1:52, hemorrhagic cystitis is not a problem with the kidneys, it's a problem with the bladder. ie it is a "cystitis" not a "nephritis. Happens (as you have mentioned) because of the acrolein metabolite formed from cyclophosphamide metabolism. Acrolein is toxic to the bladder and so causes inflammation and bleeding inside the/of the bladder.
Kidneys are also affected by cyclophosphamide. That is why sodium-2-mercapto-ethane-sulphonate also known as MESNA is given to protect the kidneys from acrolein. Also, a lot of water is given to dilute the urine and thus lower the probability of contact between the cells and acrolein on its way out of the body.
Just as a quick correction: 7+3 is Cytarabine IV continuous infusion over 24 hours for Days 1-7, and the anthracycline IV bolus for Days 1-3. It's not a total of 10 days, only a total of 7.
Great overview. The monoclonal antibodies need an update. Humanized Abs are called -zumab ie trastu-zumab (Not -umab) and still have a few percent mouse. While the fully 100% human Abs are -umabs ipilim-umab and nivol-umab (not mumabs)
Doctors...You guys are awesome, I love you, you're smart as fuck and we wouldn't be here without you. Every single one of you deserves a reward. But, y'all really suck at pronouncing chemicals and functional groups sometimes hahah Sincerely, A chemist.
What do babies new bod look like when the body cell aae normal? why is Pharam no paying for thsing tretamet tat have been provne to be a quinetitive live supot but detioting bodies imminity can caused the patinet to died fater and not cost efective it is a bdue if not poeply diagnsed patient right I suggets the patient cna tell if they wnat to be the heo to put themsleve as agney pig buyt a bi hsiul be pass for pamacetucla pay or papteint to used trial meidation so malies dont loose tehir jobs and homes
It all depends on how much you are willing to go through in order to extend your life expectancy. If you get a terminal diagnosis, perhaps you would rather have a single year with a relatively high quality of life, but if you are a young person, accepting that your will die within such a short time may be more difficult, and you may be more motivated to go through a tougher treatment, in hopes that you can beat the cancer back into remission. It's all a matter of priorities, also one should never forget, that cancer itself often causes many of the same symptoms that many cancer treatments cause, so in some cases, a milder treatment may allow you to live a much more comfortable life, because the cancer is kept down a bit, although the treatment may not prevent it from spreading further. It's not an always a question of all or nothing, treatment or no treatment - it can be a matter of which treatment, and for how long etc.
So helpful, as I study for the OCN exam. Glad these videos are available even 7 yrs later. Thank you so much!
Did you take the OCN yet
as an oncology nurse, truly enlightening, very informative!! Thanx a lot ^^
thanks bro , in my final exam today I just saw this video and I could get at least 5 marks !
Thank you so much. these are well summarised and easy to remember
i want you
1:52, hemorrhagic cystitis is not a problem with the kidneys, it's a problem with the bladder. ie it is a "cystitis" not a "nephritis. Happens (as you have mentioned) because of the acrolein metabolite formed from cyclophosphamide metabolism. Acrolein is toxic to the bladder and so causes inflammation and bleeding inside the/of the bladder.
Absolutely right. He goofed that
I too going to say
Kidneys are also affected by cyclophosphamide. That is why sodium-2-mercapto-ethane-sulphonate also known as MESNA is given to protect the kidneys from acrolein. Also, a lot of water is given to dilute the urine and thus lower the probability of contact between the cells and acrolein on its way out of the body.
Hey man i just want to thank you for doing these videos, they are great and keep it up! You are awesome!
this was very helpful thank you for this overview!
Thank you! This helped me a lot, best video on UA-cam about Cytostatics in my opinion.
Oh thank goodness! Finally - something that actually makes sense. Thank you!
SO incredibly grateful for this lecture!!!!
thank you was very helpful
So helpful thankyou
Just as a quick correction: 7+3 is Cytarabine IV continuous infusion over 24 hours for Days 1-7, and the anthracycline IV bolus for Days 1-3. It's not a total of 10 days, only a total of 7.
Saline Xiang 6tz l killjoy
Wow Thank You so much, this is really helpful.
great work
Thank you so much.
Nice job. Thank you for the information. Video is very helpful.
Thank you for the review.
Please where will get videos/slides on sulpfonamides and the rest
helpful video.
million thanks.
Very helpful! Thank you
You're a genius. Helped me a lot thanks
Great lec, very clear
Amazing👌
Excellent
A very good summary, need more of ur documents
ua-cam.com/video/Y6Dex_8SQZc/v-deo.html
I love love love this! Thanks a wholllleeee lot ❤
it was really helpful , thank you so much.
I love this
Thank you very much for this helpful video....
thank u so much amazing video and very helpful.
excellent overview!
Lilia C.
GREAT VIDEO ..ANY CHANCE CAN GET THE SLIDES FOR STUDYING ?
Thanks man 🙏
thank you so much for making this video
thank you !
Great presentation!! Are the slides available somewhere?
Not bad for a start
great work!
This is a pretty helpful summary...thanks!
Mehdi Hedjazi
Mehdi Hedjazi 我
个哦哦都
这
月
Thank you
this has been really helpful, thank you so much akh
Excellent!
Mayo Mayo
its really helpful. 😄
Thank you , it helped
Thank you...this video is very helpful
I have polycythaemia vera and klinefeltersyndrome
Great overview. The monoclonal antibodies need an update. Humanized Abs are called -zumab ie trastu-zumab (Not -umab) and still have a few percent mouse.
While the fully 100% human Abs are -umabs ipilim-umab and nivol-umab (not mumabs)
Doctors...You guys are awesome, I love you, you're smart as fuck and we wouldn't be here without you. Every single one of you deserves a reward. But, y'all really suck at pronouncing chemicals and functional groups sometimes hahah
Sincerely, A chemist.
LIFE SAVERRR!!!
What's "crit" in minute 1:40? is this short for platelets?
and what about thalidomide?
I think hematocrit
MahaAlJabri makes sense, thanks!
I ran to can was epic😂
Cer - A -BELL- AR not cerebral
Cerebellar
Why are you in such a hurry :P
What do babies new bod look like when the body cell aae normal? why is Pharam no paying for thsing tretamet tat have been provne to be a quinetitive live supot but detioting bodies imminity can caused the patinet to died fater and not cost efective it is a bdue if not poeply diagnsed patient right I suggets the patient cna tell if they wnat to be the heo to put themsleve as agney pig buyt a bi hsiul be pass for pamacetucla pay or papteint to used trial meidation so malies dont loose tehir jobs and homes
this is sick and evil im never getting chemo if i get cancer
every body thinks like you but if there is this diagnosis.....every one wants to live....no matter how....
It all depends on how much you are willing to go through in order to extend your life expectancy. If you get a terminal diagnosis, perhaps you would rather have a single year with a relatively high quality of life, but if you are a young person, accepting that your will die within such a short time may be more difficult, and you may be more motivated to go through a tougher treatment, in hopes that you can beat the cancer back into remission. It's all a matter of priorities, also one should never forget, that cancer itself often causes many of the same symptoms that many cancer treatments cause, so in some cases, a milder treatment may allow you to live a much more comfortable life, because the cancer is kept down a bit, although the treatment may not prevent it from spreading further. It's not an always a question of all or nothing, treatment or no treatment - it can be a matter of which treatment, and for how long etc.
Thank you so very much!
Excellent