Mindscape 291 | Venki Ramakrishnan on the Biology of Death and Aging
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- Опубліковано 3 жов 2024
- Patreon: / seanmcarroll
Blog post with audio player, show notes, and transcript: www.prepostero...
Aging and death happen to the best of us, but there are increasing efforts to do something about it. That effort requires that we have some reasonable understanding of why aging happens, and what processes are involved. You will be unsurprised to learn that it's complicated. Venki Ramakrishnan, who won the Nobel Prize for his work on the ribosome, investigates what we know about aging in his book Why We Die: The New Science of Aging and the Quest for Immortality. We talk about aging and death, and manage to get some thoughts in about ribosomes. Venki and many other great communicators will be speaking at New Scientist Live, which takes place at ExCeL London between 12 - 14 October 2024, and is also streamed live as well as on-demand.
Venkatraman (Venki) Ramakrishnan received his Ph.D. in physics from Ohio University. He is currently Group Leader at the MRC Laboratory of Molecular Biology, Cambridge, England, and is a Fellow of Trinity College. He previously served as President of the Royal Society of London. He shared the Nobel Prize in Chemistry for his work uncovering the structure of the ribosome.
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Having studied ribosomes some, I was frustrated that the topic of entropy as a driving force in peptidyl synthesis didn't get explored. Another aspect that I love is that there's a strong correlation between the molecular conservation of ribosomal proteins and the order in which they assemble into a mature ribosome. In alternative words, the core is strongly conserved and the embellishments vary.
Extra thoughtful guest, thanks for posting.
excellent interview. Recalled most details from a past as a computational biologist!
Haha Sean, I sighed the same time you did after the calorie restriction comment
Sean is on point at 24:08 by asking how much computation is needed to simulate the motion of a ribosome on a computer. That is the future proving ground for any hypotheses in theoretical physics because a correct hypothesis will predict the exact equations of motion for ribosome movement.
He mentions at 25:07 that people are working on computer simulation. Current computational approaches (molecular dynamics) do not compute at the quark level but rather atomic level. A true computational simulation needs to start by energizing hadron ground states and implementing the standard model. If successful, it should predict the motion of any molecule. We need to start emphasizing the testability of new physical hypothesis through computer simulation but someone needs to figure out how to render the standard model as a result of energizing hadron ground states.
I'll listen with interest as I was just diagnosed with grade 4 glioblastoma with a very poor prognosis.
Dang, I'm sorry to read that. Any progress using HIV/other viruses to combat these lesions? I thought that they were making headway years ago. Specifically with Glioblastomas. Cram those greens man. Eat a rainbow. Lean protein and walk for days. Positive thoughts your way.
Oh man…
@@JeannieFontana Yeah. It's rough. The hardest part for me (so far) has been the shock of facing my mortality vis the short runway ahead.
Good luck in your treatment
Nothing like staring reality bullseye in the eye. Way to focus on the present moment, after all, that’s all we really have. 💝🙏
5:20 start of interview.
1.00 for all of the information.
Tbh I'd settle for cartilage implants so one can age with great articulations.
1:12:22
I wonder what type or kind of "Exercise" he is referring to?? Walk? weight lifting?? IF it is weight lifting, what type of exercises, at what level of efforts, the levels of effort are expressed in the number of reps a person IS ABLE to do with a certain weight, and finding THAT weight for SPECIFIC rep ranges is a process of adding weight UNTIl the number of reps is ALL you CAN do. So what level of effort and rep ranges is he talking about IF weight lifting is what he means when he says "exercise"...?? Same questions IF he is referring to OTHER type of exercise, please.
How many or ABOUT how much caloric restriction is he referring about?? Protocol, one meal, three, five?? macro composition of those meals?? Sleep: how many hours, under what conditions, etc etc??
I enjoyed the pod, but I think going into these deeper nuances would be more helpful and USEFUL to general listeners than the "philosophical" questions and time spend on them; if living longer is the main point.
Dude, there isn't an exact science to it. One's genes even plays a role what foods to eat/how much cardiac vs anaerobic work. Eat/sleep well and EXERCISE. LAMO
@@DavidBones-m2z
YOur LMAO is stupid... we all know genes do in fact play a role, but there are still GENERAL guidelines to it all, that is why all the questions, of which you answered NONE... that is really the "LMAO" part. People like you think they are smart and jaded if they put an "LOL" or a "LMAO" at the end of all the stupid things they say.
Of course the RESULTS to all those questions varies depending on the genes.
But the general guidelines are the SAME, don't you get it!!
A 10 rep CORRECT weight is the same EFFORT to all persons, but the WEIGHT varies depending on age genes and other factors, so you must find out FIRST what that weight is... that was PARTTTT of my question!!
Puff, puff, pass 🥬💨🌬 *looks around* "who next?"