If you like our content please consider joining our patreon group patreon.com/ModernHealthspan Wellness Extract 10% discount Code MODERNWE Geranylgeraniol Essential wellnessextract.com/RICHARDWE Delta Gold Vit E Renue By Science 10% : Code MHS tinyurl.com/35jyuk33 CoQ10 bit.ly/4bX3I6P, Hyaluronic Acid tinyurl.com/2u849um4, NMN tinyurl.com/3wr8pr3t DoNotAge 10% discount code MHS tinyurl.com/6dbvhv87 March Bundle (NMN, Resveratrol, TMG) tinyurl.com/2jhw4c2n, NMN tinyurl.com/wyzj2f3d Nuchido Time+ 20% discount of first purchase with code MODERN20 nuchido.com/MODERN NMN Bio 10% off all products tinyurl.com/2af2v2fw Code ModernHealthSpan10 in link ☕If you would like to support our channel, we’d love a coffee…thank you! www.buymeacoffee.com/mhealthspan
My understanding is MK-7 can be easily broken down (catabolized) by our body into the MK-4 form as MK-4 is just a shorter carbon chain. It does not work the other way around that MK-4 can be expanded to become MK-7 and there is likely no need since the body uses MK-4 for processes. That said, the MK-7 form is a much larger molecule so it stays in the bloodstream longer and that gives it more time to decalcify the arteries while MK-4 lasts just 10 hours in the blood. This is why MK-7 is supposed to be better.
Whenever I take MK4, after half an hour or an hour I hear clicks and noises from the bones, mainly in the shoulders and fingers. I don't know why it's like this but it shouldn't be like this. Maybe MK4 removes/redirects/cleans too much calcium from soft tissue. when i take mk7 this is not happening. i think: with MK7 I feel a very slight strange sensation in my chest, a slightly increased heartbeat.
I just received my purchase of MK4 yesterday after hearing Dr. Barrie Tan's previous presentations on GG. For me, MK7 does help my knee joints and I'm in my mid-fifties. I plan to alternate between the two as my initial approach to inserting MK4 in my supplementation routine.
Hi Armando, thanks for sharing. Sounds good. My understanding from Dr Tan was that MK7 would also work as well. Though the area does not seem to be well understood, and I have not seen a reason why we only create MK4 internally.
Whenever I take MK4, after half an hour or an hour I hear clicks and noises from the bones, mainly in the shoulders and fingers. I don't know why it's like this but it shouldn't be like this. Maybe MK4 removes/redirects/cleans too much calcium from soft tissue. when i take mk7 this is not happening. i think: with MK7 I feel a very slight strange sensation in my chest, a slightly increased heartbeat.
It's like you are just starting to learn about things like Geranylgeranylation and Sumoylation like it's something new. Longevity community is an endless source of amusement to me.
@AT-xl9db Yes, but take it at night before bed and hope it wears off by the time you wake. MTor drives muscle growth as part of a proinflammatory growth phase during the day. Rapamycin supresses Mtor, so it will compromise muscle growth, but it will put you in a anti inflammatory repair phase, which usually takes place during sleep. Should use it to lean into the anti-inflammatory repair phase at night, with all the melatonin and adenosine, NADp and NADPh from the day night phosphorus shuffle of NAD+ to NADp. It will boost lifespan by boosting cellular repair but will lower lifespan via compromised muscle production. Double-edged sword. Rapamycin should only be used if you know what you're doing.
Thank you! Yes, I am, too, concerned about muscle loss, I am very lean and muscular…will have to time my HIIT after half-life decay, which is about 60 hours for Rapamycin…also limit methionine…thank you so much again, this was very helpful 😊🙏
Hi Carol, thanks for your comment. I don't think that Dr Tan's point was that MK7 is not effective. Nearly all the supplements that I can see on the market are based on MK7. I think he is pointing out that internally we make MK4 and you can raise your K2 naturally with veges (for K1) and GG.
You may be right. Only reason mk-7 is preferred is that it lasts longer than mk-4, but due to longer tail (3 units more than mk-4). Thus its reaction is accordingly much slower than that of mk-4. In opposite sense, mk-4 is more effective than mk-7. Now brand sells mk-4, quite cheap compared to the mk-7 version.😊
If you like our content please consider joining our patreon group patreon.com/ModernHealthspan
Wellness Extract 10% discount Code MODERNWE Geranylgeraniol Essential wellnessextract.com/RICHARDWE Delta Gold Vit E
Renue By Science 10% : Code MHS tinyurl.com/35jyuk33 CoQ10 bit.ly/4bX3I6P, Hyaluronic Acid tinyurl.com/2u849um4, NMN tinyurl.com/3wr8pr3t
DoNotAge 10% discount code MHS tinyurl.com/6dbvhv87 March Bundle (NMN, Resveratrol, TMG) tinyurl.com/2jhw4c2n,
NMN tinyurl.com/wyzj2f3d
Nuchido Time+ 20% discount of first purchase with code MODERN20 nuchido.com/MODERN
NMN Bio 10% off all products tinyurl.com/2af2v2fw Code ModernHealthSpan10 in link
☕If you would like to support our channel, we’d love a coffee…thank you! www.buymeacoffee.com/mhealthspan
Hi there, great video, very easy to understand. The discount code doesn't work.
Mk4 also stimulates pancreatic beta cells. May be useful on diabetes.
My understanding is MK-7 can be easily broken down (catabolized) by our body into the MK-4 form as MK-4 is just a shorter carbon chain. It does not work the other way around that MK-4 can be expanded to become MK-7 and there is likely no need since the body uses MK-4 for processes. That said, the MK-7 form is a much larger molecule so it stays in the bloodstream longer and that gives it more time to decalcify the arteries while MK-4 lasts just 10 hours in the blood. This is why MK-7 is supposed to be better.
I think it more probable that the body doesn't use MK7 otherwise it would be absorbed quickly like MK4.
Such a great explanation of the MK4 vs MK7 question. I have finally sourced an MK4 supplement.
From where you got mk4
Neither host or guests ever look younger than their biological age.
For your info., Dr.Tan is Already 108 years old even though he looks 70.
We ornamentals don't age much, until expired...😅
Yes. How to believe in what these guys say as they themselves look much older than their age Or they DO NOT look younger than their age at all!?
If human able to make MK4, then one should supplement MK7 only.
MK7 is made and used by the microbiome. Eat fermented foods to feed them.
Whenever I take MK4, after half an hour or an hour I hear clicks and noises from the bones, mainly in the shoulders and fingers.
I don't know why it's like this but it shouldn't be like this. Maybe MK4 removes/redirects/cleans too much calcium from soft tissue.
when i take mk7 this is not happening.
i think: with MK7 I feel a very slight strange sensation in my chest, a slightly increased heartbeat.
I just received my purchase of MK4 yesterday after hearing Dr. Barrie Tan's previous presentations on GG. For me, MK7 does help my knee joints and I'm in my mid-fifties. I plan to alternate between the two as my initial approach to inserting MK4 in my supplementation routine.
Hi Armando, thanks for sharing. Sounds good. My understanding from Dr Tan was that MK7 would also work as well. Though the area does not seem to be well understood, and I have not seen a reason why we only create MK4 internally.
Whenever I take MK4, after half an hour or an hour I hear clicks and noises from the bones, mainly in the shoulders and fingers.
I don't know why it's like this but it shouldn't be like this. Maybe MK4 removes/redirects/cleans too much calcium from soft tissue.
when i take mk7 this is not happening.
i think: with MK7 I feel a very slight strange sensation in my chest, a slightly increased heartbeat.
What exactly should we be taking for bone strength?
So if I eat a lot of MK4 I am all ready a step ahead.
Thank You for this video
Please do a video (deep dive summary of different supplements and diet or/and interview) osteoarthritis 🤞🏻🙏🙏🙏
Hi thanks for the suggestion. It is indeed an important topic. Let me see what I can find on it or if there is a good person to talk to.
It's like you are just starting to learn about things like Geranylgeranylation and Sumoylation like it's something new.
Longevity community is an endless source of amusement to me.
Do u think taking Rapamycin midlife makes sense? I know you are very knowledgeable….😊🙏just got the script, 48 yo, female.
@AT-xl9db Yes, but take it at night before bed and hope it wears off by the time you wake.
MTor drives muscle growth as part of a proinflammatory growth phase during the day.
Rapamycin supresses Mtor, so it will compromise muscle growth, but it will put you in a anti inflammatory repair phase, which usually takes place during sleep.
Should use it to lean into the anti-inflammatory repair phase at night, with all the melatonin and adenosine, NADp and NADPh from the day night phosphorus shuffle of NAD+ to NADp.
It will boost lifespan by boosting cellular repair but will lower lifespan via compromised muscle production. Double-edged sword.
Rapamycin should only be used if you know what you're doing.
Thank you! Yes, I am, too, concerned about muscle loss, I am very lean and muscular…will have to time my HIIT after half-life decay, which is about 60 hours for Rapamycin…also limit methionine…thank you so much again, this was very helpful 😊🙏
Thanks Richard.
Hi Ron, thanks!
Awesome
Oh dear, and I use mk7 only! I've got much thinking to do.
Any headaches while at it in higher doses?
Hi Carol, thanks for your comment. I don't think that Dr Tan's point was that MK7 is not effective. Nearly all the supplements that I can see on the market are based on MK7. I think he is pointing out that internally we make MK4 and you can raise your K2 naturally with veges (for K1) and GG.
You may be right. Only reason mk-7 is preferred is that it lasts longer than mk-4, but due to longer tail (3 units more than mk-4). Thus its reaction is accordingly much slower than that of mk-4. In opposite sense, mk-4 is more effective than mk-7.
Now brand sells mk-4, quite cheap compared to the mk-7 version.😊
Awesomeness! Next stop? GG and PQQ?
Hi Thanks for your comment. We talked about GG and Ubiquinol a bit earlier. I don't think that he discusses it again. Sorry!
@ModernHealthspan I meant pqq, there's some overlap in steroidal effects, but I was wrong on assuming gg being involved perhaps