A couple incorrect statements were mentioned. Factor II was not circled, but Factor I was circled when mentioning procoagulant factors affected by Vitamin K epoxide reductase. UFH can be used IV in addition to SQ.
thanks for sharing. corrections: your warfarin slide incorrectly circles fibrinogen and not prothrombin. also at 6:25, it says heparin is subcutaneous- that should be SC or IV.
you're wrong. Enoxaparin does bind to antithrombin, and inhibits factor Xa and IIa, however it has much greater anti-factor Xa activity than IIa activity.
i don't get why warfarin requires bridging with another coagulant , shouldn't be an ANTI-coagulant ? since we dont want excessive coagulation to begin with ! and i thought heparin binds to antithrombin no matter how long the polysccharide heparin chain is , it just doesn't form a hug with the thrombin when it's less than 18 sugar long
+Anfal Ziar You're right on both points -- sorry about the mistakes, and I'll have it fixed in the video (as annotations) soon. Thanks for pointing that out! Warfarin is bridged with a shorter-acting ANTIcoagulent: "Bridging anticoagulation refers to giving a short-acting blood thinner, usually low-molecular-weight heparin..., when warfarin is interrupted and its anticoagulant effect is outside a therapeutic range." circ.ahajournals.org/content/125/12/e496.full Heparin binding to AT: "Molecules of heparin with fewer than 18 saccharides lack the chain length to bridge between thrombin and AT and therefore are unable to inhibit thrombin." atvb.ahajournals.org/content/21/7/1094.full
+Anfal Ziar Warfarin is initially pro-coagulant because it depletes Protein C first, which is its self an anti-coagulant. After a few days Warfarin will start to work fully and act as an anti-coagulant. These first few days need to be bridged with another drug like Clexane in order to 'bridge' this period.
it also takes time to inhibit the formation of new coagulation factors when stopping the formation of potassium , the few coagulation factors in the blood before the administration are always effective nd so the anticoagulation isn't obsereved untill 4 to 5 days after the administration when the coagulation factors in the blood have ran out
Please let me know: does the blood clot injections hurt? I'm 75 kg pregnant at 9 months, this Friday I have cesarean still I get these injections? Thank u indeed!
A couple incorrect statements were mentioned.
Factor II was not circled, but Factor I was circled when mentioning procoagulant factors affected by Vitamin K epoxide reductase.
UFH can be used IV in addition to SQ.
Infact, iv is the conventional method.
And anticoagulants don’t treat VT they prevent them
on point!
thanks for sharing. corrections: your warfarin slide incorrectly circles fibrinogen and not prothrombin. also at 6:25, it says heparin is subcutaneous- that should be SC or IV.
pro trick : watch series on flixzone. I've been using it for watching lots of of movies recently.
@Emmitt Keaton Yup, I've been watching on Flixzone} for years myself :)
you're wrong. Enoxaparin does bind to antithrombin, and inhibits factor Xa and IIa, however it has much greater anti-factor Xa activity than IIa activity.
LMWH does bind ATIII which then complexes with Xa.
i don't get why warfarin requires bridging with another coagulant , shouldn't be an ANTI-coagulant ? since we dont want excessive coagulation to begin with ! and i thought heparin binds to antithrombin no matter how long the polysccharide heparin chain is , it just doesn't form a hug with the thrombin when it's less than 18 sugar long
+Anfal Ziar
You're right on both points -- sorry about the mistakes, and I'll have it fixed in the video (as annotations) soon. Thanks for pointing that out!
Warfarin is bridged with a shorter-acting ANTIcoagulent:
"Bridging anticoagulation refers to giving a short-acting blood thinner, usually low-molecular-weight heparin..., when warfarin is interrupted and its anticoagulant effect is outside a therapeutic range."
circ.ahajournals.org/content/125/12/e496.full
Heparin binding to AT:
"Molecules of heparin with fewer than 18 saccharides lack the chain length to bridge between thrombin and AT and therefore are unable to inhibit thrombin."
atvb.ahajournals.org/content/21/7/1094.full
other than this the video's been very instructive thanks
+Anfal Ziar
Warfarin is initially pro-coagulant because it depletes Protein C first, which is its self an anti-coagulant. After a few days Warfarin will start to work fully and act as an anti-coagulant. These first few days need to be bridged with another drug like Clexane in order to 'bridge' this period.
it also takes time to inhibit the formation of new coagulation factors when stopping the formation of potassium , the few coagulation factors in the blood before the administration are always effective nd so the anticoagulation isn't obsereved untill 4 to 5 days after the administration when the coagulation factors in the blood have ran out
3:00 wouldn´t it be "another anticoagulant"? not "another coagulant"... , thanks.
over all top class....thanks doc...
heparin is also used in IV drip. mostly correct but very generic info
On one slide you say fonda can be used with HIT and on the next you say it can't
How does Jane Fonda factor into this? :)
Yea he said it doesn’t induce HIT and then says it’s does when he was talking about Argatroban...
Please let me know: does the blood clot injections hurt? I'm 75 kg pregnant at 9 months, this Friday I have cesarean still I get these injections? Thank u indeed!
yes they hurt! I've been injecting lovenox since Feb twice a day..I ice before n after but it still hurts n I get huge hematomas n bruises
thanks
oh my god ,, i am in love with you MFer
you damn good.
f the university