19:50 Well summarized：“Aging is the accumulation of chemical damages (add：and operational abnormalies 😉) over time.” The end result is Death. Short and precise. To be honest, the “Good way” to immortality is not “Reversing” or Reverting such damages, instead, is having “Good copies” of bodies & genetic combinations, ready for “patching”.
@@stellarwind1946To keep it short, this summary line need NOT be too specific. It covered the underlying principle of aging with very few words, which is good enough.
The "secret" to mortality is in how cells (of multicell organisms) can form "reset" when forming an offspring. In parthenogenesis no second cell (so called fertilizing cell) is needed. Of course by that measure we are all already billions of years old. What we want to do is find a way to preserve our individuality, our consciousness, our story and that may require more then a biological approach.
I wonder this too. I think this can be mostly explained by a single cell bottleneck that forms each gametogenesis. When every cell in the organism is derived from a single genome, the process of genetic mosaicism is reset. In that same vein, there is selection that occurs among single celled gametes, so bad genomes are always thrown away and never kept around to potentially become cancerous or cause other problems. However the exception to this rule are these flatworms that can grow a whole new body from a severed head or tail, and there has been an experiment going on for quite some time that has split these worms in half over and over for 20 years or something, with no sign of aging in the progeny despite the lack of a single cell bottleneck.
I clearly remember a moment of worry around 11 years old when i calculated how old i was gonna be in 2000. Then, somehow i put it in the back of my mind for years until one day an intense thought came over me (there is nothing after this!). Again i forgot about the whole thing of death for many years…now i am 55. I have lost many loved ones and i know my turn is gonna come. One day you look in the mirror and realize that your youth is gone.
So...there's a cell cycle. for most of our cells. it starts when a mother cell divides and creates 2 daughter cells. a cell (one of the daughters) is born. from that point, a cell continuously goes through a function until it is the mother cell and divides. a number of things can happen: 1) the cell makes it through its function and then divides: the daughter cells are 'almost' replicas of the mother cell. 2) there's a problem along the way. at this point the cell undergoes apoptosis. it sacrifices itself for the greater good. 3) there's a problem along the way and cell becomes senescent or a zombie cell. this is bad, and many would say that this is possibly a contributor to age related changes. from the context of the video, it appears that 2) and 3) might be the same process. 2) is where help arrives and you are taken care of, but 3) is where there aren't enough kavorkians to clean things up. 4) cancer time. we think we need to grow. ....So what if we were able to create a solution to make sure that the transition from mother to daughter cell was perfect? same telomere length. exact copy. nanobots? could we then, at least from a dividing cells perspective remain at a certain age? (oh, and we manipulate the epigenetic clock to mimic, say, a 20 year old).
The concept of life has been a subject of philosophical debate and scientific inquiry for centuries. Traditionally defined by characteristics such as metabolism, growth, reproduction, and response to stimuli, the definition of life continues to evolve with advances in technology and understanding. This paper proposes a novel definition of life as "intentful kinematics" or "intentful effect/affect on a system," mediated by an entanglement structure. By integrating principles from quantum mechanics, information theory, and systems biology, this definition aims to encompass a broader range of phenomena, including those at the microscopic and quantum levels. The implications of this definition are profound, potentially extending the boundaries of what we consider to be living systems and offering new insights into the nature of consciousness and the origins of life. Traditional definitions of life often rely on observable biological processes such as metabolism, growth, reproduction, and response to environmental stimuli. These criteria are effective for identifying life on Earth, but they may not adequately describe potential life forms that exist under different conditions or exhibit fundamentally different characteristics. "Intentful kinematics" refers to the purposeful movement and interaction of entities within a system. This definition shifts the focus from static characteristics to dynamic processes that reflect the underlying intent or purpose of the entity. Intent in this context does not imply consciousness but rather a directedness in the interactions and movements that can be observed and measured (intent has been imprinted on). Quantum mechanics provides a framework for understanding the fundamental behaviors of particles at the smallest scales. One of the key phenomena in quantum mechanics is entanglement, where the states of two or more particles become interconnected, such that the state of one particle instantaneously influences the state of another, regardless of distance. It is also valid and true to say that entanglement represents the metaphysical boundary that is, the intrinsic definition of the construct and its parts. This interconnectedness, or entanglement structure, can be seen as a foundational element in the definition of life as intentful kinematics as we consider entanglement information more fundamental than Shannon or van Naumann information. Beyond movement, life can also be defined by its ability to produce intentful effects or affects on its environment or the systems it interacts with. This perspective includes not just physical interactions but also the transfer and processing of information, leading to changes in the state of a system. Information theory, which studies the quantification, storage, and communication of information, provides tools for analyzing how living systems process and transmit information. Systems biology, (7) (PDF) Intentful Kinematics, What is the definition of "Life"?. Available from:
53:28 "New ideas in science don't emerge because people with the wrong ideas change their minds in the light of new evidence, rather, they just die. And eventually, some new generation looks at the evidence with fresh eyes and moves on" XD
Always the same question from (old) men. How about researching how to increase fertility of females in their 30s and 40s? That would be a more profound way to 'extend life'. Especially given the changes in our culture, making it economically unfeasible and socially unattractive to start a family within the most fertile period in a women's life.
I was hoping he would isolate and interrogate leading cutting edge research but this was kind of rambling. I still want to know where are we in terms of research. Where are these billions of dollars invested and are these aging billionaires being sold snake oil to a point or is the science actually going to lead humanity to seriously long lifespans?
Imagine the trouble we'll be in when autocrats and dictators can live forever. As much as I don't want to die, and wish my friends and family wouldn't die, human individual immortality would be than ultimate disaster for the human race and this planet.
God allows death to get rid of these problems. A completely new, different universe will need to be created for eternal life. Look, it’s simple. All religions and people who have thought about this know this. It’s in all the religious writings. This guy is just selling what people want to believe.
If mice were to stay young instead of aging (and they do age) they would not be slowed down by the aging process and they would find it a lot easier to escape predators and accidents and live longer.
Most people would live longer if they ate cleanly, didn’t use drugs (yes, nicotine and alcohol are drugs, horrible ones at that…) exercised, and reduced stress. Some would live A LOT longer even… But instead of taking care of yourself people want an easy out, a miracle solution. Genetics determine you to a good degree, but how you treat yourself does matter.
In the future there may be some very unexpected options that may transcend the purely biological - the continuation of consciousness may be possible via the nonorganic chemistry such as silicon compounds that are imprinted with the available last mental state and allows further cognition via generative AI .
As one who practices meditation, I loved hearing about mitochondria breathing, producing energy. Here are a few questions for contemplation... Do cells have consciousness? Can you communicate with your cells? How important is air, water, and positive mind set? Does air and water have any sort of consciousness in its cells? That's enough. 😂😂 I love the way science has changed our view of things. Nicola Tesla said all life is Sun energy. 🌞 There's much we know, and even more that we don't know. ✌️❤️🖖
"Why we grow old?" - This question was better to be researched and talked about by a monk who lives on few hundreds of calories a day at top of a mountain, not by a citizen of our finite fossil fuels-run Western Civilisation. The finite fuels are much more precious to be burned providing an already provided answer - Life. Finite fossil fuels are dangerously hypnotic to humans, their consciousness, reasoning and mental capacity. "No matter how highly mechanised and self-powered, fossil fuels extraction requires a number of people as if the process executed by hands using buckets and ropes". Today, this number is 8 billion people - working flat out 24/7 - strong. Our Western Civilisation has been no more than a fossil fuels management operation - all along. Humans were not ready morally, ethically and intellectually to start the mass extraction of fossil fuels with the advent of the steam engine 300 years ago. The Magna Carta requires today overhauling adding to it the right for humans to understand what Energy really means before any other commandment; "In any system of energy, Control is what consumes energy the most. No energy store holds enough energy to extract an amount of energy equal to the total energy it stores. No system of energy can deliver sum useful energy in excess of the total energy put into constructing it. This universal truth applies to all systems. Energy, like time, flows from past to future" (2017).
We’ve recovered antigravity devices from crashed UFOs and have also reverse engineered these devices. Many people have invented far better devices that provide energy and are killed or silenced by government and big oil corporations, Nikola Tesla is just one example.
For life to be longer there have to be less lives! Where is the optimal balance. is living longer beneficial to anything else than the personal ego? Secondly, is not the proper way to approach/solve the aging problem by switching from biological coincidence (evolution/devolution) toward synthetic bodies with synthetic minds? To live in the vast expanse, outside this biosphere, we need bodies and minds that can deal with the time-span that traveling between stars demands. We need bodies that are sturdy enough to deal with the conditions in space, weightlessness and absence of "nature".
Current demographic research indicates that, if current trends continue, by the year 2300 the global population will be 1 billion, not 50 or 20 or even 10 but down to 1 billion. All across nature you can see the same life equation. Short lives / high mortality = high birth rate. Long lives / low mortality = low birth rate.
22:04 Someone else finally gets. It it's all magnitudes everything is the same from the bottom up and whenever we have a problem with scale it's because someone included something from the wrong magnitude. Or it's because we can't achieve that scale.
Why? It's because of the time. Get rid of the time and you won't get old. What's even better, you won't make videos with silly questions and more. Or better said, you won't have time for them!
Animals don’t know of their mortality? - says it as if anyone can objectively know that for certain. Also this pontificating on matters no human can ever fathom is getting a little old. They’d be taken more seriously when, if ever, they can tell us what life is.
Comprehending your own mortality requires the ability to perceive the passage of time and be able to distinguish between past, present, and future. This is mediated in humans by higher-order cognitive functions such as episodic memory and self-awareness, both of which appear to be rare in the animal kingdom.
Animals have intelligence generally equal that of very young human children. We observe that young human children don't understand their own mortality and therefore, it's logical to assume that animal don't either. Interestingly enough, children usually understand death in others before understanding it applies to them equally, which is also consistent with observation of animals. Of course, there is not definitive proof of this but that seems to be the most logical conclusion based on what we know.
What a strange question. We age because we do, and because it is important for the ecosystem that we eventually die. We have enough problems as is it is, without having to care for 200+ year old weirdos.
@@johncarter1150 talking about "200 year old weirdos" is objectively age-based discrimination AND obviously misses the entire point - but congratulations on your over-achievement: two declarations of idiocy in one statement 👍
No no no. Flatworms are functionally immortal. If you choose to build yourself from the building blocks that are easily replaceable, then you can become immortal. It's just that more complex things that require more complex molecules and procedures of creating those molecules can't keep up with entropy. If you can keep up with entropy, you can attempt to survive forever.
Boltzmann showed that it’s not a law, just what happens. Entropy can and will decrease in individual interactions in systems, given long enough timescales, but you’re very unlikely to witness an instance of this. So you’re correct, but in the human body, this distinction is unlikely to be very helpful…
In search of immortality?? you should be In search of health. Get to 100 and you're not Brown coding or farting ever other second and you're going to live another 300 years waiting to get that operation reserved for the young. yeah right behind you on that search. Oh look, a squirrel.
19:50 Well summarized：“Aging is the accumulation of chemical damages (add：and operational abnormalies 😉) over time.” The end result is Death. Short and precise.
To be honest, the “Good way” to immortality is not “Reversing” or Reverting such damages, instead, is having “Good copies” of bodies & genetic combinations, ready for “patching”.
lol that’s a very nonspecific explanation.
@@stellarwind1946To keep it short, this summary line need NOT be too specific. It covered the underlying principle of aging with very few words, which is good enough.
His book Why we die is one of the best I have read on aging.
This is an excellent exposé into aging considering cellular chemistry. Brilliant 🎉
Thank you Ri for this conversation with VENKI JI 👍❤️
The "secret" to mortality is in how cells (of multicell organisms) can form "reset" when forming an offspring. In parthenogenesis no second cell (so called fertilizing cell) is needed. Of course by that measure we are all already billions of years old. What we want to do is find a way to preserve our individuality, our consciousness, our story and that may require more then a biological approach.
I wonder this too. I think this can be mostly explained by a single cell bottleneck that forms each gametogenesis. When every cell in the organism is derived from a single genome, the process of genetic mosaicism is reset. In that same vein, there is selection that occurs among single celled gametes, so bad genomes are always thrown away and never kept around to potentially become cancerous or cause other problems. However the exception to this rule are these flatworms that can grow a whole new body from a severed head or tail, and there has been an experiment going on for quite some time that has split these worms in half over and over for 20 years or something, with no sign of aging in the progeny despite the lack of a single cell bottleneck.
I wanna be immortal. I also wanna be as smart as Ed Witten. Make me.
I clearly remember a moment of worry around 11 years old when i calculated how old i was gonna be in 2000. Then, somehow i put it in the back of my mind for years until one day an intense thought came over me (there is nothing after this!). Again i forgot about the whole thing of death for many years…now i am 55. I have lost many loved ones and i know my turn is gonna come. One day you look in the mirror and realize that your youth is gone.
Just wait till your 63😂😅🥵😭
So...there's a cell cycle. for most of our cells. it starts when a mother cell divides and creates 2 daughter cells. a cell (one of the daughters) is born. from that point, a cell continuously goes through a function until it is the mother cell and divides. a number of things can happen: 1) the cell makes it through its function and then divides: the daughter cells are 'almost' replicas of the mother cell. 2) there's a problem along the way. at this point the cell undergoes apoptosis. it sacrifices itself for the greater good. 3) there's a problem along the way and cell becomes senescent or a zombie cell. this is bad, and many would say that this is possibly a contributor to age related changes. from the context of the video, it appears that 2) and 3) might be the same process. 2) is where help arrives and you are taken care of, but 3) is where there aren't enough kavorkians to clean things up. 4) cancer time. we think we need to grow. ....So what if we were able to create a solution to make sure that the transition from mother to daughter cell was perfect? same telomere length. exact copy. nanobots? could we then, at least from a dividing cells perspective remain at a certain age? (oh, and we manipulate the epigenetic clock to mimic, say, a 20 year old).
The concept of life has been a subject of philosophical debate and scientific inquiry for centuries. Traditionally defined by characteristics such as metabolism, growth, reproduction, and response to stimuli, the definition of life continues to evolve with advances in technology and understanding. This paper proposes a novel definition of life as "intentful kinematics" or "intentful effect/affect on a system," mediated by an entanglement structure. By integrating principles from quantum mechanics, information theory, and systems biology, this definition aims to encompass a broader range of phenomena, including those at the microscopic and quantum levels. The implications of this definition are profound, potentially extending the boundaries of what we consider to be living systems and offering new insights into the nature of consciousness and the origins of life. Traditional definitions of life often rely on observable biological processes such as metabolism, growth, reproduction, and response to environmental stimuli. These criteria are effective for identifying life on Earth, but they may not adequately describe potential life forms that exist under different conditions or exhibit fundamentally different characteristics. "Intentful kinematics" refers to the purposeful movement and interaction of entities within a system. This definition shifts the focus from static characteristics to dynamic processes that reflect the underlying intent or purpose of the entity. Intent in this context does not imply consciousness but rather a directedness in the interactions and movements that can be observed and measured (intent has been imprinted on). Quantum mechanics provides a framework for understanding the fundamental behaviors of particles at the smallest scales. One of the key phenomena in quantum mechanics is entanglement, where the states of two or more particles become interconnected, such that the state of one particle instantaneously influences the state of another, regardless of distance. It is also valid and true to say that entanglement represents the metaphysical boundary that is, the intrinsic definition of the construct and its parts. This interconnectedness, or entanglement structure, can be seen as a foundational element in the definition of life as intentful kinematics as we consider entanglement information more fundamental than Shannon or van Naumann information. Beyond movement, life can also be defined by its ability to produce intentful effects or affects on its environment or the systems it interacts with. This perspective includes not just physical interactions but also the transfer and processing of information, leading to changes in the state of a system. Information theory, which studies the quantification, storage, and communication of information, provides tools for analyzing how living systems process and transmit information. Systems biology,
(7) (PDF) Intentful Kinematics, What is the definition of "Life"?. Available from:
I agree to die but not by aging.
Thanks!
53:28 "New ideas in science don't emerge because people with the wrong ideas change their minds in the light of new evidence, rather, they just die. And eventually, some new generation looks at the evidence with fresh eyes and moves on" XD
Always the same question from (old) men. How about researching how to increase fertility of females in their 30s and 40s? That would be a more profound way to 'extend life'. Especially given the changes in our culture, making it economically unfeasible and socially unattractive to start a family within the most fertile period in a women's life.
I was hoping he would isolate and interrogate leading cutting edge research but this was kind of rambling. I still want to know where are we in terms of research. Where are these billions of dollars invested and are these aging billionaires being sold snake oil to a point or is the science actually going to lead humanity to seriously long lifespans?
If we can manipulate gravity then yes, they most likely can
Imagine the trouble we'll be in when autocrats and dictators can live forever. As much as I don't want to die, and wish my friends and family wouldn't die, human individual immortality would be than ultimate disaster for the human race and this planet.
God allows death to get rid of these problems.
A completely new, different universe will need to be created for eternal life.
Look, it’s simple. All religions and people who have thought about this know this. It’s in all the religious writings.
This guy is just selling what people want to believe.
Because the dictators gets always replaced by democrats 😁. Oh Wait do they?🧐
they cant be killed by enemies ?
For the same reason we go number one and two😮😮
Exercise regularly. Don't eat too much. Avoid eating things that irritate your bowels.
Thanks.
Very lovely of you, pouring water for the guest..Great
We have to work hard to make life better not to make it longer...
I’m not trying to make life better for future generation. Just for myself and my generation
Why not both?
If mice were to stay young instead of aging (and they do age) they would not be slowed down by the aging process and they would find it a lot easier to escape predators and accidents and live longer.
Nice discussion but nothing really new here from a scientific or philosophical viewpoint.
. Thanks regardless.
I think its more to promote his book
Most people would live longer if they ate cleanly, didn’t use drugs (yes, nicotine and alcohol are drugs, horrible ones at that…) exercised, and reduced stress. Some would live A LOT longer even… But instead of taking care of yourself people want an easy out, a miracle solution. Genetics determine you to a good degree, but how you treat yourself does matter.
In the future there may be some very unexpected options that may transcend the purely biological - the continuation of consciousness may be possible via the nonorganic chemistry such as silicon compounds that are imprinted with
the available last mental state and allows further cognition via generative AI .
54.29 No ! sugar is not oxydated. H is oxydated and the result is water.
Wow 🤩
We know why. The question is not why we grow old but can we stop the 3rd stage degradation of DNA?
As one who practices meditation, I loved hearing about mitochondria breathing, producing energy. Here are a few questions for contemplation... Do cells have consciousness? Can you communicate with your cells? How important is air, water, and positive mind set? Does air and water have any sort of consciousness in its cells? That's enough. 😂😂
I love the way science has changed our view of things. Nicola Tesla said all life is Sun energy. 🌞
There's much we know, and even more that we don't know. ✌️❤️🖖
Brian Johnson
Such an illustrious guest, unfortunately rambling with little focus on the core topic.
What a pity about the wasted opportunity.
vague discussion on aging. no questions re recommendations, what his approach to aging. 50mins with no outcome
"Why we grow old?" - This question was better to be researched and talked about by a monk who lives on few hundreds of calories a day at top of a mountain, not by a citizen of our finite fossil fuels-run Western Civilisation.
The finite fuels are much more precious to be burned providing an already provided answer - Life.
Finite fossil fuels are dangerously hypnotic to humans, their consciousness, reasoning and mental capacity.
"No matter how highly mechanised and self-powered, fossil fuels extraction requires a number of people as if the process executed by hands using buckets and ropes".
Today, this number is 8 billion people - working flat out 24/7 - strong.
Our Western Civilisation has been no more than a fossil fuels management operation - all along.
Humans were not ready morally, ethically and intellectually to start the mass extraction of fossil fuels with the advent of the steam engine 300 years ago.
The Magna Carta requires today overhauling adding to it the right for humans to understand what Energy really means before any other commandment;
"In any system of energy, Control is what consumes energy the most.
No energy store holds enough energy to extract an amount of energy equal to the total energy it stores.
No system of energy can deliver sum useful energy in excess of the total energy put into constructing it.
This universal truth applies to all systems.
Energy, like time, flows from past to future" (2017).
We’ve recovered antigravity devices from crashed UFOs and have also reverse engineered these devices. Many people have invented far better devices that provide energy and are killed or silenced by government and big oil corporations, Nikola Tesla is just one example.
Clearly explained 👍❤
For life to be longer there have to be less lives!
Where is the optimal balance.
is living longer beneficial to anything else than the personal ego?
Secondly, is not the proper way to approach/solve the aging problem by switching from biological coincidence (evolution/devolution) toward synthetic bodies with synthetic minds? To live in the vast expanse, outside this biosphere, we need bodies and minds that can deal with the time-span that traveling between stars demands. We need bodies that are sturdy enough to deal with the conditions in space, weightlessness and absence of "nature".
Current demographic research indicates that, if current trends continue, by the year 2300 the global population will be 1 billion, not 50 or 20 or even 10 but down to 1 billion.
All across nature you can see the same life equation.
Short lives / high mortality = high birth rate.
Long lives / low mortality = low birth rate.
Oh! So Religion is the Best answer.!
if you stop the Krebs cycle then that’s death
I don't know why but I'm surprised the hostess is wearing a pair of louboutins.
Care to elaborate?
I passed on passing on my gene's
22:04 Someone else finally gets. It it's all magnitudes everything is the same from the bottom up and whenever we have a problem with scale it's because someone included something from the wrong magnitude. Or it's because we can't achieve that scale.
what about the cockroach
If Dr. Ramakrishna can share a slides of what happens to human zygote etc. doesn't make further.
You're book,😂 You're book 🤑🤑🤑
Why? It's because of the time. Get rid of the time and you won't get old. What's even better, you won't make videos with silly questions and more. Or better said, you won't have time for them!
Animals don’t know of their mortality? - says it as if anyone can objectively know that for certain. Also this pontificating on matters no human can ever fathom is getting a little old. They’d be taken more seriously when, if ever, they can tell us what life is.
Comprehending your own mortality requires the ability to perceive the passage of time and be able to distinguish between past, present, and future.
This is mediated in humans by higher-order cognitive functions such as episodic memory and self-awareness, both of which appear to be rare in the animal kingdom.
Animals have intelligence generally equal that of very young human children. We observe that young human children don't understand their own mortality and therefore, it's logical to assume that animal don't either. Interestingly enough, children usually understand death in others before understanding it applies to them equally, which is also consistent with observation of animals. Of course, there is not definitive proof of this but that seems to be the most logical conclusion based on what we know.
Most of the video is just a waste of time. At the end when it gets good it ends.
What a strange question. We age because we do, and because it is important for the ecosystem that we eventually die. We have enough problems as is it is, without having to care for 200+ year old weirdos.
What an incurious, closed and quite obviously bigoted mindset.
@@geroffmilan3328looks like you're the A hole in the comments section.
@geroffmilan3328 you're allowed a wrong opinion.
@@johncarter1150 talking about "200 year old weirdos" is objectively age-based discrimination AND obviously misses the entire point - but congratulations on your over-achievement: two declarations of idiocy in one statement 👍
Well you better get on that. The ecosystem is suffering.
The second law of thermodynics makes immortality ultimately impossible.
No no no. Flatworms are functionally immortal. If you choose to build yourself from the building blocks that are easily replaceable, then you can become immortal. It's just that more complex things that require more complex molecules and procedures of creating those molecules can't keep up with entropy. If you can keep up with entropy, you can attempt to survive forever.
It might be impossible to achieve with *biology* maybe but not impossible altogether 🙃
The second law of thermodynamics isn not a law.
What is «thermodynics»?
Boltzmann showed that it’s not a law, just what happens. Entropy can and will decrease in individual interactions in systems, given long enough timescales, but you’re very unlikely to witness an instance of this. So you’re correct, but in the human body, this distinction is unlikely to be very helpful…
In search of immortality?? you should be In search of health. Get to 100 and you're not Brown coding or farting ever other second and you're going to live another 300 years waiting to get that operation reserved for the young. yeah right behind you on that search. Oh look, a squirrel.
I am very happy to be mortal! One life is enough. Death si what makes life beautiful. Immortality would be evil!
Size matters 😛
Anyone here ever try Dilk? Asking for a friend.
Your friend can continue enjoying it - Stewie recommends it! Or even better, try the one spelled with a c😂
@@dacosta6521hahaaa, you knew 👌🏻
Beatingg around the bush,..talking about philosophy politics, theology....man you are called as a microbiologist... nonsense waste of time watching it
rambling around without focus at any specific new science discovery or insight. For me it was a waste of time.
You ca not understand😂😂😂 what he says
@@danielsebastianrode421 now in English
Why this channel deleted my comments,
... Everyone is going to die eventually...
What is wrong with the comment.
OXYMORON.
Hold my 💉💉💉💉😱🥶🤮