Is Head Transplant Surgery Possible?

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  • Опубліковано 27 чер 2024
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    News that the first-ever head transplant surgery is scheduled to take place in December 2017 quickly spread around the world…but is this even possible? The Doctors and skull base surgeon Dr. Hrayr Shahinian discuss!
    About The Doctors:
    The Doctors is an Emmy award-winning daytime talk show hosted by ER physician Dr. Travis Stork, plastic surgeon Dr. Andrew Ordon, OB-GYN Dr. Jennifer Ashton, and family medicine physician and sexologist Dr. Rachael Ross.
    The Doctors helps you understand the latest health headlines, such as the ice bucket challenge for ALS and the Ebola outbreak; delivers exclusive interviews with celebrities dealing with health issues, such as Teen Mom star Farrah Abraham, reality stars Honey Boo Boo and Mama June and activist Chaz Bono; brings you debates about health and safety claims from agricultural company Monsanto and celebrities such as Jenny McCarthy; and shows you the latest gross viral videos and explains how you can avoid an emergency situation. The Doctors also features the News in 2:00 digest of the latest celebrity health news and The Doctors’ Prescription for simple steps to get active, combat stress, eat better and live healthier.
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КОМЕНТАРІ • 617

  • @neineibravo2653
    @neineibravo2653 4 роки тому +25

    Imagine waking up to a dead person’s body attached to your head.

  • @GursimranReehal
    @GursimranReehal 7 років тому +118

    Coming Up: Real Life Vampires.
    Enough Said, 'Murica

    • @donaldjoseph4990
      @donaldjoseph4990 7 років тому +2

      Gursimran Reehal ikr 😂😂

    • @dominicthedefiant3210
      @dominicthedefiant3210 6 років тому

      I think they were just referring to Goths.

    • @SuperMadmax10000
      @SuperMadmax10000 6 років тому

      Zero Spawn says the guy with lean as a profile picture. This is a tv show, not a real doctors office.

  • @deepgeny1
    @deepgeny1 6 років тому +100

    Technically, its body transplant.

    • @zaco21_
      @zaco21_ 3 роки тому +12

      Well, It’s technically both ig

  • @rol_saave
    @rol_saave 7 років тому +201

    It would be great of they would live stream the process..

    • @breezyhillproductions349
      @breezyhillproductions349 6 років тому +9

      the whole process it supposed to take 36 hours.

    • @Thehexofspokenword
      @Thehexofspokenword 6 років тому +5

      We no... Just... No

    • @GUWOP203
      @GUWOP203 3 роки тому +1

      Maybe if they did it with an ape or monkey and the animal recovered and is fully functional then maybe I could see it...Question like the lady asked where would you get the body???Its almost like people would be waiting for people to die....So they could Preserve their organs or something..... This some freaky shit

    • @Reysmash183rd
      @Reysmash183rd 10 місяців тому

      Facts

  • @Evilfisher2
    @Evilfisher2 8 років тому +600

    in 1-2 years people will come back to this video
    already half of what he is saying is wrong.

    • @ericpa06
      @ericpa06 8 років тому +4

      +Evilfisher2 Indeed.

    • @Commievn
      @Commievn 8 років тому +11

      They could make it successful. But what about the side effect ??? This could very well be the next lobotomy.

    • @Commievn
      @Commievn 8 років тому +3

      ***** like i said, side effect, side effect. Half of people who got treatment of lobotomy came out alive and fine again... until they act differently, they still retain their memory but their emotions and thinking changed completely. The other half ? either didn't work and got worse in mentally illness or *they died*

    • @ericpa06
      @ericpa06 8 років тому +5

      Brock McClain But when we are talking about lobotomy you actually affecting the brain, you are making a measurable damaged there, on the brain, directly.
      Here you wouldn't be affecting the brain, as far we know there would be any medical reason to this have any effect upon the cognitive capability of someone.
      Also, when you make a lobotomy on someone.. the effects, the bad effects are noticed right away, not days,weeks after.

    • @Commievn
      @Commievn 8 років тому

      ***** What about Neuron ? It will def effect in long term.

  • @THEISAAC1593
    @THEISAAC1593 7 років тому +56

    this reminds me of the time when they were going to do the first face transplant, they were skeptical at first and now it's been done several dozen times

    • @dopeitsjay58
      @dopeitsjay58 7 років тому +5

      A face is just skin and it still looks pretty bad after but a entire head is ridiculous. You can't put a spinal cord together.

    • @islam_will_Dominate
      @islam_will_Dominate 3 роки тому +5

      You can't really compare two cases. Just because one worked, it doesn't mean other would work the same.

    • @LilfoxTheHybridHylian5967
      @LilfoxTheHybridHylian5967 2 роки тому

      @@dopeitsjay58 it doesn't make sense tbh

    • @liviu09hjoe
      @liviu09hjoe 2 роки тому +2

      Is God's creation, will never happen

  • @fatyowls
    @fatyowls 7 років тому +82

    I can feel a beheaded joke coming on, but I'm sure someone will get upset and lose their head over it!

  • @GibsonVienna
    @GibsonVienna 7 років тому +18

    If no one never try new things like Headtransplant, how can we to envolve to the next Step? Canavero wanna try, he have a voluntary Patient. Maybe, he lives only a few Days after Surgery, but we will newer know, if no one try.

    • @GibsonVienna
      @GibsonVienna 7 років тому +1

      Absurd Question. Why should I? Would imply my Death, if I donate my Body. But for Valeri it is a Chance for a "better" Life.

  • @adelatejeda6114
    @adelatejeda6114 7 років тому +11

    Well I kinda don't think it will work but there is this guy who will volunteer and I am rooting for him.

  • @alagazic1013
    @alagazic1013 7 років тому +32

    People thought surgery in general was unethical at first, they thought it would never work.

    • @ViolentCabbage-ym7ko
      @ViolentCabbage-ym7ko 9 місяців тому +1

      Like the doctor said. First, the animal test subject must survive before it can be done to humans. None of the animal test subject survive

  • @BuddysDIY
    @BuddysDIY 3 роки тому +7

    As a 31 year neurosurgeon, microbiologist, and a board certified orthopedic spine specialist surgeon I can tell you In confidence that this can be done soon. Trust me.
    Jk. I make youtube video on how to fix cars. Head transplant would be dope tho

  • @codenamezero7357
    @codenamezero7357 6 років тому +4

    This could save a lot of people's lives keep the science rolling

  • @mikeb2575
    @mikeb2575 3 роки тому +13

    Head transplant is possible, in fact it has been happening for some time.
    Take the case of Boris Johnson who successfully had his head removed for that of a pigs and no-one could tell the difference !!! :D

  • @AllRound_GG
    @AllRound_GG 7 років тому +4

    Good on him.
    There are people who need these kinds of surgeries to live.

  • @akinoz
    @akinoz 6 років тому +7

    One day this is going to be real and this doctors are so specific or sceptic.

  • @craftman780
    @craftman780 7 років тому +9

    It's 2017 now. Did he go through with the transplant and was it succsessful?
    Or did he not go through it and pass? It really is an interesting topic.

    • @fonixtopher6972
      @fonixtopher6972 Рік тому +1

      His wife just conceive and that alone change he's mind.

  • @the.apocalypse.is.69
    @the.apocalypse.is.69 3 роки тому +5

    Yes it will happen between 2050-2100

  • @jensenkimmBA
    @jensenkimmBA 7 років тому +10

    Congratulations Valerie; I would do the same if I was in your circumstance and have faith in modern medicine. These Doctors are amazing and would not harm anyone; the team is designed for positive results - Good Luck to you and we all look forward to your speedy recovery :) This is not a Ridiculous Procedure and most patients are Brain Dead 50% of the time.

  • @ToasterGhosts
    @ToasterGhosts 8 років тому +21

    You can not know if its possible it could be some day because we can already do so many other transplants it could be possible one day but its very unlikely in 2017

    • @salenebrom6476
      @salenebrom6476 8 років тому

      Except It is
      The problem that was preventing this
      Keeping the doner body alive/ doner who is brain dead
      Keep brain healthy/ insert tube into jugular to supply blood and oxygen
      Spine connection/ copy the case of the six month old who had to have reconective surgery

    • @mattiasdecourcy3294
      @mattiasdecourcy3294 7 років тому

      silver fairy33 but it's already done, and it is 2017, and it worked😊

    • @abd-animation-22
      @abd-animation-22 3 роки тому

      2020 Here
      it is still impossible and will remain like so forever

  • @SwedishDoomGoblin
    @SwedishDoomGoblin 8 років тому +7

    Yes ,but will the head and body survive more than 6 months? Or 1 hour? who knows?

  • @MrLo0o0o0o0o0o0o0o0L
    @MrLo0o0o0o0o0o0o0o0L 7 років тому +52

    these are real doctors?! hah, no wonder that's your president

    • @__prometheus__
      @__prometheus__ 6 років тому +4

      Amir Asadi They're just a bunch of idiots who think they know stuff. They also spread pseudoscience.

    • @Hi-hk3vu
      @Hi-hk3vu 6 років тому +2

      Fuck off bitch

    • @ghostrider9256
      @ghostrider9256 6 років тому

      Amir Asadi America is doomed.

    • @devinngeorge
      @devinngeorge 6 років тому +3

      No wonder your prophet fucked kids

    • @zaqwe
      @zaqwe 6 років тому

      Amir Asadi just look at that pretty boy pretending to be a doctor not to mention the bitch in red

  • @noirdics3404
    @noirdics3404 7 років тому +5

    I love that the guy who does tests on animals is saying that a head transplant is unethical

  • @oleggeraschenko4932
    @oleggeraschenko4932 3 місяці тому +3

    it's been 8 years. no head transplant

  • @cormelfloyd9380
    @cormelfloyd9380 8 років тому +12

    I admire the doctors who are trying to do this. While no one truly knows how possible it is or isn't, and there are those people just throwing around the term "unethical" without any explanation, these doctors have already given a blueprint of their operation plan. I once admired the doctors on this show but instead of given very vague reason for why it isn't possible I wish they were trying to be innovative and throwing out possible ways to make it happen. But still there is a place for everyone in the scientific community. The naysayers and the achievers.

    • @wololeiro2364
      @wololeiro2364 Рік тому

      They cant

    • @pilgrimsnest592
      @pilgrimsnest592 Рік тому

      Why dont you sign up as the first testpatient? scared? or what are the other excuses?

  • @shensihn1827
    @shensihn1827 3 роки тому +2

    I mean dio brando did it in 1800 or something like that. He just recovered little bit and he was fine.

  • @toomabansy6008
    @toomabansy6008 6 років тому +5

    I felt sorry for the patient, I just hope the operation success.....

  • @eduardomerisi7103
    @eduardomerisi7103 7 років тому +12

    This ladies don’t have a clue what they talking about and they don’t have vision on medicine

  • @hishgeehishgee4400
    @hishgeehishgee4400 3 роки тому +4

    2020 december still waiting 🙏😁

  • @jeng.2322
    @jeng.2322 7 років тому +82

    lol at the fact that these are supposedly real doctors. how is medicine supposed to advance if you're not willing to explore the possibilities? sure the guy with the muscular atrophy might not survive but isn't the tiny chance that it might actually be successful enough to give it a go, especially if the patient is in it 100%???? i say do it, responsibly and legally obviously. if i were brain dead and had a healthy body, and if it were an option for organ donors, i would be completely okay with having my body used for a head transplant, i think science is awesome and the surgeons who perform these types of innovative procedures are the reason why the science in medicine is where it's at right now. and even if it doesn't work, there is always success in failure because you can study your mistakes and determine what could be done better for the next trial. shame on them for not seeing that.

    • @Arunav1403
      @Arunav1403 6 років тому

      jen g. Yea.. I do think the same..

    • @gabrielrb5188
      @gabrielrb5188 3 роки тому

      I agree 100%!

    • @mechamedeamigo3984
      @mechamedeamigo3984 3 роки тому +4

      The thing is, the chance of success is zero in this case.
      If you are trying to experiment something, you have to use something as a basis, but there's nothing in medicine that can give people even a slight hope of this thing to work out, actualy there's just materials that prove that such a thing wouldn't be possible.
      Every Theory comes from somewhere, but this man who was thinking about making the first head transplant just had nothing, that was a complete shot in the dark, and this surgery would 100% go wrong

  • @kaycross3176
    @kaycross3176 6 років тому

    Where will they get the body from?

  • @NewfieCrystal
    @NewfieCrystal 7 років тому +2

    Just watched a new video that says this man is now scheduled for this head transplant in dec 2017

  • @realtalkwiththeking7862
    @realtalkwiththeking7862 Рік тому +1

    I believe this will eventually happen and can’t wait to come back to this video in 20 years.

    • @ViolentCabbage-ym7ko
      @ViolentCabbage-ym7ko 9 місяців тому +1

      Doctors cannot even find a cure for people with spinal cord injury, how are they going to attach a new head to a donor's body?

  • @samlee443
    @samlee443 6 років тому

    I hope to see the Italian doctor watching this video , after his operation succeed , and laughing on you ; doctors LOOL

  • @musicofree4853
    @musicofree4853 7 років тому

    first and last question how he will fix spinalcard ???? then i will agree if they explain this?

  • @eddydeathwishe4638
    @eddydeathwishe4638 7 років тому +1

    this reminded of people saying we could never go to the moon. when will we realize nothing is impossible

  • @justme6074
    @justme6074 8 років тому +14

    Frankenstein exists lol

  • @technicalmanmalayalam9560
    @technicalmanmalayalam9560 2 роки тому

    How leave after surgery Donor or patient

  • @windex2209
    @windex2209 6 років тому +2

    we will never know if we dont try

  • @Taylor.h
    @Taylor.h 6 років тому +2

    Even if he doesn't survive, we will still learn a lot

  • @saijapz16
    @saijapz16 2 роки тому +1

    cutting head science , i mean cutting edge

  • @user-pf3vz3rd9h
    @user-pf3vz3rd9h 8 років тому +16

    the jugular vein people!! how can you survive after it being cut?!

    • @salenebrom6476
      @salenebrom6476 8 років тому +15

      Connecting it to a tube to supply blood and oxygen while the other bits get fixed
      A six months old baby got his spine reconnected he now can walk though he'll have a brace for two years

    • @shenkeey
      @shenkeey 8 років тому

      +In Quest For Truth artificial blood circulation

  • @MommaBearsCorner
    @MommaBearsCorner 7 років тому

    i can not imagine someone seeing this and thinking this would be their answer to any sickness.

  • @rastwet
    @rastwet 7 років тому +19

    The read the HEADlines

    • @op3880
      @op3880 7 років тому +2

      XD

  • @Devine3190
    @Devine3190 7 років тому +5

    It probably won't work, but most of the medical advancements we see today people said the same.

  • @jaycarden5466
    @jaycarden5466 7 років тому +2

    I understand that is highly unlikely for this to work but at the same time we thought this with heart and limb transplants, so maybe this could work..

  • @susanbobo5098
    @susanbobo5098 2 роки тому +1

    But I wonder, could they transplant a human head onto a robot? Like “ Sofia”? I remember a gruesome clip from I think Germany long ago that scientists kept a dogs head alive with artificial tubes

  • @shoneiyahchannel7375
    @shoneiyahchannel7375 6 років тому

    2017,i want to know if the transplant is successful??

  • @blayne888
    @blayne888 3 роки тому +2

    Speaking of head transplants... 3:16

  • @ganeshuraw3503
    @ganeshuraw3503 6 років тому

    wht about blood . It should be match or not.

  • @Dzeividz
    @Dzeividz 7 років тому

    When will i able to send my mind to a robot body

  • @johnhakimpoor6266
    @johnhakimpoor6266 7 років тому

    I can't believe that last doctor said what she said, was she serious lol?

  • @stupidiz1024
    @stupidiz1024 6 років тому +2

    Back in the 60s when the first heart transplant was about to happen no one believed it would work..

    • @Woofnberg
      @Woofnberg 3 роки тому +1

      Yes I have hope!

    • @JA-gx4hb
      @JA-gx4hb 2 роки тому

      Still doesn't work that great.

  • @rainjohn4671
    @rainjohn4671 6 років тому

    So last year I had a women come into my class cause I go to Tchs for nursing & this women is one of the head people of the transplant area in Philadelphia and she told us its gonna taking 100s of doctors and nursings to do this but it is going to happen in December

  • @falconx8719
    @falconx8719 7 років тому

    There is a better chance of dinosaurs coming back from extinction or meeting aliens than a head transplant.

  • @Iwannabeamafiaboss2001
    @Iwannabeamafiaboss2001 3 роки тому

    A better way would be first get a stone mask that’ll turn you into a vampire once you’ve become a vampire then get a hamon user to defeat and when you get defeated,then get your minions to order a coffin on the same ship with hamon user that defeated you is at. Next is to make everyone in the middle of the ocean zombies so that way the it can be easier to defeat the hamon user with your laser abilities once defeating the person then you can finally steal his body. The last step is to hide in a coffin in the middle of the ocean for 100 years then head over to Egypt to get yourself an arrow that’ll give you a time stopping robot spirit

  • @bencourtney4474
    @bencourtney4474 7 років тому

    While this procedure does seem impossible I can't listen to a show which has a heading stating 'real life vampires?'

  • @dantevergil645
    @dantevergil645 3 роки тому

    How can you transplant the brain stem??how can you attach all the nucleus of cranial nerves??

  • @thenunujournals
    @thenunujournals 7 років тому

    It is actually scheduled for December 2017!

    • @mig-29
      @mig-29 2 роки тому

      What happened in 2017?

    • @thenunujournals
      @thenunujournals 2 роки тому

      @@mig-29 It didn't happen after all, I guess they cancelled to do more research or maybe they don't believe that it would succeed.

    • @mig-29
      @mig-29 2 роки тому

      @@thenunujournals too bad they didn't did it,maybe next time.

  • @dragonraopen2604
    @dragonraopen2604 7 років тому

    Oke 2017 i still wait ...

  • @msoda8516
    @msoda8516 6 років тому +1

    I am a brain tumor savior and this is madness

  • @Squidgyy_
    @Squidgyy_ 3 роки тому +1

    Even medical transplants are a JoJo reference

  • @curvinmathebula8232
    @curvinmathebula8232 6 років тому

    my problem with the surgery is the spinal cord... if the donor spinal cord is thicker than that of the recipient how are they going to handle it.. people are really diverse and it's a given that the girth of the donor and recipient's spinal cords won't match unless they're identical twins

  • @LuisPa247
    @LuisPa247 3 роки тому

    spinal cord regeneration... i wonder how they found the solution for that....

  • @tusse67
    @tusse67 Рік тому

    One of many ethical issues of the prospect of body transplant is that it is a cure to any terminal medical condition that affects the body and not the head. The discrepancy between numbers of recipiants and donors will be staggering. How to choose?

  • @noahxer4668
    @noahxer4668 2 роки тому +1

    Dio: am I a joke to you?

  • @valdale8771
    @valdale8771 7 років тому +1

    The donor is generous!!

  • @nemanume
    @nemanume 7 років тому +6

    Similar people over the history : Ooh , are you mad , only birds can fly ... And after 72 year man was flying to the moon and back.

  • @enzomaidana5369
    @enzomaidana5369 3 роки тому +1

    Poor guy don't look like he is gonna live much longer anyway. Might as well give it a whirl.

  • @mrplayer87
    @mrplayer87 Рік тому

    So do they have to remove his brain first? Bc then it would be that perosn in someone's else's body

  • @andikahetris5219
    @andikahetris5219 7 років тому +1

    It's not wise to be that certain about the chance of failing over a science advancement, let alone the hope..

  • @SaraS-jq1ln
    @SaraS-jq1ln 6 років тому

    Love how the giuy didnt actually answer where the body is coming from....

  • @YugoStrange
    @YugoStrange 3 роки тому +3

    2021, did it ever happen?

    • @victornieves1794
      @victornieves1794 3 роки тому +2

      The patient changed his mind because he fell in love with a woman, had a kid and didn’t want to risk dying.

  • @imagy27
    @imagy27 6 років тому +1

    Man, I doing my endocrinology master in france. So i dont know a lot about what this guy is going to do, I only know the basics. For what I know the experiments done in animals, show that chance of survival is way to little. But we will have to see, lets hope for the best.

  • @dangernoodle8867
    @dangernoodle8867 7 років тому +16

    Ohhhhh shit it's 2017 wtf is gannna happen I'm fucking excited to find out how long it took him to die

    • @__prometheus__
      @__prometheus__ 6 років тому

      DANGER NOODLE 10 minutes

    • @SylasTheGreat
      @SylasTheGreat 6 років тому +2

      We will see guys! You'd be surprised.

    • @williamwinn948
      @williamwinn948 6 років тому

      Instantaneously

    • @Kryogh
      @Kryogh 6 років тому

      DANGER NOODLE the russian guy backed off, a chinese is doing it next year

  • @jesswhyuwannaknow930
    @jesswhyuwannaknow930 2 роки тому

    Once the spine is severed from the brain stem YOU’RE DEAD

  • @neworldgaming4596
    @neworldgaming4596 8 років тому +1

    it's possible in some aspects like I believe that blood circulation, muscle reattachment etc. won't be a problem except for the spinal cord. The doctor performing this surgery stated that they will be using a special bio glue, I mean can't you test that out in animals first and if it does work why not use that glue to help spinal injury patients. help them walk again you know

    • @xXxxXx-yr1dd
      @xXxxXx-yr1dd 8 років тому

      it was tested on mice

    • @faridyusuf1841
      @faridyusuf1841 7 років тому +1

      No! It's not a special type of glue. It's PEG. We use that to fuse cells together.
      But, a neuron, you see, it's far more complex, with all its wiring.
      Gluing it together is not the challenging part, getting it to work is.
      Especially with up to 10,000 other connections, replacing 1 neuron itself is hard.

  • @anthonypassaro8943
    @anthonypassaro8943 Рік тому +1

    What if they could clone your body and then do the head transplant? Functional immortality if you can keep the brain healthy

  • @hydraavneet3800
    @hydraavneet3800 Місяць тому +1

    I am the first person after seeing brainbridge

  • @superjare23
    @superjare23 2 роки тому

    Just a FYI The guy who volunteered backed out for good reason.

  • @FriesLol505Official
    @FriesLol505Official Місяць тому

    ok can i just switch my head with elon musk's head?

  • @tweeked650
    @tweeked650 3 роки тому

    Wish they would transplant thyroid...lost mine in 2015.

  • @bilalnizamani2338
    @bilalnizamani2338 7 років тому

    now chinese surgeon made mice survive 7 hours

  • @dwaynecole6636
    @dwaynecole6636 3 роки тому

    If you can't reverse peroulisis, how could it be possible to do a head transplant.

  • @chikinnugets4681
    @chikinnugets4681 3 місяці тому

    Imagine how mamy anti rejection pills you would need to take for the body not to attack the brain

  • @ryanwais
    @ryanwais 7 років тому

    114 dislikes.. You guys are slowing us down. We move on to save people lives and you disappointed us. Thank You.

  • @nickdavis1898
    @nickdavis1898 6 років тому

    We will never be able to transplant a head if we just sit around and not try.

  • @lucytoyne3577
    @lucytoyne3577 7 років тому

    Isn't the first one going to be December of 2017

  • @pakottajaa
    @pakottajaa 7 років тому +3

    laughing when they make it happen

  • @Numl9ck
    @Numl9ck 3 роки тому

    Dio taking notes

  • @Vfuuuf
    @Vfuuuf 6 років тому

    Who's waiting for the surgery this 2017?

  • @allisondandrea5610
    @allisondandrea5610 7 років тому

    to the lady saying where do you even get a headless body lol people donate their bodies to science for procedures exactly like this

  • @tinnakornsai4404
    @tinnakornsai4404 3 роки тому +1

    Thanks Dr. BS. i will rooting for this.

  • @ftk_ovr_9k
    @ftk_ovr_9k 7 років тому

    Tell me more about this "Healthy Donor"

  • @Dreama40
    @Dreama40 6 років тому

    It's just a matter of time before it will be possible if not routine, maybe were not there yet but we will be one day in the not to distant future. Just look how far we've already come!

  • @aymanbasheer5114
    @aymanbasheer5114 2 роки тому

    Imagine how awkward it would be after the transplant..!! for your Family to live with a stranger !!😄

  • @infernalnasus8945
    @infernalnasus8945 8 років тому

    why they dont use the androbot

  • @1seancampbell
    @1seancampbell 3 роки тому

    Godspeed

  • @Thekidsinafrica14
    @Thekidsinafrica14 3 роки тому

    The cost of this procedure would get you to the moon and back.

  • @andrewtheking3188
    @andrewtheking3188 7 років тому

    yea thats what they said abouts hearts flipin heart the thing you need for every thing in you body

  • @infernalnasus8945
    @infernalnasus8945 8 років тому

    to be the body of a robot and itself into the first andriod or a cyborg. connect the artificial pumping heart so the brain keeps alive. like the first guy who has no heart maybe it work