedback (X inhibits Y which inhibits Z) seem like the submerged platform problem adapted for humans. I always feel smarter after one of your videos.
Было интересно !
Any idea when human trials might begin and how one might apply to participate in said trials?
Not sure, sorry!
HI,
I was wondering if you were wondering how ISRIB could be administered from a DMSO solution to humans.
Thanks.
Through the skin? Hmmm! Kind of like methylene blue? Maybe! A interesting thought to ponder.
Thx
Does this apply foe prion diseases?
The level of this video is definitely not for the average audience but I’m still trying :)
Subscribed!
eFFECTOR Therapeutics is tackling obesity. Very interesting!