Undergoing chemo now with the cell specific class of stents your short lecture was incredibly helpful and allowed me to fill in all the blanks that doctors and nurses did not talk to me about. Thankyou.
10:07 Etoposide inhibits DNA topoisomerase II which doesn't have a role regarding the mitotic spindles. The chemo drugs that inhibit the mitotic spindles are paclitaxel, vincristine and vinblastine. Vincristine and vinblastine inhibit mitotic spindle formation whereas paclitaxel inhibits mitotic spindle breakdown. Or to put it in other way, microtubule or mitotic spindle drugs work in the S phase of the cell cycle but etoposide works in the G2 phase.
Antitumor antibiotics are cell cycle non specific....couple of other discrepancies...for example: cell cycle non-specific agents- they are not specific to any phase of cell cycle and work when cells are at rest AND while in any other cell cycle phase....
you guys are best educators, keep the good work mate.
greetings from india.
Undergoing chemo now with the cell specific class of stents your short lecture was incredibly helpful and allowed me to fill in all the blanks that doctors and nurses did not talk to me about. Thankyou.
This channel deserves more subscribers
You are right. Very clear podcast & I have subscribed, all the way from New Zealand
10:07 Etoposide inhibits DNA topoisomerase II which doesn't have a role regarding the mitotic spindles. The chemo drugs that inhibit the mitotic spindles are paclitaxel, vincristine and vinblastine. Vincristine and vinblastine inhibit mitotic spindle formation whereas paclitaxel inhibits mitotic spindle breakdown. Or to put it in other way, microtubule or mitotic spindle drugs work in the S phase of the cell cycle but etoposide works in the G2 phase.
I was about to write this. Thanks for sharing.
Dear u just make my dayyy ...🥰🥰🥰🥰thanks sirrr
Antitumor antibiotics are cell cycle non specific....couple of other discrepancies...for example: cell cycle non-specific agents- they are not specific to any phase of cell cycle and work when cells are at rest AND while in any other cell cycle phase....
amazing detailed presentation, many thanks.
THe best video ever on chemotherapy!
You are the best teacher ever
This is so lovely....... I got what I was looking for 😊
Thank you from Brazil
AMAZING WORK
Awesome... Thanks
Nice and clear, thanks so much!
Are you sure that vincristine and vinblastine are at rest. I am seeing m phase therefore specific not non specific? Am I wrong?
SO helpful! thank you so much
Nice recap ⭐️🔥
Keep going Tbag 👍🏼
thank you again!!
Aren't Anti Tumour antibiotics are on Non phase specific agent?
You are correct - I will fix ASAP.
Sorry so is the second cell cycle specific agent (anti tumour antibiotics) supposed to be in the non specific section?
Thank you for your content. Very helpful. May you please cover the vestibular system as well and how it relates to pathology eg BPPV
Thank you
etoposide acts via inhibiting topoismerase -2 doctor :))))
given in first aid
Love from India
My mom has chemo that’s why I watch and I’m only 10
So sorry to hear that 😢