RESVERATROL MYSTERY: How it AFFECTS Cancer Cells?
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- Опубліковано 19 лип 2024
- If you take resveratrol… did you know resveratrol works differently in your body depending on how much you take every day?
If you’re not careful about how you take resveratrol, you may achieve completely different benefits from the ones you intended!
I couldn’t believe it either until I saw it too. And it is one of resveratrol’s biggest secrets.
And it’s kept within its polyphenol family. Which includes fisetin, quercetin, pterostilbene, and others.
Today, we’ll hear Dr David Sinclair explaining a mechanism that helps to stay younger for much longer. This mechanism is critical to decipher how resveratrol works and what it does inside our bodies.
You will clearly see what these powerful molecules do to our bodies and even to our DNA after we take them.
We’ll answer the following questions:
1. And if, in Sinclair’s study, the small dose resveratrol lived longer in both groups,why this sudden change of impact when going to high resveratrol?
2. What does resveratrol do to cancer cells?
Is resveratrol a good supplement to kill cancer?
Let’s continue with our investigation.
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Suggest watching next:
✅ NEXT: Resveratrol, Fisetin, Quercetin and senescent cells:
• RESVERATROL MYSTERY #2...
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If you missed previous videos of the investigation:
✅ Part 1: David Sinclair Study on Resveratrol: Fascinating Discovery
• David Sinclair Study o...
✅ Part 2: "How RESVERATROL affects your heart?"
• How RESVERATROL affect...
✅ Part 3: Could JUST 1mg of RESVERATROL Affect Your Longevity?
• Could JUST 1mg of RESV...
✅ Part 4: RESVERATROL Impact On Metabolism: 2021 Human Study
• RESVERATROL Impact On ...
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Study References:
I'm working on a website to include each video with all links, with each page per video.
In the meantime, I ALWAYS show the exact study titles & years and read them aloud. Go to GoogleScholar.com, put the first 4 words only, and the study will come out as the top search, guaranteed. Please double-check me!
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Chapters:
00:00 Previously in our investigation
02:54 Cancer
05:20 Cancer and Resveratrol
11:49 The Tie Breaker System
18:02 The cancer dilemma
22:27 Insights from Today
26:00 Senescent cells intro
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The Wellness Messiah podcast is available on Spotify, Apple Podcasts, and Overcast.
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Credits: Scott Buckley
Disclaimer & Disclosure: The information in this video and/or at this channel is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge, educational and information from the research and experience of Rimon, who encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.
Rimon is not a medical doctor. If there is a contradiction between the advice here to your doctor or local authorities, always go with the doctor and the authorities.
Statements made, or solutions suggested in this video and/or at this channel are not intended to diagnose, treat, cure, or prevent any disease.
The statements are not contradictory to first following authorities' guidelines of social distancing and hygiene.
Absolutely AMAZING
INTRIGUING
Just shows it's not just about BIOCHEMISTRY is important but
Dosaging is important too
Body is AMAZING
Nice to see and met you. Your presentation is fantastic, clear e well structureted. Congratulations and thank you very much.
Glad to meet you here on this platform, Marcelo. You're very kind!
Excellent explanation and breakdown! Keep up the great research 🔬
you're very kind, great to meet you here on this platform ❤
Fantastic video. I learnt so much. Thank you ☺️
Good to see you Henvest, and you're very kind. I'm still upset I haven't included a practical segment at the end, so I put in the pinned comment. Will appear in the next videos. Your comment helps with my perfectionism.
I have been practicing fasting for almost my entire life I could go down the list of the things that changed in my body that are just nothing short of a miracle but I won’t go into it here as it would just take too much space and I’m not really much on answering a lot of questions but I can tell you that fasting is just incredible way to survive stress, disease, and a variety of other issues. Totally amazing
It IS amazing carlos. I agree. Thank you for sharing this!
This is true. I went through an extremely stressful period in 2021 for about 6 months. My body refused to eat. (Involuntary) fasting was one of the only things that got me through this period. I did lose a lot of weight which was not my plan. I'm small person with a small frame and I did not need to lose 15 lb. But, I did feel good. The fasting helped my mind and body during this time. I've since gone back to fasting at times to find that sense of wellness I found it before.
Many cancer survivors tell of how fasting was an important factor in their armory of natural remedies to battle the disease. It has benefits for the body mind and soul that has been studied by allopathic as well as naturopathic medicine.
Great video, thanks for creating.
Once again thanks for this insight Rimon. For me (over 50 sic) my basic strategy would be to use high dose resveratrol intermittently as a senolytic. However pulsing doses may still be a useful strategy as periodically “make do and mend” would still have a place in a balanced approach to maintaining health, unless of course I need to suppress angiogenesis as part of a anti tumour therapy.
Btw this also nicely explains why any alcohol consumption increases cancer risk, where as moderate alcohol consumption is cardio-vascular protective. Perhaps indirectly may even explain why statin statin increase cancer risk, suppression of the mevalonte pathway, forcing damaged cells to attempt repair.
Hi David, I always enjoy reading your insights. I'm now in a deep dive into senolytics.
The world's expert says that senescent cells aren't a problem until they reach a threshold. Meaning, If I am under 60, with good health, would tone done my active targeting of these senescent cells until I have more information. Yes, despite being a hot topic in our community. Many studies are coming 2023-2024!
@@WellnessMessiah
Excellent!
Subscribed!
@@antonystringfellow5152 Hi Anthony the senolytics video just came out:
ua-cam.com/video/nk1kUA__p9k/v-deo.html&ab_channel=WellnessMessiahwithRimon
Wow I learned so much, thank you.
Great to see you again. I think our health is worth any insight we can gather ❤
I just saw this video after considering buing resveratrol for me and my elderly parents. This made me think hard about the safety of this supplement and dosage. Thanks for the video! (Edited for a spelling error.)
😮Wow....ijust went to class and i payed attention and understood every thing.
Great theory. On cell death program
Wow this is awesome and mind boggling. I just bought resveratrol yesterday and planning to take it after some more research and here you go 😅 new subscriber here. Thank you for your work!
Btw i am 46 y/o and had schemic stroke last June, do you think a 1000g helps me recover 😅 or taking low dose will. I have been doing intermittent fasting after my episode, i've lost some weight and feeling a bit better now. Thanks to all longevity videos out there including yours ❤️
Hi Leela, you're very kind ❤️
To be honest schemic stroke is not my department of expertise. I suggest consulting your doctor on this. There is a good episode on this series you can show your doctor about resveratrol and heart health, so he could decide:
"How RESVERATROL affects your heart?"
ua-cam.com/video/yT4rqxADvQI/v-deo.html
@@WellnessMessiah thank you for your reply! Appreciate it 😍
@WellnessMessiah I am 50 in years old in great health. 5 foot 10 and weigh 159 lbs. I swim 5 days a week and lift weights. What is a good dose if resveratrol for me?
1000g !!
Thank you, Sir. This is good information 👏
Thank you! I appreciate all the info
You're very kind, glad to see you here again :-)
@@WellnessMessiah Thank you for your kind reply! Your channel is my favorite so I try not to miss any videos. Thank you so much for your researches and sharing info.
thanks . great Video . I stoped Resveratrol because of Dr Brad's video. now I will start again.
You're very kind Edison. Regarding Brad, suggest checking this video:
ua-cam.com/video/Hsk-TyjywR4/v-deo.html
Edison, it was your comment that made me recheck both Rimon and Dr. Brad's videos, thanks. In the video Rimon linked above, the study mentioning significant total cholesterol increase was not referenced... So please take that in consideration on your decision.
Thank you for an excellent video.
Hey, great video, this cleared things up nicely! Question: have you considered how cancer’s unregulated metabolism may impact it’s uptake of reveratrol?Maybe there is an optimal intake that has low-dose effects on regular cells but high dose effect on cancer cells?
Hi Matteo, you're very smart.
Well, previously I showed resveratrol access via diffusion to the body. I believe that's how it accesses the cell. This means, I wouldn't expect a wide difference in uptake. However, the largest difference is indeed between tissues.
You're right in the sense that you can get low resveratrol in certain tissues and high in others (e.g. colon is probably the highest). This means, I would go either very low (50-120 mg) or very high on resveratrol (1-2 grams) to have the effect I want, and not in between.
I put here links for the rest of the investigation because my pinned comment didn't work:
✅ Part 1: David Sinclair Study on Resveratrol: Fascinating Discovery
ua-cam.com/video/Js_l_G1x8V4/v-deo.html
✅ Part 2: "How RESVERATROL affects your heart?"
ua-cam.com/video/yT4rqxADvQI/v-deo.html
✅ Part 3: Could JUST 1mg of RESVERATROL Affect Your Longevity?
ua-cam.com/video/XFgSA7gbtus/v-deo.html
✅ Part 4: RESVERATROL Impact On Metabolism: 2021 Human Study
ua-cam.com/video/MNO4U5wbF08/v-deo.html
EXCELLENT THANK YOU THIS INFORMATION MAKES CLEAR MANY IMPORTANT FACTS THAT HAVE BEEN MISSING, I AM MOST GRATEFUL, WISHING YOU SUCCESS THANKS FOR SHARING BE BLESSED AMSTERDAM HOLLAND APPRECIATES.
It's like you need to analyze your body every week to experiment with a supplement like this imo. I'm super skinny, 33yo that could go for 23yo so I'll pass for now. Love your content so far #subbed
Great video. Thanks.
Great video, maybe you could do a special one dedicated to the prevention of cancer and which supplements would best in that regard. I am thinking of a mix of Resveratrol + Luteolin + Fisetin.
Interesting!
Can you please do a video on polyphenols & Akkermansia probiotic?
Thanks for such a great video! Would you mind sharing what other supplements you take to prevent cancer? My mom just had a cancer removed from her tongue which had spread to her lymph nodes. She suffered so much and now she lives in fear that it will return and so do I.
Another great video thank you
You're very kind William!
Much thanks, Rimon
So if my car's under stress, because i use it to drive people in my organisation to work everyday, my laptop will last longer ...got it
(actually a very nice video... subbed)
haha love it :) This channel is actually longevity for laptops, but people continue to misinterpret my work.
Glad I came across this video!
Glad I came across you Nicholas! You're very kind
@@WellnessMessiah Thank you. I appreciate you taking the time to make this content.
Thanks for the update and advocacy for our freedom. This really hurts in your situation with your wife, and also for those of us who are older and already see benefits from NMN. If David Sinclair doesn't work against this claim by his company, he will indeed essentially destroy his own reputation as someone advocating NMN use and genuinely motivated by altruism. Ironically his own father may no longer be able to take NMN as the prescription uses tested by the company seem to be very limited. Is he that big a jerk??? Hope not...
Amazing break down. Thank you. How much resveratrol would you say is in a cup of itadori tea which is Japanese knotweed tea?
They found some nodules in my lungs last month and want to get a second scan done in a year to diagnose. They said nodules are common and i shouldn't be alarmed but im wanting to try resveratrol for a year amd see what the scan shows after.
Great video! Thank you so much!
I wonder if it works like this with all antioxidants??! Are they all toxic in high dosage?
Excellent. Thank you.
Thank you for sharing this. Very interesting!
Question: If your theory is correct, would this also apply to NMN dosage? i.e., would lower dose NMN (< 500mg daily) be better for longevity?
Or does taking NMN trigger a different mechanism and so it's not comparable to taking resveratrol ?
Hi Hugo, how are you? I've made my NMN research back in 2019 in my conclusion is that a lower dose WON"T be better but worse. NMN doesn't stress the DNA like resveratrol and its friends, it's more like fuel.
However, I do need to have a fresh look & investigation and catch up on all 2020-2022 studies.
Yes, I like to know the answer to this question please🤗🌺
Pls let us know the answer but maybe( Sorry forget his nsme )he can make his next video on this subject or covers this question as well.
Regards.
So that's why i feel like crap at high doses
Fantastic great video. I learnt so much. Thank you. However, my question, what is your opinion how much and when should I take resveratrol, fisetin, quarcitin? I'm 78 years old healthy lady. I appreciate for your opinion.
I ve just discovered your channel. Thank you for doing the thorough research to bring us this interesting distinction in resevatrol 's effects on human cells. In the same vein, I would love to hear what you think in term of fasting on longevity and cancer. There are contradictive arguments on fasting, I wonder if fasting also works on cells differently depending on the dose ( in this case is the length of a fast), and the age of a person, given fasting also gives a stress signal to a body/ cells just like resevatrol does. Then how much can this observation be expanded to all other types of homedic stressors. After listening to this video, my speculation is that some stress is good, but not to pass a limit, that consequently push healthy cells to undergo apoptosis. So in practice, we shouldn't stack homedic stresses at one time (eg. cold stress, heat stress, fasting all in a day), rather, we should do one at a time. Love to hear your researches on these.
Excellent question Mary.
I think the greatest difference is between intermittent fasting and long fasting.
I think of them as two different tools. The first one is great for reducing food intake, and losing weight, and is a habit.
The second is good for deep cleaning and is not a habit. Meaning, I do this every few months.
So yeah, the "dose" matters here too.
The age - IMO - not personalized advice - fasting is good at any age (unless in contradiction with drugs).
Younger people reach autophagy quicker. Older need more time to reach the same cleaning effect.
@@WellnessMessiah thanks for sharing your thoughts on this! I am in the look out for more insightful discussions from your channel.
Is OMAD expected as long fasting when compared to IF? Like to know the differences, please on your next video🤗
Compared to IF , i meant. Thank you🤗🌺
Hi Rimon! What is considered high dose in mg per kg of bodymass, and what is considered low and medium dose respectively?
Thanks
Also tell us about low dose vrs high dose vit c.
Based on this investigation, I take 50-120 mg (range) resveratrol with 3 days off every week and 24+ hours before exercise. This is my body and not a recommendation.
✅ Next video: Resveratrol, Fisetin, Quercetin, and senescent cells:
ua-cam.com/video/nk1kUA__p9k/v-deo.html
✅ Patreon - Get the 10 Resveratrol Habits Now
www.patreon.com/WellnessMessiah
The series:
✅ Part 1: David Sinclair Study on Resveratrol: Fascinating Discovery
ua-cam.com/video/Js_l_G1x8V4/v-deo.html
✅ Part 2: "How RESVERATROL affects your heart?"
ua-cam.com/video/yT4rqxADvQI/v-deo.html
✅ Part 3: Could JUST 1mg of RESVERATROL Affect Your Longevity?
ua-cam.com/video/XFgSA7gbtus/v-deo.html
✅ Part 4: RESVERATROL Impact On Metabolism: 2021 Human Study
ua-cam.com/video/MNO4U5wbF08/v-deo.html
ua-cam.com/users/sgaming/emoji/7ff574f2/emoji_u2705.png
How to take 1 mg reservetral? Supplementation?
When you say you take 3 days off, does that mean every other day or 3 straight days off?
Very interesting!
thank you Mat (mor matfritz), the next video is on senescent cells and even more so, in my opinion. Coming soon!
Frankie0 seconds ago
I take just 100mg of liposomal resverstrol x2 a week. Since resverstrol is a estrogenic mimic substance ans notice some breast production for an overweight individual such as my self. i cut back and find small micro dose more usafull for lungs, heart and circulation. Really helps with breathing but for me to much in larger doses. Now and feel whats going on in your own and body is key... I prefer at this point
pulsing the molecule it terms of and on whatever receptors it is effecting..Pulsing is a great concept to be considered? Do we need everything on afterburner when taking a multitude of substances?
Hi Frankie you sound very scientific. We all need to be our own body's scientists.
Pulsing is a great concept to consider like you very smartly expressed. In fact, it's the next episode in our investigation. Today I released the next episode of the video you've watched, the pulsing subject will come next:
ua-cam.com/video/nk1kUA__p9k/v-deo.html
Hello, how much fisetin would you think to use to produce apoptosis?
Wow that is a lot of information to absorb. Taking 1gm Resveratrol per day. I’m 52 in good health. Now I’m considering changing to the low dose until I hit 60. I also do a 7 day water fast once a year, would that be a good time to up the dose back to 1000mg? Thank you for sharing this information!
You're a very kind Christian. I'm touching water fasting and resveratrol in the 10 resveratrol habits. It will come in 1-2 months I believe. I share a summary of that with the Patrons, about 2-page document of what I've changed after this investigation which gives immediate access.
@@WellnessMessiah I will be sure to read tho 10 resveratrol habits. Thanks for the response!
Thank you for this!
What is a typical effective lower daily dose for a healthy middle-aged person?
How often should we take higher dose resveratrol to remove cancer cells (again for a middle-aged person). Based on your video, I assume 1 gram of resveratrol is sufficient for a high dose.
What is the recommended dosage of Resveratrol for a 50-year-old healthy, fit male who does not know if he "has" or "has not" got early-stage cancer?
How does this translate to knotroot bark? I don't know how much powder I should take and how often. I am 43yo.
Can someone recommend a good resveratrol brand supplement??? Thank you in advance
I would suggest stating that "it doesn't matter if reseratrol does cause damage, or the body just sees it as damage or stress" is a severe oversight. For example, in determining if an individual should take it or not, if indeed resveratrol does cause actual damage one is forced to grapple with the question what's the collateral damage in simply making the cells last longer, and is it a payoff overall to health. I give this analogy Resveratrol is the dial on a radio allowing us to choose the radio channel, only we do not know how to tune into the correct channel i.e to damage the cell to the point of needing complete replacement, or just enough to encourage renovation of a salvageable cell(s). Furthermore, if a cell is salvaged, what errors has maintenance overlooked, considering it uneconomic.
I have been taking Resveratrol, Quercetin, Spermedine, NMN, Curcumin, PPQ, Olive oil, and GLUTATHIONE in search to recover my sight, being lost due to Advanced Age-Related Macular Degeneration.
Question: Which of the above molecules behave similar to Resveratrol
Thank you
Do you think we should take resevratrol or better to avoid? I am thinking of buying one.
Great video! It really got me thinking. I have multiple myeloma cancer in remission. Now im wondering if i should cycle from low dose to high dose or back and forth
I also have mm, 22 years and still going.
@@elliottrubenstein1746 you were able to keep in remission all that time? Wishing you to keep your multiple myeloma in remission and enjoy a healthy life
So happy to hear of your progress! I’m dealing with leukemia and now learning how “good” supplements have actually been causing me to go backwards. A lot of good explanation by Rimon here, but now I am more confused than ever about my supplements protocol. I’ve been doing the longevity protocol and now clear about resveratrol but saw a comment on NMN dosage which sounds like I’m doing it wrong. Makes me feel like crying, I don’t want to have cancer anymore!
@@jeffreynester7326 Went thru 3 high dose chemo regimes and 3 bone marrow transplants at UAMS, University of Arkansaw Medical School, went into remission all three times. Currently in remission for last 11 years. It all turned around for me with life style changes, no sugar, low carbs, IF, keto. Cancer needs sugar and or insuline so keep both low. I follow Drs Fung and Sinclair and adhere to longevity protocols. Am 76 feeling better than when I was 46. Any questions feel free tol ask. Good luck with your journey.
@@elliottrubenstein1746 im doing keto and omad too. I just finished "The Cancer Code" by Dr Jason Fung. Great book. I follow Dr David Sinclair too. Glad Rimon is breaking the research down. I keep protein low to try to keep my mTOR pathway down so i don't activate growth. I do same on sugar. So far i only had the CYBORD. Now im on immune therapy. I also requested metformin to keep glucose low even though im not diabetic. I wish you best to keep cancer in remission. Keep reading as i found many great cancer books. It comes down to real food imo.
I’m HER2 positive going through targeted therapy.. is it safe to take resveratrol?
Thank you so much for this video and for your wonderful work. Could you enlighten us re the dosage of trans-resveratrol / resveratrol. I am taking the supplement from Pureclinica saying 1000mg in one pill equal to 500mg of trans-resveratrol. Is this indeed the high dosage for old and cancer cell death or is this still a low dosage for longevity. Thank you so much!
Which is the best resveratrol to buy? I have been using a reputable company (doublewood) but the capsules are brown, which dr Sinclair says is bad, and should be white. Is this true?
I think the best study on resveratrol would be the French people of a particular wine region where they live the longest life than I would believe in Dr Sinclair lab study.
Hi John, how are you? I think there is a lot of merit to what you said. This is why I concluded red wine is a great investigation tool. I published it 1 month ago:
ua-cam.com/video/XFgSA7gbtus/v-deo.html
This is another excellent video. You're really getting into the details of resveratrol's effects at different doses.
Right now I take a total of 225mg of resveratrol a day. 100mg is regular resveratrol in Longevinex, and the other 125mg is a highly bioavailable liposomal form. So it's less than 500mg, but the liposomal form should be more potent. We need more studies using liposomal resveratrol, it's delivery mechanism is much different and this may change how it affects cells and the body. Generally, from what I can tell, it improves the positive benefits.
I think what needs to be determined is whether liposomal delivery pushes low dose resveratrol into the high dose category. Or if the delivery is so different it is a separate category altogether. Bypassing the GI tract likely makes a big difference.
So I'm taking all this in, but for now I'm leaning towards sticking with what I'm doing. I'm 45, active, and healthy, unless I can see evidence that the liposomal resveratrol at this dose poses issues I'll keep taking it. But definitely something to look out for in future research.
Hi Jason, good to hear from you. You're very helpful.
Yes, I think the greatest effect of liposomal resveratrol is accessing tissues non-liposomal can't access. Not necessarily more power. I think it is promising. I'm especially interested in resveratrol access to the inside of the white blood cells (in the blood, water = not good for resveratrol) and deep inside the brain, esp. the hypothalamus.
Resveratrol accesses the brain, but the brain seems to not open all the doors for it. The hypothalamus. is deep in the center, maybe lipo. will reach there.
If you see studies on liposomal resveratrol and white blood cells (not on a dish) and the hypothalamus, please let me know.
I want your advice: Next video is about different doses of resveratrol & senescent cells.
should I wait another week to publish it? It's pretty much a lot to digest for people. It's heavy almost like this video. What's your advice here?
@@WellnessMessiah I would go ahead and publish it. Even if it's long, people can just watch later when they have the time. That's what I did with this one, published on the weekend but I watched it today.
You make good points about liposomal delivery. It does allow resveratrol to reach more cells and deeper areas in the cells - I had forgotten this. And it eliminates loss from digestion. Another factor is it stays in the bloodstream longer, so it's almost like buffered or time release supplements. The net result could be low level exposure but over a greater length of time.
@@TriangleDancing Thanks for your advice!
thank you so much . looking to control blood sugar too and live longer
Wishing you a long and healthy life Robert.
P.S. I assume you've seen the resveratrol-blood sugar in humans research published 2 weeks ago.
@@WellnessMessiah Reading every science paper or report.
@@robertreagan5173 Ho, I meant the video examining this research. It covers all human data on resveratrol vs blood sugar and insulin in humans:
RESVERATROL Impact On Metabolism: 2021 Human Study
ua-cam.com/video/MNO4U5wbF08/v-deo.html
Which is low or hight dose of resveratrol?
Can you take resveratol and quercetin together? If so how much is safe dose? (Interstitial cystitis)
Hi Jasmine, great to meet you! Most of what I know about quercetin, including potential synergy, with resveratro, I share the video published today:
ua-cam.com/video/nk1kUA__p9k/v-deo.html
Very interesting video, thanks for the literature research!
I have one question that might interest you.
In skincare, there is "anti-ageing" ingredient called Tretinoin, which is modified form of vitamin A.
Over long term topical use (at least 6 months minimum), this ingredient causes thickening of epidermis, and imrpovment of ECM in dermis - collagen and fibronectin, which leads to improved wrinkles and more youthful looking skin.
However, the treatment also increases cell turnover in epidermis, which concerns me, because I often hear (your videos included) unecessery cell replacement is not what we want.
Despite my concern, when doing brief literature review myself, I could not find any known negative effects. I even found some papers suggesting skin cancer prevetion properties.
I would love to hear your opinion on this. Could be good video idea since I have not seen real deep dive into this. Most skincare channels just say that it's safe and effective, and "anti-ageing" but in cosmetic sense. I want to know if this substance has real anti-ageing benefits not just appearance.
Thanks for answering I hope this interests you.
Hi there, I didn't know cats use creams.
Seriously, you're a spot on the principle (I'm not familiar with Tretinoin). There is so much youthfulness we are born with, and unnecessary turnover will use up some of that. It will borrow future youthfulness for present youthful looks. Just like with credit cards.
It seems to me that Tretinoin works in similar ways like Resveratrol - by stressing skin crlls…I started using it at 0.025% 6-8 months ago, always pulsing,
increased to 0.05% and can already see results…will plan on getting to the highest % which is 0.1%. Then use it for a bit at that level to get maximun effect through aggressive cell turnover….after that it will probably make sense to go back to the lower % again, even to retinoids, just to extend skin cells instead of re-building and to maintain. Plz let me know what is your plan!
Hello, is retinol effect only to increase cell division ? I don't know. But I had concerns as well. I thought it is not priority for the moment only as David Sinclair is using retinol himself. He makes his own skin cream but only mentioned retinol and NMN as ingredients.
If Rimon analyses the subject I will watch of course 😁
@@bernhardwalther I just watched the video where Dr. Sinclair talks about retinols.
Yes, Dr. Sinclair uses Retin A himself. It's very effective for wrinkles and uneven pigmentation. He says that right now we just don't know if it's good or bad for long term skin health yet. However he speculates that retinols might stimulate abundance pathways, and suggests that you might not want to use retinols while fasting.
They mentioned also something regarding autophagy but I was confused about that part.
Link to source video: ua-cam.com/video/-6Laa2LiS2E/v-deo.html at 35:00 the retinol talk starts.
Edit: I also love Rimons response about cats using creams :D priceless
I’m still confused. I have skin cancer. Am I understanding correctly that a high dose of resveratrol will attack and kill the cancer cells?
I’m already taking quercetin with bromelain and doing time restricted eating, low carb and fasting.
I appreciate the information but I'm more confused than before. I want to take Resveratrol, but what amount is okay? Seems like you went back and forth a few times about best dosage. Sinclair says 1g a day, is this fine? I'm a healthy 34 YO.
What exactly would a "low level" be?
@Wellness Messiah with Rimon Would you please clarify why Dr. Sinclair is not taking with NMN a low dosis of resveratrol if it should be better for longevity acording to your investigation results? Does he go against his own studies?
Hi Heather, it's speculation ). It could be that Sinclair has better things to do now than to go over new resveratrol studies and spend months analyzing each one (like yours truly).
Many of these studies are from 2020-2022. He has been taking high-dose resveratrol since 2004.
I will have a special video on that exact question, you're not the only to ask that.
@@WellnessMessiah I really do not think he decided a high dosis because did not remember his own studies or did not have time to analyze others. As a sciencetist for sure he has performed thousands of tests in animals and after 2004 in himself so knows somehow that the combination of (NMN + pulsed high resveratrol) works better than (NMN + non-pulsed or pulsed low resveratrol). He is the only one who can fix this controversy.
Hi love ur channel, doctors found a good tumor into my body have the operation in 3 months, what dose would you suggest taking ? I always used for 8 years a low dose 500mg every other day, would you recommend me getting higher or completely quit taking resveratrol at my case ? Iam 31 years old but look like 20 btw 😅
Hi Rene, I can't provide medical advice as I'm not an MD. If I were me, and I had an active tumor or tumor on check-up after surgery, I would be very careful with resveratrol supplements. Low dose, and even medium doses, can help cells to survive, which include cancer too. Consult your doctor with anything you do, as the video is about longevity and not personalized/medical advice on cancer recovery. Wishing you to continue to look like in your 20's, and tumor-free for life! Our longevity community needs you healthy :)
Should we takes this supplement during increased activity only.? Or also perhaps taking it every other day is a safer approach?
Hi Tam, i think I haven't seen you here. Welcome.
Based on this investigation, I take 50-120 mg (range) resveratrol with 3 days off every week and 24+ hours before exercise. Remember that heavier people need more, (e.g. 120), lighter less (50ish).
Regarding activity (Exercise?) and everyday use, check this video:
David Sinclair VS Brad Stanfield on RESVERATROL
ua-cam.com/video/Hsk-TyjywR4/v-deo.html
Hm, is there any other supstance that can be taken daily (or every 2 days) that won't interact with resveratrol but would be taken in opposite dose so it covers both cancer cells and health and longevity, or maybe taking resveratrol 50mg and on the next day 1.2 grams, are there any studies on this?
Thank you , very good investigative work. Love to see what u think of Spermidine . Thank you indeed.
Mekon nice to meet you here.
For now, there is too little data to make a deep dive research on spermidine.
My greatest concern with spermidine is the researcher from ITP stating they couldn't get it absorbed or detected in their mice. No paper was published just his thoughts.
I need to understand more about its metabolism to form an opinion.
For now, I get it from mushrooms and broccoli, not a supplement. But...that could change in a year or so. I hope Sinclair is right on spermidine. Who knows, it may be better as a hit and run in high dose, over everyday use.
I'm using Resveratrol a' 150 mg everyday. Regards from Zagreb, Croatia
So who is going to play Russian Roulette determining if they need a high or low dose of Resveratrol? Surely this would need to be very carefully determined with a complete reading of the body in question on many different parameters, not something as simple as underweight or overweight, surely!?!
what is "low" vs. "high" dose?
A few different herbal extracts have dose dependent function. Notably Black Cohosh.
so 89 mg every other day for someone like me who weighs 70kg? So is it most optimal?
Hi Joel, great to see you.
Based on this investigation, I take 50-120 mg (range) resveratrol with 3 days off every week and 24+ hours before exercise. Remember that heavier people need more, (e.g. 100-120), lighter less (50ish). Sometimes I take 50 sometimes 100, and I am around 70kg.
I will have an expansion video that will cover every aspect of timing and dosage for longevity. I promise it will be above your expectations for a lifetime habit of longevity.
Very interesting!
One question:
How much videos are about to come until we hopefully get a recommendation on how much resveratrol to take at what age?
At the moment I (>50) would tend to take it in low doses (50-100mg) but also have phases with high doses (500mg) in between...?
that was my conclusion also
Hi Otto, thank you for being with me on this journey.
You're right and I frustrated many people here!
Based on this investigation, I take 50-120 mg (range) resveratrol with 3 days off every week and 24+ hours before exercise.
It's more about weight than age. Heavier people needed more (120- maybe 130 for 6'7) and lighter people, e.g. small women, need less (50-60). That's based on my research, which may be updated if ower dose studies are done - unlikely!
I will have an expansion video that will cover every aspect of timing and dosage for longevity. I promise it will be above your expectations for a lifetime habit of longevity.
Otto, because you've been with me all along.
I have created a document for my patrons: 10 resveratrol habits. It doesn't appear on UA-cam.
you can respond here with your email. And I will send it to you, too (only).
@@WellnessMessiah
Hi, Rimon, this is soooo nice of you! Thank you so much!
@@miracoli16 yeah, you can put your email here or send one to wellnessmessiah@ gmal.com.
My girl was diagnosed with leukemia, she is 30yo 47kg weight it is okay to give her 1gramm of resveratrol?
I take 1g Trans-Res soaked in wine for an hour with 100mg of grape seed extract.
Unfortunately, resveratrol is hard to absorb. So I absorbed through the lining of the gut rather than the intestines.
I'm really scared, I've been taking trans-resveratrol 99 daily for 6 months, in powder one teaspoon of those that come in the envelope, in the morning, according to the brand, that is equivalent to 500mg, although it is not clear, because the spoon puts 1ml, have I made a serious mistake? I don't know what to do
Hi Carles, I wouldn't worry about it. High-dose resveratrol doesn't reduce lifespan compared to nothing. It seems to not hurt. Just not be as good as low dose.
Anyhow, we're talking about the lifetime habit of longevity (not illness treating). A few months won't make much difference anyway.
500mg is around medium dose - not low and not high.
I used to take 1 gram for 3 years and I'm not worried so don't be yourself.
@@WellnessMessiah thanks for you response, If I go back to it I will lower the dose, or wait for more exhaustive studies, thanks for taking the scare out of me!
Thanks. So, what is a good low dose for humans? Around 100 mg/day? every other day? BTW, maybe shhort term use of high dose, say 1 gm for 3 days every month or two, would be a good anti-cancer regime, much as higher dose fisetin for several days every month or so will help kill senescent cells. Of course, this relates to older humans, not the young.
Hi Peter, how are you? Great to meet you here. You sound very smart and I think you got everything from this video.
Based on this investigation, I take 50-120 mg (range) resveratrol with 3 days off every week and 24+ hours before exercise. Remember that heavier people need more, (e.g. 120), lighter less (50ish).
I will have an expansion video that will cover every aspect of timing and dosage for longevity. I promise it will be above your expectations for a lifetime habit of longevity.
The cancer thing, well, that requires further explanation. But your idea is right, I believe now that 1.5-2 grams of resveratrol for a few days can be a helpful tool for older people (not medical advice). I will delve into that in the 10 habits video, which will come in a 1-2 months
I'm taking for lyme. Lyme definitely hurts my longevity so I think I'll take my chances.
Hi pam, it sounds like you have missed the series of videos. This guy is very pro resveratrol in all of his series.
Hi Pam, I really like resveratrol. I suggest checking the previous part of this series.
Especially part 4 and 2 where I show resveratrol benefits.
✅ Part 1: David Sinclair Study on Resveratrol: Fascinating Discovery
ua-cam.com/video/Js_l_G1x8V4/v-deo.html
✅ Part 2: "How RESVERATROL affects your heart?"
ua-cam.com/video/yT4rqxADvQI/v-deo.html
✅ Part 3: Could JUST 1mg of RESVERATROL Affect Your Longevity?
ua-cam.com/video/XFgSA7gbtus/v-deo.html
✅ Part 4: RESVERATROL Impact On Metabolism: 2021 Human Study
ua-cam.com/video/MNO4U5wbF08/v-deo.html
Also consider bee venom (if you aren't allergic). Did wonders for my chronic fatigue and body aches.
No journal citation? Please post your citations.
Hi Patrick, Regarding the study links. I always show the exact verbatim titles and read them aloud. All the viewer needs is to google in Google Scholar the first 4 words only, it will come out, guaranteed!
I change nothing from the study and say “I quote” when I do.
I’m one man here and if I were to edit the description every time, I would not be able to produce a video once a week nor to answer virtually all comments, which is something that doesn’t happen on other natural health channels.
When I will have help (I cannot afford it financially now), I will ask them to do so.
Currently, and feel to correct me if I’m wrong, it’s not the best service for my audience to get less content and no response from me but have more description info they can get within 5 seconds of search.
Good video. It helps clarify why there’s different results from low or high doses
In Sinclair’s studies, he’s more interested in raising your NAD levels when he suggests res with NMN?
Hi how are you?
My understanding is resveratrol may increase NAD+ usage, but not vice versa. Meaning that it doesn't make sense to take more resveratrol if you take NMN.
Remember Sinclair started with NMN - I believe - 14 years after he started with 1 gram of resveratrol.
What about opc?
So how much do I take!
Hi Cathy, how are you?
Based on this investigation, I take 50-120 mg (range) resveratrol with 3 days off every week and 24+ hours before exercise.
I will have an expansion video that will cover every aspect of timing and dosage for longevity. I promise it will be above your expectations for a lifetime habit of longevity.
its confusing why you say if you had tumur not to take low dose please clarify if it does apoptosis
It's not too shocking, that is what hormetic effect is about. But the damage here seems to be more than with other things which trigger the same effects, such as fasting.
Great to meet you. Nice comment. Is your name here connected somehow to Francis M. Pottenger, who applied the ideas of Weston Price?
@@WellnessMessiah Yes!
🥇
So how much resveratrol do you take now? I was thinking about reducing my dose to 300 mg every other day. Also, do you have your supplement regimen posted anywhere? I'd be happy to pay you for it.
Hi Nicholas, for your question
Based on this investigation, I take 50-120 mg (range) resveratrol with 3 days off every week and 24+ hours before exercise. This is my body and not a recommendation.
BTW the patrons of this channel (starting with $1) have access to a 2-page document on the 10 resveratrol habits you can access now with all the tiny details.
Regarding the regimen - I'm working on a revised document on my entire supplement stack on the $10 level. It's yet to be published, when I finish I will share it with the $10 level:
www.patreon.com/WellnessMessiah/
@@WellnessMessiah Thank you! I'll probably sign up in a bit here. Sounds good.
@@WellnessMessiah Are those days off consecutive? Sorry for all the questions. I'm gonna be joining your patreon soon.
Does it mean that too much olive oil is like high dose of resveratrol effect? Because both are polyphenol?
Hi Arvin, no, they are different polyphneols :) I will show in a future video how low dose resveratrol /red wine and olive oil work in synergy activating longevity genes, none can activate on its own. . But don't tell anybody just yet :)
I'm 30, weigh about 150lbs, and I take 1 gram of Resveratrol, 1 gram of NMN, and 500mg of TMG daily. I feel good though.
Great to meet you Kris, sounds like it works for you. there is a segment where Davind Sinclair speaks about TMG here, around minute 5:
ua-cam.com/video/2jTbeyEWBIQ/v-deo.html
Haha… this is why I don’t jump on every new bandwagon. With age comes wisdom
How old are you if I may ask?
You keep saying low dose and high dose. Can you give us the mg. On what your calling low and high. It’s important to all your saying and is confusing.
What about the source of the resveratrol? You mentioned quercetin but there are other sources. Most supplements use what I think was Japanese knotweed, so invasive they won't let the live plants into the country. And of course, there's red wine, especially Malbec which has the highest resveratrol content in the skins. So I wonder, which resveratrol is being used in these studies?
Hi Daniel in most studies they don't always tell the source, but it almost 95% Japanese knotweed. But the quality they are using is usually much higher than what you would find in the health food store. Many times, they test it multiple times before are using it. the studies costs sometimes 000,000/millions, they wouldn't take the chance
@@WellnessMessiah So then many people who are taking it in supplement form may not be paralleling the studies, or am I missing something?
Also, is quercetin really a source of resveratrol or just another polyphenol?
Now all of a sudden resveratrol’s amount can actually hurt your longevity. I wonder how many of those other compounds are currently hurting people.
Hi Emil, how are you? I think we underestimate how powerful plant molecules are. with drugs with know the dose changes the effect. This is not new.
I suggest checking the previous videos in our series to make up your mind and feel confident about resveratrol (yes/no/dose) for your longevity. The episodes appear in the description/pinned comment.
I can put here the link if you want.
@@WellnessMessiah thank you!
@@zakmatew
These were the previous episode. They all touch the dose-effect.
✅ Part 1: David Sinclair Study on Resveratrol: Fascinating Discovery
ua-cam.com/video/Js_l_G1x8V4/v-deo.html
✅ Part 2: "How RESVERATROL affects your heart?"
ua-cam.com/video/yT4rqxADvQI/v-deo.html
✅ Part 3: Could JUST 1mg of RESVERATROL Affect Your Longevity?
ua-cam.com/video/XFgSA7gbtus/v-deo.html
✅ Part 4: RESVERATROL Impact On Metabolism: 2021 Human Study
ua-cam.com/video/MNO4U5wbF08/v-deo.html
@@WellnessMessiah I will check them out!
I do sports from Monday till Friday. Maybe i will took It at Saturday once a week. Maybe 200mg. Because Sports do enough stress to me.
I’m surprised at this video because polyphenols have been more of a hope than a reality. Resveratrol was studied rigorously for a couple of decades at least with no true benefit found. At one point the EU had to step in to ban phenol benefit claims in Europe for this very reason. Subsequent findings were incredibly small and of dubious value. Phenols are basically poisons. Creating small amounts of damage at low doses is bound to have benefits (what doesn’t kill you makes you stronger). The phenol does the damage, the body fixes it up. There are no studies showing resveratrol or other polyphenols are remotely comparable to any of the other longevity practices that have always been available to us.
OK, so if you're older, or have a family history of cancer, you could still take low-dose resveratrol for longevity as long as you pulsed high dose resveritrol once in awhile. For example, take low dose resveratrol for 12 weeks, and then switch to high dose for 14 days. After the pulse, you could switch right back to low dose. You can have your cake and eat it too.
Having some raisins in your porridge doesn’t hurt
😂 @ 3:36 you make cancer cells sound like the GOP
Yes. Dr. Sinclair is an expert of longevity...in worms and the worms aren't talking. He will probably be getting a hair transplant and cosmetic surgery like Dr. Michael Colgan (Optimal Sports Nutrition) and claiming he has an age much younger than his chronological age. OMG...again with the Sirtuins and the happy worms. I see a Prof. Bart Kay debunking in his future.
why does David Sinclair promote taking a gram of resveratrol a day ?
-> see "french paradoxon" . . . .
i think you could shorten the video to 20 or 15mins, 30mins is too long
Gee! You don't mention the immune system when you discuss cancer cell death. Isn't the immune system the big actor that kills cancer before it spreads and maybe you forgot about that.
If you're that worried about resveratrol, just drizzle some olive oil & vinegar into your salad every day. VOILA. Same effect.
Thank you Kelly. Personally, I'm very excited about it. It's an extremely powerful molecule.
I take poliphinol from drinking 2 tsp everyday
Who eats salad every day😅
I'm 51 ,I take 1 gram of resveratrol per day is that to much
I think he concludes that 1g is to much to take all the time, but possibly a relatively short time at 1g would be good (to force cancerous/pre-cancerous cells into death). How long is long enough though?? 1 week 1 month ????
Based on this investigation, I take 50-120 mg (range) resveratrol with 3 days off every week and 24+ hours before exercise. that's my body.
Yes, as red berries said, I think there is a use for high-dose resveratrol intermittently, but I will always qualify it not as medical advice against cancer. Will expand in the future.