My twin (monozygotic) has had MS for a long time. We are now 54 and she was diagnosed late 20s. She has a severe form. I used to worry about getting it but now I don't. She also got breast cancer recently, although they got it early. Now I worry about getting that. She has suffered a lot. Life is not fair for some people.
Omg! I’m so sorry for your sister! How awful! I’ve had my MonSter since 2004, I was 24! And now despite a very high efficacy dmt, I’m in a rapid decline! I just wish I could have one of these brilliant neurologists in America! Ours r too scared to use the higher efficacy dmt’s….! Sigh 😪
I have had ms for over 20 years, now my ultra fit and healthy son got diagnosed too. We would be a great subject for research on opposites. Unfortunately, my son has decided to stop treatment. He is doing pretty good, but I worry about his decision.
Very interesting. Your videos are my favorite. There is a lot of ugly things going on in the world but you’re a real one. Caring for others could never be a mistake. Thank you.
Fascinating stuff Dr. Beaber! I do have a family member with MS and we have different symptoms. I am excited that there is this knowledge about environmental and gut biome associations with MS. This means there are steps we can take to adjust both! Looking forward to seeing what the future research shows. Have you read Dr. Bulsiewicz’s book Fiber Fueled? It is all about gut health.
I have not read this book Vickie. I'll look into it. I think it's harder than people realize to study discordant identical twins to look for environmental factors because so often they are raised in the same household and have similar lifestyles.
I have a first cousin who had onset at in his 20's an worsenedo ver a few decades) and has EDSS of 6 or more. I wasn't diagnosed until my 50's and symptoms before diagnosis were not until my 50's or at earliest mid 40's. EDSS for me about 3.5-4. I have a 3rd cousin who has MS who's onset was also later in life like mine.
Very interesting video with I imagine many incentives for further studies aimed to hone key aspects - whether they be lower inflamation and other aspects mentioned hope there is more to follow! Thank you!
Good day. First of all I would like to congratulate you for the nice and informative videos I m neurologist practicing in Bahrain dealing with MS cases. I have three brothers with MS the youngest one being the most affected and other family with a father or relatively benign MS while his daughter developed secondary progressive in few years Do you notice the same with worse disease in the younger generations. Thanks
Interested video. Greetings from Africa. My daughter born 1993 diagnosed 2015 with MS. No history of MS in family. My son born 1987, diagnosed with MS in 2017. Yes, life is very unfair.
I’ve read articles about this topic and it’s very interesting. My mother in law was diagnosed with MS over 25 years ago with no family history. However, her father did have lupus later in life so there’s likely a genetic component. I was diagnosed 3 years ago, but had my first symptoms nearly 20 years ago at age 19. There’s also no known family history of MS in my family. However, there is a history of auto immune conditions on my mother’s side likely stemming from her father. He currently has auto immune HTTR-CM and my mother has ankylosing spondylitis. I also have a cousin on that side with hashimodos and ehlers danlos syndrome which isn’t auto immune but genetic. Her mom likely has EDS as well. Somewhat related, my mother and I both have inherited macular drusen which was interesting to my neuro ophthalmologist. They don’t cause a problem, however my MS primarily affects my vision and I have permanent vision loss in one eye. Yet, I was tested for genetic eye diseases and had no markers. Although, some of the dna was flagged as abnormal but not correlated with disease. As for the handedness discussion, my sister and I are both mixed handed but left hand dominant. Our entire known family is right handed, except my grandfather on my father’s side was also mixed handed but right hand dominant.
On my mother's side of the family, the women get MS (my mom and me) and the men get Parkinson's (4 of them). I always wondered if there was a genetic problem in this family line, but your presentation shows me that it's more likely to be similar environmental conditions that are in play, at least for the MS. There are no twins. My mom's MS and mine are very different.
That is quite a family history. There are no other relatives with MS or other autoimmune disease? To my knowledge, there isn't a proven association between MOGAD and MS.
@ thank you for answering. Our father died of hereditary demyelinating polyneuropathy in his early forties (diagnosed at his autopsy). My daughter has juvenile arthritis, so we have a lot going on in our family. Interesting to know there is no known association between MS and MOGAD.
I’m identical twin, I was diagnosed with diabetes in 1991 and with MS in 2008. My twin does not have any issues. I have MS, type one diabetes and thyroid disease. My grandmother has B12 deficiency, my aunt has thorough disease, my mum has type one diabetes.
I know this video is about twins but as far as a genetic factor, my mother had lupus and a couple other autoimmune diseases and I have MS. One of my best friends that lived across the street from me when I was younger had MS and his mother has lupus as well. My MS is really bad and he had one attack 30 years ago and then nothing after that, aka benign MS.
Have you heard of Lina and Laviai Nielsen? Identical twin Olympians (not Paralympians) with MS. Lina was diagnosed at 17, after having symptoms since she was 13. Laviai was diagnosed a long time after, at 24 I believe.
@@eaglecanfly2390 The maximum resolution for this video, as well as others on the same channel, is 360p. At this resolution, the microbiome analysis is not readable.
If you are referring to medications such as cyclosporine, there is not much evidence. Medications such as azathioprine are beneficial in multiple sclerosis at higher doses, but they are likely modestly effective.
Or the examples were examples of different disease modification drugs as much as it was MS . Kinda disagree with you still. One could have had kidney issues or so many factors. Poverty.
![Lp. Сердце Вселенной #60 РОЖДЕНИЕ ЛОЛОЛОШКИ [Финал] • Майнкрафт](http://i.ytimg.com/vi/YoR0pAV9FVQ/mqdefault.jpg)
My twin (monozygotic) has had MS for a long time. We are now 54 and she was diagnosed late 20s. She has a severe form. I used to worry about getting it but now I don't. She also got breast cancer recently, although they got it early. Now I worry about getting that. She has suffered a lot. Life is not fair for some people.
Thanks for sharing your story. Life is indeed very unfair.
Keep your vitamin D levels up! It helps to prevent both and also makes symptoms / advancement slower.
Omg! I’m so sorry for your sister! How awful! I’ve had my MonSter since 2004, I was 24! And now despite a very high efficacy dmt, I’m in a rapid decline! I just wish I could have one of these brilliant neurologists in America! Ours r too scared to use the higher efficacy dmt’s….! Sigh 😪
I have had ms for over 20 years, now my ultra fit and healthy son got diagnosed too. We would be a great subject for research on opposites. Unfortunately, my son has decided to stop treatment. He is doing pretty good, but I worry about his decision.
Ugh I’m so sorry! I have ms and I’m nervous about my son (before diagnosis) getting it. I sometimes feel guilty for trying to have another baby.
Nice video!
Thanks. Do you have patients who are identical twins?
Very interesting. Your videos are my favorite. There is a lot of ugly things going on in the world but you’re a real one. Caring for others could never be a mistake. Thank you.
Thanks Mike.
Fascinating stuff Dr. Beaber! I do have a family member with MS and we have different symptoms. I am excited that there is this knowledge about environmental and gut biome associations with MS. This means there are steps we can take to adjust both! Looking forward to seeing what the future research shows. Have you read Dr. Bulsiewicz’s book Fiber Fueled? It is all about gut health.
I have not read this book Vickie. I'll look into it. I think it's harder than people realize to study discordant identical twins to look for environmental factors because so often they are raised in the same household and have similar lifestyles.
I have a first cousin who had onset at in his 20's an worsenedo ver a few decades) and has EDSS of 6 or more. I wasn't diagnosed until my 50's and symptoms before diagnosis were not until my 50's or at earliest mid 40's. EDSS for me about 3.5-4.
I have a 3rd cousin who has MS who's onset was also later in life like mine.
Very interesting video with I imagine many incentives for further studies aimed to hone key aspects - whether they be lower inflamation and other aspects mentioned hope there is more to follow! Thank you!
Good day. First of all I would like to congratulate you for the nice and informative videos
I m neurologist practicing in Bahrain dealing with MS cases. I have three brothers with MS the youngest one being the most affected and other family with a father or relatively benign MS while his daughter developed secondary progressive in few years Do you notice the same with worse disease in the younger generations. Thanks
Interested video. Greetings from Africa. My daughter born 1993 diagnosed 2015 with MS. No history of MS in family. My son born 1987, diagnosed with MS in 2017.
Yes, life is very unfair.
I’ve read articles about this topic and it’s very interesting. My mother in law was diagnosed with MS over 25 years ago with no family history. However, her father did have lupus later in life so there’s likely a genetic component. I was diagnosed 3 years ago, but had my first symptoms nearly 20 years ago at age 19. There’s also no known family history of MS in my family. However, there is a history of auto immune conditions on my mother’s side likely stemming from her father. He currently has auto immune HTTR-CM and my mother has ankylosing spondylitis. I also have a cousin on that side with hashimodos and ehlers danlos syndrome which isn’t auto immune but genetic. Her mom likely has EDS as well. Somewhat related, my mother and I both have inherited macular drusen which was interesting to my neuro ophthalmologist. They don’t cause a problem, however my MS primarily affects my vision and I have permanent vision loss in one eye. Yet, I was tested for genetic eye diseases and had no markers. Although, some of the dna was flagged as abnormal but not correlated with disease.
As for the handedness discussion, my sister and I are both mixed handed but left hand dominant. Our entire known family is right handed, except my grandfather on my father’s side was also mixed handed but right hand dominant.
I'm mixed handed, right side dominant (though I generally hold a pen with my left). Also EDS and MS
On my mother's side of the family, the women get MS (my mom and me) and the men get Parkinson's (4 of them). I always wondered if there was a genetic problem in this family line, but your presentation shows me that it's more likely to be similar environmental conditions that are in play, at least for the MS. There are no twins. My mom's MS and mine are very different.
Great video as always! We are three siblings (F,M,M) with MS, all diagnosed at the same age. We also have a sister with MOGAD
That is quite a family history. There are no other relatives with MS or other autoimmune disease? To my knowledge, there isn't a proven association between MOGAD and MS.
@ thank you for answering. Our father died of hereditary demyelinating polyneuropathy in his early forties (diagnosed at his autopsy). My daughter has juvenile arthritis, so we have a lot going on in our family. Interesting to know there is no known association between MS and MOGAD.
Nice work
Thanks
I’m identical twin, I was diagnosed with diabetes in 1991 and with MS in 2008. My twin does not have any issues. I have MS, type one diabetes and thyroid disease.
My grandmother has B12 deficiency, my aunt has thorough disease, my mum has type one diabetes.
Could theoretically an EBV vaccine if invented exacerabate MS (after onset) ???
this also reminds my to replace my phosphatidal choline supplements which have almost ran empty last week- I guess why not?
I'm a identical twin diagnosed 2012.. relapse about every 2 yrs about.. my twin so far is Ms free
Hi, I'm an identical twin. I have MS and my brother does not. Thanks
I know this video is about twins but as far as a genetic factor, my mother had lupus and a couple other autoimmune diseases and I have MS. One of my best friends that lived across the street from me when I was younger had MS and his mother has lupus as well. My MS is really bad and he had one attack 30 years ago and then nothing after that, aka benign MS.
Have you heard of Lina and Laviai Nielsen? Identical twin Olympians (not Paralympians) with MS. Lina was diagnosed at 17, after having symptoms since she was 13. Laviai was diagnosed a long time after, at 24 I believe.
@Dr. Brandon Beaber Could you please upload a higher resolution version? Some text is impossible to read due to the low resolution.
Hm
this is probably have something to do with your youtube settings. The text on the video is pretty clear
@@eaglecanfly2390 The maximum resolution for this video, as well as others on the same channel, is 360p. At this resolution, the microbiome analysis is not readable.
Just wondering if anybody has studied anti-rejection drugs for MS?
If you are referring to medications such as cyclosporine, there is not much evidence. Medications such as azathioprine are beneficial in multiple sclerosis at higher doses, but they are likely modestly effective.
@DrBrandonBeaber OK thanks. I'm really excited about the antiviral therapies on EBV replication! 🤞
Why male twins rarely both get ms: males are less close than females, socially. Ncc.
Or the examples were examples of different disease modification drugs as much as it was MS . Kinda disagree with you still. One could have had kidney issues or so many factors. Poverty.
What?