Critical Concepts in the Nutritional Support of Mitochondria
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- Опубліковано 6 жов 2024
- Mitochondria are the powerhouses of the cell. While so much foundational science education is placed in understanding cellular energy production through these organelles, this focus is often lost in broader healthcare and nutrition practice. Yet because they are the energy source of the cell, the influence of the mitochondria is central to human health. A loss of mitochondrial function and increased cellular dependence on glycolysis has been directly linked to a variety of neurodegenerative and chronic diseases, including ALS, Parkinson’s, and cancer.
There are several dietary and microbial factors that influence mitochondrial health. As mitochondria suffer from excess oxidative stress, their capacity for aerobic respiration declines. Although carbohydrate metabolism can often compensate for decreased fatty acid metabolism, it fails to provide many types of cells with adequate and physiologically appropriate energy levels. The associated energy deficit is responsible for a loss of organ and/or system function.
Further, research has consistently illustrated a decline in mitochondrial health with age. However much of the damage that occurs in the aging process is the result of chronic imbalances between reactive oxygen species and antioxidants available to the mitochondrial membrane. Additionally, there are microbiome-generated and environmental toxins that have a deleterious effect on mitochondrial metabolism. Many of these exposures result from daily food and ingredient choices.
This discussion will review cellular energy production through fatty acid oxidation and metabolism and highlight the etiology of mitochondrial pathology, those factors that contribute to a decline in function, and the nutrients/foods that can provide significant risk reduction.
This video deserves a lot more views.
The key points about excess fructose from about the 28:00-32:00-38:00 mark deserves a repost several times a year.
it has so much information even if you do not like who is talking, have more omega 3 and less omega 6, Fats Cooking OIls, Corn Syrup Fructose, etc a lot of people live with chronic inflammation and do not have a clue what they eat builds up plaque in your arteries have more heart attacks, not enough Vitamin D so sad Western diet has become an epidemic on its own the last 40 50 years changing the food supply processed food not real food anymore.
Fruit juice is as bad as soda imo
An automobile can not operate with a faulty engine. The 'engine' of the human body is not a huge organ, it is billions of tiny organelles. Perhaps it is their invisibility that has side-tracked medicine for generations and hindered us from realizing almost all disease states have their roots in metabolic dysfunction. Health of Mitochondria is paramount!
Correct...this is why animal density..is best for mito efficiencies.
Cross out billions, friend; replace with TRILLIONS 💜!
Changing my diet saved me from debilitating back pain, nerve pain, joint pain, muscle pain, digestive issues, raised blood pressure, 20kg over weight. It took around 8 months for all these problems to resolve. Since 2020 I've been completely pain free and never felt and looked healthier.
I'm only eating fatty meats, seafood, eggs and dairy.
Prior to that I was eating the mainstream version of a healthy diet (lots of veggies, fruit, whole grains, low fat, eating the rainbow etc) for decades and watching my health slowly decline.
I learnt lots watching videos by Dr Ken Berry, Dr Shawn Baker, Dr Gary Fettke, Dr Benjamin Bikman, Dr. Malcolm Kendrick, Dr Anthony Chaffee, Dr Paul Mason etc.
And these authors videos Diana Rodgers, Robb Wolf, Lierre Keith.
I read this peer-reviewed scientific article, that shows how 2,029 people had amazing results on the diet I'm on it's called "Behavioral Characteristics and Self-Reported Health Status among
2029 Adults Consuming a Carnivore diet".
Absolutemon George but what made you eat that junk in the first place (lowlife gov propaganda nodoubt!) KarnivoreRock&roll 😁
@@Asduyrinteresting centuries of anecdotal data about proper nutrition. Extensive studies score eating a balanced diet fruit vegetable lean proteins and healthy fats is the best diet. Lowers all forms morbidity and mortality. Americans eat on average 60% of their calories from refined sugars and simple carbs. Remove this from diet and it won't matter what you eat as long as whole foods. Every study shows this and also don't eat in excess we make it too complex
Centuries of proof! we only ate fruit in autum whilst it was abundant! putting on fat for the cold winters in the northern hemisphere, our digestive tract is carnivore. Whats yours like ? a sheep or a goat? - probably not! @@jboogs49
@@jboogs49the thing is, cutting carbs to little or none makes it easier. I have cut "calories" over and over and it was never sustainable. Even a "healthy" apple or bowl of oatmeal will have me craving more carbs. If I cut these foods (as well as processed grains, etc) all together, I have no cravings and can stick to a healthier WOE.
This may change as I return to health, but I'll stick to low carb/keto for now.
Teach it!!!
Amazing video! I'm going through the exact same thing now. Cutting my Omega-6 fatty acid consumption solved many of my problems. The entire western diet is built upon Omega-6 fatty acids. I have a severe autoimmune disease to boot.
Smart...and eat more animal foods.
Kefir (fermented milk) helps a lot with autoimmune. As does fermenting your own veggies. The water is healing. That's the only veggies I consume and it's like a thin slice of fermented carrot or cucumber per day and that's it.
Thanks for a well balanced rounded lecture presented in a well balanced neutral approach without selling,marketing,scientific honest way.
Definitely marketing a non whole food supplement at end of video. Disappointing.
Regarding last question about brain health, mitochondria and the retrieval of carbohydrates from your diet Chris Palmer wrote a book called brain energy centred around metabolism, mental health and the key role of mitochondria. You'l find him on many podcasts here on youtube and what he describes is quit fascinating - and in line with subject of this video
Thank you! Lustig et al. clarified much of this initially to me, and this comprehensive additional summarizing is essential for incorporation into my understanding. Public health is in dire need of this information becoming provided by the medical paradigm, but given the 'capture' of the general medical system by 'profit at all cost' educational propaganda, not likely to be turned around any time soon. Education of individual doctors is primary to focus on, this is desperately needed IMHO! This is essential work for societal change, thank you.
Dr Lustig says the same as this lecturer , regarding seed oils , fructose , and excess carb affects on insulin resistance.
So back when… ah hem, everybody was spewing the mantra,
“I think everybody deserves healthcare”
My rebuttal was:
“I think everybody deserves health”
BIG difference!
Thanks s much. Excellent information here and very succinct.
This lecture is jam-packed with fascinating facts that certainly can build understanding and motivate us to take better care of our mitochondria and, thus, ourselves. Thank you! I’ll have this lecture on replay for sure!
There is one thing I know
We are no longer Hunters and Gathers
We are chain stores eaters 🤪🤪🤪
Now that’s where the problem lies
Once again thank you so much for this beautiful presentation.
Still leaning the terminology and big words😬😬🤣🤣🤣🤣
Could you comment on using pharmaceutical grade methylene blue as an aid in electron transport chain complex 4 in mitochondria
The comment is that it works but nothing except eating steak will make you super human.
Thank you. Thank you. Your ability to explain things so clearly is much appreciated! There is a lot to absorb here, so I will listen to it multiple times. Well worth my time. Kudos to the researchers! Kudos to those who take the time to explain things to the general public, like me. 19:41 -- Audrey F.
l love Dr Pius Ozigbe! My daughter and I loved watching him and his sister in operation Ouch and his "Dr who gave up drugs" He seems like such a genuine, empathetic, no bullshit guy who genuinely cares and makes complex issues easy to understand for the lay person❤❤❤❤☺️☺️
Great presentation! I understand now why so many are having health improvements by eating low carb and more saturated fats. It's as much what they DON'T eat as what they DO eat, meaning no sugar, no seed oils...and more protein. I love my mitochondria!
There is a problem though...my retirement job is on a golf course, inundated with toxins. I steer clear of the sprayers and chemical building, but sometimes it's unavoidable. I wonder what the life span is of those on the grounds crew, compared to others.
Thanks for the information.
Very informative, useful, and helpful! Thank you.
Dr. Bagnulo, thank you for your excellent lecture! Please consider doing more presentations as you explain metabolic concepts in a graspable manner.
I find high quality spirulina gives me lots of energy and causes no inflammation. (most other foods do). so it's a staple for me. (but costly.)
Excellent information. Thanks for sharing.
Wonderful presentation.
Thank you! I just gave up applesauce~unsweetened, organic. But thanks to you I realize it might be causing me problems!!
"An apple a day keeps the doctor away"
Since Spirulini is a blue green algae and so is Chlorella would you say people should steer clear of them?
Better tell Bryan Johnson of the blueprint protocol. He’s taking 2tbsp daily of chlorella to increase spermadine levels which is tied to longevity and increased autophagy levels.
His source is a lab grown strain.
Wheat grass juice and seaweed in the regular diet..better.
It’s pond scum?
Pond scum? But so is our gut. It supplies nutrients for the nucleus and helps to clear out waste product in our gut while expanding the life span in mitochondria and supportive tele guys. If you have adrenal dysfunction it may have your body over compensating and out if your good fats are not balanced and or have a balanced minerals in the body. I just logged on to here what he says so I may have spoke to soon. But I love my scum pond tablets. I personally notice a big difference.
Absolutely incredible 🙌🙌🙌
I was put on a diet when I was very young. It involved a lot of veg and bread (six slices per day the slogan at the time).Mind you the veg was fresher and local.
My mother was told to give me chicken and fish. But as she had five children she could not afford good meats so we got a lot of potatoes bread and veg. Me on a diet I got less so I was always starving. And ended up my body stored any surplus so I just got fatter.
Eventually after loads of health problems I was diagnosed b12 deficency and placed on injections.
My GP asked what I ate I told her I needed a bar of chocholate to get out of bed I had no energy. Low mood all the things that goes with being overweight but nutriently starved.
She advised red meat and I added butter. I take no potstoes now and only mushrooms and tomatoes and onions and peas. Cheese once per month and loads of eggs I dont drink milk. Fruit a few oranges in the Autum time.
I am ketosis unless I have a holiday.
But I do feel much better and the fat is disappearing in favour of muscle. I also take vit d and magnesium.
Blue green algiae is killing our fish and also dogs who go into the water. Its the high volume of processed cheap foods that is killing us.
Great viideo very informative.
Thankyou
Bless you!!! Listen so carefully to your body and you will not go astray....Keto often does wonders but i have herd it said that the timewill come when it will be time to go more toward palo
Mitachondria are healthier without the ingredients in processed foods .Unfortunately , most ppl don't know this .We really need to teach ppl about the long term effects of processed food "ingredients" , and how keto / carnivore etc can prevent those long term affects .
Thomas, please do video on fructose and methylglyoxal. Just watched a video that said excess fructose can harm the mitochondria through the formation of methylglyoxal
Brilliant presentation
18:14 usually promoted as healthy , but the Olive oil Omega 6-3 ratio is 10:1 🤔
Any association of liver/bile issues (enzyme/postcholecystectomy etc) and fructose/lipid pathology in brain (ataxia's)?
Excellent video ! Congratulations Dr. Jhon ❤
If fruit is bad, why is it the preferred energy source and why is it able to pass through the membrane without a transporter?
He's conflating high fructose with natural fructose. Common miscommunication on social media.
@@we_are_all_the_same glucose alone is worst than fructose
CARROTS, CELERY, and BEETROOTS for MITOCHONDRIA . 😅
Nope as these are high in oxalates
I'm more scared of pesticides rather than oxalates
NOT lower carbohydrate levels, but, lower REFINED carbohydrates!
Beautiful presentation
Love it ❤❤❤❤❤🐝🐝🐝🐝😊🐝🐝
Isn't the fructose found in whole fruits beneficial for you because of the fiber?
No, it's less bad for you because of the fiber (fiber slows the absorption of the fructose so your liver doesn't get hit with it all at once, like with juice). It's still not good for you in doses over what is suggested in this video.
People keep conflating high fructose corn syrup and fructose. Now modern fruit does have 30% sucralose and glucose and 70% fructose. So eating too much fruit isnt great cause it's gmo changed. However, these studies are on processed sugars, which are polysaccharides not monosaccharides. Sucralose and glucose fall in that category, not natural fructose.
Natural fructose doesn't need insulin to get into the cell.
@@we_are_all_the_same I don't know where you get this notion that natural fruit contains anything other than the majority of not a hundred percent fructose the way it was originally designed.
And also remember that even if your assessment of the different sugar is in the fruit is correct, the fibre in the flesh and the skin of the fruit mitigates the sugar spike.
Great talk!
I say
We are not even treating the sickness of disease
We are only returning back to the diet
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Be forewarned: Not a high level mitochondria talk. Regular low carb stuff.
Thanks, saved me an hour
There is no talk about palm oil, especially for frying
In his defense, I think it would be impossible to list everything. 😊
Is supplementation with blue green algae, like spirulina and/or chollerla, good to do? Or are these supplements detramental to mitroconina function?
Fruits have always been the main substance for chimpanzee s and great apes. They knew to move around to different locations to find ripe fruit.
How come vegans have a higher uric acid production? What has higher uric acid production beans, certain veggies, or fruits?
Black beans will be metabolised into purins when digesting in human body, this process results in higher uric acids in human body.
@@ducvomanh2389 exactly not fruits
They eat a lot of carbs, which feed fungi, mold, bad bacteria, etc that leave more uric acid behind.
Like grains
When fructose is metabolized by the liver it must have phosphorus attached to it before being used for energy, this is called phosphorylation. That process creates uric acid as a byproduct and is the reason why diets high in fruit are associated with higher levels of uric acid
Great info!!!!
I know a lot of fruiterians that have been thriving on fruit and greens for many years?
It means they have a certain biome that can behave like a ruminant and turn vegetation into protein, assuming they have not lost muscle mass. It is rare to have such a biome.
@vanessac1965 thank you
They probably don't have MTHFR variations and their haplotype and proximity to the equator helps them metabolize carbs more.
Their depletions will eventually come. Sarcopenia etc.
Dr. Jack Kruse, Dr. Zack Bush.
Thank you!
missing so much. go back to school
In which organal of the cell, most communicate with mitrochondria, is it the neucleic dna?
The greatest change is going to be to get all the excess bad fat off your body and get your BMI down before you do any of this other stuff. Good luck
Doesn't fiber along with water in certain fruits, lower the bioavaialability of fruitose in the body (a good thing). Example: watermelon.
In my opinion as a Nutritionist- taking into account blood types (Rh+\_) because blood type O’s may not thrive long term with being a vegan or vegetarian successfully. It’s really rare and function or their blood (the cells- mitochondrion’s) may function differently in regards to what may work for that individual.
Blood type sounds abit broad, I’d have thought genetics would be more specific.
I have a question
What about Macadamia nut oil ??
❤❤
I looked it up... Macadamia is a fruit, and the oil has a higher smoke point than olive oil!
What is Omega 6-3 ratio??
@@eugeniebreida1583 Despite varying conclusions in the literature, in general, the ideal n-6:n-3 fatty acid ratio is 4:1. This means that you should aim to eat 1 gram of omega-3s for every 4 grams of omega-6. [2,4,5] The Dietary Guidelines for Americans 2020-2025 recommends that adults consume 1.1-1.6 grams of omega-3s per day
It’s excellent for many reasons but the best attribute is that it is very stable and contains no polyunsaturated fat in significant quantities
I’m taking a new formulation that supports your current mitochondria and also increases the mitochondria in cells. People are getting miracle -like results. 😀
What is it?
A meat based diet would be much better!
I think your argument is contradictory. Your saying the population is suffering from an energy deficiency yet your saying fructose is bad, without really distinguishing between fruit and high fructose corn syrup. Unfortunate.
Are you in the fruits business?
@@upner4169 I'm a person thats tired of the conspiracy going around about fruit. And the ignorance.
No other species on earth consumes oil, don't you think that's a bit strange??? Think about it, take your time and think REALLY hard.
May I ask the ID of the speaker pls?
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Plant-based diet?! No thanks. I'm surprised you can suggest that in 2023. 🥺
Surprised? I thought many more people nowadays are aware of the benefits of a whole food plant-based diet. So, I guess that I am the surprised one.
Thanks for the laugh Greg. Saying "benefits of whole foods" is like betting on the horse posing as a unicorn. There's no reason for that wholeness or horn to do any magic at all.
Plants contain many substaces we need to stay healty and many that are detrimatial for us. To eat animals that have chosen their food, like game or pastured cattle, give us those too. Industry meat don't. For us who are tolerant to plants, plant based are healthy.
@@atlet1 In addition to the oxalates, plants have high levels of deuterium and glyphosate, which meat typically does not. Organic might be better, but I really don't know how anything I buy was grown. For me, animal-based makes the most sense.
@@atlet1 please name one substance i need to stay healthy that comes from a plant. I'd also urge you to look beyond your current horizons.
Just eat meat
Trehalose.
You had me up until you suggested plant based. Sorry but it just doesn’t work for me. Have cut out all plants and has changed my life for the better. Will never eat another plant.
Bryan Johnson Blueprint, Ai will soon take the guess work out of it and all gurus and snake oil salesmen will soon be gone. See you in 2500. Don't die.
No because A.I. is based off the medical industrial complex that censors Google which is based on A&P books, which are pill and surgery centric.
I was going to give a thumbs up until you promoted a non-whole food supplement at the end of the video. So disappointing.
I wonder who your audience is. In spite of the glowing comments below, I thought your talk just wasted most of mey time since it constantly contains names of chemicals and biological reactions I am not the familiar with. I cann eat or refraind from eating words. Best wishes anyway.
This guy has succumbed to seed oil hate. But there is zero negative evidence on seed oils
You are so wrong, seed oils and sugar combine are like little bombs going off in your body
Some very interesting videos by Dr Chris Knobbe on this. I found him quite convincing.