Supplements in Sinclair's AGE REVERSAL Study + One You Should Know About!
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- Опубліковано 30 вер 2024
- In the last video, I shared a recent age reversal study by Dr. David Sinclair and colleagues at Harvard. They said they found 6 chemical combinations that were successful at age reversal in their study. Here I share the specific supplements, medications or molecules used. And I save the most interesting one for last - Ca AKG.
See my previous video about the study here: • David Sinclair's NEW S...
Please check out the link to my post below for more info, or let's all chat in the comment section below! - Holly
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STUDIES & SOURCES⤵
Study - Chemically Induced Reprogramming to Reverse Cellular Aging:
www.aging-us.c...
Study on aKG - www.ncbi.nlm.n...
Study Doc Containing List of Chemical Combinations: www.aging-us.c...
My Post - Here I break down some of the study details that I find to be important and interesting:
lifeanddiy.com... & you can find a link to the file which contains the chemical compounds that were said to be successful in the study.
Sinclair video clip on aKG - I cannot find the original source for the video! I used a clip from a channel sharing a clip. I will continue looking around for the full original video and I'll share it here if I find it.
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MY AMAZON FAVORITES SHOP⤵
www.amazon.com... *
Affiliate Disclosure: * Some of the links are affiliate links and I may earn small commissions if you purchase through them.
#davidsinclair
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DISCLAIMER⤵
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I am 73 years old and have been following David Sinclare and others about the reverse aging Protocols. It is working for me. All my Bio Markers are about the age of 40... and I feel 37 not 73... This is real ...
@Dana_Swan_711, please share what you are doing.
I focus on increasing Mitochondria & ATP = Youth
Very interesting. Can you name the supplements you are taking? Thanks.
Hi. You feel 37. That's subjective. It does not mean any of these magic supplements reverse age. You can feel good just by eating better and exercising. Please with this. Since you feel 37, can you move, run, etc., like a 37-year-old?
Anyone can feel anything. It does not make it a fact. How's that GIGANTIC PLACEBO AFFECT TREATING YOU!!!!
Let me get this right. These Sinclair supplements reverse your biological age back to 40, eh? A 33-year difference? Unbelievable at the stuff you hear on UA-cam!
So, I guess you don't work out or eat right, etc. The magic pills did that, eh??? And damn, you also hold the world record for the biggest increase in biological age. You need to contact the media about this. This is revolutionary in the longevity space.
@@60-Is-The-New-30 Come on. He didn't mean it literally. Let someone be happy. He feels much younger, that's it. These chemicals have been proven to reverse aging in smaller mammals. There was a time when people said that man will never be able to build flying machines, even never be able to cross oceans. Look man has reached the moon. If you are not interested in anti-aging research, then please don't visit.
Crazy that you’re 40! You look 33 and gorgeous
Aww thanks! 🙂
I thought 30! Very impressive!
I'd say 28...
29 max
@@LifeDIY i disagree
You dont look older than 25 .
I took NMN and resveratrol for several years after Sinclair's book came out, but have since replaced them with caAKG, TMG, and NAC, in addition to my usual dose of D3 and K2. I'm 76 and active, working out everyday and maintaining a household. I can only compare myself to others my age that I'm acquainted with and I seem to have fewer physical ailments than they do. I can't really attribute it to the supplements or exercise, but I plan to continue with my regimen for the time being.
Do you take anything else? TIA I've just run out of resveratrol and am wondering about whether to continue - expensive.
@@bellakrinkle9381 That's one of the reasons I stopped taking resveratrol and NMN. They got so darned expensive. CaAKG. TMG. NAC, D3 and K2 are the only supplements I take now. I have lots of energy and haven't been sick with colds or flu in years. (I do take an annual flu shot)
be aware that Sinclair is not right about dosing of Resveratrol. One should take only 100mg every day, and every month for 2 days 1000 mg. One can combine with 50..100mg fisetin or quercetin.
Sth which almost everybody is missing out is Vit. C in combination with green tea , 1000 mg Vit C, and 800..1000ml of green tea daily. (before 3pm), plus Olive Oil.
About NMN: I am not convinced from my own experience. something is missing in the equation by just taking that. some are pointing out that it can exert the opposite effect due to respective feedback mechanisms, and be even detrimental regarding sirtx activation. I am just starting giving a new try by combining NA, or NR, together with Taurin, Quercetin, Rutin, caAKG, and adjusting the Gym routine (more zone 2 and more VO2max training)
I have been taking NAD+, NAM (probably redundant to NAD+), NAC, TMG and Pterostilbene. I am going to look to add caAKG now; researched it over a year ago and forgot about it. FYI, pterostilbene is better and a substitute for resveratrol; more bioavailable (20 times) and stays in the system up to 7 times longer so you need less daily.
Where to buy caAKG TMG and NAC also what brand you take for D3 & K2
Well if you are 40 1 you are either lying or 2 you are def taking the right stuff 😅
Yes your correct that Berberine lowers blood sugar as does metformin but don't bother doing resistance training while on either of them as both prevent any gains in strength or muscle growth while using them which is just as important for health span as taking berberine might be yet is proven not to be of benefit just like metformin.
I'm taking a ton of supplements, some for anti-aging and others for general health. My problem is that there are so many others I'm hearing about that I'd like to try, but my budget can only be stretched so far. Also, swallowing lots of capsules or mixing up lots of powders gets old after awhile.
Swallowing pills and mixing powders “ gets old”…🙄…😂
(The irony in this sentence….😃.)
Basically your attitude only means that you don’t have a well established structure in the supplements regimen that you’re taking because you think it’s a fad…and you want to try “other things” ….
if you have your basic foundational supplement system and a few which are addressing specific issues , others enhancing your well-being - you don’t have to try new every month!
so many new things have come out and they do absolutely nothing….
. Stick to your basics…. I’d only things that are absolute peak in latest research
Wow you look dam great for 40. Whatever you’re doing is clearly working!
Thanks! I'm a pharmacist that designs aging/metabolic drugs, I have a patent pending. Aging appears to be microbiome related (epigenetic) and not genetic. ...Not a fan of Dr. Sinclair, BTW.
I am a fan of Dr Sinclair
@@peterm5554 I'm a fan of the truth and using scientific method!
Thank you!
Hi...can I ask why you are not a fan of Dr Sinclair?
@northshoreplaid
Isn’t David Sinclair also a fan of the scientific method?
How else did he manage to cure blindness in mice and monkeys?
How did he manage to get on the front cover of Nature magazine if he didn’t follow the scientific method?
Wow, ur hair is so nice and thick! Please could you share your hair routine, both food and supplements and shampoo etc.
Thank you! I'll try to do videos on these topics coming up. :)
I don't think taking just an individual supplement such as forskolin or even Ca-AKG would be able to trigger all of the necessary genes that are needed to work together for the four Yamanaka factors genes that do the epigenetic age reversal/reprogramming. Ca-AKG seems to work much better for females than males, but still is only a 10 to 15% effect on lifespan, though it does do some amazing things for physical rejuvenation as shown in the video, again probably mostly in the female mice. When I took Ca-AKG it gave me loose bowels which is unsustainable because of adverse health effects with gut malabsorption of vital nutrients and it has a possible pro-inflammatory effect on the gut (another person reported this too) I did a read a paper suggesting that some polyphenols have epigenetic reprogramming effects on methylation groups but was not too compelling about age reversal. I do think there may be a combination of natural bioactives out there that have yet to be tested that can do epigenetic age reversal. The U of Mississippi School of Natural Products did a bioactives screening program and found three plant extracts that are commonly available that can activate the Nanog gene related to the Yamanka factors that affects epigenetic reprogramming. Nanog was separately shown as to "demonstrate reprogramming of DNA methylation and histone modifications on regulatory regions of the developmentally regulated OCT4 and NANOG genes by exposure ". The botanicals in the UMISS study were glossy privet seed, and Chinese chives and Russian tarragon of all things!
more on Nanog: "Nanog has been widely studied as one of the heterogeneously expressed genes in ES and induced pluripotent stem (iPS) cell populations [13, 14]. It plays a central role in maintaining the cellular self-renewal and pluripotency.
I don't know about a longevity stand point but AKG has been a game changer for me as far as energy thru out the day for work. Ran out and can't believe the difference can't wait for it to get here
To me david sinclair is a bit sketchy. If you take away the filters when he uses web interviews he doesnt look any younger than his age of 54. This is a guy who has spent decades on anti aging too. Then you throw in his nmn and resveratrol controversies and it's hard to trust him.
AKG by itself is very acidic to the gut, so if you take it straight without being complexed with calcium, arginine, ornithine, etc., you may get some stomach stress, especially since they recommend taking it away from food. I found a way around that though. I put one tsp of baking soda in a few ounces of water in a glass, then in a separate glass I put in the AKG powder {either dump the capsule, or use the straight powder}. Then I start to add the baking soda water to the AKG by the teaspoon, and when it stops fizzing, you know it is neutralized, plus when you taste it, it will not taste acidic. I do this with AKG powder, because Ca-AKG is too expensive, and I don't know why since the only other ingredient is calcium, which is cheap as dirt.
Your beauty is distracting. Picture of health
This is the first video of yours that I'm watching, but I couldn't believe you are 40yrs. You look like you are in your 20s!
Thank you so much for stopping by and watching!
Thanks. On AKG, you might be interested in a presentation by Adam Antebi on the NUS Medicine (Brian Kennedy) UA-cam channel. Starts at 7 minutes in. My take away is the low insulin appears to increase AKG (and NMN) at least in model organisms. Would be interesting to test humans with to see if the relationship holds and what the threshold for insulin might be. Low insulin is already known to be important. Seems to me that fine tuning diet and exercise (and sleep and stress) to modulate the various aging pathways is first line of defense. Also need better and cheaper testing to assess our own status as we experiment, especially with supplements. Even though I take a number of supplements I am skeptical about dumping bolus amounts in the body without consideration for circadian effects etc.
Thank you. I will check it out this weekend. I agree about how more testing should be done (in humans). I also wish there was cheaper more accessible at-home testing.
I think ornithine keto gluterate is better
"You're getting a little bit older than me." Yes, that did not come out right. Folks that are older than you were always older than you. I think what you meant to indicate is that some of the audience is falling apart and that they better do something about it fast (perhaps with untested supplements) . These older people essentially already have one foot in the grave, so it's okay to throw a little caution into the wind.
This post was made in jest, so don't take it seriously.
Thanks, Jack! :))
You look in your twenties 😇👍
I would wait for more research with the cocktail of chemicals you first discuss. I suspect most of the work on that cocktail thus far has been in cell culture, not in living animals and definitely not in humans. The AKG should be pretty safe since it is a part of the glutamine/glutamate cycle that is involved in cellular energy metabolism, with the caveat that if you have cancer it may make the tumor or cancer cells grow faster, since glucose and glutamine are the two primary energy sources for most types of cancer cells (Warburg Effect). Taking AKG will boost that energy pathway.
Glutamine - yes, but the sugar being the fuel for cancer is a myth. Cancers thrives on fatty acids. The warburg effect is that the cell is unable to oxidize sugar properly (which causes the cells to turn cancerous) and the cells start to ferment sugar (many times less efficient than oxidizing), which causes the buildup of glucose and CT scans see massive amounts of sugar in cancer cells.
Just eat healthy, exercise and avoid alcohol consumption
That's great advice in general especially if you're young, but older people who want to live longer will probably need more powerful interventions.
Hard to eat healthy nowdays when fruits & vegetables are sprayed with poison, dairy & meat are injected full of hormones & antibiotics ... 🙄
Great information on the stack of suplements. If you include Methylene Blue in this stack it will help mitochondrial energy and a plethora of health benefits including anti aging, skin and boosting your brain health.
I have the genes that make you age super slowly. I get it from my mom. People think im college aged, but i’m 43. But i dont take it for granted. I eat a super healthy diet and i take care of myself
Some more available supplements for life extension just discovered are: Astragalus extract, Cats Claw Extract, Ashwagandha K-66 Extract and Free Form L-Taurine 1-3 grams for adults FYI
Cats Claw is big in Lyme treatment
I take Ashwa daily but not for life extension. Can you refer to a study? (Yes I will also do my own research again) Thx
40? I would have guessed much lower. If you dont mind me asking, have you had any work done?
Well, thank you! I have not had any work done. I get asked this on here from time to time. No botox, fillers or procedures. I'd look younger if I had an extra 10 lbs on me though. :) I gradually lost weight over the last year or two, which was not intentional. I'm working on getting more muscle and more fit now.
Even though you found yourself dancing around the older age thing (charmingly so)😊…they were really good points you made about age groups, individual circumstances, the validity of studies, and ultimately big business bias…Those things are bound to cloud many peoples judgment on a lot of this. Thanks for sharing the info Holly, It’s always interesting…I’m now off to learn more about AKG.
Thank you, Joe! I appreciate that.
Wow Holly you do look so much younger and may I also say very pretty too
Do you know what happens with the Ca in Ca Akg
Just concerned because of past heart surgery and don't specifically want too much calcium in the arteries even though fermented foods and K2 should prevent that Holly
Love your work and also love David Sinclair's work too ❤😊🖐👍👌👏
@@ianwallis3773 It's a lower amount of calcium that goes along with AKG, 190 mg compared to the 1000 mg AKG part. I think it takes large excesses of supplemental calcium of 500 mg to 1000 mg to be a health risk for vascular calcification and having a vitamin K2 deficiency (as you mentioned) and also a pro-inflammatory/ high blood glucose milieu at the same time. The Ca AKG Rejuvant product might be patented by Brian Kennedy's research group/company and it has a steep cost like $90 a month. Regular AKG is not patented and I think its possible to take a low dose calcium supplement of 190 mg such as from calcium carbonate (a weak base) with 1000 mg of AKG which is acidic to form a buffer pair that corresponds with the same ratio as used in the Ca AKG supplement. From the chemistry point of view AKG is a weak acid and Ca CO3 is a weak base so the reaction that occurs likely results in some Ca+2 ions in solution and some bound to the AKG molecule of which Kennedy suggests the Ca part is important for its absorption in the gut. Most Ca antacid tablets are about 400 mg of elemental calcium (as 1000 mg of Ca CO3) so I had cut them in half and then took it with the AKG at the same time to get the 200 mg of Ca.
Id be happy if I could marry a girl that looks like you when 40
Great introduction around risks and paucity of research. I wish more in this space would include something like this.
Thank you so much. I appreciate your comment on this! I would love to talk about this more in future videos, exposing this topic way more. I think many people have had a basic level of trust in studies. These studies can make companies an insane amount of money, so everything should be questioned. It's becoming harder and harder to find studies that were not funded by companies that are going to profit from the favorable results. The other thing to note is what I mentioned in the video, as some products that we may be taking as supplements have very little, or very weak research on them. I think it's just best to be aware of that and then you can decide on taking it or not. I wish someone could do a documentary on this.
Valine potassium astraxanthin kelp spirulina b complex so underrated milk thistle
I have a hard time listening to anything Sinclair says. He has such a shady track record.
It's impressive how beautiful you really are. You don't need any of this antiaging products
I've been taking NMN (1g) and trans-resveratrol (500mg) supplements for 6 months, and I've noticed increased hair loss. My hair is thinning, and my scalp is showing. If I stop taking these supplements, I notice that the hair fall halts.
possible link between resveratrol, cell stress, and hair loss. They are implying that if resveratrol does indeed stress cells, it could be a contributing factor to hair loss. Has anyone experienced this? Any advice?
I have never heard of this happening before and it's hard to imagine the cause. Have you tried taking them separately? It might help to ask this on reddit here: www.reddit.com/r/NMN/
I just saw a video of yours from 3 years ago and you look the same or even younger, keep up the good work, im trying to take good care of myself as well
Thank you! That's so nice of you to say. I too am just trying to stay as healthy as possible. :) I love that some people care about their health nowadays.
Actually you look 27-28, great videos!Also I tried Akg and it didn't work,but recently I found Glycine and it works! Taurine is my #2!
Thanks so much! What are you taking the glycine for? It is one of my favorite supplements. I am going to start taking taurine soon too.
@@LifeDIY I take Glycine for spinal problems, taurine for mental focus and stamina. I will research more and if I find nothing, then Perfect Aminos from advanced bionutricionals is the way to go, BUT for the moment I'm happy with my results, cheap and effective.
How did you know AKG didn’t work ?
N acetyl cysteine (NAC) and glycine are a potent combo. I take 2 to 3 grams of each daily. Glycine helps to minimize the effects of glyphosate which is in nearly every food and in tap water too.
Geeez you look like 26-30. 😊
40? Haha... this girl is in her 20's!!
My issue with all of these mice studies is that it's becoming increasingly evident that, while we have a lot of similarities to mice and they're convenient test subjects due to their short lifespans, there are also substantial differences between us. A ton of supplements have emerged over the past decade that, in some cases, supposedly increase mice lifespans by around 50%.
I believe it was Fisetin or Quercetin that was recently suggested to have increased mice lifespans by around 40%, and there are several other ones that had dramatic effects on mice and were advertised by people like, Dr. Sinclair as age reversing. However, the vast majority of these supplements have had little to no effect on actual human test subjects.
And that's fair. It was always naïve to assume that we suddenly have access to so many substances that can extend our lifespans, but I do have an issue with how they're being advertised right from their testing on mice. It's likely to provide misleading expectations, and I think it's a dishonest practice by the people who are viewed as key figures on the subject of longevity. I'm not saying that these supplements don't have any effects at all, people have reported increased energy levels, lowered blood pressure and whatnot, but in most cases, the life extending effects are debatable at best.
you look 29 btw and more youthful beautiful skin than most 25 year olds (and of course 18yo often have acne so...)
She look good Af for 40
I really like your videos and how you present the different supplements in a fact based way. I am wondering with many of the cautionary tales of supplementing with calcium (especially if one doesn't have a bone disorder), if taking CaAKG is a wise move. Just my thoughts and question. I have been taking AKG for some time now. Since my health is good I have not noticed anything significant on a upward swing. But regarding the calcium, we get plenty in our diet, unless again there is a bone density issue, and excess calcium can easily end up in tissue, ie, on our artery walls. Taking K-2 can definitely help with the D-3 we get by placing the calcium in the bones where we all want it. Personally I do not supplement calcium. Does this make sense? Thanks again for your videos!
There is not much Calcium in Ca AKG supplements, I think less than 20 % somewhere around that percentage. So if you take the recommended dose you are at 200 mg of Calcium which should not cause any issues.
Thank you! This is a great point about the calcium in CaAKG. Thanks for mentioning that. Is your supplement AKG without the calcium? I personally stay away from any calcium supplementation. I just looked around on Google for products selling CaAKG and I found one and it stated more details about the ingredients - in a 1500mg serving, they said their product contained a minimum of 315mg of calcium (in the form of calcium hydroxide). Most products don't have those details listed and some of these products or sites do not look legit. Now I'm wondering if CaAKG is so much more bioavailable - what kind of difference in absorption is there? It's hard to find solid research on this. I have so many questions now!
@@IloveCamels335 Thanks for the comment. I think 200 mg is not too high, but I just error on the side of caution regarding calcium. I figure if I am taking a supplement that is maybe 75% making me anti-age (everyone is so different when it comes to how much supplements 'supplement') and the same percentage (or even much lesser of a percentage) that maybe the calcium is ending up in my arteries, then I'll take the AKG without the calcium, though I may be getting a lesser value of the AKG.
@@tom7471 Yes your reasoning definitely makes sense 👍
@@LifeDIY Thank you for the response. According to the reviews and answered questions from the company I buy my AKG from it is not CaAKG. Which, of course, like you say, has to beg the question, 'Are we getting enough AKG in our systems?' from the none calcium form. There is definitely a problem with companies not showing the derivation of their supplements. One has to search and research sometimes to find it. I would say that the better companies do let it be known on their labels, even if they are the higher costing ones. But one can even be fooled by that. Sometimes the less expensive products are every bit as good. Of course I look for the GMP, and if it is third party tested. And I take a lot of supplements, but ones I feel safe taking, that are studied a great deal with pretty much great track records. AKG is one of the most iffy things I take, actually. Of course to eat good and clean, and exercise, both with autophagy in mind, is perhaps for most of us the ultimate way to have a wondrous health span, and to be kind and mindful (the latter being so 'unscientific' ha ha).
I am curious about this trend in another 50 years when Sinclair and most of us are dead, & people will say, sad they waisted most of their lives trying not to die.. then they died.
😂
I've been thinking about who you look like?
I found that you look like the angel I saw when I had a cardiac arrest 5 years ago 🧚
as soon as you said ‘I’m forty’ I subscribed and will be studying all your videos cause you look absolutely incredible and I would be thrilled to look as good as you at forty. I’m 22 and I admire you so much
Thank you for the nicest comment ever! I really appreciate it. I can be your big internet sister here. :)
This is so futle, remenber that your body belongs to earth, enjoy living what you need to do
Hi Holly...Whatever you are doing...It is working...You look stunning...I follow Dr Sinclair's work and although i dont like what he is doing regarding NMN and the FDA in America...I do think his work is fascinating and he is worth listening to...
.
I have been taking NMN and various other supplements since January 2023 and definitely feel better for it.
.
Keep up the good work ❤
Thanks, Robert! I'm so happy the NMN and other supplements have been helping you. I too think it's worth listening to or staying up to date on what's going on with his research or other research in health and longevity. I also understand people being skeptical too. :)
6:25 CAPE TOWN! /\/-------------\/\
Wow you look good at 40. Was very shocked when you revealed your age.
Thank you. 🙏
You are what you eat. Your diet impacts your health.
Lower stress, reduce obesity and more exercise are key to a healthy life.
Obesity in children and adults is rising across the world.
Fast food and sugary drinks are contributing to the problem of poor health and obesity.
Eat a healthy plant based diet and exercise regularly.
Reduce or ELIMINATE cows milk, eggs, cheese and meat. Eat more salad greens, beans, fruit and vegetables. Eliminate fast food, snacks like cookies, cakes, chips, and sugary drinks and juices.
Every adult and child should own a bicycle and ride it regularly.
Regular exercise will help you sleep better. Yoga is a great stress reducer.
Obesity is all too common today. Get off the couch. Get off the phone, ipad or video game.
A variety of stretching and other exercises help with increased mobility.
Ride to work, ride to school, ride for fun.
Every city should be a bicycle city.
Speak up for bicycles in your community
The problem with Sinclair is that he always has a financial motive. Since the resveratrol debacle, I take everything he says and does with a serious grain of salt. That said, great video as always, and you certainly don't need any anti-aging drugs yet! 😊
You are stupid if you think anyone that you follow for health advice on social media doesn't have a financial motive. Try booking a visit to your doctor and tell them you need advice and won't pay them. See how far that goes.
Its not a "problem" if it is then suggest how he should finance his research?
I agree, it's a shame
@@1fires1 Apparently you're not aware of his "problematic" history - both professional and financial. You might want to spend five minutes on the Google machine before asking your question...
Why take grains of salt? Bad for heart health.
She shocked me when she said she was 40 since she looks much younger. Maybe she is using those supplemens, most of which I never heard of. But then she got to Calcium AKG which I have been using for about a month. I don't expect miracles since I am 65+, but I have noted a marked increase in sexual desire! Yikes! I also use Urolithin A, not mentioned.
Worrying about aging progress aging
Akg i found extremy efftive and ive tried most things to say the least..
What benefits have you received from using it?
What! You’re 40?! You look like late 20s, 30 years old tops. You are gorgeous! I’m 41 by the way.
You are very nice!!
Valproic Acid is sold over the counter in my country. People refuse to take it, because it lowers the iQ by 5 base points.
What are the benefits of leaving longer while struggling to complete simple task. Something to think about.
Thanks for sharing this. I read some articles about mothers taking it, and their kids having lower IQs, plus some articles about its potential impact on brain volume. No thank you. I will stay away from that!
@@LifeDIYlook into low dose lithium for brain protection and plasticity.
ALL OF HIS VIDEOS ARE RECORDED IN LOW RESOLUTION, ITS COMPLETE BS
Or blurred
Looking great at 40 I'd guess 28!
Thanks!
So I take CaAKG but the bonu blows thru it really quickly
I found the mouse study on it that it was used thru their water source at 10g/L and they recoeved it thruout the day. I am going to disolve it in water and drink throughout the day.
Hospitals, doctors offices and schools should be places where good nutrition is taught and provided not places that contribute to disease and obesity. It is crazy the hospitals are feeding people the very food that caused the heart disease, high blood pressure or cancer that they are treating. Every person in the hospital should receive some nutrition education before being released. Every doctor visit should be an opportunity to educate patients about how food choices impacts their health outcomes. The fact that doctors do not get nutrition training as part of their training makes no sense. Medicare and Medicaid should require nutrition education as part of patient care. Focus should be on food choices. Fasting should be investigated as a treatment for disease.
Lovely 40.
I have been taking M&M and big doses of collagen with lots of other supplements, which I have been taking regularly - which includes NACDPA evening primrose oil, 30000 D3. I used to take chris very true I don’t anymore. I noticed after I used my NMN powder under my tongue. It started getting much quicker results, and at one point I noticed myself great changes - my step got lighter I balanced my weight to the one I was when I was in my 30s….(I am in my 60s now.
I tried using nitric oxide. It didn’t do anything for me didn’t even see any difference in whatever it claims to do.
Thanks for sharing this! I've heard many people say that about taking NMN sublingually - under the tongue - and I do the same when I do take it.
Tried berberine numerous times. Never found it to be good at dropping blood glucose. I don't have diabetes but am super reactive glucose wise and found zero difference using berberine or not.
Thanks for sharing this. That is very interesting. I've found that the one I take does lower my blood glucose and I can't take the stuff at all anymore because I don't need it and the last time I took it I developed low blood sugar issues from it. The one I was taking was called Candibactin BR.
@@LifeDIYthank you I will try it. The supplement that I have had blow my mind is called Thiamax made in UK. Works better for me than NMN but I do use both. I run out of Thiamax I know it. Unfortunately they seem to be sold out everywhere right now. Trying to figure out where I am gonna find it. Will buy a couple bottles next time.
Sinclair..... follow the money, nothing but a paid mouth
❤Very nice to your energy, nice person at all times.
Love your content and delivery
Thank you! 🙏
Nothing stops aging. You will decline in your forties, and by fifty you're old
40? Genuinely in shock.
Wow, thank you!
@@LifeDIY I was actually trying to remember which actress you looked like then you said that! AKG is interesting, will have to read some papers on that. Hope they make an age reversal pill for my cats too though.
@@madcommodore Thank you! I need it for my cats too!
I'm taking CA AKG from DoNotAge. I'm on my 3rd bottle, so 120 days in. I'm taking a bunch of stuff, and I started 2 or 3 other supplements at the same time, so I can't say for sure it was the AKG, but I did notice and improvement in strength and fatigue. I noticed it was easier to do my workout routine.
You'll be wrestling alligators, climbing mountains and bucking broncos in no time.
That is my problem too. I take dozens of supps so when I add something new, like cAKG, I really don't feel any different. I just must assume that it is working. I am 83 so not too much time left for experimentation. I just feel great 90% of the time. I am thankful for guys like David Sinclair who are doing their best to reverse aging, not just slow it down. Hope his new stack is out soon.
@@deanmindock3680 I've only been taking stuff that has clinical trials showing effectiveness, so I'm not too worried about it working or not.
I did actually notice a difference after adding the AKG though. I noticed it was easier to do my weight routine despite having just increased weight. I'm like 90% sure it was the AKG because that is one of its documented effects.
Wow 40 you look 31, I turn 36 this year you are rather beautiful and your voice is super cute :)
Wow, thank you! 🙏
Wow i'm now officially star-struck you replied ! noway ! 😄 how are you? i've seen your videos around from time to time, Few years back i took NMN now I just take nicotinamide, i just downed right now some AAKG & bergamot tea and I feel amazing 😁 i'm currently battling CFS / M.E myself chronic fatigue syndrome . I just started DHEA which makes me feel weird soon to take pregnenolone. how's your day so far? or evening rather?🙂 @@LifeDIY
Thank you! Sorry to hear about the chronic fatigue situation. It's a nightmare. I completely understand it. And my morning is going well so far. It's crisp and cool outside where I live, which makes me think that summer will be over very soon. But, I hope not! I hope you have an amazing day today!🌞
Naww thanks ! 😄 i'm looking forward to Summer ! it's like mid-winter here in the southern hemisphere and i'm recovering from flu. which i found out yesterday might be actually more a flare-up of long standing histamine intolerance. CFS tell me about it, It's Hell primal exhaustion feeling emanating deep from within my bones from the most trivial exercise or an every day daily action. it's nuts. 🙄 and i've still yet to get tested for lyme disease from whence I was on holiday up near Canada. CFS you understand it? about Folinic Acid, B12, anti-histamines & ca-AKG/AAKG is like the only things that have helped me thus far since Coffee no longer works... sigh... 🙄 Mmmm coffee☕😁@@LifeDIY
Supplements:
Magnesium carbonate, Vit.D, taurine, NAC, and fibers.
Recovery:
Inclined Sleep Therapy *free
CPAP
Exercise:
*Rebounder*
Food:
Lean chicken/turkey replaces unhealthy calories
Dentist gum cleaning
-Healthy Old Man
🙌
Lean chicken/turkey? So you're gonna miss out on that tasty healthy skin?
Very solid advice! Maybe some creatine? And K-2 is awesome, too, unless you eat a lot of fermented foods, then you wouldn't need it. Just a friendly suggestion... I am not a doctor, LOL!
Hey Holly, great video, really got me to thinking. I might have to do a similar video, I've been thinking about doing one on AKG for a couple years. Maybe it's time to finally bite the bullet and do it. Thanks.
Thanks, Lance! It's so nice to see you here. It would be great if you did a video on AKG. I know a lot of people are curious about it.
You look like 25 years old
By the way, "infamous" is a negative term reserved for people who are famous because of their evil actions. If you mean he's famous, just say he's famous.
but he has had some controversy though, so she’s not completely wrong…
You look great so you must be doing something right!👍
Thank you, I understand Yamaka factors better and learned something more about aakg that ive been taking for over a month now. ❤❤
Thank you! I'm happy to hear it. :)
So where is the link on what supplements to take for this?
Stupid question, but how do you spell burberine? I'm Dutch, English is not my native language. Love thus video, thank you😊 would love to know what supplements you take and learn about your skincare routine 🙏
Thanks for the nice comment! It's Berberine. I'm going to do an upcoming video really soon on the supplements I take. I am also editing a skincare video right now. I have a lot of skincare videos on my channel too if you want to check out my TCA peel experience, or experience with glycolic peels, etc. I have been doing skincare experiments for almost 10 years and documenting them. I have all of that info and photos on my site here: lifeanddiy.com/before-after-microneedling-dietary-changes-tca-glycolic-peels-10-years/ if you want to check it out too. Thanks! 🙏
He is quite famous by now…😊
You look 20. BTW I'm 71. I'm listening
Wow, thank you. 🙏
I was asked about why I'm not a fan of the good Doctor. We both studied Jeanne Calment since she lived to 122. He found a product to sell, I discovered that her nightly alcohol with meals solubilized partially digested alcohol-solubile amino acids allowing their absorption through the stomach and avoiding uptake by "bad" bacteria in the intestine. It now appears that aging is caused by parasitic bacteria eating your protein groceries. They don't need fatty acids ...so old people can decline and still get fat.
thanks for sharing. random, but i see that you are pharmacist. do you know how to get rid of thrush for good? i think i have a yeast problem everywhere after using amoxicillin very briefly for u know what (starting with C).
@@partdeux992 Thanks for your confidence. I have heard that the infection we're talking about has lately been reevaluated. You may need to have this worked up. Good luck
@@roryblake7311 thx for your reply. lately been reevaluated" could u elaborate just a little more?
@@Rileyed you sound angry. are you ok?
So alcohol does clean the upper part of the intestines and lowers endotoxin load?
I love when your videos pop up :) Another good one and super-useful
Thank you!
DIY cocktail improves eyes sight within one week of beetroots juice + apple cider vinegar + Himalayan salt. It works for me and friends, so it will for others as well. Mixing with orange juice is easy to drink. Help the world to see better, tell the world.🌎🌎🌏
AKG induced age reversal is uncertain. The DNA 'methylation clock' used only 13 methyl locations, not hundreds of thousands as would be appropriate and is common elsewhere. Dodgy?
Thank you for pointing this out. When I have time, I'd like to dive into any research on it and share these very important details in a video.
My impression is it might be synergistic with another component in the cocktail. Still too soon for my personal experimentation
Youre 40? I guessed 25.
Definitely interesting as I know and have seen D Sinclair videos for a few years now
I have been taking a monthly product for removing senescent cells.
Thanks for Sharing
40? you look amazing :)
Do you care about the ingredients in skincare, makeup and food? I use Yuka to check and won’t put anything in or on my body that doesn’t have a good ✅ or excellent rating.
Im a law enforcement officer and I have to take random drug tests, are these legal supplements? I can be fired if they show up on my blood test an illegal substances
Wow had no idea you are 40 , you look great ! I'm sure you have already done this but how about a video of your routine & supplements.. thank you ❤
Thanks, Joe! I am planning on doing that type of video coming up. 🙏
@@LifeDIY thank you, I really would enjoy watching that , I want to know what your taking because you look phenomenal! Can't wait thank you Holly ❤
Thank you Joe! 🙏
Absolutely gorgeous
You look great
I love your content! Do you an updated video or place you can direct me to with your supplement routine?
I'll try to do a video on this soon. Thank you!
You must be doing something right because you look good for a 40 year old woman!
I just want to be the age or health to have someone like you in my life to share and have a healthy lifestyle after 15 years of dealing with LYme ,. Thank God Im recovering and restoring and learned about herbal treatments like the burner protocal and supplements to heal and how nutirtian is medicine or poison
Thank you. I am really sorry to hear about the chronic Lyme. I know that is a nightmare and a daily struggle. I hope you continue to get better and better every day. I know some people who have had great health improvements with keto or carnivore.
@@LifeDIY yes my first step was to address nutrition as medicine and God led me to things consecutively, he has healed me and now I'm able to help and direct others and give them support. Thank YOu for your reply. Keto is basically what I developed into before they called it keto. all illnesses is dealing with inflammation and we aren't even dealing with the same food now as before. Intermittent fasting is also a very good thing to help us heal
❤❤❤ Love your content and videos. And... The presenter is devine. 😉 Gratzi!
PS: How are you fairing since your initial health dilemma? Did you ever find out what the cause was? Did you consider a polymicrobial cause, or do you think that it was (maybe still is) primarily immune system disregulation from environmental toxins such as mold, heavy metals, and/or chemicals?
Take care.
MM
Thanks, Michael! Such a nice comment. I think you're referring to an array of health problems I had years ago. I talked about it in some past videos. I had carbon monoxide poisoning over 10 years ago and since then - during the poisoning and right after, I developed a slew of problems. I had been poisoned for close to 7 months. I'll share more details in a video someday. I am glad it wasn't my time to leave this Earth because that could have happened! I am happy to be alive and I am doing pretty well now, thank you. :))
@@LifeDIY And you are paying it forward. Thank you!!!💓
❤❤❤❤
Absolutely gorgeous!
How can you reverse upper eyelid exposure like hollowness where the upper eyelid fat just suddenly disappear 😢
The timing on all this with Sinclair is interesting. As for me, I don't trust this guy one bit. What happened to the MNM debacle I wonder? He was exposed on that issue so now he's into something else? I just think it's odd.
What is NMN debacle? I am new. Could you please help with more info. I will appreciate.
I have been taking CA-AKG for about 6 months. I plan to continue until research or my own experience says otherwise.
Thanks for sharing this. Have you noticed anything while taking it?
@@LifeDIY I want to think a little less gray in my beard. However I'm on a witches brew of supplements it's hard to say. Something is working because I'm 49 and everyone thinks I'm 35. I love your hair by the way it's beautiful.
I also noted a darkening of my facial hair and eyebrows from CaAKG.
@@LifeDIYI’ve noticed increase in libido
How about NMN ? is it by Dr Sinclair and looks like it is forgotten now.
Absolutely fascinating.