Pregabalin - 5 things you should know about prescribing in dogs and cats
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- Опубліковано 19 чер 2024
- 5 things you should know about prescribing pregabalin to dogs and cats.
Description: 🐾 Are you a veterinary professional or a pet owner who needs to know more about the ins and outs of pregabalin treatment. Or perhaps you're interested in neuropathic pain management, conditions like canine Chiari malformation and syringomyelia, feline hyperaesthesia syndrome, and feline orofacial pain? This video is for you!
🧠 Dive into the world of Pregabalin and learn how it works to alleviate pain and discomfort in dogs and cats. Discover the mechanisms behind its effectiveness in managing neuropathic pain, anxiety and related conditions.
🐶🐱 Learn the essential tips on administering Pregabalin safely and effectively to your pets, ensuring they receive the relief they deserve. We'll cover dosage, frequency, the importance of veterinary guidance and how and when to use pregabalin over gabapentin.
💊 Explore the metabolism and elimination of Pregabalin in a pet's body, helping you understand how long it stays in their system and when to adjust doses.
🚫 We'll also discuss potential adverse effects to be aware of, ensuring the well-being of your beloved companions while using Pregabalin.
🔒 Finally, don't forget that Pregabalin is a controlled drug, and it's crucial to understand the legal and ethical aspects of its use.
Join us in this informative video and become a Pregabalin expert for your pets' health and comfort. Whether you're a veterinary professional or a concerned pet owner, this knowledge can make a significant difference in your pet's life. Subscribe and hit the notification bell to stay updated on more informative content! 🐕🐈👩⚕️👨⚕️ #PregabalinForPets #NeuropathicPainManagement #PetHealth #NeuropathicPain #Pregabalin #Gabapentin #syringomyelia # Chiari #feline_hyperaesthesia_syndrome #hyperethesia #hyperaesthesia #PetPainManagement #CatsAndDogs #VeterinaryMedicine #AnimalHealth #PetCare #ChronicPain #PainRelief #FelineHealth #CanineHealth #AnimalWellness #Neuropathy #VeterinaryTreatment #PetMedication #AnimalPainManagement #CatHealth #DogHealth #VetAdvice #PetLovers
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Hello :), I just wanted to say thank you so much for these videos! I am currently studying for my Board exams in Veterinary Behaviour Medicine (American & European Colleges) and have loved watching and listening to your videos for some of the psychopharmacology and the neurology that I need to know !! Thanks again !!
thanks so much for positive comments! really appreciated. Check out the video that will be posted tomorrow morning - intended as learning tool for "headache" which is not a common subject in veterinary medicine (deazel's story)
@@clare-neurovet ah just seen it! Excellent, I will definitely have a listen! Thank you, Katrin :)
Thanks for this. 8 years ago I had a cavalier with chiari malformation and SM, and gabapentin seemed to keep her mostly comfortable for a few years and then she got more painful episodes so I changed to pregabalin. The painful episodes seemed less frequent but were still intense. They occurred out of the blue but were worse with excitement or if she was in the hot sun. One bad one occurred after someone left salty crisps lying about which she ate. I am convinced this induced a very painful episode for her. At these times she would scratch intensely at the back of her head and then collapse on the floor scratching and then he body seemed to go into a spasm as if in pain, but she was still aware and awake. They tended to last a minute or so and then she got up as if she was tired. I tried many other drugs for her as well over the years but the pregabalin seemed most effective.
thank you for your observations! - it is possible the crisps triggered something because humans with this condition can described abnormal sensation in tongue or when swallowing
Hi there professor. My dog has back pain and my vet prescribed this drug, she took it for 14 days and had all sorts of bad effects. She is 12 years old. The only prior health problem she had was her appendix that was removed. On the third day she started taking the meds, she started twitching eyes and head, walking like a drunk and even falling by herself, she stopped eating for 3 days, i had to inject food into her mouth so she would eat again but that didn't help much as she only ate a little bit. She did drink lots of water during the day and peed a lot. She would not respond fast, she became disoriented and slow. He lowered the dosage and still all the above happened. Now her kidney is screwed and she is having seizures. Her urine has blood today for the first time. The vet swears it is not this drug but i belive every animal/person is different and will react a different way to any medication. I believe the drug has intoxicated her and causes all this kidney and brain damage.
The twitching eyes and wobbliness sounds like she has vestibular disease (a balance problem) but this wouldn't explain the blood in the urine or the seizures. Having pregabalin / gabapentin wouldn't cause those very specific problems.
It is more likely that you poor pet had/has some other neurological problem that is causing balance problems, pain and seizures and the gabapentin / pregabalin was coincidence/ red herring however I can understand why you would feel otherwise because she went downhill at the same time as (coincidentally) having that drug. Dogs don't have an appendix? I cannot offer further advice than that I am afraid especially for a dog I haven't examined or seen the medical record for. Your vet can contact me for advice (through the usual channels not social media) if desired. Hope that helps and she improves
Love you Channel!
I am brazilian and I really was looking for this content and it was really hard to find, thank you so much!
I wanted to ask you, if possible of course, to do a video about neurological physical examination! Only the basic, of course!
thank you
So glad it was useful. Videos on neurological examination will come but try this for starters ua-cam.com/video/o6TKbDFbpnc/v-deo.html
@@clare-neurovetthank you so much 🙏🏼🙏🏼🙏🏼
Great webinar! What are the therapeutic serum levels in humans? also I understand that for gabapentin the human serum levels are those resulting in seizure reduction rather than analgesia; how do you interpret them? Thanks Massimo
This is a great question. In humans the EC50 of pregabalin and gabapentin is estimated to be 4.21 and 11.7 mg/L for postherpetic neuralgia (E50 = concentration of a drug that is necessary to cause half of the maximum possible effect). You are correct that the published range is typically for epilepsy with pregabalin being 2-8mg/l and gabapentin 2-20mg/l. So based on that I use the human epilepsy serum concentrations and I analyse through the UK Epilepsy Society TDM Laboratories. However I don't measure serum concentrations for pregabalin and gabapentin very often.
Dear Professor Rusbridge, thank you so much for this video, it was very informative. I have two questions, please (unrelated to Pregabalin, though).
What is your opinion on frunevetmab and bedinvetmab, please? I have been working with pets, and unfortunately it has been observed that many (some overall healthy, others with osteoarthritis) pets’ health deteriorated either shortly after the injection, or after few months of treatment. Some go blind, others get paralyzed or develop tonic/clonic seizures, ulcers, kidney issues, to name a few; or die. It has also been noticed that many vets in UK are prescribing those drugs either without a proper OA diagnosis, basing on presumptions/as a “just in case” solution; or for other health issues (for example, constipation, kidney issues…, toothache etc.). I believe many people, myself included, would greatly appreciate if you could please share your opinion on those medications.
Second question relates to pet strokes and idiopathic epilepsy. Feline patient, age 13, healthy, suddenly developed occasional tonic seizures (only), diagnosed with idiopathic epilepsy and treated with Levetiracetam. Due to misdiagnosed stroke mistaken for an epileptic attack few months later, patient was prescribed Phenobarbital on top of Levetiracetam. Developed excessive scratching of ears and face, which continues months after, despite stopping Phenobarbital after 10 days. No underlying cause can be found (vet & neurologist). Would that be a likely result of the stroke? I would appreciate if you could please discuss feline stroke in one of the videos as well.
Thank you in advance.
Respectfully,
J. Mikaelson, LLB, Pet Rescuer
LFPCSA (Lost & Found Pets in Cambridge and Surrounding Areas)
Thank you for your kind comments
I have not see the problems that you describe with the nerve root growth factor inhibitors however I would say that many older dogs/cats that are "slowing up" may be initially assumed that their signs are due to osteoarthritis and given those drugs - when in fact something else is going on. Drug reactions are not typically months after giving a drug they are usually within days.
It would be unusual for a stroke to cause a pain syndrome unless in the thalamus and in that instance the scratching would be one side only. So to which region of the brain was the stroke?
Strokes are rare in cats in the UK - there typically has to be a predisposing cause of embolism (something blocking a block vessel) and most reported cases have involved the cerebellum . I don't think I have ever seen a stoke be a cause of acquired epilepsy in a cat. Idiopathic epilepsy is when the structure of the brain was normal. If I was to give a lecture on strokes in the cat then it would be quite short and mostly the cases in this paper and a couple more pubmed.ncbi.nlm.nih.gov/17317258/ .
Some people confuse "strokes" with vestibular disease (balance problem) - some vets say "stroke" rather than vestibular disease because they think it is easier for caregivers to understand but generally that just causes confusion!
@@clare-neurovet thank you so much for reply and information. They couldn’t find anything as underlying cause of the stroke, his MRI was clear. It happened right after he stopped eating, his bowl was directly on the floor; he started walking really slowly and in circles, crossing his front paws like he didn’t know how to walk, was very confused, dilated pupils. After few seconds he sat down. I took him to the vet straight away, and by the time we got there he was fine. Prescribed phenobarb on top of levetiracetam, and after few days the scratching (both sides) has started. I then insisted on referring him back to Queens Vet Hospital to see neurologist. They did all the tests and everything was ok, but saw the video of his stroke and disagreed with his vet’s epileptic attack diagnosis. Stopped phenobarb, left levetiracetam only, as it was too much for him with both meds. The scratching continues, although it’s a bit better with steroids. Since that event, I have raised his bowls 8 cm, and it never happened again. As for his epilepsy, it started last July, completely out of the blue. He started shivering for about 2 days, then started having paw, ear or whiskers twitches; these are his only symptoms. First, we suspected FARS, but again-neurologist wasn’t sure, his tests were normal (there were some changes in the brain, but minor and apparently normal at his age), so his diagnosis is FARS or idiopathic epilepsy. His twitches happen only when he lies down, either asleep or awake. No FARS triggering sounds are present.
Hi profesor, my dog is 10 y o and has back pains. Two years ago our doctor ordered gabapentin 100 mg twice a day. Now it does not work as good as before and higher doses of gabapentin provoke side effects. Now the prescription is to switch to pregabelin 50mg twice a day. Can we switch immedately to this dose or it requires some transitional time in giving 50mg once a day or maybe giving half of daily doses of gabapentin (morning) and pregabelin (evening) on the same day. 🙂
I suggest looking at the pregabalin video (I do discuss that) but a straight switch is best / easiest.