Phosphatidylserine | Benefits, Dosage + Side Effects
Вставка
- Опубліковано 6 лют 2025
- Phosphatidylserine | Benefits, Dosage + Side Effects
🩸 At-Home Testosterone Test: trylgc.com/nut... (Use code LIBRARY30 for 30% Off)
📝 The Complete Guide To Supplementation: www.nutrilibra... (Use Code NUTRITION15 for 15% off)
📔 FREE Access To The Nutrition Library (Free supplement Guides and More) - www.nutrilibra...
💊 Gorilla Mind Supplements: bit.ly/3pnVD4y (Use Code NUTRITIONGUY for 10% off)
🧬 Health-Based Genetic Test: selfdecode.com...
-------------------------------------
Connect with me
/ nutrition_library
/ nutritionlibrary
Phosphatidylserine has been one of my go to nootropics for a long time. Even though the evidence is still preliminary, it is extremely promising. Unfortunately, there is a lot of misinformation out there concerning what it does and how it works, and so in this video we take a deep dive into pretty much everything I know about Phosphatidylserine.
Video to watch next on Ginkgo Biloba - • Ginkgo Biloba | Benefi...
Video Outline
0:00 Introduction
0:22 PS Basics
3:21 Benefits to Cognition
8:01 Benefits to Stress
9:34 Benefits to Physical Performance
10:41 Dosage
11:16 Side Effects
11:50 Synergism with Fish Oil and Ginkgo Biloba
Disclaimer - Though I do have a degree in nutrition, I am by no means giving individual advise to anyone to take anything. I am simply presenting available research on a topic related to health so that you can make an educated decision with your personal healthcare provider.
Male At-Home Hormone Panel 👉🏼 trylgc.com/nutritionlibrary (big shout out to LetsGetChecked for making an insanely good testing service and for sponsoring this video)
Can you recommend a brand.
Its ok, but could you increase your volume a little sir? Thanks for the good content.
Yes sir
Increase your volume and decrease the vocal fry
Seems it's 5 decibels low. Thanks for the info in this vid.:)
The sound is normal. You have hearing problems because you lack phosphaditilserine
I can always count on your channel when I need to learn about a new supplement I’ve never tried before. Thanks for your hard work and research, saves me so much time for real listening on my way to work
best vid I've seen on this
Use this with PS chlorine. What a home run. Al-Carnitine added is a powerful triple threat! I’m a stroke victim and this has given me back my life!
I have Bipolar Disorder and when I take Phosphatydle Serine as "sharp PS green" myy Anxiety goes away instantly! Love this stuff! If anybody suffers from
Anxiety I highly recommend it
agreed
thank you for your comment. I will try it for anxiety and adrenal fatigue.
Is it true that it can supresa the immune system?
@@Arraseldid you try it? What did it help you with? Hope you feel better soon
@danielagentile8049 I tried it yeah, to lower my cortisol.
If my cortisol is too high, it won't help.
Probably it works fine for low anxiety, but in severe anxiety it hasn't helped me.
Ashwagandha helped me the most in severe anxiety. It lowers cortisol with 30%.
Have you tried something that worked well for you?
Cows and Pigs get their Phosphatidylserine from PLANTS, and so did Humans, long before they started eating, Cows and Pigs.
This has been suggested by dr Andrew Campbell, to aid in treating mold toxicity, will having MTHFR mutations affect the utilisation of this substance?
I remember the first time I took this supplement, instructions said that I should take 200 mg. I took it for a couple of days and it didn’t really do anything for me. After reading some more information on the Internet, I came across some testimonials for a PS product which showed that 600 to approximately 800 mg a day is what is required to reap the benefits of stress control - I was extremely stressed at that point in my life. So I started taking 800 mg a day; 300 mg in the morning, 300 mg just after lunch time and 200 mg before bed. I was absolutely gobsmacked at how amazing this supplement is at helping chronic stress. It also helped clear my skin up, I’m not sure if that has something to do with endotoxin load or some other mechanism, nevertheless it really kept my skin clear.
Yeah it’s a pretty great stress reducer
Oh thank you. I did take this previously, and I took 1 a day (300) and didn't notice anything. I will increase, and try to be more consistent also.
@@XeninaCalifornia 🙏 you’re very welcome. Please do let us know how you get on 🙃
Are you tall by any chance ?
Great , thanks for your input 👍
I typically don't eat first part of my day.
I read that it should taken with food I've been taking it on an empty & with food.
Any difference for you?
Thanks
Is it safe to take it long term? I tried it years back and was fine but just recently I took a new brand and developed joint and jaw pain. I stopped mid bottle and it subsided.. I resumed taking it and again, my joints started to really hurt. I'm ordering a different brand to try again but am wondering how long can you safely take it? I like that it takes the edge off of my stress and I have, oddly enough, really nice dreams... it's why I want to give this another go. Thanks for any info on it's safety.
I’m seeing two supplements on the market, one from sunflower and one from non-GMO soy. It sounds like the Phosphatidylserine from soy doesn’t lower cortisol.
You are very good at this. Thank you.
Thank you for this critical information. I have the APOE 4/4 allele and follow most of Bredesen’s precode/Recode protocol.
Great video👍 please get closer to your mic I have my computer on max volume but it’s still low thank you
Yeah. There was something wrong with the mic.
Do you have any concern for exposure to heavy metals or other chemicals from the water supply and it’s affects on the body and mind?
I'm more worried about inflation.
Fluoride lowers iq and willpower. Buy purified water
buy a countertop water distiller.
the audio volume is way too low
Yeah I don’t know why.
True, my volume is on max
Very helpful 👍👍👍
Kindly make a video on black seeds (nigella)
I’m taking vyvanse right now do you know weather it’s safe or not if I mix with ps
Great video! I see that this video was released about a year and I am wondering what would stack well with phosphatidylserine? More so for studying, memory, focus? Thank you in advance!
Try "Mr. Happy stack" along with PS. CDP Choline, Omega 3s, and Uridine
Andrew Huberman brought me here..
Great video man! 🙏🏼
Does this help with reversing grey hair?
Mine is derived from sunflower lecithin is that good?
is this a good suppplement for low cortisol and improove sleep ? . thank you
It won’t lower cortisol but it will help you sleep
I buy 2 pounds of beef liver from the local butcher, i slice it up as thinly as possible then set it all in my food dehydrator. ~8 hours later ill remove then let it cool, before putting it all into my bullet blender. I bought a little capsule filling device called a Cap'm quik capsule filler. I use 00 sized vege capsules that can be bought online. I fill the capsules with the blended beef liver then store in the fridge. They keep for months.
That’s awesome! I’ll have to try it out! I’m a huge fan of beef liver as a supplement. I’ll have to make a video on it soon!
@@NutritionLibrary once youre set up with the equipment its super simple, ive also noticed that my body responds really well from consuming Sauerkraut, i now make my own, which is super easy. Keep up the great work.
Hi, thanks a lot for a great video, I have a question ¿Do you think Ps is better than ginkgo, for focus and helping prevent brain fog ? i'm 39 by the way
The name of the supplement really is a mouthful lol
Could you do nigel sativa (blackseed oil) next please. Thank!
Nigella sativa, Nigel's twin sister.
there are side effects, but very dependent on your physiology and situation. for example insomnia ( depends on the individual, dosage and time of the day that its being taken ) , lowering cortisol too much ( based on the current cortisol level of the individual and how they response to PS) we do need cortisol to function properly and be alert and focused.
Right ashwsgsnda lowers my cortisol too much to where I’m not functioning or alert
Is this recommended for chronic insomniac and someone who is allergic to soy? Are there any brands that dont use soy lecithin?
Jarrow uses sunflower. Great product
Anyone has tried Phosphatidylserine and Ashwagandha, their impact on reducing stress?
Which brand is good?
Can I use it continuously or take breaks?
can l-theanine be used with this supplement?
I took it for 1 month and saw no results. I've tried several nootropics and the only one that really worked for me is a good mug of organic coffee with 2000mg of Taurine.
what brand do you use ?
Does this give you that good caffiene, coffe high feeling? I'm trying to get off the caffiene, my body doesn't do well with it.
I really enjoy listening to you explain stuff to us do you have an episode on coffee fruit extract I've heard good things about this stuff and if you haven't will you think about doing one and maybe who sells the best product thank you and keep up the good work
There are only a few studies on it. Seams to increase BDNF in healthy people but there is no indication this would lead to anything observable.
I do enjoy a cup a coffee fruit tea every afternoon as a pick-me-up though. That’s what I would recommend. You can find it on Amazon. Twin engines is what I am currently drinking.
can I take it alongside magnesium L-threonate and ashwaghanda ? thank you in advance
Great content! Would love to see a video about Theacrine
I will!
so many supplements? how to choose? Curcumin or phosphatidylserine or ashwaghanda or etc. A bit overwhelming.
I know! This is why I am currently developing a class to help people choose! Coming soon!
A lot of people in your comments don’t get their questions answered.
Appreciate the knowledge. Thank you!
No problem!
Great video!!! What brands would you suggest for fish oil and Phosphatidylserine?
Fish oil is Nordic naturals and Carlson. Vitamin shop has an in house brand that is super cheap and is made by Carlson. But make sure to get the liquid bottle that you drink. The best for the money PS is either Doublewood or Jarrow. I’m also currently experimenting with Ancestral Supplements Beef brain right now too and I love it
It would be nice if you could post the references you show in the video in the description so that you don't have to manually copy the doi to look them up.
Nice video. If you could pick one nootropic for an elderly person who's suffering from memory loss which one would you pick? Also i have heard that alpha gpc is one of the best to boost brain acetylcholine levels in elderly. Do you think that Phosphatidylserine could be better than alpha gbc in this matter? Thanks.
Hi Sam , check out the” gut brain connection “ my health & brain fog cleared totally… it’s amazing
PS Chlorine is powerful for memory!
@Stlonewolf Not chlorine, it's CHoLine. Chlorine isn't safe. BTW, my PS formula includes Alpha GPC and Huperzine A. I hope you are doing well!
Can I take this along with Phosphatidylcholine?
I'm pretty sure it's the same thing, bro. Phosphorylcholine/ Phosphatidylserine/ Lecithin.
You can. But it’s alot cheaper to just eat eggs for PC
@@NutritionLibrary eggs doesn't give me the effects PC gives.
What PC do you take?
@@getdown8990 Jarrow Formula is the brand, it's very reliable.
Wow, crazy!
I just took for the first time 100mg.
Took it with my morning coffee.
As usually I got a great energy-high from the coffee, but felt way less forced and stressed by the coffeine.
I felt way more deliberate in my thinking, the work I would otherwise have to force myself to do felt just effortless.
Just crazy!
Will take another 100mg after noon, and another 100mg in evening.
You really shouldn't drink coffee in the early morning the body makes it's own energy as you wake up, coffee it's just a stimulant and should be drank late morning. But how did you get on ?
@@Super-lucky-7777
My morning coffee is my late morning coffee. Have it around 1⅓ hours after waking up.
The first Week of experimentation with PS I took the recommended dose of 300mg.
This put me in a (nearly?) manic like phase.
I just felt really, really great, had really a lot of energy, was very productive and very motivated, but slept just around 4-6hours per night.
I felt really great and was doing great in all aspects, but doubted, that this less of sleep could be healthy.
So I reduced my daily dose to 100mg, which I took nearly every day since then.
Even this dose is enough to elevate my mood to a noticeable degree.
But to be honest, I think I can get this too with a solid sleep-schedule and a few other non-supplement adjustments of life.
So next month I let the PS beside and I will rank my sleep scedule a little higher in priority.
Maybe keep the PS as a substitute for alcohol at partys.
Tried it the last weeks as a alcohol-substitute at partys - for this I took another 100mg to my daily dose - , it makes me more energetic and less anxious in social situations, but I'm more focused and motivated than with alcohol and have no hangover with PS.
@@Barbarus_Romanus you took everyday or you cycle off when weekends or when there's nothing to work ?
I'm taking 1/2 teaspoon daily. Is that about 500mg?
good video, can you talk about astaxanthin?
I will!
What does it mean when you have autoantibodies against this?
thoughts o combining phosphotidyl serine and lions mane?
EVERY PS capsule or powder sold is ONLY 20% purity and state it on their ingredients label. So dosages are way off. Where the hell do we get 100% pharma grade?
Would sunflowers lecetin extraction of phosphaditylserine be better?
*11:00*
500mg - in one go, or spaced out as 200/300? Thanks
I like it spaced out
Is nootropic depot legit ? Thanks
yes
Have you done a vid on Bromantane?
Nope not yet
Do you know anything about taking this supplement alongside SSRI's? I'm currently taking sertraline and want to try this supplement for its cognitive abilities. Any feedback would be appreciated! Thanks
I would like to know as well
Do you need to cycle this as well or can you take it indefinitely
Because it is a fundamental nutrient there is no need to cycle it.
@@NutritionLibrary How to find out whether it is a fundamental nutrient? I watched many videos of yours, not all of them mentioned about cycling..
@@exnox You can google if it's contained in stuff that people regularly eat in large quantities without any issuers. For example, Swedes eat massive amounts of pickled mackerels, which are high in PS.
Awesome video. Im sold.
Two questions: Is a phosphatide complex worth it or just take PS instead?
Also, what do you think of Oroxylum indicum?
Buy the double wood PS. It’s the best for the price.
@@NutritionLibrary Okay thanks man but what about O-indicum? It seems very promising.
What are your thoughts on supplementing PS with L-Syrine. As one is the other’s precursor. If so, is there a protocol you would recommend. Should they be taken simultaneously or in sequence?
I do t like supplementing with amino acids that can be found in foods easily.
You would probably be better off consuming PS. It is likely that a reduction in our own ability to produce PS is why supplementation shows such promise.
You seem to recommend a lot of the same supplements that Christopher Walker does. What is your opinion on his work?
He has a good head on his shoulders.
Do you feel it’s best to take in a complex or in isolation.
Isolation. The other compounds in the complex can be easily found in other places.
However I have recently become a fan of supplementing with Ancestral Supplements Beef brain and Jarrow krill oil for PS content.
What are your thoughts on this being stacked with L-Dopa?
There is also Sunflower derived PS which I take. Works well
What brand ashwa u use
Trenbolone
I used to take it and can’t remember why I stopped. Starting it back up
let me know how it goes.
Please make a video about urtica dioica , thanks for the explanations.
There’s a plethora of sunflower lecithin phosphotidylserine. Also, it’s highest in soy and eggs, particularly egg whites. (Serine, that is.) PS is mackerel , brain, heart.
Great content, thank you
Glad you enjoyed it!
What is this unknown mechanism by which PS reduces cortisol?? How can I increase it backup, mine is permanently reduced.
Licorice root raises cortisol
@@Arrasel it prevents breakdown of cortisol, doesnt raise it
Does this one need to be cycled or can it be taken indefinitely?
Does not need too be cycled
@@NutritionLibrary thanks. How long have you been taking it uninterrupted?
There are some reports that it increases dream recall (making it easier to remember dreams and making them more vivid), has this been the case for you?
Has anyone used this is Benzo detox
So it's possible to get a dose from it by just eating organ meat like liver?
It’s primarily found in the brain.
When I took this I became so shaky and had to stop.. Could that be related to the increase in energy for people who tend to have low blood glucose levels? Or might it have been coincidence since I ended up developing a mild cold shortly after?
It can increase acetylcholine. This can cause the side effects you mentioned if you are already a high producer of Acetylcholine.
I had to turn the sound up on your video, then got blasted by loud commercials.
this is super interesting ! - 2:50
Right! I’m super interested in this compound right now. Bout to order some cow brain as personal experiment lol
The sound is too low on some of your videos. Its hard to hear even when listening thru a bluetooth speaker or headphones
Yeah. I’ve been told. I’m trying to standardize the audio for my next videos so they sound better
@@NutritionLibrary please CHeck ur email
The mic volume is too low.
Does this need to be cycled? I dont want to become reliant on this or anything?
No need to cycle it. Taking a break from anything for a day here and there is good practice though
@@NutritionLibrary do you any suggestions for UK stock of this? Thanks
do you still stand by this compund?
Is it useless if you already taking creatine (increase also ATP)?
No this has a completely different mechanism. Technically they should stack well together
Appreciate the video, but can barely hear you and I have my volume all the way up
Yes it does!
Could you (or anyone else) explain how exactly there can be a difference between the bovine and soy extract? Various sources claim that they are different, but how exactly? If the supplements are a pure, monomolecular extract, and it's the same molecule, then how can it make a difference where it came from? If the two actually differ in their effects, wouldn't that sugges that either one or the other extraact was contaminated with impurities?
I think he was saying the only difference is the possibility of mad cow disease contaminating the product IMO. Plant based supplements don't have this potential for danger.:)
Do you offer consultations? I wanted to talk to u and get advice on what supplements I can take for my adhd and other ? do u offer through zoom or discord?
Email me. Zach.allison09@gmail.com
@@NutritionLibrary Ok I sent u email
Any advice on which nootropic stack to utilize that is best for someone about to start a fast-paced high stress job with a massive amount of information to learn? I currently take 1g lions mane and 5g maca in the morning with coffee and Ashwagandha KSM-66 300mg at night. I'm a healthy 30yr old male. Love the content. Thanks.
For stress and learning it is hard to beat Ashwagandha and Phosphatidylserine. They are fantastic. Lions mane is only good if you get OriVeda brand, it’s expensive but great.
I would drop the maca unless you just love it.
And if you aren’t taking a multi and fish oil and magnesium for general health. I would also consider those.
Bought myself a 60 day 300mg set, gonna test it out
Wonderful!! Thank you so much. I do also take fish oils. :)
Good. Great combination!
Is it just me or is it really hard to hear. I have my headphones all the way up and it sounds like it’s only half that.
Yeah I don’t know what happened
@@NutritionLibrary Its all good homie. Recently just found your channel 3 weeks ago. I watched all of your content, keep it up bro it’s much appreciated. Nigella Sativa next?
It’s coming up!
The audio is 12dbs too low!!!
I bought a sunflower lecithin derived extract of PS
good stuff!
Where is the soy free brands extracted from?
Your volume is extremely low. My Bluetooth speaker, broke, so I can't turn up the volume enough to hear you without putting my Peripheral to my ear, hope you have no graphics.
do you prefer Phosphatidylserine from soy or sunflower
Lovely video Zach, as always! Just a quick note about 5:47
ATPases do not produce ATP. Their name implies that they breakdown ATP in order to release energy that can be utilized for some other function in the cell. In contrast, ATP synthetases produce ATP. That's all :)
Yes. That’s what I meant to say 😅 But technically I think it’s a reversible reaction whereby ATPace both catalyzes the formation and breakdown of ATP. I could be wrong though. It’s been a few years since I took biochem.
@@NutritionLibrary For sure, it is possible! Can you reference that paper? BTW, your video made me place an order for Jarrow's Phosphatidylserine because it is from Sunflower :)
I am excited cuz I took it a year ago and it was from soy and was too sedative to me such that I am sleepy all day the next day when I took it the night before. I think it was cuz I was using a prescription that was sedative at night. Now that that thing is almost gone from my system, I wanna give it a shot but from Sunflower Lecithin
The volume is too low.
I get my phosphatidylserine from sunflower letchin.
Thank you! Btw, I have noticed one side effect, insomnia. If i take 100-300 mg PS in the evening i cannot sleep until after midnight.
Stay safe
Interesting! I’m the opposite. I sleep like a rock. Maybe you have an allergy to an ingredient. Why brand do you use?
I tried this supplement a few years ago to enhance my workouts. It worked great but even though I took it early in the day I had a hard time sleeping. That's why I quit taking it. Anyway I may give it another try. Excellent video!Thanks
Try the double wood brand. Actually tends to be more calming than stimulating
I am Immediately found side effects for upset stomach and insomnia
Definitely uncommon. May have had an allergy to a filler in the product
How long did the side effects last
Could you make a video about Iodine? Its difficult to parse the science from the pseudoscience.
Coming up!
@@NutritionLibrary Awesome!