Errata: @9:00 Aminopenicillins are NOT penicillinase-resistant penicillins. @15:52 As pointed out by a viewer, there should be a negative sign next to MSSA (at least here in the United States) due to the high rates of penicillinase production in Staph aureus. For example, MSSA is ~20% sensitive to PCN among patients at both Stanford and San Francisco General, which is definitely low enough to be considered inadequate. This may be different in other parts of the world.
I've discovered this video in 2013 during the residency and I still believe this is the best lecture on antibiotics on UA-cam to this date. The picture at 07:50 is very helpful for organizing different classes of antibiotics.
Hi! [I'm referring to 9:00/24:20.] Indeed, Aminopenicillins are NOT referred to as the penicillinase-resistant penicillins. They DO NOT resist beta-lactamases. I'm sorry to point it out, but some viewers may get the wrong message, which can be a serious issue. Apart from this, the lecture is good! Concise and clear!
+Chau-kuen Chan Ugh. I can't believe that mistake has been there for almost 3 years... thanks for pointing it out. I've added an annotation correcting it.
Hari, I'm glad you are enjoying them. Regarding organizing the lectures into systems, do you mean the antibiotic lectures specifically, or all of them? If the former, I'm going to post some more videos in the next couple of days organized by type of pathogen (e.g. gram positives, negatives, anaerobes, etc...), and have a few supplemental lectures at the end of the antibiotic series on high-frequency sites of infection (e.g. lung, skin/soft tissue, GU tract, etc...)
I am resident of ICU from India...Sir,ur lectures of antibiotics really helps me lot..i n one word sir, u r awesome...thank u very much...thnx a lot for ur video
This is helping me prepare for an interview I have coming up this week as a Supervisor in a Microbiology lab testing CRE INFECTIONS AND N. Gonorrhoeae surveillance project. Thank you for breaking it down in a clear way that is understandable. I found this to be a very helpful video to refer to.
It's true that beta lactam antibiotics are generally bactericidal. They not only inhibit new cell wall formation, they also trigger autodigestion of previously formed peptidoglycans in the cell wall, which eventually leads to cell lysis. There are a couple of unsual circumstances when they act more bacteriostatic, but these are rare exceptions.
Thank you for your lectures and for including photos of the three scientists who won the Nobel Prize for antibiotics here, especially Chain. His kind, averted eyes seem so humble. I am glad he came to UK in 1933 and did not die in the camps like his mother and sister and undoubtedly like so many brilliant minds whose innovations we will never know.
uitimate lecture ,everything is presented in a concise and crystal clear manner. It is easy to understand and all the important pont is covered without any excess.I give it 5 star.
i appreciate ur efforts to help the medical students all over the world .......good work ..DrErck. it would be more useful if the lectures are system wise organised(like cvs , cns.. etc)
Dear Dr.Drericstrong Thanks a lot from your helpful video you have download it to UA-cam and share it to all that the student can used it. I am A student bacteriology and this kind of video can help me a lot i am from Afghanistan but because in Afghanistan we dont have the master degree i have to continue in Iran so this can help me. thanks
This was fantastic, thank you for making it. Coming to the end of 4th med school year, approaching exams, I've realised that I don't really understand how antibiotics relate to each other, and I therefore have trouble remembering when to use them. This was very useful for helping me organise all the names I keep hearing, thank you so much!
Thank you so much for these truly wonderful videos sir. Id really like to appreciate the immense effort you have taken to research and put together this data along with the great slides and animations
If it's the later, there are a couple of playlists on the main channel (e.g. antibiotics, EKGs, ABGs, cardiac auscultation, etc...). Hopefully, the playlists will seem more robust once I have posted more videos.
I'm doing my presentation on antibiotics this wednesday,fingures crossed and I'm so glad i came upon this video cause I've been having trouble remembering them all (classes and mechanism of action and what note
I have other sources saying beta-lactam antibiotics are bactericidal agents. Though they do interfere with cell wall synthesis and inhibit peptidoglycan polymerization, it is said the pressure differential and the weakened cell walls cause the bacteria to explode. So I am confused whether beta-lactam antibiotics are bacteriostatic or bactericidal.
Thanks! I hope u r enjoying the videos! For the most part, my slides are created in Powerpoint. Simple diagrams/illustrations are drawn right in Powerpoint, while I use Adobe Creative Suite for the most complicated stuff. Slides are exported from Powerpoint as jpgs & imported into Adobe Premiere, where it is synched with narration that I've recorded in Audacity. There are certainly quicker workflows that can produce something superficially similar, but I find this one affords more control.
I am currently watching all of your lectures as part of my FNP coursework. They are excellent and very easy to follow! I am wondering if there is a link to just the powerpoints so I can download those for the useful tables and images. Thank you so much!
Thanks. An antifungal video is already in the works and hopefully will be posted soon. Antivirals and antiparasitic drugs will be a bit further down the road.
thank u for the reply .. a system at one place for example cvs playlist with content of some imp topics like ekg, heart failure,hypertension ...etc i know its not a one day work ...it would take some time to get in to shape as u already said...but i wanted to share my views as Ur subscriber..thank u doc !!
Great lecture.find it really helpful .Antibiotic no doubt are miracle and life saving drugs but because we doctor sometime miss used over used and abused them bugs are becoming resistant.i am an antibiotic steward and i hope all of you are too.please upload a lecture on selection of appropriate antibiotic treatment with system based guideline it will be very helpful thanks in antecepation
Hi! I'm currently in medical school and I love your video lectures. I just was wondering like an appropriate site you would suggest to do practice questions from. Your suggestion would truly be appreciated.
I don't know where you are from, but here in the US, most students use a service called USMLE World (a.k.a. "uworld") for practice questions. Unfortunately, it's a subscription service and not cheap.
I have a question for you. Last week I had a tooth infection they gave me one bottle of Antibiotics for 10 days. Those are finished. Then this week I had to get same tooth extracted then they gave me another bottle to take so my gums can heal. Is it ok to take ANOTHER bottle after I just finished a bottle?
+ralph9563 I can't offer specific medical advice here, but it's not uncommon to receive multiple courses of antibiotics right after one another, though, you should be sure to understand why that's being done. Possible explanations: the infection improved but hadn't resolved completely so the antibiotic duration needed to be extended; the original infection resolved but you developed another site of infection that needs to be treated separately; or the original antibiotic was ineffective against the infection (based upon either a lack of clinical response, or testing showing that the bacteria is resistant to the antibiotic). What can sometimes happen (which does NOT sound like is your case, but talk to your dentist if you are unsure) is that a doctor can keep throwing different antibiotics at a problem, to see none of them have any effect, only to learn weeks (or months) later that the problem isn't even infectious in origin.
+Strong Medicine I think the Antibiotic did its job it's just the tooth couldn't be saved. But when I think about it both bottles are for 2 different reasons. The first bottle was so the infection won't get worst. The second bottle was for healing after the tooth has been extracted. Thanks for the info.
Dear Eric! I like yours lectures very much. There are very clear and easy. Pictures and tables are great. I'm teacher of medicine microbiology from Russia. What books do you use? I would like to get links, if it possible. Thank you so much for these videos. It's really helpful for me. I would hope to cooperate with you. There are you from? With respect, Victoria
Victoria, thanks for your feedback. I always love to hear from other educators! One of the reasons I chose to cover antibiotics relatively early in the life of this UA-cam channel is because I was dissatisfied with the options already available that students had to learn the material. Existing textbooks or other videos were either not clinically relevant enough, or were too superficial. The resource for these videos was largely a combination of UpToDate (www.uptodate.com - paid subscription required), primary literature, guidelines from the Infectious Diseases Society of America (www.idsociety.org/IDSA_Practice_Guidelines/) and informal consultation with several ID docs here at Stanford University. I also referred to the Sanford Guide to Antimicrobial Therapy (www.sanfordguide.com/) for organism-specific or disease-specific antibiotic recommendations.
Hello Eric, I am writing a major essay on the topic of antibiotic resistant bacteria and would like to be able to source this. In order to be able to do this I would like to know which sources you have used for reliability :) //Lisa
+Zillybunny The most used sources for the antibiotic series as a whole were the Sanford Guide to Antimicrobial Therapy (42nd ed. from 2012), numerous articles from www.UpToDate.com, personal knowledge, and informal conversations with infectious disease experts at my home institution (I understand that they are not very citable). Other resources include 50+ primary papers from the literature on specific issues/topics, which honestly would take a lot of time to dig up from my old, currently nonfunctional computer. In general, the videos are intended to be more of an educational tool than scholarly publications, so I usually don't document sources for information that I would consider a part of general medical knowledge (e.g. the resistance mechanisms seen with specific antibiotics, common side effect of antibiotics, classification of bacteria, etc...), and usually only carefully cite specific statistics or borrowed graphs/tables.
I am confused by aminoglycosides. In my book they are refereed to as bactericidal, yet they are said to inhibit protein synthesis. Can they be both? Also, I was told by my teacher that vancomycins are NOT aminoglycosides even though everywhere I look says that they are. Any idea?
Errata:
@9:00 Aminopenicillins are NOT penicillinase-resistant penicillins.
@15:52 As pointed out by a viewer, there should be a negative sign next to MSSA (at least here in the United States) due to the high rates of penicillinase production in Staph aureus. For example, MSSA is ~20% sensitive to PCN among patients at both Stanford and San Francisco General, which is definitely low enough to be considered inadequate. This may be different in other parts of the world.
Thank You
ps. in 14:40 MSSA is resistant to natural PCN
I've discovered this video in 2013 during the residency and I still believe this is the best lecture on antibiotics on UA-cam to this date. The picture at 07:50 is very helpful for organizing different classes of antibiotics.
I've never seen such a concise and effective approach to antibiotics, congratulations for your content sir!
I’m a pharmacist and your lecture has done a good reversion....,excellent 👏🏼
Hi! [I'm referring to 9:00/24:20.] Indeed, Aminopenicillins are NOT referred to as the penicillinase-resistant penicillins. They DO NOT resist beta-lactamases.
I'm sorry to point it out, but some viewers may get the wrong message, which can be a serious issue. Apart from this, the lecture is good! Concise and clear!
+Chau-kuen Chan Ugh. I can't believe that mistake has been there for almost 3 years... thanks for pointing it out. I've added an annotation correcting it.
I am a first year nursing student and this has helped more than you can know thank you so much
Sounds good. Thanks for the feedback. After more videos get posted, I'll create some playlists for specific organ systems.
Hari, I'm glad you are enjoying them. Regarding organizing the lectures into systems, do you mean the antibiotic lectures specifically, or all of them? If the former, I'm going to post some more videos in the next couple of days organized by type of pathogen (e.g. gram positives, negatives, anaerobes, etc...), and have a few supplemental lectures at the end of the antibiotic series on high-frequency sites of infection (e.g. lung, skin/soft tissue, GU tract, etc...)
I am resident of ICU from India...Sir,ur lectures of antibiotics really helps me lot..i n one word sir, u r awesome...thank u very much...thnx a lot for ur video
You are a very good teacher & doctor. You have exponentially help a lot of people over the world with your very clear and simplified lectures.
This is helping me prepare for an interview I have coming up this week as a Supervisor in a Microbiology lab testing CRE INFECTIONS AND N. Gonorrhoeae surveillance project. Thank you for breaking it down in a clear way that is understandable. I found this to be a very helpful video to refer to.
Carry on... Love from indian doctor
It's true that beta lactam antibiotics are generally bactericidal. They not only inhibit new cell wall formation, they also trigger autodigestion of previously formed peptidoglycans in the cell wall, which eventually leads to cell lysis. There are a couple of unsual circumstances when they act more bacteriostatic, but these are rare exceptions.
Incredible lecture. Possibly the best one I've seen on antibiotics. Thank you.
Thank you for your lectures and for including photos of the three scientists who won the Nobel Prize for antibiotics here, especially Chain. His kind, averted eyes seem so humble. I am glad he came to UK in 1933 and did not die in the camps like his mother and sister and undoubtedly like so many brilliant minds whose innovations we will never know.
Thanks!
Thanks so much! This series of lectures is so helpful. I was really looking for a good approach to learn antibiotics and have finally found it!
Thanks so much for these amazingly clear & succinct vids! I'm in the PA program at Stanford right now and can't thank you enough... really.
Excellent presentation, well delivered, straight to the point, good voice and enthusiastic. Thank you
enjoying the lecture 11 years later😆Thanks alot
uitimate lecture ,everything is presented in a concise and crystal clear manner. It is easy to understand and all the important pont is covered without any excess.I give it 5 star.
i appreciate ur efforts to help the medical students all over the world .......good work ..DrErck.
it would be more useful if the lectures are system wise organised(like cvs , cns.. etc)
Dear Dr.Drericstrong Thanks a lot from your helpful video you have download it to UA-cam and share it to all that the student can used it. I am A student bacteriology and this kind of video can help me a lot i am from Afghanistan but because in Afghanistan we dont have the master degree i have to continue in Iran so this can help me. thanks
This course is very important for me I appreciate your hard work sir keep it up sir thaku
This was fantastic, thank you for making it.
Coming to the end of 4th med school year, approaching exams, I've realised that I don't really understand how antibiotics relate to each other, and I therefore have trouble remembering when to use them.
This was very useful for helping me organise all the names I keep hearing, thank you so much!
Jolie Miller Glad you found it helpful. Loved the cover of I See Fire!
Omgggggggggggggggg that's THE REASOn why am here
I'm becoming a better nurse by watching your videos. Pl keep uploading them. Thank you!!!
❤ very concised lecture.. Thanks a lot
i have no words to express my gratitude for You, Professor Strong!
Thank you so much for these truly wonderful videos sir. Id really like to appreciate the immense effort you have taken to research and put together this data along with the great slides and animations
If it's the later, there are a couple of playlists on the main channel (e.g. antibiotics, EKGs, ABGs, cardiac auscultation, etc...). Hopefully, the playlists will seem more robust once I have posted more videos.
thanks for the concise & helpful review!
Amazing sir..thank you so much for nice tables
Thanx for the video, it helped me to present my individual work in the Uni about antibiotics
I'm doing my presentation on antibiotics this wednesday,fingures crossed and I'm so glad i came upon this video cause I've been having trouble remembering them all (classes and mechanism of action and what note
Thanks broooo i'd liked your style in learning&explication
afarmboy76, I'm glad you've found them helpful. It's always great to hear from a fellow member of the Stanford community on here!
so very thankful to you sir. enjoyed watching. please upload more videos of different types of drug classifications like antivirals, anticancer, etc
thank you ................incredible teaching
THANKS for educating the world. Personally I have benefitted a lot.
I have other sources saying beta-lactam antibiotics are bactericidal agents. Though they do interfere with cell wall synthesis and inhibit peptidoglycan polymerization, it is said the pressure differential and the weakened cell walls cause the bacteria to explode. So I am confused whether beta-lactam antibiotics are bacteriostatic or bactericidal.
Thanks! I hope u r enjoying the videos! For the most part, my slides are created in Powerpoint. Simple diagrams/illustrations are drawn right in Powerpoint, while I use Adobe Creative Suite for the most complicated stuff. Slides are exported from Powerpoint as jpgs & imported into Adobe Premiere, where it is synched with narration that I've recorded in Audacity. There are certainly quicker workflows that can produce something superficially similar, but I find this one affords more control.
This video really helped me to prepare for my microbiology quiz...........thanks alot
22:35 What's the mechanism of synergy when using aminoglycosides in combination with beta-lactams or vancomycin?
very nice presentation...thanks for such informative videos.
Great Video, which helps me in my understanding of Antibiotics.
So good, thank you!
I am currently watching all of your lectures as part of my FNP coursework. They are excellent and very easy to follow! I am wondering if there is a link to just the powerpoints so I can download those for the useful tables and images. Thank you so much!
ua-cam.com/video/iJiUBFsvdtg/v-deo.html
Awesome Lecture! I spent time looking for videos and luckily I found this one. Thanks!
Superb..clear and concise...It would be very helpful if you have antiviral,antifungal,antiparasitic drug presentations too
Thanks. An antifungal video is already in the works and hopefully will be posted soon. Antivirals and antiparasitic drugs will be a bit further down the road.
Faropenem available in oral form .
What are its coverage that make it different from rest 3 of the..
Lecture 1and 2,where i will get these?
Great video, thank you
Very Good
Thank you
Thank you! That helped clear it up very well! Your videos have helped me a lot in my research.
very useful,,,GOD BLESS U SIR...
اللهم علمنا ما ينفعنا وانفعنا بما علمتنا وذدنا علما يا كريم اللهم امين
thanks dr eric , i cant wait ti finish the series
thank u for the reply .. a system at one place for example cvs playlist with content of some imp topics like ekg, heart failure,hypertension ...etc i know its not a one day work ...it would take some time to get in to shape as u already said...but i wanted to share my views as Ur subscriber..thank u doc !!
Great lecture.find it really helpful .Antibiotic no doubt are miracle and life saving drugs but because we doctor sometime miss used over used and abused them bugs are becoming resistant.i am an antibiotic steward and i hope all of you are too.please upload a lecture on selection of appropriate antibiotic treatment with system based guideline it will be very helpful thanks in antecepation
I love you videos !!!! easy to understand, thorough explanation !!! you made my day :) keep it up!!
Very nice information & It is the best review
An excellent presentation
Awesomely informative and perfectly explained! Thank you so much! 😊😊 17/3/2019
Great review on the main antimicrobials. Thanks a lot.
Thanx sir for your lectures...may god bless you...once again thanx
I'm quite curious to know why a large share of people never mention membrane-disrupting antibiotics, is there any particular reason for this ?
Awesome sir great information
This was actually very good
I like the subject I just learned It, this week very good.
very comprehensive n useful ...thank u ....
Thank you Eric. very useful talk.
Thank you! Very helpful presentation.
Amazing lecture ! God blesss you !
Wonderful presentation
How can l get handout of this lectures?
Great lecture. Thanks doc!
I missed this information all these days!!!!!!!!
Does the glycopeptide antibiotics as the vancomycin enter the group of the inhibitors of the cell wall??
Hi. What's your reference for the generations of Cephalosporins?
This is sooooo extremely helpful! Thank you so much!!!
great work keep it up
Hi! I'm currently in medical school and I love your video lectures. I just was wondering like an appropriate site you would suggest to do practice questions from. Your suggestion would truly be appreciated.
I don't know where you are from, but here in the US, most students use a service called USMLE World (a.k.a. "uworld") for practice questions. Unfortunately, it's a subscription service and not cheap.
This is just fentastic..
Thank you for the great lectures.
thanx man. u r just f***in genius. upload more videos nd abt antibiotic resistance
Thanks for watching and for the feedback! Lecture 9 from this series is all about antibiotic resistance.
Thank you! A very good lecture!
Thanks it helped with primary school project
I have a question for you.
Last week I had a tooth infection they gave me one bottle of Antibiotics for 10 days. Those are finished. Then this week I had to get same tooth extracted then they gave me another bottle to take so my gums can heal. Is it ok to take ANOTHER bottle after I just finished a bottle?
+ralph9563 I can't offer specific medical advice here, but it's not uncommon to receive multiple courses of antibiotics right after one another, though, you should be sure to understand why that's being done. Possible explanations: the infection improved but hadn't resolved completely so the antibiotic duration needed to be extended; the original infection resolved but you developed another site of infection that needs to be treated separately; or the original antibiotic was ineffective against the infection (based upon either a lack of clinical response, or testing showing that the bacteria is resistant to the antibiotic). What can sometimes happen (which does NOT sound like is your case, but talk to your dentist if you are unsure) is that a doctor can keep throwing different antibiotics at a problem, to see none of them have any effect, only to learn weeks (or months) later that the problem isn't even infectious in origin.
+Strong Medicine I think the Antibiotic did its job it's just the tooth couldn't be saved. But when I think about it both bottles are for 2 different reasons. The first bottle was so the infection won't get worst. The second bottle was for healing after the tooth has been extracted. Thanks for the info.
Dear Eric! I like yours lectures very much. There are very clear and easy. Pictures and tables are great. I'm teacher of medicine microbiology from Russia. What books do you use? I would like to get links, if it possible. Thank you so much for these videos. It's really helpful for me. I would hope to cooperate with you. There are you from?
With respect,
Victoria
Victoria, thanks for your feedback. I always love to hear from other educators! One of the reasons I chose to cover antibiotics relatively early in the life of this UA-cam channel is because I was dissatisfied with the options already available that students had to learn the material. Existing textbooks or other videos were either not clinically relevant enough, or were too superficial. The resource for these videos was largely a combination of UpToDate (www.uptodate.com - paid subscription required), primary literature, guidelines from the Infectious Diseases Society of America (www.idsociety.org/IDSA_Practice_Guidelines/) and informal consultation with several ID docs here at Stanford University. I also referred to the Sanford Guide to Antimicrobial Therapy (www.sanfordguide.com/) for organism-specific or disease-specific antibiotic recommendations.
Hello Eric, I am writing a major essay on the topic of antibiotic resistant bacteria and would like to be able to source this. In order to be able to do this I would like to know which sources you have used for reliability :)
//Lisa
+Zillybunny The most used sources for the antibiotic series as a whole were the Sanford Guide to Antimicrobial Therapy (42nd ed. from 2012), numerous articles from www.UpToDate.com, personal knowledge, and informal conversations with infectious disease experts at my home institution (I understand that they are not very citable). Other resources include 50+ primary papers from the literature on specific issues/topics, which honestly would take a lot of time to dig up from my old, currently nonfunctional computer. In general, the videos are intended to be more of an educational tool than scholarly publications, so I usually don't document sources for information that I would consider a part of general medical knowledge (e.g. the resistance mechanisms seen with specific antibiotics, common side effect of antibiotics, classification of bacteria, etc...), and usually only carefully cite specific statistics or borrowed graphs/tables.
Do u use powerpoint program to create ur slides
They are awesome ^_^
I am confused by aminoglycosides. In my book they are refereed to as bactericidal, yet they are said to inhibit protein synthesis. Can they be both? Also, I was told by my teacher that vancomycins are NOT aminoglycosides even though everywhere I look says that they are. Any idea?
Excuse, but in video you say that cephalosporines do not influence enterococcus, but in Pharm. Encyclopedia we have the contrary...
really good sir
is possible to have this presentation in PDF files
Good work
Jack Ryan ok
Thank you for the wonderful video!
thank you for this ppt. video
Thank you! The video was very helpful!
this video is fantastic thank you!
I think daptomycin act on cell membrane not on cell wall which is mentioned here
Thank you ,,really u help me more