It FINALLY Happened!
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- Опубліковано 10 вер 2024
- Study Enrolment Link Here: www.aotearoatr...
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Study Enrolment Link Here: www.aotearoatrials.nz/enrolling-studies#!/study/1786
So participants have to be in Auckland? Is Hawke's Bay too far away?
Expand it to people in Amsterdam who already exercise a lot and I’m all in!
Whatsup Doc? Would you consider Australian resident for your study?
I've applied, I live in Akl... Hope I get accepted 😊
Whats next? Microvitamin will still raise money. Will you make more studies?
Dr. Brad is always so energetic and positive, he’s like character from inter dimensional cable TV in Rick and Morty. We don’t deserve him.
Let's not get too far ahead of ourselves.
This comment is underrated 😅
Lmao what
Finally, congrats and well deserved!
This is great news, keep us updated about the progression! 💪🏼
Wish I lived in Auckland and not just for this trial
Congratulations look forward to seeing the results!
Awesome! Well done!
From age 14 to almost 59 now, I've just continued to lift heavy, working around injuries etc and staying on point with recovery and nutirtion. If continued lifting is possible for you, just do it.
The concept here is about a once a week supplement that potentially could prevent injury as well as other potential benefits including reduction of misfolded proteins. If the targeted 24 hours of catabolic state doesn’t throw off the 144 hours of mostly anabolic state, it’s the best of all worlds.
agreed. well done
@@DrBradStanfield thanks doc. Love the microvitamin too!
@@DrBradStanfield But that's not how rapamycin works (24/144h).
First, the half-life of rapamycin is about 60 hours, which means it won't be fully out of your system for almost two weeks.
Second, the duration of rapamycin's biological activity, particularly in terms of mTOR inhibition, is not strictly tied to its half-life. mTOR activity is typically suppressed as long as rapamycin is bound to its target, which can extend beyond the plasma half-life due to the drug's binding affinity and tissue distribution.
Generally, significant mTOR inhibition is observed for about 24 to 72 hours after a single dose of rapamycin, depending on the dose and individual response. After this period, mTOR activity likely begins to recover, returning to more than 90% of its baseline activity about 4 to 5 days after a single dose for most individuals.
For this reason, dosing every week may not be the optimal strategy for balancing mTOR activity and muscle preservation. Do we really need a "spring cleaning" every week, Brad? I'd consider having a trial group doing dosing every fortnight or even monthly for comparison. Happy to participate. 😉
Congratulations!
We need to see a meta analysis on human after 2-3 years. Understanding the cancerous effects etc is vital. Guys do not jump in every hype and do not buy the fomo. Good luck !
This drug has absolutely horrible side effects. Would be interesting to see how this would be any better than fasting. If I'm not mistaken, fasting had the longest life extension in rats ever recorded.
@@CommanderRiker0 Only if started at a very early age, otherwise the lifespan extension effects are marginal at best. Fasting by itself induces muscle wasting while rapamycin once a week wouldn't have thaf effect.
@@CommanderRiker0 They generally use a low dose for life extension investigation. Nothing like they use for organ transplants. Some people get mouth sores, that is about it. Typically.
And no, it was not fasting, it was calorie restriction (CR). This is a very unpleasant lifestyle. Some people are doing this. Bowl of frozen berries in the morning and a small lunch with some beans...starving the rest of the time.
You are never going to get millions of people onboard with eating 30% fewer calories than their weight and height suggest they need. And that can be dangerous as you have to get all the nutrients your body requires. That means fairly close doctor supervision.
That said, there are other choices that have been very successful in rodents: Acarbose did great, and Berberine did great. Probably doing the same thing. Rapamycin is likely a different mechanism, but perhaps not. I hope he measures body temperature, as, I suspect, body temp is really how the vast majority of things work in rodents.
Could fail in humans because humans will just wear more clothes, put more covers on the bed or turn up the heat and such to stay warm.
@@volos_olympus They have gone back in forth on the mechanism of this drug between mtor and other pathways. Most still believe its mtor, which fasting directly acts on via calorie restriction. If that's true I would rather fast since fasting has other benefits as well. I am very doubtful this will beat fasting in any meaningful way. Hopeful, but I don't see it.
Congrats Brad and good luck with the next step! 😁
Rapamycin is synonymous with sirolimus, a drug mainly used in organ transplant as it suppresses (I should probably say “erases”) immunity. It’s also known for causing hypertension, non reversible vascular kidney damage, and for its heavy metabolic side-effects (frequently even causing diabetes mellitus).
This safety study should be interesting, provided the patients are followed for long enough to see if the dose difference keeps them free from those side-effects, as the molecule is meant here to be used for longevity.
Im so happy for us and specially for you Brad, thank God who placed you in our path brother. May Jesus bless you and your family!
Congratulations Brad, wonderful news on each the green light for the Rapamycin trail.
Congrats doc. Well done mate. 🎉🥳
We don't need any drug to trigger Autophagy.
There are a lot of ways to get Autophagy and stay healthy.
don't be mean bro. Say thank you to Papa Brad
You are the Guy that i trust, not another scumbag from UA-cam. I believe in what you do and finger crossed for research.
Brad. Have you considered reaching out to Bryan Johnson to interview him and his journey, and he may even contribute funds to your channel
His face looks swollen.
His eyes are always blood shot too. I wonder if he is having some kind of reaction to one of his supplements.
@@Grushenke89 No. Simply too much time in front of a computer screen.
I noticed that as well
@@georgek3627 😱
WOW! Congratulations Dr. Brad.
At point, this is a hypothesis, only. Because it's a self-report format, it's not clear whether there's a verification of compliance. Most folks 65 and older also have polypharmacy regimes, which is another variable. Diet, gender, ethnicity, race, pre-existing conditions, are all variables that have to be assessed and accounted for. We haven't even seen the pre-test, post-test protocols, yet. If and when the results are published in a reputable peer-reviewed journal, I'd like to hear Dr.Nicholas Verhoeven's analysis over at Physionic. Analyzing the strengths and weaknesses of published research is his thing, and he's superb in that realm. Until then, Dr. Stanfield has an interesting hypothesis, and perhaps an interesting pilot study, but too much is unknown and unknowable, at this point, for some of accolades in the comments. As is often said, "The Devil is in the details."
omg...I've been following this channel since the beginning. Anyways, congrats!!!
Congrats! Absolutely love your content.
This is insanely great and I am so happy for you, my only thought is, there are so little people meeting that description and getting the exposure on UA-cam but I really hope you get it all set up, lots of love :)
a bit too click baity, please hint of the subject at least. usually I respect the grind, but brad you are a doctor. it's becoming a habit
what's him being a doctor got to do with anything? it's not like clickbait is against the hippocratic oath lol
Brilliant 👏 💐 I'm lovin it!
Congratulations 🎉🎉🎉🎉thank you for your time Dr.
Your enthusiasm is so lovely to see ! I’m so happy for you, Dr, and I’m very excited to follow this study and see what you discover !
Dr.S: I’m so glad you shared this story.
It establishes you as a visionary thinker.
Who is committed to making a real contribution to humanity selflessly.
I hope you stay humble.
Don’t let power corrupt you as it has so many who came before.
And thank you.
The biggest aspect of all of this is the ethics around the study. I feel Dr. Stanfield seems to have a high bar to uphold those ethics to provide us with the the most transparent data and results.
Thanks for all you do, Dr. Brad!
Looking forward to the results.
So cool!! I've been using sirolimus with exercise for 2 years now and gained so much in terms of health, strength, and muscles. We need better dará showing this, so more folks can use this! ❤
Well done. I’m running a similar RCT on low dose naltrexone. A similar ole molecule , off patent, cheap. Took 2 years to get going for identical reasons
i wish you make it happen! It will an immense and valuable contribution to humanity...
Congratulations, Dr. Stanfield! ( I wish that I could help, but not qualified for the study due to the location) I'm looking forward to the outcomes.
Great news! Thank you for your contribution to anti-aging research!
Congrats Dr Stanfield, very exiting news.
Congratulations
Congratulations Dr. Stanfield! I'd love to participate / support any of the phases remotely if possible. 😊
Congratulations!!
Congrats Dr Stanfield!
what considerations have been made as rapamycin seems to increase the risk of skin cancer which is even mentioned in the leaflet
wow!!!! great achievement, Doc🤩 all the best with the trail!!!!!💚✊
That's great to hear, congrats! Very exciting!
You Are The Bestest!
Let's go! 🎉🎉🎉
Congrats Dr. Stanfield!!
Amazing news, Brad. ❤
Congratulations Dr. Brad.
🎉🎉🎉 Congratulations
Go Brad!
Wow I had heard about your proposed trial but I did not understand the logic behind it. Best wishes sounds wonderful
Fabulous news!!!
I have an autoimmune condition and have been taking rapamycin for the past couple of months it has been a dramatic impact on my health and I cannot say enough about how much I think others should be trying it with autoimmune conditions
Wish the trial was open in the states. I’m currently participating in an intermittent fasting trial at the University of Oklahoma. Good luck, hope it goes well.
Great news 👏
Cheers to you Brad. Way to get stuff done!
Great work, Brad!
Congrats, Brad. Noble work, and long time coming!
Cool stuff! Good luck!
Congratulations on your commitment and dedication. I was just sad to see the price of rapamycin here in Brazil. Why is it so expensive?
Way to go, Brad!
Already taking Rapamycin. Always interested in new research into this powerful drug
Hi ,What dose have you chosen and what reference did you base that on?
SO EXCITING!!!!! Thank you.
Congrats, Brad!
Good luck! There's probably some suitable Facebook groups you could share this to? Maybe even get NZ Herald etc to cover this?
Well done Dr. Stainfield. Keep pushing!!
Would love to see you expand the study and track these people over multiple years, also checking other markers and disease.
As it’s fully funded, the continued income stream from Microvitamin surely creates some options, doesn’t it?
Man, people are dying... They need shortcuts to solutions, not 10 year timelines.
Very cool .. congrats and keep up the good work.
Congrats!
Congratulations!! I’ve been hearing so much about this drug and finally through your diligent work you’ve been able to put it into a study that might bring this therapy to the public and help many people stay strong into their golden years . I watched my own parents become weak and frail, and if this can be turned around and really work more power to you and thanks again!
Hes 45 years old he looks incredible
Congrats Doc!🎉
It's really cool that you funded a study partially using a product.
In a certain way you used your own money to do it, because you could have just kept the money as profits from your sales. Respect!
Good Luck!
Congratulations Dr.Brad, I look forward to the results of this trila to know wether or not my parents should take rapamycin!
Congratulations, wonderful news 💯👏🏼👏🏼
My concern is that Mtor may not be reactivated once you stop using rapamycin. Like the testicles shutting down with TRT and not potentially reactivating once you stop TRT.
Congratulations! Proud to be one of your first Patreon Supporters!
Thank you!
Great! Congrats!
By advertising on your channel, you already select a specific group that already cares about a specific lifestyle.
This could screw up the entire project, I think.
You need to select people from channels with a more diverse audience.
Great news. Congrats. I wish I could participate but I don't live in NZ.
Feels like we are going along with you on your journey! Love it!
I'm over 65 and sedentary but I live in the states. How long is the study for? I'd love to see New Zealand.
Huge congratulations, Dr. Brad!
What's the difference of being a hard laborer all ones life (like farming, construction worker, ect...) and exercising? Maybe VO2 max and general cardio?
What strength of rapamycin are they going to take on Saturday?
Wow, congrats! Just curious what’s your dosage per week?
You are no 1👍👍👍👍👍👍
Please make a video about C15 that is a fatty acid with longevity benefits similar to Rapamycin
Hey Brad, if someone gave you $1 billion specifically for aging, how would you use it?
great! keep going!
Yeah, but it doesn’t matter if it works-- no doctor is going to prescribe rapamycin to a healthy adult. Also we need to know if it works without exercise because it actually may be the exercise which is making the difference.
I am 36, would it be a good idea to take it now? I am willing to accept the risks and any potential consequences.
lol then why not ^^
Hi Brad. What weekly dosage of Rapamycin will be used?
6mg once weekly :-)
Congratulations on obtaining the funding required to carry out proper clinical trials. I hope you are able to raise funds for other worthwhile trials also- - I am sure you have many in mind.
Can’t we just cycle protein consumption , exercise and fasting to accomplish the same thing?
Can you make Multivitamin available in the whole EU? I'm from Romania and can't buy it
well I am 69 and i am stronger than most people half my age, pity the study wasn't here in Spain.